Mechanisms of hepatic stellate cell activation

Osteopontin is a proximal effector of leptin-mediated non-alcoholic steatohepatitis (NASH) fibrosis

(2016) Jason D. Coombes et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

p62/SQSTM1 by Binding to Vitamin D Receptor Inhibits Hepatic Stellate Cell Activity, Fibrosis, and Liver Cancer

(2016) Angeles Duran et al.   CANCER CELL

Efficacy and safety study of cenicriviroc for the treatment of non-alcoholic steatohepatitis in adult subjects with liver fibrosis: CENTAUR Phase 2b study design

(2016) Scott Friedman et al.   Contemporary Clinical Trials

Lysyl oxidase activity contributes to collagen stabilization during liver fibrosis progression and limits spontaneous fibrosis reversal in mice

(2016) Susan B. Liu et al.   FASEB JOURNAL

Elafibranor, an Agonist of the Peroxisome Proliferator−Activated Receptor−α and −δ, Induces Resolution of Nonalcoholic Steatohepatitis Without Fibrosis Worsening

(2016) Vlad Ratziu et al.   GASTROENTEROLOGY

Endoplasmic Reticulum Stress in Hepatic Stellate Cells Promotes Liver Fibrosis via PERK-Mediated Degradation of HNRNPA1 and Up-regulation of SMAD2

(2016) Ja Hyun Koo et al.   GASTROENTEROLOGY

The LATS2 tumor suppressor inhibits SREBP and suppresses hepatic cholesterol accumulation

(2016) Yael Aylon et al.   GENES & DEVELOPMENT

Epigenetics in liver disease: from biology to therapeutics

(2016) Timothy Hardy et al.   GUT

Exosome-mediated activation of toll-like receptor 3 in stellate cells stimulates interleukin-17 production by γδ T cells in liver fibrosis

(2016) Wonhyo Seo et al.   HEPATOLOGY

Hedgehog regulates yes-associated protein 1 in regenerating mouse liver

(2016) Marzena Swiderska-Syn et al.   HEPATOLOGY

Systemic PEGylated TRAIL treatment ameliorates liver cirrhosis in rats by eliminating activated hepatic stellate cells

(2016) Yumin Oh et al.   HEPATOLOGY

Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes

(2016) Zobair M. Younossi et al.   HEPATOLOGY

Differentiation therapy for hepatocellular carcinoma: Multifaceted effects of miR-148a on tumor growth and phenotype and liver fibrosis

(2016) Kwang Hwa Jung et al.   HEPATOLOGY

Myocardin-related transcription factor A (MRTF-A) plays an essential role in hepatic stellate cell activation by epigenetically modulating TGF-β signaling

(2016) Wenfang Tian et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Sirtuin 3 (SIRT3) Regulates α-Smooth Muscle Actin (α-SMA) Production through the Succinate Dehydrogenase-G Protein-coupled Receptor 91 (GPR91) Pathway in Hepatic Stellate Cells

(2016) Ying Hui Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Novel functions of platelets in the liver

(2016) Tomohiro Kurokawa et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Hepatic expression of Sonic Hedgehog induces liver fibrosis and promotes hepatocarcinogenesis in a transgenic mouse model

(2016) Sook In Chung et al.   JOURNAL OF HEPATOLOGY

Interleukin-15 receptor α on hepatic stellate cells regulates hepatic fibrogenesis in mice

(2016) Jingjing Jiao et al.   JOURNAL OF HEPATOLOGY

Antifibrotic Therapies: Where Are We Now?

(2016) Young Yoon et al.   SEMINARS IN LIVER DISEASE

PAK proteins and YAP-1 signalling downstream of integrin beta-1 in myofibroblasts promote liver fibrosis

(2016) Katherine Martin et al.   Nature Communications

MicroRNA-378 limits activation of hepatic stellate cells and liver fibrosis by suppressing Gli3 expression

(2016) Jeongeun Hyun et al.   Nature Communications

FXR agonist obeticholic acid reduces hepatic inflammation and fibrosis in a rat model of toxic cirrhosis

(2016) Len Verbeke et al.   Scientific Reports

Long noncoding RNAs expressed in human hepatic stellate cells form networks with extracellular matrix proteins

(2016) Chan Zhou et al.   Genome Medicine

Antifibrotic Effects of the Dual CCR2/CCR5 Antagonist Cenicriviroc in Animal Models of Liver and Kidney Fibrosis

(2016) Eric Lefebvre et al.   PLoS One

Wnt Pathway Stabilizes MeCP2 Protein to Repress PPAR-γ in Activation of Hepatic Stellate Cells

(2016) Soo-Mi Kweon et al.   PLoS One

The XBP1 Arm of the Unfolded Protein Response Induces Fibrogenic Activity in Hepatic Stellate Cells Through Autophagy

(2016) Rosa S. Kim et al.   Scientific Reports

Suppression of fibrogenic signaling in hepatic stellate cells by Twist1-dependent microRNA-214 expression: Role of exosomes in horizontal transfer of Twist1

(2015) Li Chen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Succinate causes α-SMA production through GPR91 activation in hepatic stellate cells

(2015) Ying Hui Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Hepatic stellate cell-expressed endosialin balances fibrogenesis and hepatocyte proliferation during liver damage

(2015) C. Mogler et al.   EMBO Molecular Medicine

Pathobiology of liver fibrosis: a translational success story

(2015) Youngmin A Lee et al.   GUT

CD248/endosialin critically regulates hepatic stellate cell proliferation during chronic liver injury via a PDGF-regulated mechanism

(2015) Annika Wilhelm et al.   GUT

A hepatic stellate cell gene expression signature associated with outcomes in hepatitis C cirrhosis and hepatocellular carcinoma after curative resection

(2015) David Y Zhang et al.   GUT

Resolution of liver fibrosis requires myeloid cell-driven sinusoidal angiogenesis

(2015) Chahrazade Kantari-Mimoun et al.   HEPATOLOGY

Liver X receptors balance lipid stores in hepatic stellate cells through Rab18, a retinoid responsive lipid droplet protein

(2015) Fiona O'Mahony et al.   HEPATOLOGY

Liver fibrosis occurs through dysregulation of MyD88-dependent innate B-cell activity

(2015) Manoj Thapa et al.   HEPATOLOGY

The Hippo pathway effector YAP controls mouse hepatic stellate cell activation

(2015) Inge Mannaerts et al.   JOURNAL OF HEPATOLOGY

Accumulation of duct cells with activated YAP parallels fibrosis progression in non-alcoholic fatty liver disease

(2015) Mariana Verdelho Machado et al.   JOURNAL OF HEPATOLOGY

β-PDGF receptor expressed by hepatic stellate cells regulates fibrosis in murine liver injury, but not carcinogenesis

(2015) Peri Kocabayoglu et al.   JOURNAL OF HEPATOLOGY

Gas6/Axl pathway is activated in chronic liver disease and its targeting reduces fibrosis via hepatic stellate cell inactivation

(2015) Cristina Bárcena et al.   JOURNAL OF HEPATOLOGY

Hepatic fibrosis: Concept to treatment

(2015) Christian Trautwein et al.   JOURNAL OF HEPATOLOGY

Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, non-alcoholic steatohepatitis (FLINT): a multicentre, randomised, placebo-controlled trial

(2015) Brent A Neuschwander-Tetri et al.   LANCET

Orphan nuclear receptor NR4A1 regulates transforming growth factor-β signaling and fibrosis

(2015) Katrin Palumbo-Zerr et al.   NATURE MEDICINE

High-yield and high-purity isolation of hepatic stellate cells from normal and fibrotic mouse livers

(2015) Ingmar Mederacke et al.   Nature Protocols

Adipocytokines and hepatic fibrosis

(2015) Neeraj K. Saxena et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Integrative miRNA and Gene Expression Profiling Analysis of Human Quiescent Hepatic Stellate Cells

