Hederagenin Induces Apoptosis in Cisplatin-Resistant Head and Neck Cancer Cells by Inhibiting the Nrf2-ARE Antioxidant Pathway

Hederagenin and α-hederin promote degradation of proteins in neurodegenerative diseases and improve motor deficits in MPTP-mice

(2017) An-Guo Wu et al.   PHARMACOLOGICAL RESEARCH

Hederagenin Supplementation Alleviates the Pro-Inflammatory and Apoptotic Response to Alcohol in Rats

(2017) Gyeong-Ji Kim et al.   Nutrients

Targeting Nrf2 with wogonin overcomes cisplatin resistance in head and neck cancer

(2016) Eun Hye Kim et al.   APOPTOSIS

Follow-up in Head and Neck Cancer: Do More Does It Mean Do Better? A Systematic Review and Our Proposal Based on Our Experience

(2016) Nerina Denaro et al.   Clinical and Experimental Otorhinolaryngology

Trends in Head and Neck Cancer in South Korea Between 1999 and 2012

(2016) Jeffrey D. Suh et al.   Clinical and Experimental Otorhinolaryngology

Cytoplasmic localization of Nrf2 promotes colorectal cancer with more aggressive tumors via upregulation of PSMD4

(2016) Po-Lin Lin et al.   FREE RADICAL BIOLOGY AND MEDICINE

Global cancer statistics, 2012

(2015) Lindsey A. Torre et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Tumor Regression Patterns Based on Follow-up Duration in Patients With Head and Neck Squamous Cell Carcinoma Treated With Radiotherapy or Chemoradiotherapy

(2015) Moonkyoo Kong et al.   Clinical and Experimental Otorhinolaryngology

Hederagenin as a triterpene template for the development of new antitumor compounds

(2015) Diego Rodríguez-Hernández et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Bioassay Guided Fractionation Identified Hederagenin as a Major Cytotoxic Agent from Cyclocarya paliurus Leaves

(2015) Ying Gao et al.   PLANTA MEDICA

Piperlongumine selectively kills cancer cells and increases cisplatin antitumor activity in head and neck cancer

(2015) Jong-Lyel Roh et al.   Oncotarget

Targeting antioxidants for cancer therapy

(2014) Andrea Glasauer et al.   BIOCHEMICAL PHARMACOLOGY

Hederagenin from the leaves of ivy (Hedera helix L.) induces apoptosis in human LoVo colon cells through the mitochondrial pathway

(2014) Bao-Xin-Zi Liu et al.   BMC Complementary and Alternative Medicine

Concomitant platinum-based chemotherapy or cetuximab with radiotherapy for locally advanced head and neck cancer: A systematic review and meta-analysis of published studies

(2014) Fausto Petrelli et al.   ORAL ONCOLOGY

The Nrf2 regulatory network provides an interface between redox and intermediary metabolism

(2014) John D. Hayes et al.   TRENDS IN BIOCHEMICAL SCIENCES

Systems biology of cisplatin resistance: past, present and future

(2014) L Galluzzi et al.   Cell Death & Disease

Modulation of oxidative stress as an anticancer strategy

(2013) Chiara Gorrini et al.   NATURE REVIEWS DRUG DISCOVERY

Roles of Keap1-Nrf2 System in Upper Aerodigestive Tract Carcinogenesis

(2012) A. Ohkoshi et al.   Cancer Prevention Research

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis

(2011) Gina M. DeNicola et al.   NATURE

Selective killing of cancer cells by a small molecule targeting the stress response to ROS

(2011) Lakshmi Raj et al.   NATURE

Nrf2 and Keap1 Abnormalities in Non-Small Cell Lung Carcinoma and Association with Clinicopathologic Features

(2010) L. M. Solis et al.   CLINICAL CANCER RESEARCH

Nrf2 Enhances Cell Proliferation and Resistance to Anticancer Drugs in Human Lung Cancer

(2009) S. Homma et al.   CLINICAL CANCER RESEARCH

Macranthoside B, a hederagenin saponin extracted from Lonicera macranthoides and its anti-tumor activities in vitro and in vivo

(2009) Jia Wang et al.   FOOD AND CHEMICAL TOXICOLOGY

Association of reactive oxygen species levels and radioresistance in cancer stem cells

(2009) Maximilian Diehn et al.   NATURE

Loss of Keap1 Function Activates Nrf2 and Provides Advantages for Lung Cancer Cell Growth

(2008) T. Ohta et al.   CANCER RESEARCH

Nrf2 enhances resistance of cancer cells to chemotherapeutic drugs, the dark side of Nrf2

(2008) X.-J. Wang et al.   CARCINOGENESIS

Head and neck cancer

(2008) Athanassios Argiris et al.   LANCET

Recent Advances in Head and Neck Cancer

(2008) Robert I. Haddad et al.   NEW ENGLAND JOURNAL OF MEDICINE

Role of the Nrf2-antioxidant system in cytotoxicity mediated by anticancer cisplatin: Implication to cancer cell resistance

(2007) Jeong-Min Cho et al.   CANCER LETTERS