Central role of mitochondria in drug-induced liver injury

CYP2C9-Mediated Metabolic Activation of Losartan Detected by a Highly Sensitive Cell-Based Screening Assay

(2011) A. Iwamura et al.   DRUG METABOLISM AND DISPOSITION

HLA-DQA1*02:01 Is a Major Risk Factor for Lapatinib-Induced Hepatotoxicity in Women With Advanced Breast Cancer

(2011) Colin F. Spraggs et al.   JOURNAL OF CLINICAL ONCOLOGY

Macrophage activation by factors released from acetaminophen-injured hepatocytes: Potential role of HMGB1

(2011) Ana-Cristina Dragomir et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Myeloperoxidase-mediated bioactivation of 5-hydroxythiabendazole: A possible mechanism of thiabendazole toxicity

(2011) Joseph D. Jamieson et al.   TOXICOLOGY IN VITRO

Noncirrhotic portal hypertension in HIV-infected patients: unique clinical and pathological findings

(2010) Eugenia Vispo et al.   AIDS

Mitochondrial damage in adipose tissue of untreated HIV-infected patients

(2010) Glòria Garrabou et al.   AIDS

Enhanced oxidative stress and increased mitochondrial mass during Efavirenz-induced apoptosis in human hepatic cells

(2010) N Apostolova et al.   BRITISH JOURNAL OF PHARMACOLOGY

Neutrophil- and Myeloperoxidase-Mediated Metabolism of Reduced Nimesulide: Evidence for Bioactivation

(2010) Min Yang et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Nimesulide-Induced Electrophile Stress Activates Nrf2 in Human Hepatocytes and Mice but Is Not Sufficient to Induce Hepatotoxicity in Nrf2-Deficient Mice

(2010) Vijay M. Kale et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Use of Pharmaco-Metabonomics for Early Prediction of Acetaminophen-Induced Hepatotoxicity in Humans

(2010) J H Winnike et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Cytochrome P450-Mediated Bioactivation of the Epidermal Growth Factor Receptor Inhibitor Erlotinib to a Reactive Electrophile

(2010) X. Li et al.   DRUG METABOLISM AND DISPOSITION

In Vitro Metabolism Studies of Nomifensine Monooxygenation Pathways: Metabolite Identification, Reaction Phenotyping, and Bioactivation Mechanism

(2010) J. Yu et al.   DRUG METABOLISM AND DISPOSITION

Enhanced Susceptibility of HLA-mediated Ticlopidine-induced Idiosyncratic Hepatotoxicity by CYP2B6 Polymorphism in Japanese

(2010) Noritaka Ariyoshi et al.   Drug Metabolism and Pharmacokinetics

Keratin Variants Predispose to Acute Liver Failure and Adverse Outcome: Race and Ethnic Associations

(2010) Pavel Strnad et al.   GASTROENTEROLOGY

Mitochondrial superoxide dismutase and glutathione peroxidase in idiosyncratic drug-induced liver injury

(2010) M. Isabel Lucena et al.   HEPATOLOGY

Pharmacogenetics of drug-induced liver injury

(2010) Stefan Russmann et al.   HEPATOLOGY

Clinical syndromes and consequences of antiretroviral-related hepatotoxicity

(2010) Marina Núñez   HEPATOLOGY

Polymerase γ Gene POLG determines the risk of sodium valproate-induced liver toxicity

(2010) Joanna D. Stewart et al.   HEPATOLOGY

Inhibition of mitochondrial function by efavirenz increases lipid content in hepatic cells

(2010) Ana Blas-García et al.   HEPATOLOGY

Effect of Antipsychotic Medications on Glucose and Lipid Levels

(2010) Parminder S. Chaggar et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Drug-induced toxicity on mitochondria and lipid metabolism: Mechanistic diversity and deleterious consequences for the liver

(2010) Karima Begriche et al.   JOURNAL OF HEPATOLOGY

Drug Antigenicity, Immunogenicity, and Costimulatory Signaling: Evidence for Formation of a Functional Antigen through Immune Cell Metabolism

(2010) A. Elsheikh et al.   JOURNAL OF IMMUNOLOGY

Role of c-Jun N-terminal kinase (JNK) in regulating tumor necrosis factor-alpha (TNF-α) mediated increase of acetaminophen (APAP) and chlorpromazine (CPZ) toxicity in murine hepatocytes

(2010) Adarsh Gandhi et al.   JOURNAL OF TOXICOLOGICAL SCIENCES

Mechanism-Based Inactivation of Cytochrome P450 3A4 by Lapatinib

(2010) W. C. Teng et al.   MOLECULAR PHARMACOLOGY

Circulating mitochondrial DAMPs cause inflammatory responses to injury

(2010) Qin Zhang et al.   NATURE

A genome-wide study identifies HLA alleles associated with lumiracoxib-related liver injury

(2010) Jonathan B Singer et al.   NATURE GENETICS

Antipsychotic drug action on SREBPs-related lipogenesis and cholesterogenesis in primary rat hepatocytes

(2010) Emilie Lauressergues et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Fas-associated death domain (FADD) is a negative regulator of T-cell receptor-mediated necroptosis

(2010) S. L. Osborn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial CYP2E1 is sufficient to mediate oxidative stress and cytotoxicity induced by ethanol and acetaminophen

(2010) Laetitia Knockaert et al.   TOXICOLOGY IN VITRO

Direct toxicity effects of sulfo-conjugated troglitazone on human hepatocytes

(2010) Sudipta Saha et al.   TOXICOLOGY LETTERS

Generation of T cell responses targeting the reactive metabolite of halothane in mice

(2010) Qiang You et al.   TOXICOLOGY LETTERS

HIV-associated lipodystrophy: from fat injury to premature aging

(2010) Martine Caron-Debarle et al.   TRENDS IN MOLECULAR MEDICINE

Mitochondrial DNA Depletion in Rat Liver Induced by Fosalvudine Tidoxil, a Novel Nucleoside Reverse Transcriptase Inhibitor Prodrug

(2009) A. C. Venhoff et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

R964C Mutation of DNA Polymerase   Imparts Increased Stavudine Toxicity by Decreasing Nucleoside Analog Discrimination and Impairing Polymerase Activity

(2009) C. M. Bailey et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Adaptation to Oxidative Stress, Chemoresistance, and Cell Survival

(2009) Matteo Landriscina et al.   ANTIOXIDANTS & REDOX SIGNALING

Betulinic acid induces cytochrome c release and apoptosis in a Bax/Bak-independent, permeability transition pore dependent fashion

(2009) Franziska B. Mullauer et al.   APOPTOSIS

Stabilization and translocation of p53 to mitochondria is linked to Bax translocation to mitochondria in simvastatin-induced apoptosis

(2009) Sang Kyu Lee et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Mitochondrial peroxiredoxin involvement in antioxidant defence and redox signalling

(2009) Andrew G. Cox et al.   BIOCHEMICAL JOURNAL

Inhibition of hepatic carnitine palmitoyl-transferase I (CPT IA) by valproyl-CoA as a possible mechanism of valproate-induced steatosis

(2009) Cátia C.P. Aires et al.   BIOCHEMICAL PHARMACOLOGY

Bioactivation of the Epidermal Growth Factor Receptor Inhibitor Gefitinib: Implications for Pulmonary and Hepatic Toxicities

(2009) Xiaohai Li et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Metabolic Oxidative Cleavage of Thioesters: Evidence for the Formation of Sulfenic Acid Intermediates in the Bioactivation of the Antithrombotic Prodrugs Ticlopidine and Clopidogrel

(2009) Patrick M. Dansette et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Metabolic and Chemical Origins of Cross-Reactive Immunological Reactions to Arylamine Benzenesulfonamides: T-Cell Responses to Hydroxylamine and Nitroso Derivatives

(2009) J. Luis Castrejon et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Metabolic activation of the phenothiazine antipsychotics chlorpromazine and thioridazine to electrophilic iminoquinone species in human liver microsomes and recombinant P450s

(2009) Bo Wen et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Association of Noncirrhotic Portal Hypertension in HIV‐Infected Persons and Antiretroviral Therapy with Didanosine: A Nested Case‐Control Study

(2009) Helen Kovari et al.   CLINICAL INFECTIOUS DISEASES

PGC-1α, SIRT1 and AMPK, an energy sensing network that controls energy expenditure

(2009) Carles Cantó et al.   CURRENT OPINION IN LIPIDOLOGY

Drugs interfering with mitochondrial disorders

(2009) Josef Finsterer et al.   DRUG AND CHEMICAL TOXICOLOGY

Metabolic Activation of Nevirapine in Human Liver Microsomes: Dehydrogenation and Inactivation of Cytochrome P450 3A4

(2009) B. Wen et al.   DRUG METABOLISM AND DISPOSITION

The metabolic syndrome in overweight epileptic patients treated with valproic acid

(2009) Alberto Verrotti et al.   EPILEPSIA

Nonalcoholic fatty liver disease during valproate therapy

(2009) Alberto Verrotti et al.   EUROPEAN JOURNAL OF PEDIATRICS

Impairment of mitochondrial function by minocycline

(2009) Kathleen Kupsch et al.   FEBS Journal

Apoptosis and autophagy: Regulation of apoptosis by DNA damage signalling - roles of p53, p73 and HIPK2

(2009) Nadja Bitomsky et al.   FEBS Journal

Mouse population-guided resequencing reveals that variants in CD44 contribute to acetaminophen-induced liver injury in humans

(2009) A. H. Harrill et al.   GENOME RESEARCH

Liver injury in acute fatty liver of pregnancy: Possible link to placental mitochondrial dysfunction and oxidative stress

(2009) Sathish Kumar Natarajan et al.   HEPATOLOGY

Oral medications with significant hepatic metabolism at higher risk for hepatic adverse events

(2009) Craig Lammert et al.   HEPATOLOGY

Valproate-Induced Insulin Resistance and Obesity in Children

(2009) Alberto Verrotti et al.   HORMONE RESEARCH

Lysosomes as “Suicide Bags” in Cell Death: Myth or Reality?

(2009) Boris Turk et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sulindac Metabolism and Synergy with Tumor Necrosis Factor-  in a Drug-Inflammation Interaction Model of Idiosyncratic Liver Injury

(2009) W. Zou et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Hepatic Mitochondrial DNA Depletion after an Alcohol Binge in Mice: Probable Role of Peroxynitrite and Modulation by Manganese Superoxide Dismutase

(2009) I. Larosche et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

HLA-B*5701 genotype is a major determinant of drug-induced liver injury due to flucloxacillin

(2009) Ann K Daly et al.   NATURE GENETICS

Genetic polymorphisms in the 5′-flanking region of human UDP-glucuronosyltransferase 2B7 affect the Nrf2-dependent transcriptional regulation

(2009) Akiko Nakamura et al.   Pharmacogenetics and Genomics

Protective effect of bicyclol on tetracycline-induced fatty liver in mice

(2009) Hong-Yan Yu et al.   TOXICOLOGY

Functional and toxicological consequences of metabolic bioactivation of methapyrilene via thiophene S-oxidation: Induction of cell defence, apoptosis and hepatic necrosis

(2009) Amy E. Mercer et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Underlying mitochondrial dysfunction triggers flutamide-induced oxidative liver injury in a mouse model of idiosyncratic drug toxicity

(2009) Rohini Kashimshetty et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Troglitazone, but not rosiglitazone, damages mitochondrial DNA and induces mitochondrial dysfunction and cell death in human hepatocytes

(2009) Lyudmila I. Rachek et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

2-ABT-S-oxide detoxification by glutathioneS-transferases A1-1, M1-1 and P1-1: Implications for toxicity associated with zileuton

(2009) E.M. Joshi et al.   XENOBIOTICA

Comparison of mechanism-based inhibition of human cytochrome P450 2C19 by ticlopidine, clopidogrel, and prasugrel

(2009) Y. Nishiya et al.   XENOBIOTICA

Acetaminophen bioactivation by human cytochrome P450 enzymes and animal microsomes

(2009) J. E. Laine et al.   XENOBIOTICA

Pyrimidine Nucleoside Depletion Sensitizes to the Mitochondrial Hepatotoxicity of the Reverse Transcriptase Inhibitor Stavudine

(2008) Bernhard Setzer et al.   AMERICAN JOURNAL OF PATHOLOGY

In Vitro Metabolism of a Model Cyclopropylamine to Reactive Intermediate: Insights into Trovafloxacin-Induced Hepatotoxicity

(2008) Qin Sun et al.   CHEMICAL RESEARCH IN TOXICOLOGY

In Vitro Nimesulide Studies toward Understanding Idiosyncratic Hepatotoxicity: Diiminoquinone Formation and Conjugation

(2008) Fengping Li et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Bioactivation of Lumiracoxib by Peroxidases and Human Liver Microsomes: Identification of Multiple Quinone Imine Intermediates and GSH Adducts

(2008) Ping Kang et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Bioactivation of the tricyclic antidepressant amitriptyline and its metabolite nortriptyline to arene oxide intermediates in human liver microsomes and recombinant P450s

(2008) Bo Wen et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Mitochondrial dysfunction and delayed hepatotoxicity: another lesson from troglitazone

(2008) N. L. Julie et al.   DIABETOLOGIA

Markers of Electrophilic Stress Caused by Chemically Reactive Metabolites in Human Hepatocytes

(2008) H. Takakusa et al.   DRUG METABOLISM AND DISPOSITION

Effect of valproic acid treatment on body composition, leptin and the soluble leptin receptor in epileptic children

(2008) M. Rauchenzauner et al.   EPILEPSY RESEARCH

Deletion of Apoptosis Signal-Regulating Kinase 1 Attenuates Acetaminophen-Induced Liver Injury by Inhibiting c-Jun N-Terminal Kinase Activation

(2008) Hayato Nakagawa et al.   GASTROENTEROLOGY

GlutathioneS-transferase m1 and t1 null genotypes increase susceptibility to idiosyncratic drug-induced liver injury

(2008) M. Isabel Lucena et al.   HEPATOLOGY

Liver damage underlying unexplained transaminase elevation in human immunodeficiency virus-1 mono-infected patients on antiretroviral therapy

(2008) Patrick Ingiliz et al.   HEPATOLOGY

Relationship between daily dose of oral medications and idiosyncratic drug-induced liver injury: Search for signals

(2008) Craig Lammert et al.   HEPATOLOGY

Hepatitis C is a predictor of acute liver injury among hospitalizations for acetaminophen overdose in the United States: A nationwide analysis

(2008) Geoffrey C. Nguyen et al.   HEPATOLOGY

Inhibition of mitochondrial fatty acid oxidation in vivo only slightly suppresses gluconeogenesis but enhances clearance of glucose in mice

(2008) Terry G. J. Derks et al.   HEPATOLOGY

Role of JNK Translocation to Mitochondria Leading to Inhibition of Mitochondria Bioenergetics in Acetaminophen-induced Liver Injury

(2008) Naoko Hanawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of the Thiophene Ring of Methapyrilene as a Novel Bioactivation-Dependent Hepatic Toxicophore

(2008) E. E. Graham et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Tumor Necrosis Factor  Is a Proximal Mediator of Synergistic Hepatotoxicity from Trovafloxacin/Lipopolysaccharide Coexposure

(2008) P. J. Shaw et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Polymorphism T → C (−34 base pairs) of gene CYP17 promoter in women with polycystic ovary syndrome is associated with increased body weight and insulin resistance: a preliminary study

(2008) Bárbara Echiburú et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Mechanism of apoptosis induction by inhibition of the anti-apoptotic BCL-2 proteins

(2008) J. E. Chipuk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Apoptosis is triggered when prosurvival Bcl-2 proteins cannot restrain Bax

(2008) J. I. Fletcher et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Acute clozapine exposure in vivo induces lipid accumulation and marked sequential changes in the expression of SREBP, PPAR, and LXR target genes in rat liver

(2008) Johan Fernø et al.   PSYCHOPHARMACOLOGY

In Vitro Assessment of Mitochondrial Dysfunction and Cytotoxicity of Nefazodone, Trazodone, and Buspirone

(2008) James A. Dykens et al.   TOXICOLOGICAL SCIENCES

Coexposure of Mice to Trovafloxacin and Lipopolysaccharide, a Model of Idiosyncratic Hepatotoxicity, Results in a Unique Gene Expression Profile and Interferon Gamma–Dependent Liver Injury

(2008) Patrick J. Shaw et al.   TOXICOLOGICAL SCIENCES

Biguanide-induced mitochondrial dysfunction yields increased lactate production and cytotoxicity of aerobically-poised HepG2 cells and human hepatocytes in vitro

(2008) James A. Dykens et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Prolonged ethanol administration depletes mitochondrial DNA in MnSOD-overexpressing transgenic mice, but not in their wild type littermates

(2008) Isabelle Larosche et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Steatohepatitis-inducing drugs trigger cytokeratin cross-links in hepatocytes. Possible contribution to Mallory-Denk body formation

(2008) Marie-Anne Robin et al.   TOXICOLOGY IN VITRO

Prediction of drug-induced liver injury in humans by using in vitro methods: The case of ximelagatran

(2007) Kerstin Kenne et al.   TOXICOLOGY IN VITRO