Experimental models of liver fibrosis

The importance of the interaction between hepatocyte and hepatic stellate cells in fibrogenesis induced by fatty accumulation

(2015) Pablo J. Giraudi et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Mouse models of metabolic liver injury

(2015) P Ramadori et al.   LABORATORY ANIMALS

The carbon tetrachloride model in mice

(2015) D Scholten et al.   LABORATORY ANIMALS

Standard Operating Procedures in Experimental Liver Research: Thioacetamide model in mice and rats

(2015) MC Wallace et al.   LABORATORY ANIMALS

Management of cirrhotic ascites

(2015) Julie Steen Pedersen et al.   Therapeutic Advances in Chronic Disease

Establishment and Characterization of Rat Portal Myofibroblast Cell Lines

(2015) Michel Fausther et al.   PLoS One

Isolation and culture of hepatic stellate cells from mouse liver

(2014) Wenju Chang et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Review article: the efficacy of biomarkers in chronic fibroproliferative diseases - early diagnosis and prognosis, with liver fibrosis as an exemplar

(2014) M. A. Karsdal et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Role of adipose tissue in methionine–choline-deficient model of non-alcoholic steatohepatitis (NASH)

(2014) Pooja Jha et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

A new histone deacetylase inhibitor improves liver fibrosis in BDL rats through suppression of hepatic stellate cells

(2014) Ki Cheong Park et al.   BRITISH JOURNAL OF PHARMACOLOGY

High-fat and high-cholesterol diet rapidly induces non-alcoholic steatohepatitis with advanced fibrosis in Sprague-Dawley rats

(2014) Mayuko Ichimura et al.   HEPATOLOGY RESEARCH

Deletion of the Collagen-specific Molecular Chaperone Hsp47 Causes Endoplasmic Reticulum Stress-mediated Apoptosis of Hepatic Stellate Cells

(2014) Kunito Kawasaki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CXCL10 plays a key role as an inflammatory mediator and a non-invasive biomarker of non-alcoholic steatohepatitis

(2014) Xiang Zhang et al.   JOURNAL OF HEPATOLOGY

Endoplasmic reticulum stress-induced hepatic stellate cell apoptosis through calcium-mediated JNK/P38 MAPK and Calpain/Caspase-12 pathways

(2014) Yan Huang et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

HCC Development Is Associated to Peripheral Insulin Resistance in a Mouse Model of NASH

(2014) Samuele De Minicis et al.   PLoS One

The Effect of Antifibrotic Drugs in Rat Precision-Cut Fibrotic Liver Slices

(2014) Inge M. Westra et al.   PLoS One

Inhibitory Effect of Tanshinone IIA on Rat Hepatic Stellate Cells

(2014) Ya-Wei Liu et al.   PLoS One

Origin of myofibroblasts in the fibrotic liver in mice

(2014) K. Iwaisako et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TGF-β1-elevated TRPM7 channel regulates collagen expression in hepatic stellate cells via TGF-β1/Smad pathway

(2014) Ling Fang et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

High fat diet feeding results in gender specific steatohepatitis and inflammasome activation

(2014) Michal Ganz   WORLD JOURNAL OF GASTROENTEROLOGY

Non-invasive diagnosis of advanced fibrosis and cirrhosis

(2014) Suraj Sharma   WORLD JOURNAL OF GASTROENTEROLOGY

Hepatic inflammation and progressive liver fibrosis in chronic liver disease

(2014) Albert J Czaja   WORLD JOURNAL OF GASTROENTEROLOGY

Hepatitis B Virus Infection and Immunopathogenesis in a Humanized Mouse Model: Induction of Human-Specific Liver Fibrosis and M2-Like Macrophages

(2014) Moses T. Bility et al.   PLoS Pathogens

Molecular Mechanisms for Biliary Phospholipid and Drug Efflux Mediated by ABCB4 and Bile Salts

(2014) Shin-ya Morita et al.   Biomed Research International

Origins and functions of liver myofibroblasts

(2013) Sara Lemoinne et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Comparative proteomic analysis of thiol proteins in the liver after oxidative stress induced by diethylnitrosamine

(2013) Diana I. Aparicio-Bautista et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Fructose-1,6-bisphosphate induces phenotypic reversion of activated hepatic stellate cell

(2013) Fernanda C. de Mesquita et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Genomic aspects of NAFLD pathogenesis

(2013) Adviti Naik et al.   GENOMICS

Thymoquinone attenuates liver fibrosis via PI3K and TLR4 signaling pathways in activated hepatic stellate cells

(2013) Ting Bai et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Combined Taurine, Epigallocatechin Gallate and Genistein Therapy Reduces HSC-T6 Cell Proliferation and Modulates the Expression of Fibrogenic Factors

(2013) Yan Li et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Precision-cut liver slices: A tool to model the liver ex vivo

(2013) Peter Olinga et al.   JOURNAL OF HEPATOLOGY

The burden of liver disease in Europe: A review of available epidemiological data

(2013) Martin Blachier et al.   JOURNAL OF HEPATOLOGY

Bile salt-stimulated phospholipid efflux mediated by ABCB4 localized in nonraft membranes

(2013) Shin-ya Morita et al.   JOURNAL OF LIPID RESEARCH

Spheroid-based three-dimensional liver-on-a-chip to investigate hepatocyte–hepatic stellate cell interactions and flow effects

(2013) Seung-A Lee et al.   LAB ON A CHIP

Strain dependence of diet-induced NASH and liver fibrosis in obese mice is linked to diabetes and inflammatory phenotype

(2013) Geoffrey C. Farrell et al.   LIVER INTERNATIONAL

Dietary modification dampens liver inflammation and fibrosis in obesity-related fatty liver disease

(2013) Claire Z. Larter et al.   Obesity

Sex and age differences in heavy binge drinking and its effects on alcohol responsivity following abstinence

(2013) Laverne C. Melón et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Overexpression of Endoglin Modulates TGF-β1-Signalling Pathways in a Novel Immortalized Mouse Hepatic Stellate Cell Line

(2013) Steffen K. Meurer et al.   PLoS One

Genetic Characteristics of the Human Hepatic Stellate Cell Line LX-2

(2013) Ralf Weiskirchen et al.   PLoS One

Precision-cut liver slices as a model for the early onset of liver fibrosis to test antifibrotic drugs

(2013) Inge M. Westra et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Rodent models of alcoholic liver disease: Of mice and men

(2012) Elizabeth Brandon-Warner et al.   ALCOHOL

Deactivation of Hepatic Stellate Cells During Liver Fibrosis Resolution in Mice

(2012) Juliane S. Troeger et al.   GASTROENTEROLOGY

Transcriptional regulation of methionine adenosyltransferase 2A by peroxisome proliferator-activated receptors in rat hepatic stellate cells

(2012) Komal Ramani et al.   HEPATOLOGY

Reduced hepatic stellate cell expression of kruppel-like factor 6 tumor suppressor isoforms amplifies fibrosis during acute and chronic rodent liver injury

(2012) Zahra Ghiassi-Nejad et al.   HEPATOLOGY

Kuppfer Cells Trigger Nonalcoholic Steatohepatitis Development in Diet-induced Mouse Model through Tumor Necrosis Factor-α Production

(2012) Annie-Carole Tosello-Trampont et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hepatitis C virus core protein stimulates fibrogenesis in hepatic stellate cells involving the obese receptor

(2012) Ching-Fen Wu et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Regression of cirrhosis during treatment with tenofovir disoproxil fumarate for chronic hepatitis B: a 5-year open-label follow-up study

(2012) Patrick Marcellin et al.   LANCET

Generation of a humanized mouse model with both human immune system and liver cells to model hepatitis C virus infection and liver immunopathogenesis

(2012) Moses T Bility et al.   Nature Protocols

Antiplatelet therapy prevents hepatocellular carcinoma and improves survival in a mouse model of chronic hepatitis B

(2012) G. Sitia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Myofibroblasts revert to an inactive phenotype during regression of liver fibrosis

(2012) T. Kisseleva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Preparation and culture of precision-cut organ slices from human and animal

(2012) Robyn L. Fisher et al.   XENOBIOTICA

Differential Regulation of TGF-β/Smad Signaling in Hepatic Stellate Cells between Acute and Chronic Liver Injuries

(2012) Katsunori Yoshida et al.   Frontiers in Physiology

Large-scale determinants of intestinal schistosomiasis and intermediate host snail distribution across Africa: does climate matter?

(2011) Anna-Sofie Stensgaard et al.   ACTA TROPICA

Development of Ethanol Withdrawal-Related Sensitization and Relapse Drinking in Mice Selected for High- or Low-Ethanol Preference

(2011) Marcelo F. Lopez et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Increased contractility of hepatic stellate cells in cirrhosis is mediated by enhanced Ca2+-dependent and Ca2+-sensitization pathways

(2011) Masateru Iizuka et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Animal models for the study of liver fibrosis: new insights from knockout mouse models

(2011) Hiromitsu Hayashi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Animal models for the study of hepatic fibrosis

(2011) Peter Starkel et al.   BEST PRACTICE & RESEARCH IN CLINICAL GASTROENTEROLOGY

Anti-fibrogenic strategies and the regression of fibrosis

(2011) Tatiana Kisseleva et al.   BEST PRACTICE & RESEARCH IN CLINICAL GASTROENTEROLOGY

Mechanisms of hepatic fibrogenesis

(2011) Ursula E. Lee et al.   BEST PRACTICE & RESEARCH IN CLINICAL GASTROENTEROLOGY

Hepatic Free Cholesterol Accumulates in Obese, Diabetic Mice and Causes Nonalcoholic Steatohepatitis

(2011) Derrick M. Van Rooyen et al.   GASTROENTEROLOGY

Lineage tracing demonstrates no evidence of cholangiocyte epithelial-to-mesenchymal transition in murine models of hepatic fibrosis

(2011) Andrew S. Chu et al.   HEPATOLOGY

Hepatoprotection of silymarin against thioacetamide-induced chronic liver fibrosis

(2011) I-Shu Chen et al.   JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE

Kaerophyllin inhibits hepatic stellate cell activation by apoptotic bodies from hepatocytes

(2011) Ting-Fang Lee et al.   LIVER INTERNATIONAL

S-Nitroso-N-acetylcysteine induces de-differentiation of activated hepatic stellate cells and promotes antifibrotic effects in vitro

(2011) J.T. Stefano et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Cannabidiol causes activated hepatic stellate cell death through a mechanism of endoplasmic reticulum stress-induced apoptosis

(2011) M P Lim et al.   Cell Death & Disease

Update on hepatic stellate cells: pathogenic role in liver fibrosis and novel isolation techniques

(2011) Frank Tacke et al.   Expert Review of Gastroenterology & Hepatology

Mechanisms and cell signaling in alcoholic liver disease

(2010) Juliane I. Beier et al.   BIOLOGICAL CHEMISTRY

RNA interference targeting the platelet-derived growth factor receptor β subunit ameliorates experimental hepatic fibrosis in rats

(2010) Si-Wen Chen et al.   LIVER INTERNATIONAL

Anti-fibrotic Effects of a Methylenedioxybenzene Compound, CW209292 on Dimethylnitrosamine-Induced Hepatic Fibrosis in Rats

(2009) Se-Woong Oh et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Differences in betaine-homocysteine methyltransferase expression, endoplasmic reticulum stress response, and liver injury between alcohol-fed mice and rats

(2009) Masao Shinohara et al.   HEPATOLOGY

Hepatocytes do not undergo epithelial-mesenchymal transition in liver fibrosis in mice

(2009) Kojiro Taura et al.   HEPATOLOGY

Maintaining hepatocyte differentiation in vitro through co-culture with hepatic stellate cells

(2009) Petra Krause et al.   IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL

Experimental mouse models for hepatocellular carcinoma research

(2009) Femke Heindryckx et al.   INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY

Roles of adipose restriction and metabolic factors in progression of steatosis to steatohepatitis in obese, diabetic mice

(2009) Claire Z Larter et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

A novel model of CCl4-induced cirrhosis with ascites in the mouse

(2009) Marco Domenicali et al.   JOURNAL OF HEPATOLOGY

Accelerative effect of leflunomide on recovery from hepatic fibrosis involves TRAIL-mediated hepatic stellate cell apoptosis

(2009) Xiaoming Tang et al.   LIFE SCIENCES

Expression of extracellular matrix genes in cultured hepatic oval cells: an origin of hepatic stellate cells through transforming growth factor beta?

(2009) Ping Wang et al.   LIVER INTERNATIONAL

Carbogen Gas–Challenge BOLD MR Imaging in a Rat Model of Diethylnitrosamine-induced Liver Fibrosis

(2009) Ning Jin et al.   RADIOLOGY

Characterization of time-related changes after experimental bile duct ligation

(2008) P. Georgiev et al.   BRITISH JOURNAL OF SURGERY

Hepatic stellate cells display a functional vascular smooth muscle cell phenotype in a three-dimensional co-culture model with endothelial cells

(2008) W. Wirz et al.   DIFFERENTIATION

Functional linkage of cirrhosis-predictive single nucleotide polymorphisms of toll-like receptor 4 to hepatic stellate cell responses

(2008) Jinsheng Guo et al.   HEPATOLOGY

Dietary cholesterol, rather than liver steatosis, leads to hepatic inflammation in hyperlipidemic mouse models of nonalcoholic steatohepatitis

(2008) Kristiaan Wouters et al.   HEPATOLOGY

Mesenchymal origin of hepatic stellate cells, submesothelial cells, and perivascular mesenchymal cells during mouse liver development

(2008) Kinji Asahina et al.   HEPATOLOGY

Comparison of three research models of portal hypertension in mice: macroscopic, histological and portal pressure evaluation

(2008) Anja M. Geerts et al.   INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY

Development of dual-compartment perfusion bioreactor for serial coculture of hepatocytes and stellate cells in poly(lactic-co-glycolic acid)-collagen scaffolds

(2008) F. Wen et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS

Animal models of NASH: Getting both pathology and metabolic context right

(2008) Claire Z Larter et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Activation of hepatic stellate cells is associated with cytokine expression in thioacetamide-induced hepatic fibrosis in mice

(2008) Rebeca Salguero Palacios et al.   LABORATORY INVESTIGATION

Increased sinusoidal resistance is responsible for the basal state and endothelin-induced venoconstriction in perfused cirrhotic rat liver

(2008) Toshishige Shibamoto et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Hepatic Stellate Cells: Protean, Multifunctional, and Enigmatic Cells of the Liver

(2008) Scott L. Friedman   PHYSIOLOGICAL REVIEWS

Reevaluation of Experimental Model of Hepatic Fibrosis Induced by Hepatotoxic Drugs: An Easy, Applicable, and Reproducible Model

(2008) J.H. Jang et al.   TRANSPLANTATION PROCEEDINGS

Antagonizing TGF-β induced liver fibrosis by a retinoic acid derivative through regulation of ROS and calcium influx

(2007) Kun-Lin Yang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The inhalation exposure of carbon tetrachloride promote rat liver carcinogenesis in a medium-term liver bioassay

(2007) K TSUJIMURA et al.   TOXICOLOGY LETTERS