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Title
In Vitro Liver Toxicity Testing of Chemicals: A Pragmatic Approach
Authors
Keywords
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Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 22, Issue 9, Pages 5038
Publisher
MDPI AG
Online
2021-05-10
DOI
10.3390/ijms22095038
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Note: Only part of the references are listed.- The use of adverse outcome pathways in the safety evaluation of food additives
- (2020) Mathieu Vinken et al. ARCHIVES OF TOXICOLOGY
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- (2020) Yibao Ma et al. Scientific Reports
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- (2020) Xiuli Dong et al. Scientific Reports
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- (2020) Céline Hoffmann et al. Scientific Reports
- Macrophage Phenotype and Function in Liver Disorder
- (2020) Lang Dou et al. Frontiers in Immunology
- Robustness testing and optimization of an adverse outcome pathway on cholestatic liver injury
- (2020) Eva Gijbels et al. ARCHIVES OF TOXICOLOGY
- Slc43a3 is a regulator of free fatty acid flux
- (2020) Kathrin B Hasbargen et al. JOURNAL OF LIPID RESEARCH
- Evaluation of Oxidative Stress in Biological Samples Using the Thiobarbituric Acid Reactive Substances Assay
- (2020) Jesús Aguilar Diaz De Leon et al. Jove-Journal of Visualized Experiments
- Human Liver Spheroids as a Model to Study Aetiology and Treatment of Hepatic Fibrosis
- (2020) Tracey Hurrell et al. Cells
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- (2020) Xiang Cheng et al. Cell Metabolism
- Collagen: quantification, biomechanics and role of minor subtypes in cartilage
- (2020) Benjamin J. Bielajew et al. Nature Reviews Materials
- Organic fluorescent probes for detecting mitochondrial membrane potential
- (2020) Xuechen Li et al. COORDINATION CHEMISTRY REVIEWS
- Sorafenib reduces steatosis‐induced fibrogenesis in a human 3D co‐culture model of non‐alcoholic fatty liver disease
- (2020) Guilherme Ribeiro Romualdo et al. ENVIRONMENTAL TOXICOLOGY
- Approaches and Methods to Measure Oxidative Stress in Clinical Samples: Research Applications in the Cancer Field
- (2019) Meghri Katerji et al. Oxidative Medicine and Cellular Longevity
- Mechanisms and in vitro models of drug-induced cholestasis
- (2019) Eva Gijbels et al. ARCHIVES OF TOXICOLOGY
- Stem cell models as an in vitro model for predictive toxicology
- (2019) Stephen Lynch et al. BIOCHEMICAL JOURNAL
- Cell death: a review of the major forms of apoptosis, necrosis and autophagy
- (2019) Mark S D’Arcy CELL BIOLOGY INTERNATIONAL
- Human Multilineage 3D Spheroids as a Model of Liver Steatosis and Fibrosis
- (2019) Piero Pingitore et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
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- (2019) Vânia Vilas-Boas et al. CHEMICAL RESEARCH IN TOXICOLOGY
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- (2019) Dariusz Lachowski et al. Scientific Reports
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- (2019) Xuyang Wang et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
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- (2019) Yitian Zhou et al. Frontiers in Pharmacology
- The application of omics-based human liver platforms for investigating the mechanism of drug-induced hepatotoxicity in vitro
- (2019) Jian Jiang et al. ARCHIVES OF TOXICOLOGY
- Mitochondria as multifaceted regulators of cell death
- (2019) Florian J. Bock et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- High-throughput screening to evaluate inhibition of bile acid transporters using human hepatocytes isolated from chimeric mice
- (2019) Hiroshi Kohara et al. TOXICOLOGICAL SCIENCES
- Cholestatic liver injury induced by food additives, dietary supplements and parenteral nutrition
- (2019) Vânia Vilas-Boas et al. ENVIRONMENT INTERNATIONAL
- Metabolic Hallmarks of Hepatic Stellate Cells in Liver Fibrosis
- (2019) Olga Khomich et al. Cells
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- (2018) Robim M. Rodrigues et al. ARCHIVES OF TOXICOLOGY
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- (2018) Pallabi Mitra et al. DRUG METABOLISM AND DISPOSITION
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- (2018) Ayesha Idrees et al. INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS
- Ultrabright and Fluorogenic Probes for Multicolor Imaging and Tracking of Lipid Droplets in Cells and Tissues
- (2018) Mayeul Collot et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- An overview of apoptosis assays detecting DNA fragmentation
- (2018) Pavlína Majtnerová et al. MOLECULAR BIOLOGY REPORTS
- Inter-individual differences in the susceptibility of primary human hepatocytes towards drug-induced cholestasis are compound and time dependent
- (2018) Céline Parmentier et al. TOXICOLOGY LETTERS
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- (2018) Tingting Yang et al. DRUG DISCOVERY TODAY
- Recent Advances in Fluorescent Probes for Lipid Droplets
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- (2017) Giampaolo Morciano et al. Nature Protocols
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- (2017) Takuma Tsuchida et al. Nature Reviews Gastroenterology & Hepatology
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- (2016) Kyunghee Yang et al. JOURNAL OF PHARMACEUTICAL SCIENCES
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- (2016) Michelle M. Angrish et al. TOXICOLOGICAL SCIENCES
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- (2016) Xuan Ni et al. Scientific Reports
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- (2016) Christina E. M. Krämer et al. Scientific Reports
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- (2016) Arwa B. Raies et al. Wiley Interdisciplinary Reviews-Computational Molecular Science
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- (2016) Sabine Daemen et al. Molecular Metabolism
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- (2016) Nils A. Kraus et al. Adipocyte
- The BUME method: a new rapid and simple chloroform-free method for total lipid extraction of animal tissue
- (2016) Lars Löfgren et al. Scientific Reports
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- (2016) Delilah F. G. Hendriks et al. Scientific Reports
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- (2015) Sara Crespo Yanguas et al. ARCHIVES OF TOXICOLOGY
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- (2015) G. Yu. Lomakina et al. BIOCHEMISTRY-MOSCOW
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- (2015) Judith Rumin et al. Biotechnology for Biofuels
- Adverse Outcome Pathways and Drug-Induced Liver Injury Testing
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- Substrate-zymography: a still worthwhile method for gelatinases analysis in biological samples
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- (2015) David S. Goldberg et al. GASTROENTEROLOGY
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- (2015) Natalie Burden et al. JOURNAL OF APPLIED TOXICOLOGY
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- (2015) Errol L. G. Samuel et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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- (2015) Joost Willebrords et al. PROGRESS IN LIPID RESEARCH
- Quantification of Drug-Induced Inhibition of Canalicular Cholyl-l-Lysyl-Fluorescein Excretion From Hepatocytes by High Content Cell Imaging
- (2015) Jane A. Barber et al. TOXICOLOGICAL SCIENCES
- Biokinetics in repeated-dosing in vitro drug toxicity studies
- (2015) Nynke I. Kramer et al. TOXICOLOGY IN VITRO
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- (2015) Katsumori Segawa et al. TRENDS IN CELL BIOLOGY
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- (2015) Cristina Segnani et al. PLoS One
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- (2014) Peter J. O'Brien BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
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- (2014) Shyam Sundhar Bale et al. EXPERIMENTAL BIOLOGY AND MEDICINE
- Mass Spectrometry Methodology in Lipid Analysis
- (2014) Lin Li et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
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- (2014) Raed Lattouf et al. JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY
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- (2014) Tom De Bruyn et al. JOURNAL OF PHARMACEUTICAL SCIENCES
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- (2014) BING QIU et al. Molecular Medicine Reports
- Regulated necrosis: the expanding network of non-apoptotic cell death pathways
- (2014) Tom Vanden Berghe et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Applying Adverse Outcome Pathways (AOPs) to support Integrated Approaches to Testing and Assessment (IATA)
- (2014) Knut Erik Tollefsen et al. REGULATORY TOXICOLOGY AND PHARMACOLOGY
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- (2014) Amrita Banerjee et al. FEBS Open Bio
- Digital image analysis approach for lipid droplet size quantitation of Oil Red O-stained cultured cells
- (2013) Manuel J. Deutsch et al. ANALYTICAL BIOCHEMISTRY
- Primary hepatocytes and their cultures in liver apoptosis research
- (2013) Mathieu Vinken et al. ARCHIVES OF TOXICOLOGY
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- (2013) Christine C. Winterbourn BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
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- (2013) Guillermo Mariño et al. CELL RESEARCH
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- (2013) William M. Lee Clinics in Liver Disease
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- (2013) M. Vinken et al. CURRENT MEDICINAL CHEMISTRY
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- (2013) Tom De Bruyn et al. Expert Opinion on Drug Metabolism & Toxicology
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- (2013) Jae H. Chang et al. MOLECULAR PHARMACEUTICS
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- (2013) Jennifer Vandooren et al. NATURE METHODS
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- (2013) Annika Mehlem et al. Nature Protocols
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- (2013) Don C. Rockey et al. PLoS One
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- (2012) J. Fraczek et al. ARCHIVES OF TOXICOLOGY
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- (2012) Alexander P. Demchenko CYTOTECHNOLOGY
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- (2012) Mounir Bouhifd et al. FOOD AND CHEMICAL TOXICOLOGY
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- (2012) Adam P Levene et al. HISTOPATHOLOGY
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- (2012) Robim M. Rodrigues et al. TOXICOLOGY IN VITRO
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- (2011) A. H. Henkin et al. Acta Physiologica
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- (2011) J. S. Au et al. ALIMENTARY PHARMACOLOGY & THERAPEUTICS
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- (2011) J. C. Cohen et al. SCIENCE
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- (2009) Christine J Weydert et al. Nature Protocols
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- (2009) Ignazio Grattagliano et al. WORLD JOURNAL OF GASTROENTEROLOGY
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- (2008) Lisa K. Folkes et al. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
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- (2008) Russell K. Soon et al. Clinics in Liver Disease
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- (2008) Statis Pataridis et al. JOURNAL OF SEPARATION SCIENCE
- Analysis of apoptosis by cytometry using TUNEL assay
- (2008) Zbigniew Darzynkiewicz et al. METHODS
- Hydrophobic characterization of intracellular lipids in situ by Nile Red red/yellow emission ratio
- (2008) Giacomo Diaz et al. MICRON
- Neutral red uptake assay for the estimation of cell viability/cytotoxicity
- (2008) Guillermo Repetto et al. Nature Protocols
- The selective detection of mitochondrial superoxide by live cell imaging
- (2008) Kristine M Robinson et al. Nature Protocols
- Hepatic Stellate Cells: Protean, Multifunctional, and Enigmatic Cells of the Liver
- (2008) Scott L. Friedman PHYSIOLOGICAL REVIEWS
- A bioluminescent cytotoxicity assay for assessment of membrane integrity using a proteolytic biomarker
- (2008) Ming-Hsuang Cho et al. TOXICOLOGY IN VITRO
- Cytochrome c-mediated oxidation of hydroethidine and mito-hydroethidine in mitochondria: Identification of homo- and heterodimers
- (2007) Jacek Zielonka et al. FREE RADICAL BIOLOGY AND MEDICINE
- Detection of 2-hydroxyethidium in cellular systems: a unique marker product of superoxide and hydroethidine
- (2007) Jacek Zielonka et al. Nature Protocols
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