Characterization of hepatocyte-based in vitro systems for reliable toxicity testing

The molecular functions of hepatocyte nuclear factors – In and beyond the liver

(2018) Hwee Hui Lau et al.   JOURNAL OF HEPATOLOGY

Assessment of stem cell differentiation based on genome-wide expression profiles

(2018) Patricio Godoy et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

The ascending pathophysiology of cholestatic liver disease

(2017) Peter L.M. Jansen et al.   HEPATOLOGY

In vitro testing of basal cytotoxicity: Establishment of an adverse outcome pathway from chemical insult to cell death

(2017) Mathieu Vinken et al.   TOXICOLOGY IN VITRO

Gene network activity in cultivated primary hepatocytes is highly similar to diseased mammalian liver tissue

(2016) Patricio Godoy et al.   ARCHIVES OF TOXICOLOGY

Bile canaliculi formation and biliary transport in 3D sandwich-cultured hepatocytes in dependence of the extracellular matrix composition

(2016) Daniela Deharde et al.   ARCHIVES OF TOXICOLOGY

Model-guided identification of a therapeutic strategy to reduce hyperammonemia in liver diseases

(2016) Ahmed Ghallab et al.   JOURNAL OF HEPATOLOGY

Sandwich-Cultured Hepatocytes as a Tool to Study Drug Disposition and Drug-Induced Liver Injury

(2016) Kyunghee Yang et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Experimental models of hepatotoxicity related to acute liver failure

(2016) Michaël Maes et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Bile canalicular dynamics in hepatocyte sandwich cultures

(2015) Raymond Reif et al.   ARCHIVES OF TOXICOLOGY

Preventing Drug-Induced Liver Injury: How Useful Are Animal Models?

(2015) François Ballet   DIGESTIVE DISEASES

Gene networks and transcription factor motifs defining the differentiation of stem cells into hepatocyte-like cells

(2015) Patricio Godoy et al.   JOURNAL OF HEPATOLOGY

Structural and functional hepatocyte polarity and liver disease

(2015) Paul Gissen et al.   JOURNAL OF HEPATOLOGY

Strategies, models and biomarkers in experimental non-alcoholic fatty liver disease research

(2015) Joost Willebrords et al.   PROGRESS IN LIPID RESEARCH

Toxicogenomics directory of chemically exposed human hepatocytes

(2014) Marianna Grinberg et al.   ARCHIVES OF TOXICOLOGY

Primary hepatocytes and their cultures in liver apoptosis research

(2013) Mathieu Vinken et al.   ARCHIVES OF TOXICOLOGY

Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME

(2013) Patricio Godoy et al.   ARCHIVES OF TOXICOLOGY

Drug-Induced Liver Injury: Mechanisms, Types and Biomarkers

(2013) M. Vinken et al.   CURRENT MEDICINAL CHEMISTRY

Primary hepatocyte cultures as prominentin vitrotools to study hepatic drug transporters

(2013) Eva Ramboer et al.   DRUG METABOLISM REVIEWS

Development of an Adverse Outcome Pathway From Drug-Mediated Bile Salt Export Pump Inhibition to Cholestatic Liver Injury

(2013) Mathieu Vinken et al.   TOXICOLOGICAL SCIENCES

Primary hepatocyte cultures for pharmaco-toxicological studies: at the busy crossroad of various anti-dedifferentiation strategies

(2012) J. Fraczek et al.   ARCHIVES OF TOXICOLOGY

Biomarkers for Hepatocellular Apoptosis in the Management of Liver Diseases

(2012) Marie V. St-Pierre et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Characterization of spontaneous cell death in monolayer cultures of primary hepatocytes

(2011) Mathieu Vinken et al.   ARCHIVES OF TOXICOLOGY

A physiologically based toxicokinetic modelling approach to predict relevant concentrations for in vitro testing

(2010) Hans Mielke et al.   ARCHIVES OF TOXICOLOGY

A Comparison of Whole Genome Gene Expression Profiles of HepaRG Cells and HepG2 Cells to Primary Human Hepatocytes and Human Liver Tissues

(2010) S. N. Hart et al.   DRUG METABOLISM AND DISPOSITION

Serum acetaminophen concentrations after acute overdose are not altered by opioid co-ingestion

(2008) W. Stephen Waring et al.   JOURNAL OF TOXICOLOGICAL SCIENCES