Isodeoxyelephantopin Inactivates Thioredoxin Reductase 1 and Activates ROS-Mediated JNK Signaling Pathway to Exacerbate Cisplatin Effectiveness in Human Colon Cancer Cells

Sanguinarine as a new chemical entity of thioredoxin reductase inhibitor to elicit oxidative stress and promote tumor cell apoptosis

(2020) Juan Yao et al.   FREE RADICAL BIOLOGY AND MEDICINE

Potent inhibition of gastric cancer cells by a natural compound via inhibiting TrxR1 activity and activating ROS-mediated p38 MAPK pathway

(2019) Wei He et al.   FREE RADICAL RESEARCH

Cisplatin resistance involves a metabolic reprogramming through ROS and PGC-1α in NSCLC which can be overcome by OXPHOS inhibition

(2019) Alberto Cruz-Bermúdez et al.   FREE RADICAL BIOLOGY AND MEDICINE

Inositol-triphosphate 3-kinase B confers cisplatin resistance by regulating NOX4-dependent redox balance

(2019) Chaoyun Pan et al.   JOURNAL OF CLINICAL INVESTIGATION

Perioperative chemotherapy with fluorouracil plus leucovorin, oxaliplatin, and docetaxel versus fluorouracil or capecitabine plus cisplatin and epirubicin for locally advanced, resectable gastric or gastro-oesophageal junction adenocarcinoma (FLOT4): a randomised, phase 2/3 trial

(2019) Salah-Eddin Al-Batran et al.   LANCET

Virtual screening-guided discovery of thioredoxin reductase inhibitors

(2019) Ruijuan Liu et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

p62/SQSTM1 protects against cisplatin-induced oxidative stress in kidneys by mediating the cross talk between autophagy and the Keap1-Nrf2 signalling pathway

(2019) Weitang Liao et al.   FREE RADICAL RESEARCH

Identification of Withaferin A as a Potential Candidate for Anti-Cancer Therapy in Non-Small Cell Lung Cancer

(2019) Hsu et al.   Cancers

Curcuminoid WZ26, a TrxR1 inhibitor, effectively inhibits colon cancer cell growth and enhances cisplatin-induced cell death through the induction of ROS

(2019) Tingting Zhang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Cisplatin increases PD-L1 expression and optimizes immune check-point blockade in non-small cell lung cancer

(2019) Ludovic Fournel et al.   CANCER LETTERS

Isodeoxyelephantopin, a Sesquiterpene Lactone Induces ROS Generation, Suppresses NF-κB Activation, Modulates LncRNA Expression and Exhibit Activities Against Breast Cancer

(2019) Sumit S. Verma et al.   Scientific Reports

FePt-Cys nanoparticles induce ROS-dependent cell toxicity, and enhance chemo-radiation sensitivity of NSCLC cells in vivo and in vitro

(2018) Yingming Sun et al.   CANCER LETTERS

Ginsenoside Rg3 sensitizes hypoxic lung cancer cells to cisplatin via blocking of NF-κB mediated epithelial–mesenchymal transition and stemness

(2018) Jingjing Wang et al.   CANCER LETTERS

Radioresistant Cervical Cancers Are Sensitive to Inhibition of Glycolysis and Redox Metabolism

(2018) Ramachandran Rashmi et al.   CANCER RESEARCH

Modulation of reactive oxygen species via ERK and STAT3 dependent signalling are involved in the response of meso thelioma cells to exemestane

(2018) Barbara Nuvoli et al.   FREE RADICAL BIOLOGY AND MEDICINE

The A to Z of modulated cell patterning by mammalian thioredoxin reductases

(2018) Markus Dagnell et al.   FREE RADICAL BIOLOGY AND MEDICINE

Biomarkers of tumour redox status in response to modulations of glutathione and thioredoxin antioxidant pathways

(2018) Julie Kengen et al.   FREE RADICAL RESEARCH

A HIF-independent, CD133-mediated mechanism of cisplatin resistance in glioblastoma cells

(2018) Eroje M. Ahmed et al.   CELLULAR ONCOLOGY

β-Lapachone and its iodine derivatives cause cell cycle arrest at G2/M phase and reactive oxygen species-mediated apoptosis in human oral squamous cell carcinoma cells

(2018) Rosane Borges Dias et al.   FREE RADICAL BIOLOGY AND MEDICINE

Oridonin Enhances Radiation-Induced Cell Death by Promoting DNA Damage in Non-Small Cell Lung Cancer Cells

(2018) Hyejin Park et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Vitexin compound 1, a novel extraction from a Chinese herb, suppresses melanoma cell growth through DNA damage by increasing ROS levels

(2018) Nian Liu et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

ROS and the DNA damage response in cancer

(2018) Upadhyayula Sai Srinivas et al.   Redox Biology

The antimetastatic effect and underlying mechanisms of thioredoxin reductase inhibitor ethaselen

(2018) Xiaoqing Zheng et al.   FREE RADICAL BIOLOGY AND MEDICINE

Aspirin plus sorafenib potentiates cisplatin cytotoxicity in resistant head and neck cancer cells through xCT inhibition

(2017) Jong-Lyel Roh et al.   FREE RADICAL BIOLOGY AND MEDICINE

Osimertinib induces autophagy and apoptosis via reactive oxygen species generation in non-small cell lung cancer cells

(2017) Zheng-Hai Tang et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Isodeoxyelephantopin induces protective autophagy in lung cancer cells via Nrf2-p62-keap1 feedback loop

(2017) Yang Wang et al.   Cell Death & Disease

Role of β-catenin in cisplatin resistance, relapse and prognosis of head and neck squamous cell carcinoma

(2017) Souvick Roy et al.   CELLULAR ONCOLOGY

Piperlongumine as a direct TrxR1 inhibitor with suppressive activity against gastric cancer

(2016) Peng Zou et al.   CANCER LETTERS

Details in the catalytic mechanism of mammalian thioredoxin reductase 1 revealed using point mutations and juglone-coupled enzyme activities

(2016) Jianqiang Xu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Intracellular labile iron determines H 2 O 2 -induced apoptotic signaling via sustained activation of ASK1/JNK-p38 axis

(2016) M.D. Mantzaris et al.   FREE RADICAL BIOLOGY AND MEDICINE

Global patterns and trends in colorectal cancer incidence and mortality

(2016) Melina Arnold et al.   GUT

Targeting Thioredoxin Reductase by Parthenolide Contributes to Inducing Apoptosis of HeLa Cells

(2016) Dongzhu Duan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Natural Products as Sources of New Drugs from 1981 to 2014

(2016) David J. Newman et al.   JOURNAL OF NATURAL PRODUCTS

Glutathione biosynthesis is a metabolic vulnerability in PI(3)K/Akt-driven breast cancer

(2016) Evan C. Lien et al.   NATURE CELL BIOLOGY

Dual-function nanosystem for synergetic cancer chemo-/radiotherapy through ROS-mediated signaling pathways

(2015) Lizhen He et al.   BIOMATERIALS

Glutathione and Thioredoxin Antioxidant Pathways Synergize to Drive Cancer Initiation and Progression

(2015) Isaac S. Harris et al.   CANCER CELL

Trx1/TrxR1 system regulates post-selected DP thymocytes survival by modulating ASK1-JNK/p38 MAPK activities

(2015) Rong Jin et al.   IMMUNOLOGY AND CELL BIOLOGY

Synthesis and biological evaluation of a novel class of curcumin analogs as anti-inflammatory agents for prevention and treatment of sepsis in mouse model

(2015) Chenguang Zhao et al.   Drug Design Development and Therapy

Targeting antioxidants for cancer therapy

(2014) Andrea Glasauer et al.   BIOCHEMICAL PHARMACOLOGY

ROS Function in Redox Signaling and Oxidative Stress

(2014) Michael Schieber et al.   CURRENT BIOLOGY

Isodeoxyelephantopin from Elephantopus scaber (Didancao) induces cell cycle arrest and caspase-3-mediated apoptosis in breast carcinoma T47D cells and lung carcinoma A549 cells

(2014) Farha Kabeer et al.   Chinese Medicine

Modulation of oxidative stress as an anticancer strategy

(2013) Chiara Gorrini et al.   NATURE REVIEWS DRUG DISCOVERY

Quantitative proteomics characterization on the antitumor effects of isodeoxyelephantopin against nasopharyngeal carcinoma

(2013) Guang-Rong Yan et al.   PROTEOMICS

Glutathione and Glutaredoxin Act as a Backup of Human Thioredoxin Reductase 1 to Reduce Thioredoxin 1 Preventing Cell Death by Aurothioglucose

(2012) Yatao Du et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Drug Combination Studies and Their Synergy Quantification Using the Chou-Talalay Method

(2010) T.-C. Chou   CANCER RESEARCH

Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?

(2009) Dunyaporn Trachootham et al.   NATURE REVIEWS DRUG DISCOVERY

Crystal Structure and Catalysis of the Selenoprotein Thioredoxin Reductase 1

(2008) Qing Cheng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY