A Critical Analysis of the Available In Vitro and Ex Vivo Methods to Study Retinal Angiogenesis

Transcription factor SP1 mediates hyperglycemia-induced upregulation of roundabout4 in retinal microvascular endothelial cells

(2017) Jia'nan Xie et al.   GENE

Identification of a synergistic interaction between endothelial cells and retinal pigment epithelium

(2017) Carrie Spencer et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Diabetic retinopathy and dysregulated innate immunity

(2017) Heping Xu et al.   VISION RESEARCH

Cytochrome P450 Oxidase 2C Inhibition Adds to ω-3 Long-Chain Polyunsaturated Fatty Acids Protection Against Retinal and Choroidal NeovascularizationHighlights

(2016) Yan Gong et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Tat PTD-Endostatin-RGD: A novel protein with anti-angiogenesis effect in retina via eye drops

(2016) Yan Li et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Design, synthesis and biological evaluation of photoaffinity probes of antiangiogenic homoisoflavonoids

(2016) Bit Lee et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Cnidium officinale extract and butylidenephthalide inhibits retinal neovascularization in vitro and in vivo

(2016) Yun Mi Lee et al.   BMC Complementary and Alternative Medicine

High glucose-induced hyperosmolarity contributes to COX-2 expression and angiogenesis: implications for diabetic retinopathy

(2016) Rosalinda Madonna et al.   Cardiovascular Diabetology

Macrophages promote vasculogenesis of retinal neovascularization in an oxygen-induced retinopathy model in mice

(2016) Xiang Gao et al.   CELL AND TISSUE RESEARCH

Retinal Angiogenesis Effects of TGF-β1 and Paracrine Factors Secreted from Human Placental Stem Cells in Response to a Pathological Environment

(2016) Kyung-Sul Kim et al.   CELL TRANSPLANTATION

4-Hydroxy-7-oxo-5-heptenoic Acid Lactone Induces Angiogenesis through Several Different Molecular Pathways

(2016) Junhong Guo et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Role of Autophagy in Hypoxia-Induced Angiogenesis of RF/6A Cells in vitro

(2016) Rong Li et al.   CURRENT EYE RESEARCH

Upregulation of Thrombin/Matrix Metalloproteinase-1/Protease-Activated Receptor-1 Chain in Proliferative Diabetic Retinopathy

(2016) Ahmed M. Abu El-Asrar et al.   CURRENT EYE RESEARCH

Interleukin-17A neutralization alleviated ocular neovascularization by promoting M2 and mitigating M1 macrophage polarization

(2016) Yanji Zhu et al.   IMMUNOLOGY

Endothelial STAT3 Activation Increases Vascular Leakage Through Downregulating Tight Junction Proteins: Implications for Diabetic Retinopathy

(2016) Jang-Hyuk Yun et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Hyperglycemia Induces Bioenergetic Changes in Adipose-Derived Stromal Cells While Their Pericytic Function Is Retained

(2016) Ghazaleh Hajmousa et al.   STEM CELLS AND DEVELOPMENT

VEGF-A/Notch-Induced Podosomes Proteolyse Basement Membrane Collagen-IV during Retinal Sprouting Angiogenesis

(2016) Pirjo Spuul et al.   Cell Reports

Fenofibrate Inhibits Cytochrome P450 Epoxygenase 2C Activity to Suppress Pathological Ocular Angiogenesis

(2016) Yan Gong et al.   EBioMedicine

CD34 Promotes Pathological Epi-Retinal Neovascularization in a Mouse Model of Oxygen-Induced Retinopathy

(2016) Martin J. Siemerink et al.   PLoS One

Interleukin-12 inhibits pathological neovascularization in mouse model of oxygen-induced retinopathy

(2016) Yedi Zhou et al.   Scientific Reports

Erianin inhibits high glucose-induced retinal angiogenesis via blocking ERK1/2-regulated HIF-1α-VEGF/VEGFR2 signaling pathway

(2016) Zengyang Yu et al.   Scientific Reports

Microfluidic Multiculture Assay to Analyze Biomolecular Signaling in Angiogenesis

(2015) Ashleigh B. Theberge et al.   ANALYTICAL CHEMISTRY

Imidazole-based alkaloid derivative LCB54-0009 suppresses ocular angiogenesis and lymphangiogenesis in models of experimental retinopathy and corneal neovascularization

(2015) Byung-Hak Kim et al.   BRITISH JOURNAL OF PHARMACOLOGY

lncRNA-MIAT Regulates Microvascular Dysfunction by Functioning as a Competing Endogenous RNANovelty and Significance

(2015) Biao Yan et al.   CIRCULATION RESEARCH

Therapeutic Potential of Anti-Angiogenic Multitarget N,O -Sulfated E. Coli K5 Polysaccharide in Diabetic Retinopathy

(2015) Sara Rezzola et al.   DIABETES

The role of extracellular matrix in retinal vascular development and preretinal neovascularization

(2015) Paul N. Bishop   EXPERIMENTAL EYE RESEARCH

Synthesis and Biological Evaluation of Novel Homoisoflavonoids for Retinal Neovascularization

(2015) Halesha D. Basavarajappa et al.   JOURNAL OF MEDICINAL CHEMISTRY

Quercetin Inhibits Vascular Endothelial Growth Factor-Induced Choroidal and Retinal Angiogenesis in vitro

(2015) Fangting Li et al.   OPHTHALMIC RESEARCH

Vascular permeability—the essentials

(2015) Lena Claesson-Welsh   UPSALA JOURNAL OF MEDICAL SCIENCES

Antiangiogenic and Neurogenic Activities ofSleeping Beauty-Mediated PEDF-Transfected RPE CellsIn VitroandIn Vivo

(2015) Sandra Johnen et al.   Biomed Research International

Diabetic Retinopathy: Vascular and Inflammatory Disease

(2015) F. Semeraro et al.   Journal of Diabetes Research

Extracellular vesicles derived from mesenchymal stem cells induce features of diabetic retinopathy in vitro

(2014) Elena Beltramo et al.   ACTA DIABETOLOGICA

BIGH3 protein and macrophages in retinal endothelial cell apoptosis

(2014) Albert A. Mondragon et al.   APOPTOSIS

Endothelial Deletion of Phospholipase D2 Reduces Hypoxic Response and Pathological Angiogenesis

(2014) Jaewang Ghim et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Endothelial PFKFB3 Plays a Critical Role in Angiogenesis

(2014) Yiming Xu et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

VEGF-binding aptides and the inhibition of choroidal and retinal neovascularization

(2014) Dong Hyun Jo et al.   BIOMATERIALS

Comparison of Tetrazolium Salt Assays for Evaluation of Drug Activity against Leishmania spp.

(2014) M. Ginouves et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Anti-angiogenic actions of the mangosteen polyphenolic xanthone derivative α-mangostin

(2014) Kanjana Jittiporn et al.   MICROVASCULAR RESEARCH

Effects of p75 neurotrophin receptor on regulating hypoxia-induced angiogenic factors in retinal pigment epithelial cells

(2014) Jingjing Zhang et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Domain I-IV of β2-glycoprotein I inhibits advanced glycation end product-induced angiogenesis by down-regulating vascular endothelial growth factor 2 signaling

(2014) QIAN-QIAN WANG et al.   Molecular Medicine Reports

EGF-Like-Domain-7 Is Required for VEGF-Induced Akt/ERK Activation and Vascular Tube Formation in an Ex Vivo Angiogenesis Assay

(2014) Kimio Takeuchi et al.   PLoS One

Angiopoietin-like protein 4 (ANGPTL4) is induced by high glucose in retinal pigment epithelial cells and exhibits potent angiogenic activity on retinal endothelial cells

(2013) Hirotaka Yokouchi et al.   ACTA OPHTHALMOLOGICA

Targeting the IRE1α/XBP1 and ATF6 Arms of the Unfolded Protein Response Enhances VEGF Blockade to Prevent Retinal and Choroidal Neovascularization

(2013) Li Liu et al.   AMERICAN JOURNAL OF PATHOLOGY

Long-term suppression of ocular neovascularization by intraocular injection of biodegradable polymeric particles containing a serpin-derived peptide

(2013) Ron B. Shmueli et al.   BIOMATERIALS

A novel ex vivo murine retina angiogenesis (EMRA) assay

(2013) Sara Rezzola et al.   EXPERIMENTAL EYE RESEARCH

Decorin inhibits angiogenic potential of choroid-retinal endothelial cells by downregulating hypoxia-induced Met, Rac1, HIF-1α and VEGF expression in cocultured retinal pigment epithelial cells

(2013) Shanshan Du et al.   EXPERIMENTAL EYE RESEARCH

Semaphorin 3F forms an anti-angiogenic barrier in outer retina

(2013) Anima Buehler et al.   FEBS LETTERS

Anti-angiogenic effect of KH902 on retinal neovascularization

(2013) Fei Wang et al.   GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY

Various methods available for detection of apoptotic cells- A review

(2013) KL Kumaraswamy et al.   INDIAN JOURNAL OF CANCER

Ocular neovascularization

(2013) Peter A. Campochiaro   JOURNAL OF MOLECULAR MEDICINE-JMM

Antiangiogenesis Effects of Endostatin in Retinal Neovascularization

(2013) Yu-jing Bai et al.   JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS

Effects of vascular endothelial growth factor B on proliferation and migration in EA.Hy926 cells

(2013) Guang-hong Zhang et al.   MOLECULAR BIOLOGY REPORTS

Inhibition of ocular neovascularization by a novel peptide derived from human placenta growth factor-1

(2012) Ying Zheng et al.   ACTA OPHTHALMOLOGICA

MEF2C Ablation in Endothelial Cells Reduces Retinal Vessel Loss and Suppresses Pathologic Retinal Neovascularization in Oxygen-Induced Retinopathy

(2012) Zhenhua Xu et al.   AMERICAN JOURNAL OF PATHOLOGY

Actions of bevacizumab and ranibizumab on microvascular retinal endothelial cells: similarities and differences

(2012) Heidrun L Deissler et al.   BRITISH JOURNAL OF OPHTHALMOLOGY

Candesartan, an angiotensin II type 1 receptor antagonist, inhibits pathological retinal neovascularization by downregulating VEGF receptor-2 expression

(2012) Shinsuke Nakamura et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

A novel and effective human hepatocyte growth factor kringle 1 domain inhibits ocular neovascularization

(2012) Qing Lu et al.   EXPERIMENTAL EYE RESEARCH

Deep sequencing reveals predominant expression of miR-21 amongst the small non-coding RNAs in retinal microvascular endothelial cells

(2012) Jasenka Guduric-Fuchs et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Role of the retinal vascular endothelial cell in ocular disease

(2012) Arpita S. Bharadwaj et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Multiple Applications of Alamar Blue as an Indicator of Metabolic Function and Cellular Health in Cell Viability Bioassays

(2012) Sephra N. Rampersad   SENSORS

Tissue Kallikrein Inhibits Retinal Neovascularization via the Cleavage of Vascular Endothelial Growth Factor-165

(2011) Shinsuke Nakamura et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Comparing protein VEGF inhibitors: In vitro biological studies

(2011) Lanlan Yu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Isoliquiritigenin from licorice root suppressed neovascularisation in experimental ocular angiogenesis models

(2011) V. Jhanji et al.   BRITISH JOURNAL OF OPHTHALMOLOGY

Insulin-Like Growth Factor Binding Protein-Related Protein 1 Mediates VEGF-Induced Proliferation, Migration and Tube Formation of Retinal Endothelial Cells

(2011) Tao Sun et al.   CURRENT EYE RESEARCH

Comparison of choroidal and retinal endothelial cells: Characteristics and response to VEGF isoforms and anti-VEGF treatments

(2011) Elizabeth A. Stewart et al.   EXPERIMENTAL EYE RESEARCH

The Matricellular Protein Cysteine-rich Protein 61 (CCN1/Cyr61) Enhances Physiological Adaptation of Retinal Vessels and Reduces Pathological Neovascularization Associated with Ischemic Retinopathy

(2011) Adeel Hasan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Thymidine Analogues for Tracking DNA Synthesis

(2011) Brenton L. Cavanagh et al.   MOLECULES

A Two-Way Communication between Microglial Cells and Angiogenic Sprouts Regulates Angiogenesis in Aortic Ring Cultures

(2011) Simin F. Rymo et al.   PLoS One

PEDF Regulates Vascular Permeability by a γ-Secretase-Mediated Pathway

(2011) Jun Cai et al.   PLoS One

Cell Migration and Invasion Assays as Tools for Drug Discovery

(2011) Keren I. Hulkower et al.   Pharmaceutics

Moderate GSK-3β inhibition improves neovascular architecture, reduces vascular leakage, and reduces retinal hypoxia in a model of ischemic retinopathy

(2010) Mien V. Hoang et al.   ANGIOGENESIS

Albendazole inhibits endothelial cell migration, tube formation, vasopermeability, VEGF receptor-2 expression and suppresses retinal neovascularization in ROP model of angiogenesis

(2010) Mohammad H. Pourgholami et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Calpain inhibitors reduce retinal hypoxia in ischemic retinopathy by improving neovascular architecture and functional perfusion

(2010) Mien V. Hoang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

The inhibition of retinal neovascularization by gold nanoparticles via suppression of VEGFR-2 activation

(2010) Jin Hyoung Kim et al.   BIOMATERIALS

Effects of Pegaptanib Sodium on Retinal Function in Isolated Perfused Vertebrate Retina

(2010) Matthias Lüke et al.   CURRENT EYE RESEARCH

The Retinal Pigment Epithelium: Something More than a Constituent of the Blood-Retinal Barrier—Implications for the Pathogenesis of Diabetic Retinopathy

(2010) Rafael Simó et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Chronic whole-body hypoxia induces intussusceptive angiogenesis and microvascular remodeling in the mouse retina

(2010) Alyssa C. Taylor et al.   MICROVASCULAR RESEARCH

Preparation of retinal explant cultures to study ex vivo tip endothelial cell responses

(2010) Suphansa Sawamiphak et al.   Nature Protocols

Regulation of Pathologic Retinal Angiogenesis in Mice and Inhibition of VEGF-VEGFR2 Binding by Soluble Heparan Sulfate

(2010) Koji M. Nishiguchi et al.   PLoS One

Matrigel: A complex protein mixture required for optimal growth of cell culture

(2010) Chris S. Hughes et al.   PROTEOMICS

Inhibition of APE1/Ref-1 redox activity with APX3330 blocks retinal angiogenesis in vitro and in vivo

(2010) Aihua Jiang et al.   VISION RESEARCH

Atrial Natriuretic Peptide Reduces Vascular Leakage and Choroidal Neovascularization

(2009) Nuria Lara-Castillo et al.   AMERICAN JOURNAL OF PATHOLOGY

CYP1B1 and endothelial nitric oxide synthase combine to sustain proangiogenic functions of endothelial cells under hyperoxic stress

(2009) Yixin Tang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

The endothelial cell tube formation assay on basement membrane turns 20: state of the science and the art

(2009) Irina Arnaoutova et al.   ANGIOGENESIS

Targeting retinal and choroid neovascularization using the small molecule inhibitor carboxyamidotriazole

(2009) Aqeela Afzal et al.   BRAIN RESEARCH BULLETIN

The effects of nepafenac and amfenac on retinal angiogenesis

(2009) Susan E. Yanni et al.   BRAIN RESEARCH BULLETIN

The effects of ranibizumab (Lucentis) on retinal function in isolated perfused vertebrate retina

(2009) M Luke et al.   BRITISH JOURNAL OF OPHTHALMOLOGY

Robo1: A Potential Role in Ocular Angiogenesis

(2009) Lvzhen Huang et al.   CURRENT EYE RESEARCH

MAP Kinase Pathway is Involved in IGF-1-Stimulated Proliferation of Human Retinal Pigment Epithelial Cells (hRPE)

(2009) Christina Y. Weng et al.   CURRENT EYE RESEARCH

Rosmarinic acid suppresses retinal neovascularization via cell cycle arrest with increase of p21WAF1 expression

(2009) Jeong Hun Kim et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Modulating the hypoxia-inducible factor signaling pathway as a therapeutic modality to regulate retinal angiogenesis

(2009) M. DeNiro et al.   EXPERIMENTAL EYE RESEARCH

Ruboxistaurin, a PKCβ inhibitor, inhibits retinal neovascularization via suppression of phosphorylation of ERK1/2 and Akt

(2009) Shinsuke Nakamura et al.   EXPERIMENTAL EYE RESEARCH

Maintaining retinal astrocytes normalizes revascularization and prevents vascular pathology associated with oxygen-induced retinopathy

(2009) Michael I. Dorrell et al.   GLIA

Calpain Inhibitor SNJ-1945 Attenuates Events Prior to Angiogenesis in Cultured Human Retinal Endothelial Cells

(2009) Hong Ma et al.   JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS

N-Hydroxy-7-(2-naphthylthio) Heptanomide Inhibits Retinal and Choroidal Angiogenesis

(2009) Jeong Hun Kim et al.   MOLECULAR PHARMACEUTICS

Regulation of endothelial cell functions by basement membrane- and arachidonic acid-derived products

(2009) Ambra Pozzi et al.   Wiley Interdisciplinary Reviews-Systems Biology and Medicine

Attenuation of retinal endothelial cell migration and capillary morphogenesis in the absence of bcl-2

(2008) Shuji Kondo et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Suppression of Retinal Neovascularization With an Antagonist to Vascular Endothelial Cadherin

(2008) Deepti Navaratna   ARCHIVES OF OPHTHALMOLOGY

Antiangiogenic properties of fasudil, a potent Rho-Kinase inhibitor

(2008) Yasuaki Hata et al.   JAPANESE JOURNAL OF OPHTHALMOLOGY

Novel organotypic culture model of adult mammalian neurosensory retina in co-culture with retinal pigment epithelium

(2008) Stefanie Kaempf et al.   JOURNAL OF NEUROSCIENCE METHODS

Comparative Proteomic Phenotyping of Cell Lines and Primary Cells to Assess Preservation of Cell Type-specific Functions

(2008) Cuiping Pan et al.   MOLECULAR & CELLULAR PROTEOMICS

Role of Soluble Vascular Endothelial Growth Factor Receptor-1 in the Vitreous in Proliferative Diabetic Retinopathy

(2008) Nozomu Matsunaga et al.   OPHTHALMOLOGY

Vaccinium myrtillus(Bilberry) Extracts Reduce AngiogenesisIn VitroandIn Vivo

(2007) Nozomu Matsunaga et al.   Evidence-based Complementary and Alternative Medicine

Rifampicin inhibits the retinal neovascularization in vitro and in vivo

(2007) Yuichi Chikaraishi et al.   EXPERIMENTAL EYE RESEARCH