Primary hepatocyte cultures for pharmaco-toxicological studies: at the busy crossroad of various anti-dedifferentiation strategies

Microfluidic Platforms for Hepatocyte Cell Culture: New Technologies and Applications

(2011) Vasiliy N. Goral et al.   ANNALS OF BIOMEDICAL ENGINEERING

Simple and quick method for whole-liver decellularization: a novel in vitro three-dimensional bioengineering tool?

(2011) Joery De Kock et al.   ARCHIVES OF TOXICOLOGY

The Behaviors of Long-Term Cryopreserved Human Hepatocytes on Different Biomaterials

(2011) Jui-Nan Lu et al.   ARTIFICIAL ORGANS

Rat Primary Hepatocytes Show Enhanced Performance and Sensitivity to Acetaminophen During Three-Dimensional Culture on a Polystyrene Scaffold Designed for Routine Use

(2011) Maaike Schutte et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

Micro RNAs: Tiny sequences with enormous potential

(2011) K. Shruti et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Spheroid Formation and Expression of Liver-Specific Functions of Human Hepatocellular Carcinoma-Derived FLC-4 Cells Cultured in Lactose−Silk Fibroin Conjugate Sponges

(2011) Yohko Gotoh et al.   BIOMACROMOLECULES

Three-dimensional culture of hepatocytes on porcine liver tissue-derived extracellular matrix

(2011) Ren Lang et al.   BIOMATERIALS

Modular bioreactor for primary human hepatocyte culture: Medium flow stimulates expression and activity of detoxification genes

(2011) Bruna Vinci et al.   Biotechnology Journal

Gas-permeable membranes and co-culture with fibroblasts enable high-density hepatocyte culture as multilayered liver tissues

(2011) Fanny Evenou et al.   BIOTECHNOLOGY PROGRESS

DNA hypermethylation as a chemotherapy target

(2011) Juan Ren et al.   CELLULAR SIGNALLING

Opportunities for an alternative integrating testing strategy for carcinogen hazard assessment?

(2011) Tatyana Y. Doktorova et al.   CRITICAL REVIEWS IN TOXICOLOGY

Culture Period-Dependent Changes in the Uptake of Transporter Substrates in Sandwich-Cultured Rat and Human Hepatocytes

(2011) N. Kotani et al.   DRUG METABOLISM AND DISPOSITION

Human hepatic stem cell and maturational liver lineage biology

(2011) Rachael Turner et al.   HEPATOLOGY

Culture of porcine hepatocytes or bile duct epithelial cells by inductive serum-free media

(2011) Thomas J. Caperna et al.   IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL

A cocktail of metabolic probes demonstrates the relevance of primary human hepatocyte cultures in a microfluidic biochip for pharmaceutical drug screening

(2011) Jean-Matthieu Prot et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Synergetic effects of DNA demethylation and histone deacetylase inhibition in primary rat hepatocytes

(2011) Joanna Edyta Fraczek et al.   INVESTIGATIONAL NEW DRUGS

Microfibrillated Cellulose Sheets Coating Oxygen-Permeable PDMS Membranes Induce Rat Hepatocytes 3D Aggregation into Stably-Attached 3D Hemispheroids

(2011) Fanny Evenou et al.   JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION

Hepatogenic engineering from human bone marrow mesenchymal stem cells in porous polylactic glycolic acid scaffolds under perfusion culture

(2011) Jinfu Wang et al.   Journal of Tissue Engineering and Regenerative Medicine

Expression of albumin and cytochrome P450 enzymes in HepG2 cells cultured with a nanotechnology-based culture plate with microfabricated scaffold

(2011) Kazuaki Nakamura et al.   JOURNAL OF TOXICOLOGICAL SCIENCES

Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes

(2011) Marcus Bantscheff et al.   NATURE BIOTECHNOLOGY

Managing the challenge of chemically reactive metabolites in drug development

(2011) B. Kevin Park et al.   NATURE REVIEWS DRUG DISCOVERY

Discovering Networks of Perturbed Biological Processes in Hepatocyte Cultures

(2011) Christopher D. Lasher et al.   PLoS One

Effect of Trichostatin A on miRNA expression in cultures of primary rat hepatocytes

(2011) Jennifer Bolleyn et al.   TOXICOLOGY IN VITRO

Merging bioreactor technology with 3D hepatocyte-fibroblast culturing approaches: Improved in vitro models for toxicological applications

(2011) Sofia B. Leite et al.   TOXICOLOGY IN VITRO

Nanometric self-assembling peptide layers maintain adult hepatocyte phenotype in sandwich cultures

(2011) Jonathan Wu et al.   JOURNAL OF NANOBIOTECHNOLOGY

MicroRNA-21 is upregulated during the proliferative phase of liver regeneration, targets Pellino-1, and inhibits NF-κB signaling

(2010) Rebecca T. Marquez et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Identification of microRNAs during rat liver regeneration after partial hepatectomy and modulation by ursodeoxycholic acid

(2010) Rui E. Castro et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

DNA methylation and demethylation probed by small molecules

(2010) Moshe Szyf   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Interplay between microRNAs and the epigenetic machinery: An intricate network

(2010) Marilena V. Iorio et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Histone deacetylase inhibitors: A chemical genetics approach to understanding cellular functions

(2010) Paul A. Marks   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

MicroRNAs: Synthesis, mechanism, function, and recent clinical trials

(2010) Fazli Wahid et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Primary rat hepatocyte culture on 3D nanofibrous polymer scaffolds for toxicology and pharmaceutical research

(2010) Jeanette Bierwolf et al.   BIOTECHNOLOGY AND BIOENGINEERING

Drug bioactivation and protein adduct formation in the pathogenesis of drug-induced toxicity

(2010) B.K. Park et al.   CHEMICO-BIOLOGICAL INTERACTIONS

The FoxA factors in organogenesis and differentiation

(2010) Klaus H Kaestner   CURRENT OPINION IN GENETICS & DEVELOPMENT

HNF4α—role in drug metabolism and potential drug target?

(2010) Wendy W Hwang-Verslues et al.   CURRENT OPINION IN PHARMACOLOGY

In Vitro Evaluation of Potential Hepatotoxicity Induced by Drugs

(2010) M.J. Gomez-Lechon et al.   CURRENT PHARMACEUTICAL DESIGN

Secretion of Albumin and Induction of CYP1A2 and CYP3A4 in Novel Three-dimensional Culture System for Human Hepatocytes using Micro-space Plate

(2010) Masuhiro Nishimura et al.   Drug Metabolism and Pharmacokinetics

Expression Levels of Drug-Metabolizing Enzyme, Transporter, and Nuclear Receptor mRNAs in a Novel Three-Dimensional Culture System for Human Hepatocytes Using Micro-space Plates

(2010) Masuhiro Nishimura et al.   Drug Metabolism and Pharmacokinetics

Gene expression profiling of drug-resistant small cell lung cancer cells by combining microRNA and cDNA expression analysis

(2010) Linlang Guo et al.   EUROPEAN JOURNAL OF CANCER

MicroRNAs control hepatocyte proliferation during liver regeneration

(2010) Guisheng Song et al.   HEPATOLOGY

Small noncoding RNAs: Biogenesis, function, and emerging significance in toxicology

(2010) Supratim Choudhuri   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

Regulating the Regulators: The Post-Translational Code of Class I HDAC1 and HDAC2

(2010) Chiara V. Segré et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Evaluation of drug toxicity with hepatocytes cultured in a micro-space cell culture system

(2010) Kazuaki Nakamura et al.   JOURNAL OF BIOSCIENCE AND BIOENGINEERING

Biological functions of microRNAs: a review

(2010) Yong Huang et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

Network Analysis of Primary Hepatocyte Dedifferentiation Using a Shotgun Proteomics Approach

(2010) Cliff Rowe et al.   JOURNAL OF PROTEOME RESEARCH

Perfusion-based microfluidic device for three-dimensional dynamic primary human hepatocyte cell culture in the absence of biological or synthetic matrices or coagulants

(2010) Vasiliy N. Goral et al.   LAB ON A CHIP

Chemical biology of Histone acetyltransferase natural compounds modulators

(2010) Fabrizio Dal Piaz et al.   MOLECULAR DIVERSITY

Nanofabrication of Nonfouling Surfaces for Micropatterning of Cell and Microtissue

(2010) Hidenori Otsuka   MOLECULES

Preparation and incubation of precision-cut liver and intestinal slices for application in drug metabolism and toxicity studies

(2010) Inge A M de Graaf et al.   Nature Protocols

Mechanistic Insights on the Inhibition of C5 DNA Methyltransferases by Zebularine

(2010) Christine Champion et al.   PLoS One

3D Hepatic Cultures Simultaneously Maintain Primary Hepatocyte and Liver Sinusoidal Endothelial Cell Phenotypes

(2010) Yeonhee Kim et al.   PLoS One

Matrigel: A complex protein mixture required for optimal growth of cell culture

(2010) Chris S. Hughes et al.   PROTEOMICS

Autocrine-Controlled Formation and Function of Tissue-Like Aggregates by Primary Hepatocytes in Micropatterned Hydrogel Arrays

(2010) Courtney M. Williams et al.   TISSUE ENGINEERING PART A

Hepatic Stellate Cell-Mediated Three-Dimensional Hepatocyte and Endothelial Cell Triculture Model

(2010) Junichi Kasuya et al.   TISSUE ENGINEERING PART A

A Comparative Study of Genome-Wide Transcriptional Profiles of Primary Hepatocytes in Collagen Sandwich and Monolayer Cultures

(2010) Yeonhee Kim et al.   TISSUE ENGINEERING PART C-METHODS

Pluripotent stem cell derived hepatocyte like cells and their potential in toxicity screening

(2010) Sebastian Greenhough et al.   TOXICOLOGY

Purpose-driven biomaterials research in liver-tissue engineering

(2010) Abhishek Ananthanarayanan et al.   TRENDS IN BIOTECHNOLOGY

Histone deacetylase inhibitors: clinical implications for hematological malignancies

(2010) Francesco Paolo Tambaro et al.   Clinical Epigenetics

Tissue-specific extracellular matrix coatings for the promotion of cell proliferation and maintenance of cell phenotype

(2009) Yuanyuan Zhang et al.   BIOMATERIALS

MicroRNA-29b induces global DNA hypomethylation and tumor suppressor gene reexpression in acute myeloid leukemia by targeting directly DNMT3A and 3B and indirectly DNMT1

(2009) R. Garzon et al.   BLOOD

ADDME – Avoiding Drug Development Mistakes Early: central nervous system drug discovery perspective

(2009) Katya Tsaioun et al.   BMC Neurology

Histone deacetylase inhibitors as anti-neoplastic agents

(2009) Nicolas Batty et al.   CANCER LETTERS

Serum-free collagen sandwich cultures of adult rat hepatocytes maintain liver-like properties long term: A valuable model for in vitro toxicity and drug–drug interaction studies

(2009) Gregor Tuschl et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Solving the Dnmt2 enigma

(2009) Matthias Schaefer et al.   CHROMOSOMA

Rational Combinations Using HDAC Inhibitors

(2009) M. Bots et al.   CLINICAL CANCER RESEARCH

Transcriptional Regulation of Cytochrome P450 Genes by the Nuclear Receptor Hepatocyte Nuclear Factor 4-Alpha

(2009) Ramiro Jover et al.   CURRENT DRUG METABOLISM

Epigenetics and cancer treatment

(2009) Lasse Sommer Kristensen et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Integrated approach for the identification of human hepatocyte nuclear factor 4α target genes using protein binding microarrays

(2009) Eugene Bolotin et al.   HEPATOLOGY

Histone deacetylase inhibition and the regulation of cell growth with particular reference to liver pathobiology

(2009) Fraczek Joanna et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Functionalized self-assembling peptide hydrogel enhance maintenance of hepatocyte activity in vitro

(2009) Elsa Genové et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Role of epigenetics in liver-specific gene transcription, hepatocyte differentiation and stem cell reprogrammation

(2009) Sarah Snykers et al.   JOURNAL OF HEPATOLOGY

Lysine Acetylation Targets Protein Complexes and Co-Regulates Major Cellular Functions

(2009) C. Choudhary et al.   SCIENCE

Exploratory drug safety: A discovery strategy to reduce attrition in development

(2009) Alan S. Bass et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

Cultured rat hepatocytes upregulate Akt and ERK in an ErbB-2-dependent manner

(2008) Lawrence A. Scheving et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

The Hepatic Microvascular System in Health and Its Response to Toxicants

(2008) Robert S. Mccuskey   Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology

Epigenetics, DNA Methylation, and Chromatin Modifying Drugs

(2008) Moshe Szyf   Annual Review of Pharmacology and Toxicology

Which in vitro models could be best used to study hepatocyte polarity?

(2008) Catherine Decaens et al.   BIOLOGY OF THE CELL

Demethylation of (Cytosine-5-C-methyl) DNA and regulation of transcription in the epigenetic pathways of cancer development

(2008) Samir Kumar Patra et al.   CANCER AND METASTASIS REVIEWS

Methylation Mediated Silencing of MicroRNA-1 Gene and Its Role in Hepatocellular Carcinogenesis

(2008) J. Datta et al.   CANCER RESEARCH

Obstacles and Opportunities in New Drug Development

(2008) KI Kaitin   CLINICAL PHARMACOLOGY & THERAPEUTICS

C/EBPs: recipients of extracellular signals through proteome modulation

(2008) Claus Nerlov   CURRENT OPINION IN CELL BIOLOGY

Evaluation of HepaRG Cells as an in Vitro Model for Human Drug Metabolism Studies

(2008) K. P. Kanebratt et al.   DRUG METABOLISM AND DISPOSITION

Regulation of Hepatocyte Nuclear Factor 4α-mediated Transcription

(2008) Frank J. Gonzalez   Drug Metabolism and Pharmacokinetics

The role of earlyin vivotoxicity testing in drug discovery toxicology

(2008) Mark R Fielden et al.   Expert Opinion On Drug Safety

Glucagon Receptor Signaling Is Essential for Control of Murine Hepatocyte Survival

(2008) Elaine M. Sinclair et al.   GASTROENTEROLOGY

The noncoding RNA, miR-126, suppresses the growth of neoplastic cells by targeting phosphatidylinositol 3-kinase signaling and is frequently lost in colon cancers

(2008) Chunguang Guo et al.   GENES CHROMOSOMES & CANCER

Zn(II)-dependent histone deacetylase inhibitors: Suberoylanilide hydroxamic acid and trichostatin A

(2008) Rachel Codd et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Modes of action of the DNA methyltransferase inhibitors azacytidine and decitabine

(2008) Carlo Stresemann et al.   INTERNATIONAL JOURNAL OF CANCER

Screening of amide analogues of Trichostatin A in cultures of primary rat hepatocytes: search for potent and safe HDAC inhibitors

(2008) Joanna Fraczek et al.   INVESTIGATIONAL NEW DRUGS

Epigenetic interplay between histone modifications and DNA methylation in gene silencing

(2008) T VAISSIERE et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

Mammalian DNA Methyltransferases: A Structural Perspective

(2008) Xiaodong Cheng et al.   STRUCTURE

Towards an Extended Functional Hepatocyte In Vitro Culture

(2008) Joana P. Miranda et al.   TISSUE ENGINEERING PART C-METHODS

Microarray analysis in rat liver slices correctly predicts in vivo hepatotoxicity

(2008) M ELFERINK et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Liver slices as a model to study fibrogenesis and test the effects of anti-fibrotic drugs on fibrogenic cells in human liver

(2008) M. van de Bovenkamp et al.   TOXICOLOGY IN VITRO

Differential effects of hydroxamate histone deacetylase inhibitors on cellular functionality and gap junctions in primary cultures of mitogen-stimulated hepatocytes

(2008) Tom Henkens et al.   TOXICOLOGY LETTERS

Cytochrome P450 and Chemical Toxicology

(2007) F. Peter Guengerich   CHEMICAL RESEARCH IN TOXICOLOGY

Microfluidics for drug discovery and development: From target selection to product lifecycle management

(2007) L KANG   DRUG DISCOVERY TODAY

Genomics and proteomics analysis of cultured primary rat hepatocytes

(2007) Juergen Beigel et al.   TOXICOLOGY IN VITRO