(2015) Mar Coll et al.   Scientific Reports

Natural killer T cells in liver injury, inflammation and cancer

(2015) Hua Wang et al.   Expert Review of Gastroenterology & Hepatology

Deficiency of NOX1 or NOX4 Prevents Liver Inflammation and Fibrosis in Mice through Inhibition of Hepatic Stellate Cell Activation

(2015) Tian Lan et al.   PLoS One

Activation of Mir-29a in Activated Hepatic Stellate Cells Modulates Its Profibrogenic Phenotype through Inhibition of Histone Deacetylases 4

(2015) Ying-Hsien Huang et al.   PLoS One

Cellular and molecular mechanisms in liver fibrogenesis

(2014) Erica Novo et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Purinergic Signaling in Liver Disease

(2014) Byron P. Vaughn et al.   DIGESTIVE DISEASES

Extrahepatic Platelet-Derived Growth Factor-β, Delivered by Platelets, Promotes Activation of Hepatic Stellate Cells and Biliary Fibrosis in Mice

(2014) Shuhei Yoshida et al.   GASTROENTEROLOGY

Vascular Endothelial Growth Factor Promotes Fibrosis Resolution and Repair in Mice

(2014) Liu Yang et al.   GASTROENTEROLOGY

Enhanced expression of BMP6 inhibits hepatic fibrosis in non-alcoholic fatty liver disease

(2014) Stephanie Arndt et al.   GUT

Reduced lipoapoptosis, hedgehog pathway activation and fibrosis in caspase-2 deficient mice with non-alcoholic steatohepatitis

(2014) M V Machado et al.   GUT

Novel role of nuclear receptor rev-erbα in hepatic stellate cell activation: Potential therapeutic target for liver injury

(2014) Ting Li et al.   HEPATOLOGY

IL-20 and IL-20R1 antibodies protect against liver fibrosis

(2014) Yi-Shu Chiu et al.   HEPATOLOGY

Angiotensin-II type 1 receptor-mediated Janus kinase 2 activation induces liver fibrosis

(2014) Michaela Granzow et al.   HEPATOLOGY

GATA4 loss in the septum transversum mesenchyme promotes liver fibrosis in mice

(2014) Irene Delgado et al.   HEPATOLOGY

Alcohol dehydrogenase III exacerbates liver fibrosis by enhancing stellate cell activation and suppressing natural killer cells in mice

(2014) Hyon-Seung Yi et al.   HEPATOLOGY

PNPLA3 has retinyl-palmitate lipase activity in human hepatic stellate cells

(2014) Carlo Pirazzi et al.   HUMAN MOLECULAR GENETICS

Deletion of the Collagen-specific Molecular Chaperone Hsp47 Causes Endoplasmic Reticulum Stress-mediated Apoptosis of Hepatic Stellate Cells

(2014) Kunito Kawasaki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Acyl-CoA:cholesterol acyltransferase 1 mediates liver fibrosis by regulating free cholesterol accumulation in hepatic stellate cells

(2014) Kengo Tomita et al.   JOURNAL OF HEPATOLOGY

Origin of myofibroblasts in the fibrotic liver in mice

(2014) K. Iwaisako et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

GIV/Girdin is a central hub for profibrogenic signalling networks during liver fibrosis

(2014) Inmaculada Lopez-Sanchez et al.   Nature Communications

Origins and functions of liver myofibroblasts

(2013) Sara Lemoinne et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Non-Cell-Autonomous Tumor Suppression by p53

(2013) Amaia Lujambio et al.   CELL

A Vitamin D Receptor/SMAD Genomic Circuit Gates Hepatic Fibrotic Response

(2013) Ning Ding et al.   CELL

Contributions of metabolic dysregulation and inflammation to nonalcoholic steatohepatitis, hepatic fibrosis, and cancer

(2013) Abigale Lade et al.   CURRENT OPINION IN ONCOLOGY

The Hippo pathway: regulators and regulations

(2013) F.-X. Yu et al.   GENES & DEVELOPMENT

Myofibroblastic cells function as progenitors to regenerate murine livers after partial hepatectomy

(2013) M Swiderska-Syn et al.   GUT

Jnk1 in murine hepatic stellate cells is a crucial mediator of liver fibrogenesis

(2013) Gang Zhao et al.   GUT

Cross-talk between Notch and Hedgehog regulates hepatic stellate cell fate in mice

(2013) Guanhua Xie et al.   HEPATOLOGY

Cannabinoid receptor 2 counteracts interleukin-17-induced immune and fibrogenic responses in mouse liver

(2013) Adrien Guillot et al.   HEPATOLOGY

Hepatic macrophages but not dendritic cells contribute to liver fibrosis by promoting the survival of activated hepatic stellate cells in mice

(2013) Jean-Philippe Pradere et al.   HEPATOLOGY

Hepatoprotective effects of the dual peroxisome proliferator-activated receptor alpha/delta agonist, GFT505, in rodent models of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis

(2013) Bart Staels et al.   HEPATOLOGY

Free cholesterol accumulation in hepatic stellate cells: Mechanism of liver fibrosis aggravation in nonalcoholic steatohepatitis in mice

(2013) Kengo Tomita et al.   HEPATOLOGY

NLRP3 inflammasome activation results in hepatocyte pyroptosis, liver inflammation, and fibrosis in mice

(2013) Alexander Wree et al.   HEPATOLOGY

Epigenetic regulation of connective tissue growth factor by MicroRNA-214 delivery in exosomes from mouse or human hepatic stellate cells

(2013) Li Chen et al.   HEPATOLOGY

Role of platelets in chronic liver disease and acute liver injury

(2013) Takeshi Nowatari et al.   HEPATOLOGY RESEARCH

Interleukin-33-Dependent Innate Lymphoid Cells Mediate Hepatic Fibrosis

(2013) Tamar Mchedlidze et al.   IMMUNITY

Pharmacological cholesterol lowering reverses fibrotic NASH in obese, diabetic mice with metabolic syndrome

(2013) Derrick M. Van Rooyen et al.   JOURNAL OF HEPATOLOGY

Endoplasmic reticulum stress induces fibrogenic activity in hepatic stellate cells through autophagy

(2013) Virginia Hernández-Gea et al.   JOURNAL OF HEPATOLOGY

Cell-specific PPARγ deficiency establishes anti-inflammatory and anti-fibrogenic properties for this nuclear receptor in non-parenchymal liver cells

(2013) Eva Morán-Salvador et al.   JOURNAL OF HEPATOLOGY

Chemokine Receptor CXCR6-Dependent Hepatic NK T Cell Accumulation Promotes Inflammation and Liver Fibrosis

(2013) A. Wehr et al.   JOURNAL OF IMMUNOLOGY

5-HT2Areceptor antagonists inhibit hepatic stellate cell activation and facilitate apoptosis

(2013) Dong Chan Kim et al.   LIVER INTERNATIONAL

Divergent angiocrine signals from vascular niche balance liver regeneration and fibrosis

(2013) Bi-Sen Ding et al.   NATURE

Targeting of αv integrin identifies a core molecular pathway that regulates fibrosis in several organs

(2013) Neil C Henderson et al.   NATURE MEDICINE

The Chemokine CCL3 Promotes Experimental Liver Fibrosis in Mice

(2013) Daniel Heinrichs et al.   PLoS One

Regression of Fibrosis and Reversal of Cirrhosis in Rats by Galectin Inhibitors in Thioacetamide-Induced Liver Disease

(2013) Peter G. Traber et al.   PLoS One

Fate tracing reveals hepatic stellate cells as dominant contributors to liver fibrosis independent of its aetiology

(2013) Ingmar Mederacke et al.   Nature Communications

Hepatic recruitment of macrophages promotes nonalcoholic steatohepatitis through CCR2

(2012) Kouichi Miura et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Selective activation of Toll-like receptor 7 in activated hepatic stellate cells may modulate their profibrogenic phenotype

(2012) Ming-Huei Chou et al.   BIOCHEMICAL JOURNAL

Regulation of hepatic stellate cells by connective tissue growth factor

(2012) Guangcun Huang   Frontiers in Bioscience-Landmark

Autophagy Releases Lipid That Promotes Fibrogenesis by Activated Hepatic Stellate Cells in Mice and in Human Tissues

(2012) Virginia Hernández–Gea et al.   GASTROENTEROLOGY

A Liver Full of JNK: Signaling in Regulation of Cell Function and Disease Pathogenesis, and Clinical Approaches

(2012) Ekihiro Seki et al.   GASTROENTEROLOGY

Interleukin-17 Signaling in Inflammatory, Kupffer Cells, and Hepatic Stellate Cells Exacerbates Liver Fibrosis in Mice

(2012) Fanli Meng et al.   GASTROENTEROLOGY

Deactivation of Hepatic Stellate Cells During Liver Fibrosis Resolution in Mice

(2012) Juliane S. Troeger et al.   GASTROENTEROLOGY

MicroRNA-221/222 upregulation indicates the activation of stellate cells and the progression of liver fibrosis

(2012) Tomohiro Ogawa et al.   GUT

Hepatic activation of IKK/NFκB signaling induces liver fibrosis via macrophage-mediated chronic inflammation

(2012) Yoshiaki Sunami et al.   HEPATOLOGY

Nicotinamide adenine dinucleotide phosphate oxidase in experimental liver fibrosis: GKT137831 as a novel potential therapeutic agent

(2012) Tomonori Aoyama et al.   HEPATOLOGY

The basic helix-loop-helix transcription factor, heart and neural crest derivatives expressed transcript 2, marks hepatic stellate cells in zebrafish: Analysis of stellate cell entry into the developing liver

(2012) Chunyue Yin et al.   HEPATOLOGY

Interleukin-22 induces hepatic stellate cell senescence and restricts liver fibrosis in mice

(2012) Xiaoni Kong et al.   HEPATOLOGY

A morphometric and immunohistochemical study to assess the benefit of a sustained virological response in hepatitis C virus patients with cirrhosis

(2012) Roberta D'Ambrosio et al.   HEPATOLOGY

Toll-like receptor 2 and palmitic acid cooperatively contribute to the development of nonalcoholic steatohepatitis through inflammasome activation in mice

(2012) Kouichi Miura et al.   HEPATOLOGY

Clinical evidence for the regression of liver fibrosis

(2012) Elizabeth L. Ellis et al.   JOURNAL OF HEPATOLOGY

Activation of toll-like receptor 3 attenuates alcoholic liver injury by stimulating Kupffer cells and stellate cells to produce interleukin-10 in mice

(2012) Jin-Seok Byun et al.   JOURNAL OF HEPATOLOGY

miR-133a mediates TGF-β-dependent derepression of collagen synthesis in hepatic stellate cells during liver fibrosis

(2012) Christoph Roderburg et al.   JOURNAL OF HEPATOLOGY

miR-122 regulates collagen production via targeting hepatic stellate cells and suppressing P4HA1 expression

(2012) Jiang Li et al.   JOURNAL OF HEPATOLOGY

NK cells from HCV-infected patients effectively induce apoptosis of activated primary human hepatic stellate cells in a TRAIL-, FasL- and NKG2D-dependent manner

(2012) Andreas Glässner et al.   LABORATORY INVESTIGATION

Regression of cirrhosis during treatment with tenofovir disoproxil fumarate for chronic hepatitis B: a 5-year open-label follow-up study

(2012) Patrick Marcellin et al.   LANCET

Protection from liver fibrosis by a peroxisome proliferator-activated receptor   agonist

(2012) K. Iwaisako et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Myofibroblasts revert to an inactive phenotype during regression of liver fibrosis

(2012) T. Kisseleva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differential Ly-6C expression identifies the recruited macrophage phenotype, which orchestrates the regression of murine liver fibrosis

(2012) P. Ramachandran et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DNMT1-mediated PTEN hypermethylation confers hepatic stellate cell activation and liver fibrogenesis in rats

(2012) Er-Bao Bian et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Liver Fibrogenesis in Non-Alcoholic Steatohepatitis

(2012) Zhaolian Bian et al.   Frontiers in Physiology

Adiponectin Regulation of Stellate Cell Activation via PPARγ-Dependent and -Independent Mechanisms

(2011) Mahnoush S. Shafiei et al.   AMERICAN JOURNAL OF PATHOLOGY

A High-Cholesterol Diet Exacerbates Liver Fibrosis in Mice via Accumulation of Free Cholesterol in Hepatic Stellate Cells

(2011) Toshiaki Teratani et al.   GASTROENTEROLOGY

Role of Differentiation of Liver Sinusoidal Endothelial Cells in Progression and Regression of Hepatic Fibrosis in Rats

(2011) Guanhua Xie et al.   GASTROENTEROLOGY

Absence of hepatic stellate cell retinoid lipid droplets does not enhance hepatic fibrosis but decreases hepatic carcinogenesis

(2011) J. Kluwe et al.   GUT

Suppression of innate immunity (natural killer cell/interferon-γ) in the advanced stages of liver fibrosis in mice

(2011) Won-Il Jeong et al.   HEPATOLOGY

Elastin accumulation is regulated at the level of degradation by macrophage metalloelastase (MMP-12) during experimental liver fibrosis

(2011) Antonella Pellicoro et al.   HEPATOLOGY

Protease-activated receptor 2 promotes experimental liver fibrosis in mice and activates human hepatic stellate cells

(2011) Virginia Knight et al.   HEPATOLOGY

Osteopontin, an oxidant stress sensitive cytokine, up-regulates collagen-I via integrin αVβ3 engagement and PI3K/pAkt/NFκB signaling

(2011) Raquel Urtasun et al.   HEPATOLOGY

A role for autophagy during hepatic stellate cell activation

(2011) Lien F.R. Thoen et al.   JOURNAL OF HEPATOLOGY

Scraping fibrosis: Expressway to the core of fibrosis

(2011) Wajahat Z Mehal et al.   NATURE MEDICINE

Stimulating healthy tissue regeneration by targeting the 5-HT2B receptor in chronic liver disease

(2011) Mohammad R Ebrahimkhani et al.   NATURE MEDICINE

Hippo signaling: growth control and beyond

(2010) G. Halder et al.   DEVELOPMENT

Reduced Nicotinamide Adenine Dinucleotide Phosphate Oxidase 2 Plays a Key Role in Stellate Cell Activation and Liver Fibrogenesis In Vivo

(2010) Joy X. Jiang et al.   GASTROENTEROLOGY

Liver X Receptor Signaling Is a Determinant of Stellate Cell Activation and Susceptibility to Fibrotic Liver Disease

(2010) Simon W. Beaven et al.   GASTROENTEROLOGY

CX3CL1-CX3CR1 interaction prevents carbon tetrachloride-induced liver inflammation and fibrosis in mice

(2010) Tomonori Aoyama et al.   HEPATOLOGY

Osteopontin is induced by hedgehog pathway activation and promotes fibrosis progression in nonalcoholic steatohepatitis

(2010) Wing-Kin Syn et al.   HEPATOLOGY

Long-term entecavir therapy results in the reversal of fibrosis/cirrhosis and continued histological improvement in patients with chronic hepatitis B

(2010) Ting-Tsung Chang et al.   HEPATOLOGY

Homozygosity for the patatin-like phospholipase-3/adiponutrin I148M polymorphism influences liver fibrosis in patients with nonalcoholic fatty liver disease

(2010) Luca Valenti et al.   HEPATOLOGY

Down-regulation of cyclin E1 expression by microrna-195 accounts for interferon-β-induced inhibition of hepatic stellate cell proliferation

(2010) Yumiko Sekiya et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Antagonism of the chemokine Ccl5 ameliorates experimental liver fibrosis in mice

(2010) Marie-Luise Berres et al.   JOURNAL OF CLINICAL INVESTIGATION

Hedgehog signaling in the liver

(2010) Alessia Omenetti et al.   JOURNAL OF HEPATOLOGY

Intracellular reactive oxygen species are required for directional migration of resident and bone marrow-derived hepatic pro-fibrogenic cells

(2010) Erica Novo et al.   JOURNAL OF HEPATOLOGY

Allosteric inhibition of lysyl oxidase–like-2 impedes the development of a pathologic microenvironment

(2010) Vivian Barry-Hamilton et al.   NATURE MEDICINE

Pioglitazone, Vitamin E, or Placebo for Nonalcoholic Steatohepatitis

(2010) Arun J. Sanyal et al.   NEW ENGLAND JOURNAL OF MEDICINE

Liver fibrosis causes downregulation of miRNA-150 and miRNA-194 in hepatic stellate cells, and their overexpression causes decreased stellate cell activation

(2009) Senthil K. Venugopal et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Over-expressed microRNA-27a and 27b influence fat accumulation and cell proliferation during rat hepatic stellate cell activation

(2009) Juling Ji et al.   FEBS LETTERS

MeCP2 Controls an Epigenetic Pathway That Promotes Myofibroblast Transdifferentiation and Fibrosis

(2009) Jelena Mann et al.   GASTROENTEROLOGY

Modulation of Hepatic Fibrosis by c-Jun-N-Terminal Kinase Inhibition

(2009) Johannes Kluwe et al.   GASTROENTEROLOGY

Hepatic recruitment of the inflammatory Gr1+monocyte subset upon liver injury promotes hepatic fibrosis

(2009) Karlin Raja Karlmark et al.   HEPATOLOGY

CCR2 promotes hepatic fibrosis in mice

(2009) Ekihiro Seki et al.   HEPATOLOGY

The role of stem cells in liver repair and fibrosis

(2009) Linda E. Greenbaum et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

miR-15b and miR-16 are implicated in activation of the rat hepatic stellate cell: An essential role for apoptosis

(2009) Can-Jie Guo et al.   JOURNAL OF HEPATOLOGY

Role of TLR9 in hepatic stellate cells and experimental liver fibrosis

(2008) Erwin Gäbele et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Senescence of Activated Stellate Cells Limits Liver Fibrosis

(2008) Valery Krizhanovsky et al.   CELL

Functional linkage of cirrhosis-predictive single nucleotide polymorphisms of toll-like receptor 4 to hepatic stellate cell responses

(2008) Jinsheng Guo et al.   HEPATOLOGY

Sinusoidal endothelial cells prevent rat stellate cell activation and promote reversion to quiescence

(2008) Laurie D. DeLeve et al.   HEPATOLOGY

p75 neurotrophin receptor signaling regulates hepatic myofibroblast proliferation and apoptosis in recovery from rodent liver fibrosis

(2008) Timothy J. Kendall et al.   HEPATOLOGY

Diverse roles of invariant natural killer T cells in liver injury and fibrosis induced by carbon tetrachloride

(2008) Ogyi Park et al.   HEPATOLOGY

Farnesoid X Receptor Deficiency Induces Nonalcoholic Steatohepatitis in Low-Density Lipoprotein Receptor-Knockout Mice Fed a High-Fat Diet

(2008) B. Kong et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Resolution of liver cirrhosis using vitamin A–coupled liposomes to deliver siRNA against a collagen-specific chaperone

(2008) Yasushi Sato et al.   NATURE BIOTECHNOLOGY

Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease

(2008) Stefano Romeo et al.   NATURE GENETICS

Hepatic Stellate Cells: Protean, Multifunctional, and Enigmatic Cells of the Liver

(2008) Scott L. Friedman   PHYSIOLOGICAL REVIEWS

Abrogation of the Antifibrotic Effects of Natural Killer Cells/Interferon-γ Contributes to Alcohol Acceleration of Liver Fibrosis

(2007) Won–Il Jeong et al.   GASTROENTEROLOGY