Trisubstituted-Imidazoles Induce Apoptosis in Human Breast Cancer Cells by Targeting the Oncogenic PI3K/Akt/mTOR Signaling Pathway

Adamantyl-tethered-biphenylic compounds induce apoptosis in cancer cells by targeting Bcl homologs

(2016) Sebastian Anusha et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis of 1,2-benzisoxazole tethered 1,2,3-triazoles that exhibit anticancer activity in acute myeloid leukemia cell lines by inhibiting histone deacetylases, and inducing p21 and tubulin acetylation

(2015) Nanjundaswamy Ashwini et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Novel synthetic coumarins that targets NF-κB in Hepatocellular carcinoma

(2015) Mahabaleshwaraiah Neelgundmath et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Microwave-assisted synthesis, characterization and cytotoxic studies of novel estrogen receptor α ligands towards human breast cancer cells

(2015) Hanumantharayappa Bharathkumar et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Novel synthetic bisbenzimidazole that targets angiogenesis in Ehrlich ascites carcinoma bearing mice

(2015) Rangaswamy Roopashree et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Signaling through the Phosphatidylinositol 3-Kinase (PI3K)/Mammalian Target of Rapamycin (mTOR) Axis Is Responsible for Aerobic Glycolysis mediated by Glucose Transporter in Epidermal Growth Factor Receptor (EGFR)-mutated Lung Adenocarcinoma

(2015) Hideki Makinoshima et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular Events Linking Oxidative Stress and Inflammation to Insulin Resistance andβ-Cell Dysfunction

(2015) Kevin Noel Keane et al.   Oxidative Medicine and Cellular Longevity

Target prediction utilising negative bioactivity data covering large chemical space

(2015) Lewis H. Mervin et al.   Journal of Cheminformatics

Development of a Novel Azaspirane That Targets the Janus Kinase-Signal Transducer and Activator of Transcription (STAT) Pathway in Hepatocellular Carcinomain Vitroandin Vivo

(2014) Chakrabhavi Dhananjaya Mohan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Novel Synthetic Biscoumarins Target Tumor Necrosis Factor-α in Hepatocellular Carcinomain Vitroandin Vivo

(2014) Hosadurga Kumar Keerthy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A New Ibuprofen Derivative Inhibits Platelet Aggregation and ROS Mediated Platelet Apoptosis

(2014) Kodagahalli S. Rakesh et al.   PLoS One

CXCL12-CXCR4 axis promotes the natural selection of breast cancer cell metastasis

(2014) Yanan Sun et al.   TUMOR BIOLOGY

Emodin inhibits growth and induces apoptosis in an orthotopic hepatocellular carcinoma model by blocking activation of STAT3

(2013) Aruljothi Subramaniam et al.   BRITISH JOURNAL OF PHARMACOLOGY

Induction of Apoptosis by 4-(3-(tert-butylamino)imidazo[1,2-α]pyridine-2-yl) Benzoic Acid in Breast Cancer Cells via Upregulation of PTEN

(2013) Sumit Siddharth et al.   ONCOLOGY RESEARCH

CG0009, a Novel Glycogen Synthase Kinase 3 Inhibitor, Induces Cell Death through Cyclin D1 Depletion in Breast Cancer Cells

(2013) Hyun Mi Kim et al.   PLoS One

Embelin inhibits growth and induces apoptosis through the suppression of Akt/mTOR/S6K1 signaling cascades

(2012) Seong Won Kim et al.   PROSTATE

Celastrol inhibits tumor cell proliferation and promotes apoptosis through the activation of c-Jun N-terminal kinase and suppression of PI3 K/Akt signaling pathways

(2011) Radhamani Kannaiyan et al.   APOPTOSIS

β-Caryophyllene oxide inhibits growth and induces apoptosis through the suppression of PI3K/AKT/mTOR/S6K1 pathways and ROS-mediated MAPKs activation

(2011) Kyung-Ran Park et al.   CANCER LETTERS

N-Fused Imidazoles As Novel Anticancer Agents That Inhibit Catalytic Activity of Topoisomerase IIα and Induce Apoptosis in G1/S Phase

(2011) Ashish T. Baviskar et al.   JOURNAL OF MEDICINAL CHEMISTRY

ChEMBL: a large-scale bioactivity database for drug discovery

(2011) A. Gaulton et al.   NUCLEIC ACIDS RESEARCH

Dual Targeting of the Insulin-Like Growth Factor and Collateral Pathways in Cancer: Combating Drug Resistance

(2011) Joseph A. Ludwig et al.   Cancers

Deciphering the Role of PI3K/Akt/mTOR Pathway in Breast Cancer Biology and Pathogenesis

(2010) Priscilla F. McAuliffe et al.   Clinical Breast Cancer

Expanding therapeutic targets in bladder cancer: the PI3K/Akt/mTOR pathway

(2010) Christina Barbara Ching et al.   LABORATORY INVESTIGATION

The role of signaling pathways in the development and treatment of hepatocellular carcinoma

(2010) S Whittaker et al.   ONCOGENE

Targeting the PI3K/AKT/mTOR signaling network in acute myelogenous leukemia

(2009) Alberto M Martelli et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Targeting the phosphoinositide 3-kinase pathway in cancer

(2009) Pixu Liu et al.   NATURE REVIEWS DRUG DISCOVERY

PubChem: a public information system for analyzing bioactivities of small molecules

(2009) Y. Wang et al.   NUCLEIC ACIDS RESEARCH

Synthesis of 4,5-Substituted Imidazoles by a Fast Condensation of 1,2-Diketones and Urotropine in Heterogeneous Medium

(2009) George Bratulescu   SYNTHESIS-STUTTGART

Targeting the PI3K–AKT–mTOR pathway: progress, pitfalls, and promises

(2008) Timothy A Yap et al.   CURRENT OPINION IN PHARMACOLOGY

Targeting the PI3K/Akt/mTOR pathway: Effective combinations and clinical considerations

(2008) J LOPICCOLO et al.   DRUG RESISTANCE UPDATES

Protonate3D: Assignment of ionization states and hydrogen coordinates to macromolecular structures

(2008) Paul Labute   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Synthesis, characterization and evaluation of benzimidazole derivative and its precursors as inhibitors of MDA-MB-231 human breast cancer cell proliferation

(2007) N.R. Thimmegowda et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS