Casticin-Induced Inhibition of Cell Growth and Survival Are Mediated through the Dual Modulation of Akt/mTOR Signaling Cascade

Pan-HDAC inhibition by panobinostat mediates chemosensitization to carboplatin in non-small cell lung cancer via attenuation of EGFR signaling

(2018) Lingzhi Wang et al.   CANCER LETTERS

Formononetin-induced oxidative stress abrogates the activation of STAT3/5 signaling axis and suppresses the tumor growth in multiple myeloma preclinical model

(2018) Chulwon Kim et al.   CANCER LETTERS

Casticin inhibits growth and enhances ionizing radiation-induced apoptosis through the suppression of STAT3 signaling cascade

(2018) Jong Hyun Lee et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Casticin impairs cell growth and induces cell apoptosis via cell cycle arrest in human oral cancer SCC-4 cells

(2017) Guan-Ling Chou et al.   ENVIRONMENTAL TOXICOLOGY

Casticin impairs cell migration and invasion of mouse melanoma B16F10 cells via PI3K/AKT and NF-κB signaling pathways

(2017) Yung-Luen Shih et al.   ENVIRONMENTAL TOXICOLOGY

MDM2 antagonists synergize with PI3K/mTOR inhibition in well-differentiated/dedifferentiated liposarcomas

(2017) Audrey Laroche et al.   Oncotarget

Casticin inhibits interleukin-1β–induced ICAM-1 and MUC5AC expression by blocking NF-κB, PI3K-Akt, and MAPK signaling in human lung epithelial cells

(2017) Chian-Jiun Liou et al.   Oncotarget

Incidence and severity of self-reported chemotherapy side effects in routine care: A prospective cohort study

(2017) Alison Pearce et al.   PLoS One

Casticin Induced Apoptosis in A375.S2 Human Melanoma Cells through the Inhibition of NF-κB and Mitochondria-Dependent Pathways In Vitro and Inhibited Human Melanoma Xenografts in a Mouse Model In Vivo

(2016) Yin-Wen Shiue et al.   AMERICAN JOURNAL OF CHINESE MEDICINE

Proliferation, survival and metabolism: the role of PI3K/AKT/mTOR signalling in pluripotency and cell fate determination

(2016) Jason S. L. Yu et al.   DEVELOPMENT

Ginkgolic Acid Inhibits Invasion and Migration and TGF-β-Induced EMT of Lung Cancer Cells Through PI3K/Akt/mTOR Inactivation

(2016) Seung Ho Baek et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Trisubstituted-Imidazoles Induce Apoptosis in Human Breast Cancer Cells by Targeting the Oncogenic PI3K/Akt/mTOR Signaling Pathway

(2016) Chakrabhavi Dhananjaya Mohan et al.   PLoS One

Cancer prevention and therapy through the modulation of transcription factors by bioactive natural compounds

(2016) Muthu K Shanmugam et al.   SEMINARS IN CANCER BIOLOGY

Targeting arachidonic acid pathway by natural products for cancer prevention and therapy

(2016) Nagendra Sastry Yarla et al.   SEMINARS IN CANCER BIOLOGY

Judicious Toggling of mTOR Activity to Combat Insulin Resistance and Cancer: Current Evidence and Perspectives

(2016) Pei Shi Ong et al.   Frontiers in Pharmacology

Roles of the Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways in controlling growth and sensitivity to therapy-implications for cancer and aging

(2016) Linda S. Steelman et al.   Aging-US

Chemomodulating Effects of Flavonoids in Human Leukemia Cells

(2015) Katrin Sak et al.   Anti-Cancer Agents in Medicinal Chemistry

NF-κB in cancer therapy

(2015) Feng Li et al.   ARCHIVES OF TOXICOLOGY

Isorhamnetin augments the anti-tumor effect of capeciatbine through the negative regulation of NF-κB signaling cascade in gastric cancer

(2015) Kanjoormana A. Manu et al.   CANCER LETTERS

Casticin, an active compound isolated from Vitex Fructus, ameliorates the cigarette smoke-induced acute lung inflammatory response in a murine model

(2015) Hyeonhoon Lee et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Targeting the PI3K/Akt signaling pathway in gastric carcinoma: A reality for personalized medicine?

