Omics-based responses induced by bosentan in human hepatoma HepaRG cell cultures

From the Cover: MechanisticInsights in Cytotoxic and Cholestatic Potential of the Endothelial Receptor Antagonists Using HepaRG Cells

(2017) Matthew Gibson Burbank et al.   TOXICOLOGICAL SCIENCES

Validation of precision-cut liver slices to study drug-induced cholestasis: a transcriptomics approach

(2016) Suresh Vatakuti et al.   ARCHIVES OF TOXICOLOGY

Disruption of BSEP Function in HepaRG Cells Alters Bile Acid Disposition and Is a Susceptive Factor to Drug-Induced Cholestatic Injury

(2016) Xi Qiu et al.   MOLECULAR PHARMACEUTICS

Rho-kinase/myosin light chain kinase pathway plays a key role in the impairment of bile canaliculi dynamics induced by cholestatic drugs

(2016) Ahmad Sharanek et al.   Scientific Reports

Bile canalicular dynamics in hepatocyte sandwich cultures

(2015) Raymond Reif et al.   ARCHIVES OF TOXICOLOGY

New paradigms in the treatment of hepatic cholestasis: From UDCA to FXR, PXR and beyond

(2015) Ulrich Beuers et al.   JOURNAL OF HEPATOLOGY

Comparative Localization and Functional Activity of the Main Hepatobiliary Transporters in HepaRG Cells and Primary Human Hepatocytes

(2015) Pamela Bachour-El Azzi et al.   TOXICOLOGICAL SCIENCES

Cellular Accumulation and Toxic Effects of Bile Acids in Cyclosporine A-Treated HepaRG Hepatocytes

(2015) Ahmad Sharanek et al.   TOXICOLOGICAL SCIENCES

Branched-chain amino acids in metabolic signalling and insulin resistance

(2014) Christopher J. Lynch et al.   Nature Reviews Endocrinology

Evaluation of the Endothelin Receptor Antagonists Ambrisentan, Bosentan, Macitentan, and Sitaxsentan as Hepatobiliary Transporter Inhibitors and Substrates in Sandwich-Cultured Human Hepatocytes

(2014) Eve-Irene Lepist et al.   PLoS One

Regulation of human class I alcohol dehydrogenases by bile acids

(2013) Cédric Langhi et al.   JOURNAL OF LIPID RESEARCH

Development of an Adverse Outcome Pathway From Drug-Mediated Bile Salt Export Pump Inhibition to Cholestatic Liver Injury

(2013) Mathieu Vinken et al.   TOXICOLOGICAL SCIENCES

Hepatocyte-based in vitro model for assessment of drug-induced cholestasis

(2013) Sagnik Chatterjee et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

A Novel Method for the Simultaneous Enrichment, Identification, and Quantification of Phosphopeptides and Sialylated Glycopeptides Applied to a Temporal Profile of Mouse Brain Development

(2012) Giuseppe Palmisano et al.   MOLECULAR & CELLULAR PROTEOMICS

The determination and interpretation of the therapeutic index in drug development

(2012) Patrick Y. Muller et al.   NATURE REVIEWS DRUG DISCOVERY

Drug-induced cholestasis

(2011) Manmeet S. Padda et al.   HEPATOLOGY

Universal and Confident Phosphorylation Site Localization Using phosphoRS

(2011) Thomas Taus et al.   JOURNAL OF PROTEOME RESEARCH

Systematic and quantitative comparison of digest efficiency and specificity reveals the impact of trypsin quality on MS-based proteomics

(2011) Julia Maria Burkhart et al.   Journal of Proteomics

BSEP inhibition – In vitro screens to assess cholestatic potential of drugs

(2011) Emese Kis et al.   TOXICOLOGY IN VITRO

Evaluation of the endothelin receptor antagonists ambrisentan, darusentan, bosentan, and sitaxsentan as substrates and inhibitors of hepatobiliary transporters in sandwich-cultured human hepatocytesThis article is one of a selection of papers published in the two-part special issue entitled 20 Years of Endothelin Research.

(2010) J. Craig Hartman et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Drug-induced toxicity on mitochondria and lipid metabolism: Mechanistic diversity and deleterious consequences for the liver

(2010) Karima Begriche et al.   JOURNAL OF HEPATOLOGY

New molecular insights into the mechanisms of cholestasis

(2009) Martin Wagner et al.   JOURNAL OF HEPATOLOGY

Universal sample preparation method for proteome analysis

(2009) Jacek R Wiśniewski et al.   NATURE METHODS

Mechanisms of Cholestasis

(2008) Gernot Zollner et al.   Clinics in Liver Disease

Drug-induced liver injury through mitochondrial dysfunction: mechanisms and detection during preclinical safety studies

(2008) Gilles Labbe et al.   FUNDAMENTAL & CLINICAL PHARMACOLOGY