Sandwich-cultured hepatocytes: utility forin vitroexploration of hepatobiliary drug disposition and drug-induced hepatotoxicity

Recovery of Mature Hepatocytic Phenotype following Bile Ductular Transdifferentiation of Rat Hepatocytes in Vitro

(2012) Masayuki Sone et al.   AMERICAN JOURNAL OF PATHOLOGY

Tissue specific synthetic ECM hydrogels for 3-D in vitro maintenance of hepatocyte function

(2012) Aleksander Skardal et al.   BIOMATERIALS

Suppression of Hepatocyte Proliferation by Hepatocyte Nuclear Factor 4α in Adult Mice

(2012) Jessica A. Bonzo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Assessment of Biliary Clearance in Early Drug Discovery using Sandwich-cultured Hepatocyte Model

(2012) Guoyu Pan et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Physiologically Based Modeling of Pravastatin Transporter-Mediated Hepatobiliary Disposition and Drug-Drug Interactions

(2012) Manthena V. S. Varma et al.   PHARMACEUTICAL RESEARCH

Application of quantitative time-lapse imaging (QTLI) for evaluation of Mrp2-based drug–drug interaction induced by liver metabolites

(2012) Takeo Nakanishi et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Novel insight into mechanisms of cholestatic liver injury

(2012) Benjamin L Woolbright   WORLD JOURNAL OF GASTROENTEROLOGY

An ‘all-inclusive’ 96-well cytochrome P450 induction method: Measuring enzyme activity, mRNA levels, protein levels, and cytotoxicity from one well using cryopreserved human hepatocytes

(2012) Jason S. Halladay et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

Evaluation of metabolism-mediated herb-drug interactions

(2011) Dong Hee Na et al.   ARCHIVES OF PHARMACAL RESEARCH

The Behaviors of Long-Term Cryopreserved Human Hepatocytes on Different Biomaterials

(2011) Jui-Nan Lu et al.   ARTIFICIAL ORGANS

Bile salt export pump inhibitors are associated with bile acid-dependent drug-induced toxicity in sandwich-cultured hepatocytes

(2011) Eiichiro Ogimura et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Screening of Antibiotics That Interact with Organic Anion-Transporting Polypeptides 1B1 and 1B3 Using Fluorescent Probes

(2011) Hiroaki Yamaguchi et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Predicting Clearance in Humans from In Vitro Data

(2011) R. Scott Obach   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Quantitative Time-Lapse Imaging-Based Analysis of Drug-Drug Interaction Mediated by Hepatobiliary Transporter, Multidrug Resistance-Associated Protein 2, in Sandwich-Cultured Rat Hepatocytes

(2011) T. Nakanishi et al.   DRUG METABOLISM AND DISPOSITION

Effect of Culture Time on the Basal Expression Levels of Drug Transporters in Sandwich-Cultured Primary Rat Hepatocytes

(2011) E. H. Tchaparian et al.   DRUG METABOLISM AND DISPOSITION

Complex Drug Interactions of HIV Protease Inhibitors 1: Inactivation, Induction, and Inhibition of Cytochrome P450 3A by Ritonavir or Nelfinavir

(2011) B. J. Kirby et al.   DRUG METABOLISM AND DISPOSITION

Culture Period-Dependent Changes in the Uptake of Transporter Substrates in Sandwich-Cultured Rat and Human Hepatocytes

(2011) N. Kotani et al.   DRUG METABOLISM AND DISPOSITION

Time-course activities of Oct1, Mrp3, and cytochrome P450s in cultures of cryopreserved rat hepatocytes

(2011) Jacob Kramer Jacobsen et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

The stable repression of mesenchymal program is required for hepatocyte identity: A novel role for hepatocyte nuclear factor 4α

(2011) Laura Santangelo et al.   HEPATOLOGY

Mechanisms Underlying Differences in Systemic Exposure of Structurally Similar Active Metabolites: Comparison of Two Preclinical Hepatic Models

(2011) G. Z. Yan et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Novel In Vitro-In Vivo Extrapolation (IVIVE) Method to Predict Hepatic Organ Clearance in Rat

(2011) Ken-ichi Umehara et al.   PHARMACEUTICAL RESEARCH

A Critical Analysis of the Interplay between Cytochrome P450 3A and P-Glycoprotein: Recent Insights from Knockout and Transgenic Mice