(2015) Shikha Satendra Singh   WORLD JOURNAL OF GASTROENTEROLOGY

Role of Flavonoids in Future Anticancer Therapy by Eliminating the Cancer Stem Cells

(2015) Katrin Sak et al.   Current Stem Cell Research & Therapy

Natural Bioactives in Cancer Treatment and Prevention

(2015) Yih-Shou Hsieh et al.   Biomed Research International

Molecular Mechanisms of Casticin Action: an Update on its Antitumor Functions

(2015) Azhar Rasul et al.   Asian Pacific Journal of Cancer Prevention

γ-tocotrienol inhibits angiogenesis-dependent growth of human hepatocellular carcinoma through abrogation of AKT/mTOR pathway in an orthotopic mouse model

(2015) Kodappully Sivaraman Siveen et al.   Oncotarget

Luteolin enhances paclitaxel-induced apoptosis in human breast cancer MDA-MB-231 cells by blocking STAT3

(2014) Mon-Yuan Yang et al.   CHEMICO-BIOLOGICAL INTERACTIONS

NVP-BEZ235, a dual PI3K/mTOR inhibitor synergistically potentiates the antitumor effects of cisplatin in bladder cancer cells

(2014) DU G. MOON et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Abnormal activation of the EGFR signaling pathway mediates the downregulation of miR-145 through the ERK1/2 in non-small cell lung cancer

(2014) YUE-HUI GUO et al.   ONCOLOGY REPORTS

Novel Medicines and Strategies in Cancer Treatment and Prevention

(2014) Chih-Hsin Tang et al.   Biomed Research International

Casticin suppresses self-renewal and invasion of lung cancer stem-like cells from A549 cells through down-regulation of pAkt

(2013) F. Liu et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Combinations of Plant Polyphenols & Anti-Cancer Molecules: A Novel Treatment Strategy for Cancer Chemotherapy

(2013) Aarti Mohan et al.   Anti-Cancer Agents in Medicinal Chemistry

Natural Bioactives and Phytochemicals Serve in Cancer Treatment and Prevention

(2013) Shun-Fa Yang et al.   Evidence-based Complementary and Alternative Medicine

Cytotoxicity of Vitex agnus-castus fruit extract and its major component, casticin, correlates with differentiation status in leukemia cell lines

(2013) HIDETOMO KIKUCHI et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Molecular targets for cancer therapy in the PI3K/AKT/mTOR pathway

(2013) Jiri Polivka et al.   PHARMACOLOGY & THERAPEUTICS

Casticin induces ovarian cancer cell apoptosis by repressing FoxM1 through the activation of FOXO3a

(2013) LING JIANG et al.   Oncology Letters

Induction of apoptosis by casticin in cervical cancer cells: reactive oxygen species-dependent sustained activation of Jun N-terminal kinase

(2012) F. Zeng et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Plants as a Source of Therapeutic and Health Products

(2012) Philippe Christen et al.   CHIMIA

First Evidence That  -Tocotrienol Inhibits the Growth of Human Gastric Cancer and Chemosensitizes It to Capecitabine in a Xenograft Mouse Model through the Modulation of NF- B Pathway

(2012) K. A. Manu et al.   CLINICAL CANCER RESEARCH

History of Antibiotics. From Salvarsan to Cephalosporins

(2012) Lorenzo Zaffiri et al.   JOURNAL OF INVESTIGATIVE SURGERY

A Hexane Fraction of Guava Leaves (Psidium guajava L.) Induces Anticancer Activity by Suppressing AKT/Mammalian Target of Rapamycin/Ribosomal p70 S6 Kinase in Human Prostate Cancer Cells

(2012) Nae Hyung Ryu et al.   JOURNAL OF MEDICINAL FOOD

Casticin, a flavonoid, potentiates TRAIL-induced apoptosis through modulation of anti-apoptotic proteins and death receptor 5 in colon cancer cells

(2012) SAN-YUAN TANG et al.   ONCOLOGY REPORTS

Embelin inhibits growth and induces apoptosis through the suppression of Akt/mTOR/S6K1 signaling cascades

(2012) Seong Won Kim et al.   PROSTATE

mTOR-Dependent Cell Survival Mechanisms

(2012) C.-M. Hung et al.   Cold Spring Harbor Perspectives in Biology

Multifaceted link between cancer and inflammation

(2011) Gautam Sethi et al.   BIOSCIENCE REPORTS

β-Caryophyllene oxide inhibits growth and induces apoptosis through the suppression of PI3K/AKT/mTOR/S6K1 pathways and ROS-mediated MAPKs activation

(2011) Kyung-Ran Park et al.   CANCER LETTERS

Targeting Cell Signaling and Apoptotic Pathways by Dietary Agents: Role in the Prevention and Treatment of Cancer

(2011) Muthu Shanmugam et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Isolation and immunomodulatory properties of a flavonoid, casticin fromVitex agnus-castus

(2009) M. Ahmed Mesaik et al.   PHYTOTHERAPY RESEARCH

Potential pharmacological control of the NF-κB pathway

(2009) Gautam Sethi et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

The PTEN/PI3K/AKT Signalling Pathway in Cancer, Therapeutic Implications

(2008) Amancio Carnero et al.   CURRENT CANCER DRUG TARGETS

Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity

(2008) S.-M. Maira et al.   MOLECULAR CANCER THERAPEUTICS