Diversity and versatility of p38 kinase signalling in health and disease

Requirement for epithelial p38α in KRAS-driven lung tumor progression

(2020) Jessica Vitos-Faleato et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gut stem cell aging is driven by mTORC1 via a p38 MAPK-p53 pathway

(2020) Dan He et al.   Nature Communications

A new regulatory mechanism of protein phosphatase 2A activity via SET in acute myeloid leukemia

(2020) Elena Arriazu et al.   Blood Cancer Journal

p38 MAPK signalling regulates cytokine production in IL-33 stimulated Type 2 Innate Lymphoid cells

(2020) Tsvetana Petrova et al.   Scientific Reports

Non-Canonical Caspase Activity Antagonizes p38 MAPK Stress-Priming Function to Support Development

(2020) Benjamin P. Weaver et al.   DEVELOPMENTAL CELL

An updated patent review of p38 MAP kinase inhibitors (2014-2019)

(2020) Vanessa Haller et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Protective and Detrimental Roles of p38α MAPK in Different Stages of Nonalcoholic Fatty Liver Disease

(2020) Seonghwan Hwang et al.   HEPATOLOGY

Blockade of p38 kinase impedes the mobilization of protumorigenic myeloid populations to impact breast cancer metastasis

(2020) Justin Zonneville et al.   INTERNATIONAL JOURNAL OF CANCER

The p38 Pathway: From Biology to Cancer Therapy

(2020) Adrián Martínez-Limón et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The MKK-Dependent Phosphorylation of p38α Is Augmented by Arginine Methylation on Arg49/Arg149 during Erythroid Differentiation

(2020) Mei-Yin Liu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Blocking elevated p38 MAPK restores efferocytosis and inflammatory resolution in the elderly

(2020) Roel P. H. De Maeyer et al.   NATURE IMMUNOLOGY

Reactive oxygen species (ROS) as pleiotropic physiological signalling agents

(2020) Helmut Sies et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Tumor suppressor death-associated protein kinase 1 inhibits necroptosis by p38 MAPK activation

(2020) Yung-Hsuan Wu et al.   Cell Death & Disease

Activity-dependent isomerization of Kv4.2 by Pin1 regulates cognitive flexibility

(2020) Jia–Hua Hu et al.   Nature Communications

A selective p38α/β MAPK inhibitor alleviates neuropathology and cognitive impairment, and modulates microglia function in 5XFAD mouse

(2020) Min Sung Gee et al.   Alzheimers Research & Therapy

P38 MAPK Promotes Migration and Metastatic Activity of BRAF Mutant Melanoma Cells by Inducing Degradation of PMCA4b

(2020) Randa Naffa et al.   Cells

TGF-β Signaling

(2020) Kalliopi Tzavlaki et al.   Biomolecules

Multi-phenotype CRISPR-Cas9 Screen Identifies p38 Kinase as a Target for Adoptive Immunotherapies

(2020) Devikala Gurusamy et al.   CANCER CELL

The Global Phosphorylation Landscape of SARS-CoV-2 Infection

(2020) Mehdi Bouhaddou et al.   CELL

Mining the PDB for Tractable Cases Where X-ray Crystallography Combined with Fragment Screens Can Be Used to Systematically Design Protein–Protein Inhibitors: Two Test Cases Illustrated by IL1β-IL1R and p38α–TAB1 Complexes

(2020) Charlie Nichols et al.   JOURNAL OF MEDICINAL CHEMISTRY

Stress-responsive MTK1 SAPKKK serves as a redox sensor that mediates delayed and sustained activation of SAPKs by oxidative stress

(2020) Moe Matsushita et al.   Science Advances

Optimal linker length for small molecule PROTACs that selectively target p38α and p38β for degradation

(2020) Craig Donoghue et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Nuclear P38: Roles in Physiological and Pathological Processes and Regulation of Nuclear Translocation

(2020) Galia Maik-Rachline et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Functions of p38 MAP Kinases in the Central Nervous System

(2020) Prita R. Asih et al.   Frontiers in Molecular Neuroscience

An Interferon-Driven Oxysterol-Based Defense against Tumor-Derived Extracellular Vesicles

(2019) Angelica Ortiz et al.   CANCER CELL

P-TEFb Activation by RBM7 Shapes a Pro-survival Transcriptional Response to Genotoxic Stress

(2019) Andrii Bugai et al.   MOLECULAR CELL

Macrophage p38α promotes nutritional steatohepatitis through M1 polarization

(2019) Xiang Zhang et al.   JOURNAL OF HEPATOLOGY

G protein-coupled receptors activate p38 MAPK via a non-canonical TAB1-TAB2 and TAB1-TAB3 dependent pathway in endothelial cells

(2019) Neil J. Grimsey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

BRN2 suppresses apoptosis, reprograms DNA damage repair, and is associated with a high somatic mutation burden in melanoma

(2019) Katharine Herbert et al.   GENES & DEVELOPMENT

ADAM17 selectively activates the IL‐6 trans‐signaling/ERK MAPK axis in KRAS‐addicted lung cancer

(2019) Mohamed I Saad et al.   EMBO Molecular Medicine

Autophagy-induced senescence is regulated by p38α signaling

(2019) Konstantin Slobodnyuk et al.   Cell Death & Disease

Functional Network Analysis Reveals the Relevance of SKIIP in the Regulation of Alternative Splicing by p38 SAPK

(2019) Caterina Carbonell et al.   Cell Reports

p38 Stabilizes Snail by Suppressing DYRK2-Mediated Phosphorylation that is Required for GSK3β-βTrCP-Induced Snail Degradation

(2019) Ki-Jun Ryu et al.   CANCER RESEARCH

Prmt7 promotes myoblast differentiation via methylation of p38MAPK on arginine residue 70

(2019) Hyeon-Ju Jeong et al.   CELL DEATH AND DIFFERENTIATION

PI31 Is an Adaptor Protein for Proteasome Transport in Axons and Required for Synaptic Development

(2019) Kai Liu et al.   DEVELOPMENTAL CELL

IKKα Kinase Regulates the DNA Damage Response and Drives Chemo-resistance in Cancer

(2019) Carlota Colomer et al.   MOLECULAR CELL

Alternative ZAP70-p38 signals prime a classical p38 pathway through LAT and SOS to support regulatory T cell differentiation

(2019) Jesse E. Jun et al.   Science Signaling

Regulation of tumor angiogenesis and mesenchymal–endothelial transition by p38α through TGF-β and JNK signaling

(2019) Raquel Batlle et al.   Nature Communications

Activation of DR3 signaling causes loss of ILC3s and exacerbates intestinal inflammation

(2019) Jingyu Li et al.   Nature Communications

Astrocytic p38α MAPK drives NMDA receptor-dependent long-term depression and modulates long-term memory

(2019) Marta Navarrete et al.   Nature Communications

Inhibition of p38 MAPK in the brain through nasal administration of p38 inhibitor loaded in chitosan nanocapsules

(2019) Álvaro Casadomé-Perales et al.   Nanomedicine

Tanycytes Regulate Lipid Homeostasis by Sensing Free Fatty Acids and Signaling to Key Hypothalamic Neuronal Populations via FGF21 Secretion

(2019) Sarah Geller et al.   Cell Metabolism

A randomized, double-blind, placebo-controlled phase 1b/2 study of ralimetinib, a p38 MAPK inhibitor, plus gemcitabine and carboplatin versus gemcitabine and carboplatin for women with recurrent platinum-sensitive ovarian cancer

(2019) Ignace Vergote et al.   GYNECOLOGIC ONCOLOGY

Zc3h10 Acts as a Transcription Factor and Is Phosphorylated to Activate the Thermogenic Program

(2019) Danielle Yi et al.   Cell Reports

p38α Mitogen-Activated Protein Kinase Is a Druggable Target in Pancreatic Adenocarcinoma

(2019) Ling Yang et al.   Frontiers in Oncology

Targeting p38α Increases DNA Damage, Chromosome Instability, and the Anti-tumoral Response to Taxanes in Breast Cancer Cells

(2018) Begoña Cánovas et al.   CANCER CELL

Reciprocal Regulation of DUSP9 and DUSP16 Expression by HIF-1 Controls ERK and p38 MAP Kinase Activity and Mediates Chemotherapy-Induced Breast Cancer Stem Cell Enrichment

(2018) Haiquan Lu et al.   CANCER RESEARCH

Myeloid p38α signaling promotes intestinal IGF‐1 production and inflammation‐associated tumorigenesis

(2018) Catrin Youssif et al.   EMBO Molecular Medicine

Selective inhibition of the p38α MAPK–MK2 axis inhibits inflammatory cues including inflammasome priming signals

(2018) Chun Wang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

DNA Replication Determines Timing of Mitosis by Restricting CDK1 and PLK1 Activation

(2018) Bennie Lemmens et al.   MOLECULAR CELL

MSK1 regulates luminal cell differentiation and metastatic dormancy in ER+ breast cancer

(2018) Sylwia Gawrzak et al.   NATURE CELL BIOLOGY

Intensity and duration of TCR signaling is limited by p38 phosphorylation of ZAP-70T293and destabilization of the signalosome

(2018) Maria Letizia Giardino Torchia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MK2 contributes to tumor progression by promoting M2 macrophage polarization and tumor angiogenesis

(2018) Lucia Suarez-Lopez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dynamic activation and regulation of the mitogen-activated protein kinase p38

(2018) Ganesan Senthil Kumar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of p38/MAPKs in Alzheimer’s disease: implications for amyloid beta toxicity targeted therapy

(2018) Ghazaleh Kheiri et al.   REVIEWS IN THE NEUROSCIENCES

The nuclear translocation of the kinases p38 and JNK promotes inflammation-induced cancer

(2018) Galia Maik-Rachline et al.   Science Signaling

Inflammatory but not mitogenic contexts prime synovial fibroblasts for compensatory signaling responses to p38 inhibition

(2018) Douglas S. Jones et al.   Science Signaling

Inhibition of the ER stress IRE1α inflammatory pathway protects against cell death in mitochondrial complex I mutant cells

(2018) Meghan S. Soustek et al.   Cell Death & Disease

Phosphorylation of Parkin at serine 131 by p38 MAPK promotes mitochondrial dysfunction and neuronal death in mutant A53T α-synuclein model of Parkinson’s disease

(2018) Jialong Chen et al.   Cell Death & Disease

Inhibiting p38 MAPK alpha rescues axonal retrograde transport defects in a mouse model of ALS

(2018) Katherine L. Gibbs et al.   Cell Death & Disease

p38-MK2 signaling axis regulates RNA metabolism after UV-light-induced DNA damage

(2018) Marina E. Borisova et al.   Nature Communications

p38-mediated phosphorylation at T367 induces EZH2 cytoplasmic localization to promote breast cancer metastasis

(2018) Talha Anwar et al.   Nature Communications

Mutual Stabilization between TRIM9 Short Isoform and MKK6 Potentiates p38 Signaling to Synergistically Suppress Glioblastoma Progression

(2018) Kunpeng Liu et al.   Cell Reports

Metabolic benefits of inhibition of p38α in white adipose tissue in obesity

(2018) Shengjie Zhang et al.   PLOS BIOLOGY

p38α blocks brown adipose tissue thermogenesis through p38δ inhibition

(2018) Nuria Matesanz et al.   PLOS BIOLOGY

The nuclear translocation of the kinases p38 and JNK promotes inflammation-induced cancer

(2018) Galia Maik-Rachline et al.   Science Signaling

Inflammatory but not mitogenic contexts prime synovial fibroblasts for compensatory signaling responses to p38 inhibition

(2018) Douglas S. Jones et al.   Science Signaling

An exploratory clinical study of p38α kinase inhibition in Alzheimer's disease

(2018) Philip Scheltens et al.   Annals of Clinical and Translational Neurology

Inhibition of the Stromal p38MAPK/MK2 Pathway Limits Breast Cancer Metastases and Chemotherapy-Induced Bone Loss

(2018) Bhavna Murali et al.   CANCER RESEARCH

Fibroblasts Mobilize Tumor Cell Glycogen to Promote Proliferation and Metastasis

(2018) Marion Curtis et al.   Cell Metabolism

IL-33 regulates cytokine production and neutrophil recruitment via the p38 MAPK-activated kinases MK2/3

(2018) Pierre C. McCarthy et al.   IMMUNOLOGY AND CELL BIOLOGY

P38α/JNK signaling restrains erythropoiesis by suppressing Ezh2-mediated epigenetic silencing of Bim

(2018) Ping Hu et al.   Nature Communications

Cell-to-Cell Heterogeneity in p38-Mediated Cross-Inhibition of JNK Causes Stochastic Cell Death

