A selective p38α/β MAPK inhibitor alleviates neuropathology and cognitive impairment, and modulates microglia function in 5XFAD mouse

Sodium rutin ameliorates Alzheimer’s disease–like pathology by enhancing microglial amyloid-β clearance

(2019) Rui-Yuan Pan et al.   Science Advances

Exenatide alleviates mitochondrial dysfunction and cognitive impairment in the 5×FAD mouse model of Alzheimer’s disease

(2019) Jingjing An et al.   BEHAVIOURAL BRAIN RESEARCH

Picrorhiza kurroa Prevents Memory Deficits by Inhibiting NLRP3 Inflammasome Activation and BACE1 Expression in 5xFAD Mice

(2019) Namkwon Kim et al.   Neurotherapeutics

Tetrazolium salts and formazan products in Cell Biology: Viability assessment, fluorescence imaging, and labeling perspectives

(2018) Juan C. Stockert et al.   ACTA HISTOCHEMICA

Motor function deficits in the 12 month-old female 5xFAD mouse model of Alzheimer’s disease

(2018) T.P. O’Leary et al.   BEHAVIOURAL BRAIN RESEARCH

Role of p38/MAPKs in Alzheimer’s disease: implications for amyloid beta toxicity targeted therapy

(2018) Ghazaleh Kheiri et al.   REVIEWS IN THE NEUROSCIENCES

An Inflammation-Centric View of Neurological Disease: Beyond the Neuron

(2018) Stephen D. Skaper et al.   Frontiers in Cellular Neuroscience

Blocking p38 Signaling Reduces the Activation of Pro-inflammatory Cytokines and the Phosphorylation of p38 in the Habenula and Reverses Depressive-Like Behaviors Induced by Neuroinflammation

(2018) Ya-wei Zhao et al.   Frontiers in Pharmacology

An exploratory clinical study of p38α kinase inhibition in Alzheimer's disease

(2018) Philip Scheltens et al.   Annals of Clinical and Translational Neurology

A Novel and Selective p38 Mitogen-Activated Protein Kinase Inhibitor Attenuates LPS-Induced Neuroinflammation in BV2 Microglia and a Mouse Model

(2018) Min Sung Gee et al.   NEUROCHEMICAL RESEARCH

Microglia in Alzheimer’s disease

(2017) David V. Hansen et al.   JOURNAL OF CELL BIOLOGY

Retention of normal glia function by an isoform-selective protein kinase inhibitor drug candidate that modulates cytokine production and cognitive outcomes

(2017) Zhengqiu Zhou et al.   Journal of Neuroinflammation

Recent Advances in the Inhibition of p38 MAPK as a Potential Strategy for the Treatment of Alzheimer’s Disease

(2017) Jong Kil Lee et al.   MOLECULES

Neurotoxic reactive astrocytes are induced by activated microglia

(2017) Shane A. Liddelow et al.   NATURE

Role of neuroinflammation in neurodegeneration: new insights

(2017) Róisín M. McManus et al.   Alzheimers Research & Therapy

Alzheimer's Disease: The Role of Microglia in Brain Homeostasis and Proteopathy

(2017) Kevin A. Clayton et al.   Frontiers in Neuroscience

Alzheimer's Disease and the Amyloid-β Peptide

(2017) M. Paul Murphy et al.   JOURNAL OF ALZHEIMERS DISEASE

Neuronal p38α mediates synaptic and cognitive dysfunction in an Alzheimer’s mouse model by controlling β-amyloid production

(2017) Sandra Colié et al.   Scientific Reports

ToxId: an efficient algorithm to solve occlusions when tracking multiple animals

(2017) Alvaro Rodriguez et al.   Scientific Reports

Role of neuroinflammation in neurodegenerative diseases (Review)

(2016) WEI-WEI CHEN et al.   Molecular Medicine Reports

A polarizing question: do M1 and M2 microglia exist?

(2016) Richard M Ransohoff   NATURE NEUROSCIENCE

Selective suppression of the α isoform of p38 MAPK rescues late-stage tau pathology

(2016) Nicole Maphis et al.   Alzheimers Research & Therapy

Targeting Human Central Nervous System Protein Kinases: An Isoform Selective p38αMAPK Inhibitor That Attenuates Disease Progression in Alzheimer’s Disease Mouse Models

(2015) Saktimayee M. Roy et al.   ACS Chemical Neuroscience

Synthesis and biological evaluation of N-cyclopropylbenzamide-benzophenone hybrids as novel and selective p38 mitogen activated protein kinase (MAPK) inhibitors

(2015) Jinyuk Heo et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Microglial M1/M2 polarization and metabolic states

(2015) Ruben Orihuela et al.   BRITISH JOURNAL OF PHARMACOLOGY

Deficiency of Neuronal p38α MAPK Attenuates Amyloid Pathology in Alzheimer Disease Mouse and Cell Models through Facilitating Lysosomal Degradation of BACE1

(2015) Laura Schnöder et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neuroinflammation in Alzheimer's disease

(2015) Michael T Heneka et al.   LANCET NEUROLOGY

Neuroinflammation and M2 microglia: the good, the bad, and the inflamed

(2014) Jonathan D Cherry et al.   Journal of Neuroinflammation

Behavioral and EEG changes in male 5xFAD mice

(2014) F. Schneider et al.   PHYSIOLOGY & BEHAVIOR

Microglia, neuroinflammation, and beta-amyloid protein in Alzheimer's disease

(2013) Zhiyou Cai et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

Alzheimer Mechanisms and Therapeutic Strategies

(2012) Yadong Huang et al.   CELL

Current and future treatments for Alzheimer’s disease

(2012) Konstantina G. