Comprehensive Evaluation of Organotypic and Microphysiological Liver Models for Prediction of Drug-Induced Liver Injury
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Title
Comprehensive Evaluation of Organotypic and Microphysiological Liver Models for Prediction of Drug-Induced Liver Injury
Authors
Keywords
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Journal
Frontiers in Pharmacology
Volume 10, Issue -, Pages -
Publisher
Frontiers Media SA
Online
2019-09-24
DOI
10.3389/fphar.2019.01093
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Note: Only part of the references are listed.- Bioprinted liver provides early insight into the role of Kupffer cells in TGF-β1 and methotrexate-induced fibrogenesis
- (2019) Leah M. Norona et al. PLoS One
- Differentiation of the human liver progenitor cell line (HepaRG) on a microfluidic‐based biochip
- (2019) Mi Jang et al. Journal of Tissue Engineering and Regenerative Medicine
- Integrated in vitro models for hepatic safety and metabolism: evaluation of a human Liver-Chip and liver spheroid
- (2019) Alison J. Foster et al. ARCHIVES OF TOXICOLOGY
- 3D Primary Hepatocyte Culture Systems for Analyses of Liver Diseases, Drug Metabolism, and Toxicity: Emerging Culture Paradigms and Applications
- (2019) Volker M. Lauschke et al. Biotechnology Journal
- Exosomal transport of hepatocyte‐derived drug‐modified proteins to the immune system
- (2019) Monday O. Ogese et al. HEPATOLOGY
- Generation of expandable human pluripotent stem cell-derived hepatocyte-like liver organoids
- (2019) Seon Ju Mun et al. JOURNAL OF HEPATOLOGY
- Vascularized Liver Organoids Generated Using Induced Hepatic Tissue and Dynamic Liver-Specific Microenvironment as a Drug Testing Platform
- (2018) Yoonhee Jin et al. ADVANCED FUNCTIONAL MATERIALS
- Application of Microphysiological Systems to Enhance Safety Assessment in Drug Discovery
- (2018) Lorna Ewart et al. Annual Review of Pharmacology and Toxicology
- Physiologically Based Pharmacokinetic and Pharmacodynamic Analysis Enabled by Microfluidically Linked Organs-on-Chips
- (2018) Rachelle Prantil-Baun et al. Annual Review of Pharmacology and Toxicology
- Comparison of Drug Metabolism and Its Related Hepatotoxic Effects in HepaRG, Cryopreserved Human Hepatocytes, and HepG2 Cell Cultures
- (2018) Yuichi Yokoyama et al. BIOLOGICAL & PHARMACEUTICAL BULLETIN
- Organs-on-a-Chip: A Fast Track for Engineered Human Tissues in Drug Development
- (2018) Kacey Ronaldson-Bouchard et al. Cell Stem Cell
- Liver Safety of Fasiglifam (TAK-875) in Patients with Type 2 Diabetes: Review of the Global Clinical Trial Experience
- (2018) John F. Marcinak et al. DRUG SAFETY
- Liver ‘organ on a chip’
- (2018) Colin H. Beckwitt et al. EXPERIMENTAL CELL RESEARCH
- Three-Dimensional Bioprinting of Hepatic Structures with Directly Converted Hepatocyte-Like Cells
- (2018) Kyojin Kang et al. TISSUE ENGINEERING PART A
- Prediction of Drug-Induced Hepatotoxicity Using Long-Term Stable Primary Hepatic 3D Spheroid Cultures in Chemically Defined Conditions
- (2018) Sabine U Vorrink et al. TOXICOLOGICAL SCIENCES
- Comparison of Hepatic 2D Sandwich Cultures and 3D Spheroids for Long-term Toxicity Applications: A Multicenter Study
- (2018) Catherine C Bell et al. TOXICOLOGICAL SCIENCES
- Perfused human hepatocyte microtissues identify reactive metabolite-forming and mitochondria-perturbing hepatotoxins
- (2018) Cliff Rowe et al. TOXICOLOGY IN VITRO
- Bioinks for 3D bioprinting: an overview
- (2018) P. Selcan Gungor-Ozkerim et al. Biomaterials Science
- Bioprinting Perfusion-Enabled Liver Equivalents for Advanced Organ-on-a-Chip Applications
- (2018) Tobias Grix et al. Genes
- Assessment of the Biotransformation of Low Turnover Drugs in the HμREL Human Hepatocyte Coculture Model
- (2018) Richard D. Burton et al. DRUG METABOLISM AND DISPOSITION
- Human liver spheroids in chemically defined conditions for studies of gene–drug, drug–drug and disease–drug interactions
- (2018) Magnus Ingelman-Sundberg et al. PHARMACOGENOMICS
- Human hepatic 3D spheroids as a model for steatosis and insulin resistance
- (2018) Mikael Kozyra et al. Scientific Reports
- Characterisation of a functional rat hepatocyte spheroid model
- (2018) Jonathan A. Kyffin et al. TOXICOLOGY IN VITRO
- Application of microfluidic chip technology in pharmaceutical analysis: A review
- (2018) Ping Cui et al. Journal of Pharmaceutical Analysis
- Control of oxygen tension recapitulates zone-specific functions in human liver microphysiology systems
- (2017) Felipe T Lee-Montiel et al. EXPERIMENTAL BIOLOGY AND MEDICINE
- A decade of drug metabolite safety testing: industry and regulatory shared learning
- (2017) Debra Luffer-Atlas et al. Expert Opinion on Drug Metabolism & Toxicology
- Endogenous and xenobiotic metabolic stability of primary human hepatocytes in long-term 3D spheroid cultures revealed by a combination of targeted and untargeted metabolomics
- (2017) Sabine U. Vorrink et al. FASEB JOURNAL
- Generation of Multilayered 3D Structures of HepG2 Cells Using a Bio-printing Technique
- (2017) Hyeryeon Jeon et al. Gut and Liver
- Hepatic differentiation of human iPSCs in different 3D models: A comparative study
- (2017) Florian Meier et al. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
- Utility of human hepatocyte spheroids without feeder cells for evaluation of hepatotoxicity
- (2017) Takuo Ogihara et al. JOURNAL OF TOXICOLOGICAL SCIENCES
- A liver microphysiological system of tumor cell dormancy and inflammatory responsiveness is affected by scaffold properties
- (2017) A. M. Clark et al. LAB ON A CHIP
- Exploring Chronic Drug Effects on Microengineered Human Liver Cultures Using Global Gene Expression Profiling
- (2017) Brenton R. Ware et al. TOXICOLOGICAL SCIENCES
- From the Cover: Three-Dimensional (3D) HepaRG Spheroid Model With Physiologically Relevant Xenobiotic Metabolism Competence and Hepatocyte Functionality for Liver Toxicity Screening
- (2017) Sreenivasa C. Ramaiahgari et al. TOXICOLOGICAL SCIENCES
- Long-enduring primary hepatocyte-based co-cultures improve prediction of hepatotoxicity
- (2017) Eric I. Novik et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
- Engineered Liver Platforms for Different Phases of Drug Development
- (2017) Brenton R. Ware et al. TRENDS IN BIOTECHNOLOGY
- Qualitative and quantitative prediction of human in vivo metabolic pathways in a human hepatocyte-murine stromal cell co-culture model
- (2017) Kenneth C. Cassidy et al. XENOBIOTICA
- Multiorgan Microphysiological Systems for Drug Development: Strategies, Advances, and Challenges
- (2017) Ying I. Wang et al. Advanced Healthcare Materials
- Metabolic zonation of the liver: The oxygen gradient revisited
- (2017) Thomas Kietzmann Redox Biology
- Biophysical Regulation of Cell Behavior—Cross Talk between Substrate Stiffness and Nanotopography
- (2017) Yong Yang et al. Engineering
- An Automated Multiplexed Hepatotoxicity and CYP Induction Assay Using HepaRG Cells in 2D and 3D
- (2017) Lindsey M. Ott et al. SLAS Discovery
- Comparative analysis of 3D culture methods on human HepG2 cells
- (2016) Claudia Luckert et al. ARCHIVES OF TOXICOLOGY
- A multicenter assessment of single-cell models aligned to standard measures of cell health for prediction of acute hepatotoxicity
- (2016) Rowena L. Sison-Young et al. ARCHIVES OF TOXICOLOGY
- Phenotypic Characterization of Toxic Compound Effects on Liver Spheroids Derived from iPSC Using Confocal Imaging and Three-Dimensional Image Analysis
- (2016) Oksana Sirenko et al. ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES
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- (2016) Leonard J. Nelson et al. BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
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- (2016) Jingyu Wang et al. BIOMATERIALS
- A comprehensive review on droplet-based bioprinting: Past, present and future
- (2016) Hemanth Gudapati et al. BIOMATERIALS
- Novel human hepatic organoid model enables testing of drug-induced liver fibrosis in vitro
- (2016) Sofia B. Leite et al. BIOMATERIALS
- Current advances and future perspectives in extrusion-based bioprinting
- (2016) Ibrahim T. Ozbolat et al. BIOMATERIALS
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- (2016) Volker M. Lauschke et al. CHEMICAL RESEARCH IN TOXICOLOGY
- Stem cell-derived models to improve mechanistic understanding and prediction of human drug-induced liver injury
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- Massive rearrangements of cellular MicroRNA signatures are key drivers of hepatocyte dedifferentiation
- (2016) Volker M. Lauschke et al. HEPATOLOGY
- The Importance of Patient-Specific Factors for Hepatic Drug Response and Toxicity
- (2016) Volker Lauschke et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Engineering a perfusable 3D human liver platform from iPS cells
- (2016) Arnout Schepers et al. LAB ON A CHIP
- Functionally Enhanced Human Stem Cell Derived Hepatocytes in Galactosylated Cellulosic Sponges for Hepatotoxicity Testing
- (2016) Farah Tasnim et al. MOLECULAR PHARMACEUTICS
- Use of HμREL Human Coculture System for Prediction of Intrinsic Clearance and Metabolite Formation for Slowly Metabolized Compounds
- (2016) Ia Hultman et al. MOLECULAR PHARMACEUTICS
- A 3D bioprinting system to produce human-scale tissue constructs with structural integrity
- (2016) Hyun-Wook Kang et al. NATURE BIOTECHNOLOGY
- Deterministically patterned biomimetic human iPSC-derived hepatic model via rapid 3D bioprinting
- (2016) Xuanyi Ma et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Efficient One-Step Production of Microencapsulated Hepatocyte Spheroids with Enhanced Functions
- (2016) Hon Fai Chan et al. Small
- Drug-induced cholestasis risk assessment in sandwich-cultured human hepatocytes
- (2016) Marlies Oorts et al. TOXICOLOGY IN VITRO
- Cytotoxicity evaluation using cryopreserved primary human hepatocytes in various culture formats
- (2016) Lysiane Richert et al. TOXICOLOGY LETTERS
- A Bioprinted Liver-on-a-Chip for Drug Screening Applications
- (2016) Stephanie Knowlton et al. TRENDS IN BIOTECHNOLOGY
- Advances in Engineered Liver Models for Investigating Drug-Induced Liver Injury
- (2016) Christine Lin et al. Biomed Research International
- Characterization of a functional C3A liver spheroid model
- (2016) Harriet Gaskell et al. Toxicology Research
- Comparison of Liver Cell Models Using the Basel Phenotyping Cocktail
- (2016) Benjamin Berger et al. Frontiers in Pharmacology
- Bioprinted 3D Primary Liver Tissues Allow Assessment of Organ-Level Response to Clinical Drug Induced Toxicity In Vitro
- (2016) Deborah G. Nguyen et al. PLoS One
- Characterization of primary human hepatocyte spheroids as a model system for drug-induced liver injury, liver function and disease
- (2016) Catherine C. Bell et al. Scientific Reports
- Hepatic 3D spheroid models for the detection and study of compounds with cholestatic liability
- (2016) Delilah F. G. Hendriks et al. Scientific Reports
- A hydrogel bioink toolkit for mimicking native tissue biochemical and mechanical properties in bioprinted tissue constructs
- (2015) Aleksander Skardal et al. Acta Biomaterialia
- Three-dimensional (3D) spheroid cultures improve the metabolic gene expression profiles of HepaRG cells
- (2015) Yu Takahashi et al. BIOSCIENCE REPORTS
- Characterization of Conserved Toxicogenomic Responses in Chemically Exposed Hepatocytes across Species and Platforms
- (2015) Nehme El-Hachem et al. ENVIRONMENTAL HEALTH PERSPECTIVES
- Enhancing the functional maturity of induced pluripotent stem cell-derived human hepatocytes by controlled presentation of cell-cell interactionsin vitro
- (2015) Dustin R. Berger et al. HEPATOLOGY
- Phenotypic and functional analyses show stem cell-derived hepatocyte-like cells better mimic fetal rather than adult hepatocytes
- (2015) Melissa Baxter et al. JOURNAL OF HEPATOLOGY
- Three-dimensional co-culture of human hepatocytes and mesenchymal stem cells: improved functionality in long-term bioreactor cultures
- (2015) Sofia P. Rebelo et al. Journal of Tissue Engineering and Regenerative Medicine
- Daclizumab HYP versus Interferon Beta-1a in Relapsing Multiple Sclerosis
- (2015) Ludwig Kappos et al. NEW ENGLAND JOURNAL OF MEDICINE
- Prediction of Drug-Induced Liver Injury in Micropatterned Co-cultures Containing iPSC-Derived Human Hepatocytes
- (2015) Brenton R. Ware et al. TOXICOLOGICAL SCIENCES
- Bioreactor technologies to support liver function in vitro
- (2014) Mohammad R. Ebrahimkhani et al. ADVANCED DRUG DELIVERY REVIEWS
- The application of 3D cell models to support drug safety assessment: Opportunities & challenges
- (2014) Adrian Roth et al. ADVANCED DRUG DELIVERY REVIEWS
- A 3D in vitro model of differentiated HepG2 cell spheroids with improved liver-like properties for repeated dose high-throughput toxicity studies
- (2014) Sreenivasa C. Ramaiahgari et al. ARCHIVES OF TOXICOLOGY
- HepaRG microencapsulated spheroids in DMSO-free culture: novel culturing approaches for enhanced xenobiotic and biosynthetic metabolism
- (2014) Sofia P. Rebelo et al. ARCHIVES OF TOXICOLOGY
- Toxicogenomics directory of chemically exposed human hepatocytes
- (2014) Marianna Grinberg et al. ARCHIVES OF TOXICOLOGY
- Pluripotent stem cell-derived hepatocyte-like cells
- (2014) R.E. Schwartz et al. BIOTECHNOLOGY ADVANCES
- Spontaneous dormancy of metastatic breast cancer cells in an all human liver microphysiologic system
- (2014) S E Wheeler et al. BRITISH JOURNAL OF CANCER
- Evaluation of Human Hepatocytes Cultured by Three-dimensional Spheroid Systems for Drug Metabolism
- (2014) Takako Ohkura et al. Drug Metabolism and Pharmacokinetics
- Competency of different cell models to predict human hepatotoxic drugs
- (2014) M José Gómez-Lechón et al. Expert Opinion on Drug Metabolism & Toxicology
- Idiosyncratic Drug-Induced Liver Injury Is Associated With Substantial Morbidity and Mortality Within 6 Months From Onset
- (2014) Robert J. Fontana et al. GASTROENTEROLOGY
- HepaRG culture in tethered spheroids as anin vitrothree-dimensional model for drug safety screening
- (2014) Zenan Wang et al. JOURNAL OF APPLIED TOXICOLOGY
- Dynamic interplay of flow and collagen stabilizes primary hepatocytes culture in a microfluidic platform
- (2014) Manjunath Hegde et al. LAB ON A CHIP
- Lessons learned from the fate of AstraZeneca's drug pipeline: a five-dimensional framework
- (2014) David Cook et al. NATURE REVIEWS DRUG DISCOVERY
- Fluorometric assessment of acetaminophen-induced toxicity in rat hepatocyte spheroids seeded on micro-space cell culture plates
- (2014) Seigo Sanoh et al. TOXICOLOGY IN VITRO
- Morphological behaviour and metabolic capacity of cryopreserved human primary hepatocytes cultivated in a perfused multiwell device
- (2014) Aurelie Vivares et al. XENOBIOTICA
- Metabolism by conjugation appears to confer resistance to paracetamol (acetaminophen) hepatotoxicity in the cynomolgus monkey
- (2014) Hong Yu et al. XENOBIOTICA
- Sandwich-cultured hepatocytes: utility forin vitroexploration of hepatobiliary drug disposition and drug-induced hepatotoxicity
- (2013) Tom De Bruyn et al. Expert Opinion on Drug Metabolism & Toxicology
- Incidence, Presentation, and Outcomes in Patients With Drug-Induced Liver Injury in the General Population of Iceland
- (2013) Einar S. Björnsson et al. GASTROENTEROLOGY
- Proteome-wide analyses of human hepatocytes during differentiation and dedifferentiation
- (2013) Cliff Rowe et al. HEPATOLOGY
- 3D Organotypic Cultures of Human HepaRG Cells: A Tool for In Vitro Toxicity Studies
- (2013) Patrina Gunness et al. TOXICOLOGICAL SCIENCES
- 3D organotypic HepaRG cultures as in vitro model for acute and repeated dose toxicity studies
- (2013) Daniel Mueller et al. TOXICOLOGY IN VITRO
- Feline Drug Metabolism and Disposition
- (2013) Michael H. Court VETERINARY CLINICS OF NORTH AMERICA-SMALL ANIMAL PRACTICE
- Quantitative Analysis of Molecular Absorption into PDMS Microfluidic Channels
- (2012) Jack D. Wang et al. ANNALS OF BIOMEDICAL ENGINEERING
- Multi-cell type human liver microtissues for hepatotoxicity testing
- (2012) S. Messner et al. ARCHIVES OF TOXICOLOGY
- 3D spheroid culture of hESC/hiPSC-derived hepatocyte-like cells for drug toxicity testing
- (2012) Kazuo Takayama et al. BIOMATERIALS
- Analysis of drug metabolism activities in a miniaturized liver cell bioreactor for use in pharmacological studies
- (2012) Stefan A. Hoffmann et al. BIOTECHNOLOGY AND BIOENGINEERING
- Serum-free culture of primary human hepatocytes in a miniaturized hollow-fibre membrane bioreactor for pharmacologicalin vitrostudies
- (2012) Marc Lübberstedt et al. Journal of Tissue Engineering and Regenerative Medicine
- Use of Micropatterned Cocultures to Detect Compounds That Cause Drug-Induced Liver Injury in Humans
- (2012) Salman R. Khetani et al. TOXICOLOGICAL SCIENCES
- Three-Dimensional HepaRG Model As An Attractive Tool for Toxicity Testing
- (2012) Sofia B. Leite et al. TOXICOLOGICAL SCIENCES
- Determination of Drug Toxicity Using 3D Spheroids Constructed From an Immortal Human Hepatocyte Cell Line
- (2012) Stephen J. Fey et al. TOXICOLOGICAL SCIENCES
- Acetaminophen-induced liver injury in rats and mice: Comparison of protein adducts, mitochondrial dysfunction, and oxidative stress in the mechanism of toxicity
- (2012) Mitchell R. McGill et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
- Three-Dimensional Human Tissue Chips Fabricated by Rapid and Automatic Inkjet Cell Printing
- (2012) Michiya Matsusaki et al. Advanced Healthcare Materials
- Novel in vitro and mathematical models for the prediction of chemical toxicity
- (2012) Dominic P. Williams et al. Toxicology Research
- Rat Primary Hepatocytes Show Enhanced Performance and Sensitivity to Acetaminophen During Three-Dimensional Culture on a Polystyrene Scaffold Designed for Routine Use
- (2011) Maaike Schutte et al. ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES
- Human liver cell spheroids in extended perfusion bioreactor culture for repeated-dose drug testing
- (2011) Rui M. Tostões et al. HEPATOLOGY
- Scaling Down of a Clinical Three-Dimensional Perfusion Multicompartment Hollow Fiber Liver Bioreactor Developed for Extracorporeal Liver Support to an Analytical Scale Device Useful for Hepatic Pharmacological In Vitro Studies
- (2011) Katrin Zeilinger et al. TISSUE ENGINEERING PART C-METHODS
- Biocompatibility and Reduced Drug Absorption of Sol−Gel-Treated Poly(dimethyl siloxane) for Microfluidic Cell Culture Applications
- (2010) Rafael Gomez-Sjoberg et al. ANALYTICAL CHEMISTRY
- Primary rat hepatocyte culture on 3D nanofibrous polymer scaffolds for toxicology and pharmaceutical research
- (2010) Jeanette Bierwolf et al. BIOTECHNOLOGY AND BIOENGINEERING
- Assessment of a Micropatterned Hepatocyte Coculture System to Generate Major Human Excretory and Circulating Drug Metabolites
- (2010) W. W. Wang et al. DRUG METABOLISM AND DISPOSITION
- A Comparison of Whole Genome Gene Expression Profiles of HepaRG Cells and HepG2 Cells to Primary Human Hepatocytes and Human Liver Tissues
- (2010) S. N. Hart et al. DRUG METABOLISM AND DISPOSITION
- Sandwich-cultured hepatocytes: anin vitromodel to evaluate hepatobiliary transporter-based drug interactions and hepatotoxicity
- (2010) Brandon Swift* et al. DRUG METABOLISM REVIEWS
- Enhancement of the predicted drug hepatotoxicity in gel entrapped hepatocytes within polysulfone-g-poly (ethylene glycol) modified hollow fiber
- (2010) Chong Shen et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
- Fabrication of three-dimensional porous cell-laden hydrogel for tissue engineering
- (2010) Chang Mo Hwang et al. Biofabrication
- Evaluation of a microfluidic based cell culture platform with primary human hepatocytes for the prediction of hepatic clearance in human
- (2009) P. Chao et al. BIOCHEMICAL PHARMACOLOGY
- A microfluidic hepatic coculture platform for cell-based drug metabolism studies
- (2009) Eric Novik et al. BIOCHEMICAL PHARMACOLOGY
- Human hepatocyte functions in a crossed hollow fiber membrane bioreactor
- (2009) Loredana De Bartolo et al. BIOMATERIALS
- Predicting Circulating Human Metabolites: How Good Are We?
- (2009) Shelby Anderson et al. CHEMICAL RESEARCH IN TOXICOLOGY
- Assessment of Three Human in Vitro Systems in the Generation of Major Human Excretory and Circulating Metabolites
- (2009) Deepak Dalvie et al. CHEMICAL RESEARCH IN TOXICOLOGY
- Cytometric analysis for drug-induced steatosis in HepG2 cells
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- (2008) Jinghai J. Xu et al. TOXICOLOGICAL SCIENCES
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