Macrophage Phenotype and Function in Liver Disorder

Myeloid cells in liver and bone marrow acquire a functionally distinct inflammatory phenotype during obesity-related steatohepatitis

(2019) Oliver Krenkel et al.   GUT

Hepatitis B Virus-induced modulation of liver macrophage function promotes hepatocyte infection

(2019) Suzanne Faure-Dupuy et al.   JOURNAL OF HEPATOLOGY

Integrin β1-enriched extracellular vesicles mediate monocyte adhesion and promote liver inflammation in murine NASH

(2019) Qianqian Guo et al.   JOURNAL OF HEPATOLOGY

Resolving the fibrotic niche of human liver cirrhosis at single-cell level

(2019) P. Ramachandran et al.   NATURE

Increased Tim-3 expression alleviates liver injury by regulating macrophage activation in MCD-induced NASH mice

(2018) Xianhong Du et al.   Cellular & Molecular Immunology

A randomized, placebo-controlled trial of cenicriviroc for treatment of nonalcoholic steatohepatitis with fibrosis

(2018) Scott L. Friedman et al.   HEPATOLOGY

STING-mediated inflammation in Kupffer cells contributes to progression of nonalcoholic steatohepatitis

(2018) Yongsheng Yu et al.   JOURNAL OF CLINICAL INVESTIGATION

The role of macrophages in nonalcoholic fatty liver disease and nonalcoholic steatohepatitis

(2018) Konstantin Kazankov et al.   Nature Reviews Gastroenterology & Hepatology

Single cell RNA sequencing of human liver reveals distinct intrahepatic macrophage populations

(2018) Sonya A. MacParland et al.   Nature Communications

Hepatitis C virus-induced CCL5 secretion from macrophages activates hepatic stellate cells

(2017) Reina Sasaki et al.   HEPATOLOGY

MicroRNA 181b-3p and its target importin α5 regulate toll-like receptor 4 signaling in Kupffer cells and liver injury in mice in response to ethanol

(2017) Paramananda Saikia et al.   HEPATOLOGY

Targeting hepatic macrophages to treat liver diseases

(2017) Frank Tacke   JOURNAL OF HEPATOLOGY

Dynamic plasticity of macrophage functions in diseased liver

(2017) Thomas Ritz et al.   CELLULAR IMMUNOLOGY

Antiviral activity of various interferons and pro-inflammatory cytokines in non-transformed cultured hepatocytes infected with hepatitis B virus

(2016) Nathalie Isorce et al.   ANTIVIRAL RESEARCH

Distinct Functions of Senescence-Associated Immune Responses in Liver Tumor Surveillance and Tumor Progression

(2016) Tobias Eggert et al.   CANCER CELL

A Reservoir of Mature Cavity Macrophages that Can Rapidly Invade Visceral Organs to Affect Tissue Repair

(2016) Jing Wang et al.   CELL

Hepatic macrophages in homeostasis and liver diseases: from pathogenesis to novel therapeutic strategies

(2016) Cynthia Ju et al.   Cellular & Molecular Immunology

Pathogenesis of Alcoholic Liver Disease

(2016) Winston Dunn et al.   Clinics in Liver Disease

Lipid-Induced Signaling Causes Release of Inflammatory Extracellular Vesicles From Hepatocytes

(2016) Petra Hirsova et al.   GASTROENTEROLOGY

Tumor-Associated Neutrophils Recruit Macrophages and T-Regulatory Cells to Promote Progression of Hepatocellular Carcinoma and Resistance to Sorafenib

(2016) Shao-Lai Zhou et al.   GASTROENTEROLOGY

Pathogenesis of Nonalcoholic Steatohepatitis

(2016) Mariana Verdelho Machado et al.   GASTROENTEROLOGY

Alcohol stimulates macrophage activation through caspase-dependent hepatocyte derived release of CD40L containing extracellular vesicles

(2016) Vikas K. Verma et al.   JOURNAL OF HEPATOLOGY

The pro-inflammatory effects of miR-155 promote liver fibrosis and alcohol-induced steatohepatitis

(2016) Shashi Bala et al.   JOURNAL OF HEPATOLOGY

Tumor-infiltrating monocytes/macrophages promote tumor invasion and migration by upregulating S100A8 and S100A9 expression in cancer cells

(2016) S Y Lim et al.   ONCOGENE

Specification of tissue-resident macrophages during organogenesis

(2016) E. Mass et al.   SCIENCE

The spleen as an extramedullary source of inflammatory cells responding to acetaminophen-induced liver injury

(2016) Mili Mandal et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Bone marrow-derived monocytes give rise to self-renewing and fully differentiated Kupffer cells

(2016) Charlotte L. Scott et al.   Nature Communications

The Cannabinoid Receptor 2 Protects Against Alcoholic Liver Disease Via a Macrophage Autophagy-Dependent Pathway

(2016) Timothé Denaës et al.   Scientific Reports

Targeting of tumour-infiltrating macrophages via CCL2/CCR2 signalling as a therapeutic strategy against hepatocellular carcinoma

(2015) Xiaoguang Li et al.   GUT

Plasma cholesteryl ester transfer protein is predominantly derived from Kupffer cells

(2015) Yanan Wang et al.   HEPATOLOGY

Kupffer cell-monocyte communication is essential for initiating murine liver progenitor cell-mediated liver regeneration

(2015) Caryn L. Elsegood et al.   HEPATOLOGY

Myeloid cells in hepatocellular carcinoma

(2015) Shanshan Wan et al.   HEPATOLOGY

Mixed lineage kinase 3 mediates release of C-X-C motif ligand 10-bearing chemotactic extracellular vesicles from lipotoxic hepatocytes

(2015) Samar H. Ibrahim et al.   HEPATOLOGY

Alternatively activated (M2) macrophages promote tumour growth and invasiveness in hepatocellular carcinoma

(2015) Oscar W.H. Yeung et al.   JOURNAL OF HEPATOLOGY

Metabolic danger signals, uric acid and ATP, mediate inflammatory cross-talk between hepatocytes and immune cells in alcoholic liver disease

(2015) Jan Petrasek et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Phenotype, development, and biological function of myeloid-derived suppressor cells

(2015) Yang Zhao et al.   OncoImmunology

Interactions Between the Intestinal Microbiome and Liver Diseases

(2014) Bernd Schnabl et al.   GASTROENTEROLOGY

Macrophage Activation and Polarization: Nomenclature and Experimental Guidelines

(2014) Peter J. Murray et al.   IMMUNITY

Transcriptome-Based Network Analysis Reveals a Spectrum Model of Human Macrophage Activation

(2014) Jia Xue et al.   IMMUNITY

The role of Kupffer cells in hepatitis B and hepatitis C virus infections

(2014) Arjan Boltjes et al.   JOURNAL OF HEPATOLOGY

The chemotaxis of M1 and M2 macrophages is regulated by different chemokines

(2014) Wenjuan Xuan et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Chronic alcohol ingestion modulates hepatic macrophage populations and functions in mice

(2014) Meng Wang et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Macrophages: central regulators of iron balance

(2014) Elena Gammella et al.   Metallomics

Hepatitis B Virus Infection and Immunopathogenesis in a Humanized Mouse Model: Induction of Human-Specific Liver Fibrosis and M2-Like Macrophages

(2014) Moses T. Bility et al.   PLoS Pathogens

Role of Toll-Like Receptors in Immune Activation and Tolerance in the Liver

(2014) Nobuhiro Nakamoto et al.   Frontiers in Immunology

Nr4a1-Dependent Ly6Clow Monocytes Monitor Endothelial Cells and Orchestrate Their Disposal

(2013) Leo M. Carlin et al.   CELL

Hepatic macrophages but not dendritic cells contribute to liver fibrosis by promoting the survival of activated hepatic stellate cells in mice

(2013) Jean-Philippe Pradere et al.   HEPATOLOGY

Hepatitis C Virus Induces Interleukin-1  (IL-1 )/IL-18 in Circulatory and Resident Liver Macrophages

(2013) S. Shrivastava et al.   JOURNAL OF VIROLOGY

Immune surveillance by the liver

(2013) Craig N Jenne et al.   NATURE IMMUNOLOGY

IL-1β Production through the NLRP3 Inflammasome by Hepatic Macrophages Links Hepatitis C Virus Infection with Liver Inflammation and Disease

(2013) Amina A. Negash et al.   PLoS Pathogens

The Proinflammatory Myeloid Cell Receptor TREM-1 Controls Kupffer Cell Activation and Development of Hepatocellular Carcinoma

(2012) Juan Wu et al.   CANCER RESEARCH

Adaptive immunity suppresses formation and progression of diethylnitrosamine-induced liver cancer

(2012) Carlo Schneider et al.   GUT

Tim-3/galectin-9 signaling pathway mediates T-cell dysfunction and predicts poor prognosis in patients with hepatitis B virus-associated hepatocellular carcinoma

(2012) Hang Li et al.   HEPATOLOGY

Upregulation of the Tim-3/Galectin-9 Pathway of T Cell Exhaustion in Chronic Hepatitis B Virus Infection

(2012) Gaia Nebbia et al.   PLoS One

Differential Ly-6C expression identifies the recruited macrophage phenotype, which orchestrates the regression of murine liver fibrosis

(2012) P. Ramachandran et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Lineage of Myeloid Cells Independent of Myb and Hematopoietic Stem Cells

(2012) C. Schulz et al.   SCIENCE

The Inflammatory Microenvironment in Hepatocellular Carcinoma: A Pivotal Role for Tumor-Associated Macrophages

(2012) Daria Capece et al.   Biomed Research International

Monocytic CCR2+ Myeloid-Derived Suppressor Cells Promote Immune Escape by Limiting Activated CD8 T-cell Infiltration into the Tumor Microenvironment

(2011) A. M. Lesokhin et al.   CANCER RESEARCH

Hepatitis B virus particles preferably induce Kupffer cells to produce TGF-β1 over pro-inflammatory cytokines

(2011) Hai Li et al.   DIGESTIVE AND LIVER DISEASE

Alcoholic Liver Disease: Pathogenesis and New Therapeutic Targets

(2011) Bin Gao et al.   GASTROENTEROLOGY

An essential role for monocyte chemoattractant protein-1 in alcoholic liver injury: Regulation of proinflammatory cytokines and hepatic steatosis in mice

(2011) Pranoti Mandrekar et al.   HEPATOLOGY

Senescence surveillance of pre-malignant hepatocytes limits liver cancer development

(2011) Tae-Won Kang et al.   NATURE

Local Macrophage Proliferation, Rather than Recruitment from the Blood, Is a Signature of TH2 Inflammation

(2011) S. J. Jenkins et al.   SCIENCE

HCV-Related Proteins Activate Kupffer Cells Isolated from Human Liver Tissues

(2010) Naohiro Hosomura et al.   DIGESTIVE DISEASES AND SCIENCES

Up-regulation of MicroRNA-155 in Macrophages Contributes to Increased Tumor Necrosis Factor α (TNFα) Production via Increased mRNA Half-life in Alcoholic Liver Disease

(2010) Shashi Bala et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A longitudinal analysis of innate and adaptive immune profile during hepatic flares in chronic hepatitis B

(2010) Anthony T. Tan et al.   JOURNAL OF HEPATOLOGY

Kupffer Cell Suppression of CD8+ T Cells in Human Hepatocellular Carcinoma Is Mediated by B7-H1/Programmed Death-1 Interactions

(2009) K. Wu et al.   CANCER RESEARCH

Hepatitis C Virus Core Protein Subverts the Antiviral Activities of Human Kupffer Cells

(2009) Zhengkun Tu et al.   GASTROENTEROLOGY

Not interferon, but interleukin-6 controls early gene expression in hepatitis B virus infection

(2009) Marianna Hösel et al.   HEPATOLOGY

Activated monocytes in peritumoral stroma of hepatocellular carcinoma foster immune privilege and disease progression through PD-L1

(2009) Dong-Ming Kuang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Alternative M2 Activation of Kupffer Cells by PPARδ Ameliorates Obesity-Induced Insulin Resistance

(2008) Justin I. Odegaard et al.   Cell Metabolism

Mechanism of T cell tolerance induction by murine hepatic Kupffer cells

(2008) Qiang You et al.   HEPATOLOGY

High tumor-infiltrating macrophage density predicts poor prognosis in patients with primary hepatocellular carcinoma after resection

(2008) Tong Ding et al.   HUMAN PATHOLOGY

Tumor-infiltrating macrophages can predict favorable prognosis in hepatocellular carcinoma after resection

(2008) Yi-Wei Li et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Macrophages in Hepatitis B and Hepatitis C Virus Infections

(2008) M. Heydtmann   JOURNAL OF VIROLOGY

TREM-1 Expression in Tumor-associated Macrophages and Clinical Outcome in Lung Cancer

(2007) Chao-Chi Ho et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE