Intricate role of mitochondrial lipid in mitophagy and mitochondrial apoptosis: its implication in cancer therapeutics

The role of cardiolipin in promoting the membrane pore-forming activity of BAX oligomers

(2018) Yei-Chen Lai et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

PUMA dependent mitophagy by Abrus agglutinin contributes to apoptosis through ceramide generation

(2018) Prashanta Kumar Panda et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

(2018) Lorenzo Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

Pleckstrin homology domain of p210 BCR-ABL interacts with cardiolipin to regulate its mitochondrial translocation and subsequent mitophagy

(2017) Kentaro Shimasaki et al.   GENES TO CELLS

Cardiolipin Regulates Mitophagy through the Protein Kinase C Pathway

(2017) Zheni Shen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Cytotoxic Action of Cytochrome C/Cardiolipin Nanocomplex (Cyt-CL) on Cancer Cells in Culture

(2017) Yury A. Vladimirov et al.   PHARMACEUTICAL RESEARCH

Sphingosine kinase 2 activates autophagy and protects neurons against ischemic injury through interaction with Bcl-2 via its putative BH3 domain

(2017) Dan-Dan Song et al.   Cell Death & Disease

Human Atg8-cardiolipin interactions in mitophagy: Specific properties of LC3B, GABARAPL2 and GABARAP

(2016) Zuriñe Antón et al.   Autophagy

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

(2016) Daniel J Klionsky et al.   Autophagy

Targeting FLT3-ITD signaling mediates ceramide-dependent mitophagy and attenuates drug resistance in AML

(2016) Mohammed Dany et al.   BLOOD

NDPK-D (NM23-H4)-mediated externalization of cardiolipin enables elimination of depolarized mitochondria by mitophagy

(2016) V E Kagan et al.   CELL DEATH AND DIFFERENTIATION

Diverting CERT-mediated ceramide transport to mitochondria triggers Bax-dependent apoptosis

(2016) Amrita Jain et al.   JOURNAL OF CELL SCIENCE

High levels of sphingolipids in human breast cancer

(2016) Masayuki Nagahashi et al.   JOURNAL OF SURGICAL RESEARCH

Sphingosine kinase 2 promotes colorectal cancer cell proliferation and invasion by enhancing MYC expression

(2016) Lan Zhang et al.   TUMOR BIOLOGY

Intramembrane protease PARL defines a negative regulator of PINK1- and PARK2/Parkin-dependent mitophagy

(2015) Cathrin Meissner et al.   Autophagy

Cardiolipin remodeling by TAZ/tafazzin is selectively required for the initiation of mitophagy

(2015) Paul Hsu et al.   Autophagy

Ceramide induced mitophagy and tumor suppression

(2015) Mohammed Dany et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Emerging therapeutic drugs for AML

(2015) E. M. Stein et al.   BLOOD

Mitochondrial apoptosis: killing cancer using the enemy within

(2015) J Lopez et al.   BRITISH JOURNAL OF CANCER

Tumor Necrosis Factor-α (TNFα)-induced Ceramide Generation via Ceramide Synthases Regulates Loss of Focal Adhesion Kinase (FAK) and Programmed Cell Death

(2015) María José Hernández-Corbacho et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Sphingosine Kinase 2 Inhibitor ABC294640 Reduces the Growth of Prostate Cancer Cells and Results in Accumulation of Dihydroceramides In Vitro and In Vivo

(2015) H. Venant et al.   MOLECULAR CANCER THERAPEUTICS

Bcl-2-like protein 13 is a mammalian Atg32 homologue that mediates mitophagy and mitochondrial fragmentation

(2015) Tomokazu Murakawa et al.   Nature Communications

LC3 binds externalized cardiolipin on injured mitochondria to signal mitophagy in neurons

(2014) Charleen T Chu et al.   Autophagy

Stress-induced ceramide generation and apoptosis via the phosphorylation and activation of nSMase1 by JNK signaling

(2014) T Yabu et al.   CELL DEATH AND DIFFERENTIATION

AMBRA1 is able to induce mitophagy via LC3 binding, regardless of PARKIN and p62/SQSTM1

(2014) F Strappazzon et al.   CELL DEATH AND DIFFERENTIATION

Mitochondrial cardiolipin/phospholipid trafficking: The role of membrane contact site complexes and lipid transfer proteins

(2014) Uwe Schlattner et al.   CHEMISTRY AND PHYSICS OF LIPIDS

PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity

(2014) Lesley A. Kane et al.   JOURNAL OF CELL BIOLOGY

Ubiquitin is phosphorylated by PINK1 to activate parkin

(2014) Fumika Koyano et al.   NATURE

Metabolism and function of mitochondrial cardiolipin

(2014) Mindong Ren et al.   PROGRESS IN LIPID RESEARCH

Phospholipid Synthesis and Transport in Mammalian Cells

(2014) Jean E. Vance   TRAFFIC

PINK1 is degraded through the N-end rule pathway

(2013) Koji Yamano et al.   Autophagy

BAK activation is necessary and sufficient to drive ceramide synthase-dependent ceramide accumulation following inhibition of BCL2-like proteins

(2013) Levi J. Beverly et al.   BIOCHEMICAL JOURNAL

Role of Lysines in Cytochrome c–Cardiolipin Interaction

(2013) Federica Sinibaldi et al.   BIOCHEMISTRY

Involvement of cardiolipin in tBID-induced activation of BAX during apoptosis

(2013) Etienne Raemy et al.   CHEMISTRY AND PHYSICS OF LIPIDS

tBid Undergoes Multiple Conformational Changes at the Membrane Required for Bax Activation

(2013) Aisha Shamas-Din et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeting the apoptosis pathway in hematologic malignancies

(2013) Shadia Zaman et al.   LEUKEMIA & LYMPHOMA

Delivery of Chemically Glycosylated Cytochrome c Immobilized in Mesoporous Silica Nanoparticles Induces Apoptosis in HeLa Cancer Cells

(2013) Jessica Méndez et al.   MOLECULAR PHARMACEUTICS

Cardiolipin externalization to the outer mitochondrial membrane acts as an elimination signal for mitophagy in neuronal cells

(2013) Charleen T. Chu et al.   NATURE CELL BIOLOGY

Biological Characterization of 3-(2-amino-ethyl)-5-[3-(4-butoxyl-phenyl)-propylidene]-thiazolidine-2,4-dione (K145) as a Selective Sphingosine Kinase-2 Inhibitor and Anticancer Agent

(2013) Kai Liu et al.   PLoS One

Downregulation of the Mitochondrial Phosphatase PTPMT1 Is Sufficient to Promote Cancer Cell Death

(2013) Natalie M. Niemi et al.   PLoS One

Lipids of mitochondria

(2013) Susanne E. Horvath et al.   PROGRESS IN LIPID RESEARCH

Identification of cardiolipin binding sites on cytochrome c oxidase at the entrance of proton channels

(2013) C. Arnarez et al.   Scientific Reports

Ceramide synthases at the centre of sphingolipid metabolism and biology

(2012) Thomas D. Mullen et al.   BIOCHEMICAL JOURNAL

The targeted intracellular delivery of cytochrome C protein to tumors using lipid-apolipoprotein nanoparticles

(2012) Sang Kyoon Kim et al.   BIOMATERIALS

Sphingolipid Metabolism Cooperates with BAK and BAX to Promote the Mitochondrial Pathway of Apoptosis

(2012) Jerry E. Chipuk et al.   CELL

The pathways of mitophagy for quality control and clearance of mitochondria

(2012) G Ashrafi et al.   CELL DEATH AND DIFFERENTIATION

Mitochondria and Mitophagy

(2012) Dieter A. Kubli et al.   CIRCULATION RESEARCH

Apoptosis and Human Diseases: Mitochondrion Damage and Lethal Role of Released Cytochrome c as Proapoptotic Protein

(2012) P. Caroppi et al.   CURRENT MEDICINAL CHEMISTRY

Ceramide-Antiestrogen Nanoliposomal Combinations--Novel Impact of Hormonal Therapy in Hormone-Insensitive Breast Cancer

(2012) S. A. F. Morad et al.   MOLECULAR CANCER THERAPEUTICS

Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cells

(2012) Lei Liu et al.   NATURE CELL BIOLOGY

Ceramide targets autophagosomes to mitochondria and induces lethal mitophagy

(2012) R David Sentelle et al.   Nature Chemical Biology

Lipid packing variations induced by pH in cardiolipin-containing bilayers: The driving force for the cristae-like shape instability

(2011) Nada Khalifat et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

C6-Ceramide and targeted inhibition of acid ceramidase induce synergistic decreases in breast cancer cell growth

(2011) Margaret Flowers et al.   BREAST CANCER RESEARCH AND TREATMENT

Novel Pathway of Ceramide Production in Mitochondria

(2011) Sergei A. Novgorodov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The multiple functions of cytochrome c and their regulation in life and death decisions of the mammalian cell: From respiration to apoptosis

(2011) Maik Hüttemann et al.   MITOCHONDRION

Mitochondrial Ceramide-Rich Macrodomains Functionalize Bax upon Irradiation

(2011) Hyunmi Lee et al.   PLoS One

Tubular network formation protects mitochondria from autophagosomal degradation during nutrient starvation

(2011) A. S. Rambold et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sphingosine-1-phosphate signaling and its role in disease

(2011) Michael Maceyka et al.   TRENDS IN CELL BIOLOGY

Ceramide and activated Bax act synergistically to permeabilize the mitochondrial outer membrane

(2010) Vidyaramanan Ganesan et al.   APOPTOSIS

Bnip3-mediated mitochondrial autophagy is independent of the mitochondrial permeability transition pore

(2010) Melissa N. Quinsay et al.   Autophagy

Combined anticancer effects of sphingosine kinase inhibitors and sorafenib

(2010) Vladimir Beljanski et al.   INVESTIGATIONAL NEW DRUGS

Developmentally Regulated Ceramide Synthase 6 Increases Mitochondrial Ca2+Loading Capacity and Promotes Apoptosis

(2010) Sergei A. Novgorodov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial membrane potential regulates PINK1 import and proteolytic destabilization by PARL

(2010) Seok Min Jin et al.   JOURNAL OF CELL BIOLOGY

Mitochondria and cell death: outer membrane permeabilization and beyond

(2010) Stephen W. G. Tait et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Inhibition of acid ceramidase by a 2-substituted aminoethanol amide synergistically sensitizes prostate cancer cells to N-(4-hydroxyphenyl) retinamide

(2010) Valérie Gouazé-Andersson et al.   PROSTATE

Nix is a selective autophagy receptor for mitochondrial clearance

(2009) Ivana Novak et al.   EMBO REPORTS

Targeting the sphingolipid metabolism to defeat pancreatic cancer cell resistance to the chemotherapeutic gemcitabine drug

(2009) J. Guillermet-Guibert et al.   MOLECULAR CANCER THERAPEUTICS

Combining Nanoliposomal Ceramide with Sorafenib Synergistically Inhibits Melanoma and Breast Cancer Cell Survival to Decrease Tumor Development

(2008) M. A. Tran et al.   CLINICAL CANCER RESEARCH

Anti-apoptotic Bcl-2 Family Proteins Disassemble Ceramide Channels

(2008) Leah J. Siskind et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

(2008) Derek Narendra et al.   JOURNAL OF CELL BIOLOGY

Update of the LIPID MAPS comprehensive classification system for lipids

(2008) Eoin Fahy et al.   JOURNAL OF LIPID RESEARCH

Membrane lipids: where they are and how they behave

(2008) Gerrit van Meer et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Ceramide Biogenesis Is Required for Radiation-Induced Apoptosis in the Germ Line of C. elegans

(2008) X. Deng et al.   SCIENCE

Ceramide induces p38 MAPK-dependent apoptosis and Bax translocation via inhibition of Akt in HL-60 cells

(2007) Hae Jong Kim et al.   CANCER LETTERS