(2018) Haruko Miura et al.   Cell Reports

The role of Pitx2 and Pitx3 in muscle stem cells gives new insights into P38α MAP kinase and redox regulation of muscle regeneration

(2018) Aurore Lhonore et al.   eLife

TLR8-Mediated Metabolic Control of Human Treg Function: A Mechanistic Target for Cancer Immunotherapy

(2018) Lingyun Li et al.   Cell Metabolism

Protein kinase p38α signaling in dendritic cells regulates colon inflammation and tumorigenesis

(2018) Tingting Zheng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

p38α MAPK signaling drives pharmacologically reversible brain and gastrointestinal phenotypes in the SERT Ala56 mouse

(2018) Matthew J. Robson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The protein kinase p38α destabilizes p63 to limit epidermal stem cell frequency and tumorigenic potential

(2018) Min-Kyung Choo et al.   Science Signaling

The p38α Stress Kinase Suppresses Aneuploidy Tolerance by Inhibiting Hif-1α

(2018) Susana Simões-Sousa et al.   Cell Reports

Protein imbalance in the development of skeletal muscle wasting in tumour-bearing mice

(2018) Jacob L. Brown et al.   Journal of Cachexia Sarcopenia and Muscle

Oncogenic RAS Signaling Promotes Tumor Immunoresistance by Stabilizing PD-L1 mRNA

(2017) Matthew A. Coelho et al.   IMMUNITY

Novel Noncatalytic Substrate-Selective p38α-Specific MAPK Inhibitors with Endothelial-Stabilizing and Anti-Inflammatory Activity

(2017) Nirav G. Shah et al.   JOURNAL OF IMMUNOLOGY

The p38-MK2/3 Module Is Critical for IL-33–Induced Signaling and Cytokine Production in Dendritic Cells

(2017) Christiane Göpfert et al.   JOURNAL OF IMMUNOLOGY

MK2 Phosphorylates RIPK1 to Prevent TNF-Induced Cell Death

(2017) Isabel Jaco et al.   MOLECULAR CELL

Recent Advances in the Inhibition of p38 MAPK as a Potential Strategy for the Treatment of Alzheimer’s Disease

(2017) Jong Kil Lee et al.   MOLECULES

Interplay between metabolic identities in the intestinal crypt supports stem cell function

(2017) Maria J. Rodríguez-Colman et al.   NATURE

p38MAPK/MK2-dependent phosphorylation controls cytotoxic RIPK1 signalling in inflammation and infection

(2017) Manoj B. Menon et al.   NATURE CELL BIOLOGY

MK2 phosphorylation of RIPK1 regulates TNF-mediated cell death

(2017) Yves Dondelinger et al.   NATURE CELL BIOLOGY

Regulation of Hippo pathway transcription factor TEAD by p38 MAPK-induced cytoplasmic translocation

(2017) Kimberly C. Lin et al.   NATURE CELL BIOLOGY

Structural Basis for the Subversion of MAP Kinase Signaling by an Intrinsically Disordered Parasite Secreted Agonist

(2017) Erika Pellegrini et al.   STRUCTURE

p38γ and p38δ: From Spectators to Key Physiological Players

(2017) Ana Cuenda et al.   TRENDS IN BIOCHEMICAL SCIENCES

MKK6 controls T3-mediated browning of white adipose tissue

(2017) Nuria Matesanz et al.   Nature Communications

Praja1 E3 ubiquitin ligase promotes skeletal myogenesis through degradation of EZH2 upon p38α activation

(2017) Silvia Consalvi et al.   Nature Communications

Phosphorylation of LAMP2A by p38 MAPK couples ER stress to chaperone-mediated autophagy

(2017) Wenming Li et al.   Nature Communications

Dendritic cell MST1 inhibits Th17 differentiation

(2017) Chunxiao Li et al.   Nature Communications

Induction of oxidative metabolism by the p38α/MK2 pathway

(2017) Natalia Trempolec et al.   Scientific Reports

miRNA-32 Drives Brown Fat Thermogenesis and Trans-activates Subcutaneous White Fat Browning in Mice

(2017) Raymond Ng et al.   Cell Reports

Changes in the free-energy landscape of p38α MAP kinase through its canonical activation and binding events as studied by enhanced molecular dynamics simulations

(2017) Antonija Kuzmanic et al.   eLife

MMI‐0100 Inhibits Cardiac Fibrosis in a Mouse Model Overexpressing Cardiac Myosin Binding Protein C

(2017) Qinghang Meng et al.   Journal of the American Heart Association

Genetic Correction of SOD1 Mutant iPSCs Reveals ERK and JNK Activated AP1 as a Driver of Neurodegeneration in Amyotrophic Lateral Sclerosis

(2017) Akshay Bhinge et al.   Stem Cell Reports

Neuronal p38α mediates synaptic and cognitive dysfunction in an Alzheimer’s mouse model by controlling β-amyloid production

(2017) Sandra Colié et al.   Scientific Reports

Targeting p38 or MK2 Enhances the Anti-Leukemic Activity of Smac-Mimetics

(2016) Najoua Lalaoui et al.   CANCER CELL

ERK and p38 MAPK Activities Determine Sensitivity to PI3K/mTOR Inhibition via Regulation of MYC and YAP

(2016) Taru Muranen et al.   CANCER RESEARCH

Metabolic Stress-Induced Phosphorylation of KAP1 Ser473 Blocks Mitochondrial Fusion in Breast Cancer Cells

(2016) C.-T. Cheng et al.   CANCER RESEARCH

Proline isomerisation as a novel regulatory mechanism for p38MAPK activation and functions

(2016) A Brichkina et al.   CELL DEATH AND DIFFERENTIATION

p38α Activates Purine Metabolism to Initiate Hematopoietic Stem/Progenitor Cell Cycling in Response to Stress

(2016) Daiki Karigane et al.   Cell Stem Cell

p38MAPK builds a hyaluronan cancer niche to drive lung tumorigenesis

(2016) Anna Brichkina et al.   GENES & DEVELOPMENT

A senescence secretory switch mediated by PI3K/AKT/mTOR activation controls chemoprotective endothelial secretory responses

(2016) Eric H. Bent et al.   GENES & DEVELOPMENT

Effect of Losmapimod on Cardiovascular Outcomes in Patients Hospitalized With Acute Myocardial Infarction

(2016) Michelle L. O’Donoghue et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Loss of Functionally Redundant p38 Isoforms in T Cells Enhances Regulatory T Cell Induction

(2016) Morisada Hayakawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The N-Terminal Phosphorylation of RB by p38 Bypasses Its Inactivation by CDKs and Prevents Proliferation in Cancer Cells

(2016) Albert Gubern et al.   MOLECULAR CELL

Mechanism of early dissemination and metastasis in Her2+ mammary cancer

(2016) Kathryn L. Harper et al.   NATURE

Excessive fatty acid oxidation induces muscle atrophy in cancer cachexia

(2016) Tomoya Fukawa et al.   NATURE MEDICINE

Cell Signaling and Stress Responses

(2016) Gökhan S. Hotamisligil et al.   Cold Spring Harbor Perspectives in Biology

Inactivation of nuclear GSK3β by Ser389 phosphorylation promotes lymphocyte fitness during DNA double-strand break response

(2016) Tina M. Thornton et al.   Nature Communications

Mechanical cell competition kills cells via induction of lethal p53 levels

(2016) Laura Wagstaff et al.   Nature Communications

miR-625-3p regulates oxaliplatin resistance by targeting MAP2K6-p38 signalling in human colorectal adenocarcinoma cells

(2016) Mads Heilskov Rasmussen et al.   Nature Communications

Thioredoxin-interacting protein regulates haematopoietic stem cell ageing and rejuvenation by inhibiting p38 kinase activity

(2016) Haiyoung Jung et al.   Nature Communications

Mincle-mediated translational regulation is required for strong nitric oxide production and inflammation resolution

(2016) Wook-Bin Lee et al.   Nature Communications

CUG-binding protein 1 regulates HSC activation and liver fibrogenesis

(2016) Xingxin Wu et al.   Nature Communications

ASK1 signalling regulates brown and beige adipocyte function

(2016) Kazuki Hattori et al.   Nature Communications

The lipid sensor GPR120 promotes brown fat activation and FGF21 release from adipocytes

(2016) Tania Quesada-López et al.   Nature Communications

BMP7 retards peripheral myelination by activating p38 MAPK in Schwann cells

(2016) Xiaoyu Liu et al.   Scientific Reports

MAPK-Mediated YAP Activation Controls Mechanical-Tension-Induced Pulmonary Alveolar Regeneration

(2016) Zhe Liu et al.   Cell Reports

Targeting Human Central Nervous System Protein Kinases: An Isoform Selective p38αMAPK Inhibitor That Attenuates Disease Progression in Alzheimer’s Disease Mouse Models

(2015) Saktimayee M. Roy et al.   ACS Chemical Neuroscience

A Pleiotropic RNA-Binding Protein Controls Distinct Cell Cycle Checkpoints to Drive Resistance of p53 -Defective Tumors to Chemotherapy

(2015) Ian G. Cannell et al.   CANCER CELL

The Stress Kinase p38  as a Target for Cancer Therapy

(2015) A. Igea et al.   CANCER RESEARCH

A Synergistic Interaction between Chk1- and MK2 Inhibitors in KRAS-Mutant Cancer

(2015) Felix Dietlein et al.   CELL

A First-in-Human Phase I Study of the Oral p38 MAPK Inhibitor, Ralimetinib (LY2228820 Dimesylate), in Patients with Advanced Cancer

(2015) A. Patnaik et al.   CLINICAL CANCER RESEARCH

Roles of p38α mitogen-activated protein kinase in mouse models of inflammatory diseases and cancer

(2015) Jalaj Gupta et al.   FEBS Journal

Molecular mechanisms linking amyloid β toxicity and Tau hyperphosphorylation in Alzheimer׳s disease

(2015) A. Lloret et al.   FREE RADICAL BIOLOGY AND MEDICINE

Stress kinases in the modulation of metabolism and energy balance

(2015) Elisa Manieri et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Role of Reactive Oxygen Species in the Abrogation of Oxaliplatin Activity by Cetuximab in Colorectal Cancer

(2015) Valeria Santoro et al.   JNCI-Journal of the National Cancer Institute

Stress Induces p38 MAPK-Mediated Phosphorylation and Inhibition of Drosha-Dependent Cell Survival

(2015) Qian Yang et al.   MOLECULAR CELL

Systematic discovery of linear binding motifs targeting an ancient protein interaction surface on MAP kinases

(2015) A. Zeke et al.   Molecular Systems Biology

mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype

(2015) Nicolás Herranz et al.   NATURE CELL BIOLOGY

Selective inhibition of the p38 alternative activation pathway in infiltrating T cells inhibits pancreatic cancer progression

(2015) Muhammad S Alam et al.   NATURE MEDICINE

The scaffold protein RACK1 mediates the RANKL-dependent activation of p38 MAPK in osteoclast precursors

(2015) Jingjing Lin et al.   Science Signaling

The E3 ubiquitin ligase Itch inhibits p38α signaling and skin inflammation through the ubiquitylation of Tab1

(2015) Balamayooran Theivanthiran et al.   Science Signaling

MK2 inhibitory peptide delivered in nanopolyplexes prevents vascular graft intimal hyperplasia

(2015) Brian C. Evans et al.   Science Translational Medicine

The p38α mitogen-activated protein kinase is a key regulator of myelination and remyelination in the CNS

(2015) S-H Chung et al.   Cell Death & Disease

Oscillation of p38 activity controls efficient pro-inflammatory gene expression

(2015) Taichiro Tomida et al.   Nature Communications

Tumour-derived SPARC drives vascular permeability and extravasation through endothelial VCAM1 signalling to promote metastasis

(2015) Mélanie Tichet et al.   Nature Communications

The stress-responsive kinases MAPKAPK2/MAPKAPK3 activate starvation-induced autophagy through Beclin 1 phosphorylation

(2015) Yongjie Wei et al.   eLife

Role of Reactive Oxygen Species in the Abrogation of Oxaliplatin Activity by Cetuximab in Colorectal Cancer

(2015) Valeria Santoro et al.   JNCI-Journal of the National Cancer Institute

The scaffold protein RACK1 mediates the RANKL-dependent activation of p38 MAPK in osteoclast precursors

(2015) Jingjing Lin et al.   Science Signaling

The E3 ubiquitin ligase Itch inhibits p38α signaling and skin inflammation through the ubiquitylation of Tab1

(2015) Balamayooran Theivanthiran et al.   Science Signaling

The case for inhibiting p38 mitogen-activated protein kinase in heart failure

(2015) Pelin Arabacilar et al.   Frontiers in Pharmacology

PP2AC Level Determines Differential Programming of p38-TSC-mTOR Signaling and Therapeutic Response to p38-Targeted Therapy in Colorectal Cancer

(2015) Yanjie Zhang et al.   EBioMedicine

p38 MAPK in cardioprotection - are we there yet?

(2014) E D Martin et al.   BRITISH JOURNAL OF PHARMACOLOGY

Dual Function of p38α MAPK in Colon Cancer: Suppression of Colitis-Associated Tumor Initiation but Requirement for Cancer Cell Survival

(2014) Jalaj Gupta et al.   CANCER CELL

p38 MAPK: A Potential Target of Chronic Pain

(2014) X. Lin et al.   CURRENT MEDICINAL CHEMISTRY

F-Box Only Protein 31 (FBXO31) Negatively Regulates p38 Mitogen-activated Protein Kinase (MAPK) Signaling by Mediating Lysine 48-linked Ubiquitination and Degradation of Mitogen-activated Protein Kinase Kinase 6 (MKK6)

(2014) Jia Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Counter-regulation of T cell effector function by differentially activated p38

(2014) Muhammad S. Alam et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Macrophage Deletion of p38  Partially Impairs Lipopolysaccharide-Induced Cellular Activation

(2014) Y. J. Kang et al.   JOURNAL OF IMMUNOLOGY

Losmapimod, a novel p38 mitogen-activated protein kinase inhibitor, in non-ST-segment elevation myocardial infarction: a randomised phase 2 trial

(2014) L Kristin Newby et al.   LANCET

Colon cancer cells colonize the lung from established liver metastases through p38 MAPK signalling and PTHLH

(2014) Jelena Urosevic et al.   NATURE CELL BIOLOGY

The kinase p38 activated by the metabolic regulator AMPK and scaffold TAB1 drives the senescence of human T cells

(2014) Alessio Lanna et al.   NATURE IMMUNOLOGY

In vivo RNAi screening identifies a mechanism of sorafenib resistance in liver cancer

(2014) Ramona Rudalska et al.   NATURE MEDICINE

Allosteric enhancement of MAP kinase p38α's activity and substrate selectivity by docking interactions

(2014) Yuji Tokunaga et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Ubiquitin-conjugating enzyme Ubc13 controls breast cancer metastasis through a TAK1-p38 MAP kinase cascade

(2014) X. Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TNF and MAP kinase signalling pathways

(2014) Guadalupe Sabio et al.   SEMINARS IN IMMUNOLOGY

p38MAPK Plays a Crucial Role in Stromal-Mediated Tumorigenesis

(2014) E. Alspach et al.   Cancer Discovery

SnapShot: p38 MAPK Substrates

(2013) Natalia Trempolec et al.   CELL

Inhibition of p38 MAPK sensitizes tumour cells to cisplatin-induced apoptosis mediated by reactive oxygen species and JNK

(2013) Lorena Pereira et al.   EMBO Molecular Medicine

Beta-Like Importins Mediate the Nuclear Translocation of Mitogen-Activated Protein Kinases

(2013) E. Zehorai et al.   MOLECULAR AND CELLULAR BIOLOGY

Disruption of TAB1/p38α Interaction Using a Cell-permeable Peptide Limits Myocardial Ischemia/Reperfusion Injury

(2013) Qingyang Wang et al.   MOLECULAR THERAPY

Mechanism and consequence of the autoactivation of p38α mitogen-activated protein kinase promoted by TAB1

(2013) Gian Felice De Nicola et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Efficacy and safety of the oral p38 inhibitor PH-797804 in chronic obstructive pulmonary disease: a randomised clinical trial

(2013) William MacNee et al.   THORAX

The TGF -induced phosphorylation and activation of p38 mitogen-activated protein kinase is mediated by MAP3K4 and MAP3K10 but not TAK1

(2013) G. P. Sapkota   Open Biology

The many faces of p38 mitogen-activated protein kinase in progenitor/stem cell differentiation

(2012) Feride Oeztuerk-Winder et al.   BIOCHEMICAL JOURNAL

Differential p38-dependent signalling in response to cellular stress and mitogenic stimulation in fibroblasts

(2012) Dagmar Faust et al.   Cell Communication and Signaling

The stress-activated protein kinases p38α/β and JNK1/2 cooperate with Chk1 to inhibit mitotic entry upon DNA replication arrest

(2012) Alba Llopis et al.   CELL CYCLE

Gadd45γ and Map3k4 Interactions Regulate Mouse Testis Determination via p38 MAPK-Mediated Control of Sry Expression

(2012) Nick Warr et al.   DEVELOPMENTAL CELL

Ubiquitination-mediated regulation of interferon responses

(2012) Serge Y. Fuchs   GROWTH FACTORS

Mammalian MAPK Signal Transduction Pathways Activated by Stress and Inflammation: A 10-Year Update

(2012) John M. Kyriakis et al.   PHYSIOLOGICAL REVIEWS

Serine/threonine acetylation of TGF -activated kinase (TAK1) by Yersinia pestis YopJ inhibits innate immune signaling

(2012) N. Paquette et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

p38MAPK is a novel DNA damage response-independent regulator of the senescence-associated secretory phenotype

(2011) Adam Freund et al.   EMBO JOURNAL

A novel cardioprotective p38-MAPK/mTOR pathway

(2011) Gonzalo Hernández et al.   EXPERIMENTAL CELL RESEARCH

Role of p38 Protein Kinase in the Ligand-independent Ubiquitination and Down-regulation of the IFNAR1 Chain of Type I Interferon Receptor

(2011) Sabyasachi Bhattacharya et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Acetylation of a Conserved Lysine Residue in the ATP Binding Pocket of p38 Augments Its Kinase Activity during Hypertrophy of Cardiomyocytes

(2011) V. B. Pillai et al.   MOLECULAR AND CELLULAR BIOLOGY

Genetic analysis of specific and redundant roles for p38  and p38  MAPKs during mouse development

(2011) I. del Barco Barrantes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanisms and functions of p38 MAPK signalling

(2010) Ana Cuadrado et al.   BIOCHEMICAL JOURNAL

Mechanisms of mRNA translation of interferon stimulated genes

(2010) Sonali Joshi et al.   CYTOKINE

Cross-talk between the p38α and JNK MAPK Pathways Mediated by MAP Kinase Phosphatase-1 Determines Cellular Sensitivity to UV Radiation

(2010) Christopher J. Staples et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The p38 MAPK pathway is essential for skeletogenesis and bone homeostasis in mice

(2010) Matthew B. Greenblatt et al.   JOURNAL OF CLINICAL INVESTIGATION

p38 Mitogen-Activated Protein Kinase Promotes Cell Survival in Response to DNA Damage but Is Not Required for the G2 DNA Damage Checkpoint in Human Cancer Cells

(2010) M. S. Phong et al.   MOLECULAR AND CELLULAR BIOLOGY

Oxidation-induced intramolecular disulfide bond inactivates mitogen-activated protein kinase kinase 6 by inhibiting ATP binding

(2010) Y. Diao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of the immune response by stress-activated protein kinases

(2009) Mercedes Rincón et al.   IMMUNOLOGICAL REVIEWS

T Cell Receptor-mediated Activation of p38α by Mono-phosphorylation of the Activation Loop Results in Altered Substrate Specificity

(2009) Paul R. Mittelstadt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Role for p38 Stress-Activated Protein Kinase in Regulation of Cell Growth via TORC1

(2009) M. Cully et al.   MOLECULAR AND CELLULAR BIOLOGY

Targeting innate immunity protein kinase signalling in inflammation

(2009) Matthias Gaestel et al.   NATURE REVIEWS DRUG DISCOVERY

The p38 MAPK stress pathway as a tumor suppressor or more?

(2008) Mathew Loesch   Frontiers in Bioscience-Landmark

MAPKAP kinase 2-deficiency prevents neurons from cell death by reducing neuroinflammation – relevance in a mouse model of Parkinson’s disease

(2008) Tobias Thomas et al.   JOURNAL OF NEUROCHEMISTRY

Phosphorylation by p38 MAPK as an Alternative Pathway for GSK3  Inactivation

(2008) T. M. Thornton et al.   SCIENCE

Activation of MKK6, an upstream activator of p38, in Alzheimer's disease

(2003) Xiongwei Zhu et al.   JOURNAL OF NEUROCHEMISTRY

p38 Kinase Is Activated in the Alzheimer's Disease Brain

(2003) Kenneth Hensley et al.   JOURNAL OF NEUROCHEMISTRY