(2011) R. A. B. van Waterschoot et al.   PHARMACOLOGICAL REVIEWS

Isolation of Primary Human Hepatocytes from Normal and Diseased Liver Tissue: A One Hundred Liver Experience

(2011) Ricky H. Bhogal et al.   PLoS One

Differential Disposition of Chenodeoxycholic Acid versus Taurocholic Acid in Response to Acute Troglitazone Exposure in Rat Hepatocytes

(2011) Tracy L. Marion et al.   TOXICOLOGICAL SCIENCES

Glutathione depletion by valproic acid in sandwich-cultured rat hepatocytes: Role of biotransformation and temporal relationship with onset of toxicity

(2011) Tony K.L. Kiang et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Scaling In Vivo Pharmacokinetics from In Vitro Metabolic Stability Data in Drug Discovery

(2010) Wendy Klopf et al.   COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING

Inhibition of Hepatic Organic Anion-Transporting Polypeptide by RNA Interference in Sandwich-Cultured Human Hepatocytes: An In Vitro Model to Assess Transporter-Mediated Drug-Drug Interactions

(2010) M. Liao et al.   DRUG METABOLISM AND DISPOSITION

Estimation of Transporters Involved in the Hepatobiliary Transport of TA-0201CA Using Sandwich-Cultured Rat Hepatocytes from Normal and Multidrug Resistance-Associated Protein 2-Deficient Rats

(2010) H. Fukuda et al.   DRUG METABOLISM AND DISPOSITION

In Vitro Investigation of the Hepatobiliary Disposition Mechanisms of the Antifungal Agent Micafungin in Humans and Rats

(2010) S. B. Yanni et al.   DRUG METABOLISM AND DISPOSITION

Sandwich-cultured hepatocytes: anin vitromodel to evaluate hepatobiliary transporter-based drug interactions and hepatotoxicity

(2010) Brandon Swift* et al.   DRUG METABOLISM REVIEWS

Sulindac and Its Metabolites Inhibit Multiple Transport Proteins in Rat and Human Hepatocytes

(2010) J. K. Lee et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Improved Extrapolation of Hepatobiliary Clearance fromin VitroSandwich Cultured Rat Hepatocytes through Absolute Quantification of Hepatobiliary Transporters

(2010) Na Li et al.   MOLECULAR PHARMACEUTICS

Evaluation of 99mTechnetium-Mebrofenin and 99mTechnetium-Sestamibi as Specific Probes for Hepatic Transport Protein Function in Rat and Human Hepatocytes

(2010) Brandon Swift et al.   PHARMACEUTICAL RESEARCH

Role of Oxidative Metabolism in the Effect of Valproic Acid on Markers of Cell Viability, Necrosis, and Oxidative Stress in Sandwich-Cultured Rat Hepatocytes

(2010) Tony K. L. Kiang et al.   TOXICOLOGICAL SCIENCES

Interference with Bile Salt Export Pump Function Is a Susceptibility Factor for Human Liver Injury in Drug Development

(2010) Ryan E. Morgan et al.   TOXICOLOGICAL SCIENCES

LC−MS/MS Mediated Absolute Quantification and Comparison of Bile Salt Export Pump and Breast Cancer Resistance Protein in Livers and Hepatocytes across Species

(2009) Na Li et al.   ANALYTICAL CHEMISTRY

Serum-free collagen sandwich cultures of adult rat hepatocytes maintain liver-like properties long term: A valuable model for in vitro toxicity and drug–drug interaction studies

(2009) Gregor Tuschl et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Glucuronidation and Covalent Protein Binding of Benoxaprofen and Flunoxaprofen in Sandwich-Cultured Rat and Human Hepatocytes

(2009) J. Q. Dong et al.   DRUG METABOLISM AND DISPOSITION

An In Vitro Assay to Assess Transporter-Based Cholestatic Hepatotoxicity Using Sandwich-Cultured Rat Hepatocytes

(2009) J. H. Ansede et al.   DRUG METABOLISM AND DISPOSITION

Investigation of the Rate-Determining Process in the Hepatic Elimination of HMG-CoA Reductase Inhibitors in Rats and Humans

(2009) T. Watanabe et al.   DRUG METABOLISM AND DISPOSITION

Species-Specific Interaction of HIV Protease Inhibitors With Accumulation of Cholyl-Glycylamido-Fluorescein (CGamF) in Sandwich-Cultured Hepatocytes

(2009) Zhi-Wei Ye et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Hepatobiliary Disposition of Troglitazone and Metabolites in Rat and Human Sandwich-Cultured Hepatocytes: Use of Monte Carlo Simulations to Assess the Impact of Changes in Biliary Excretion on Troglitazone Sulfate Accumulation

(2009) J. K. Lee et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Quantitative Expression Profile of Hepatobiliary Transporters in Sandwich Cultured Rat and Human Hepatocytes

(2009) Na Li et al.   MOLECULAR PHARMACEUTICS

Interplay of Drug Metabolism and Transport: A Real Phenomenon or an Artifact of the Site of Measurement?

(2009) Christopher J. Endres et al.   MOLECULAR PHARMACEUTICS

Influence of Seeding Density and Extracellular Matrix on Bile Acid Transport and Mrp4 Expression in Sandwich-Cultured Mouse Hepatocytes

(2009) Brandon Swift et al.   MOLECULAR PHARMACEUTICS

Bile-acid-induced cell injury and protection

(2009) Maria J Perez et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Expression and hepatobiliary transport characteristics of the concentrative and equilibrative nucleoside transporters in sandwich-cultured human hepatocytes

(2008) Rajgopal Govindarajan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

General Framework for the Prediction of Oral Drug Interactions Caused by CYP3A4 Induction from In Vivo Information

(2008) Yoshiyuki Ohno et al.   CLINICAL PHARMACOKINETICS

Effect of Albumin on the Biliary Clearance of Compounds in Sandwich-Cultured Rat Hepatocytes

(2008) K. K. Wolf et al.   DRUG METABOLISM AND DISPOSITION

Absolute Difference of Hepatobiliary Transporter Multidrug Resistance-Associated Protein (MRP2/Mrp2) in Liver Tissues and Isolated Hepatocytes from Rat, Dog, Monkey, and Human

(2008) N. Li et al.   DRUG METABOLISM AND DISPOSITION

Effect of Plasma Protein Binding on in Vitro-in Vivo Correlation of Biliary Excretion of Drugs Evaluated by Sandwich-Cultured Rat Hepatocytes

(2008) H. Fukuda et al.   DRUG METABOLISM AND DISPOSITION

Use of Sandwich-Cultured Human Hepatocytes to Predict Biliary Clearance of Angiotensin II Receptor Blockers and HMG-CoA Reductase Inhibitors

(2008) K. Abe et al.   DRUG METABOLISM AND DISPOSITION

PREDICTION OF DRUG-DRUG INTERACTIONS FROM IN VITRO INDUCTION DATA: Application of the Relative Induction Score Approach Using Cryopreserved Human Hepatocytes

(2008) O. A. Fahmi et al.   DRUG METABOLISM AND DISPOSITION

Drug-induced Hyperbilirubinemia and the Clinical Influencing Factors

(2008) Young-Mi Ah et al.   DRUG METABOLISM REVIEWS

In Vitro Biliary Clearance of Angiotensin II Receptor Blockers and 3-Hydroxy-3-methylglutaryl-Coenzyme A Reductase Inhibitors in Sandwich-Cultured Rat Hepatocytes: Comparison with in Vivo Biliary Clearance

(2008) K. Abe et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Clearance and clearance inhibition of the HIV-1 protease inhibitors ritonavir and saquinavir in sandwich-cultured rat hepatocytes and rat microsomes

(2008) N. Treijtel et al.   TOXICOLOGY IN VITRO

Comparison of the induction profile for drug disposition proteins by typical nuclear receptor activators in human hepatic and intestinal cells

(2007) P Martin et al.   BRITISH JOURNAL OF PHARMACOLOGY

Modulation of sinusoidal and canalicular elimination of bilirubin-glucuronides by rifampicin and other cholestatic drugs in a sandwich culture of rat hepatocytes

(2007) György Lengyel et al.   HEPATOLOGY RESEARCH

Modulation of trabectedin (ET-743) hepatobiliary disposition by multidrug resistance-associated proteins (Mrps) may prevent hepatotoxicity

(2007) Jin Kyung Lee et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY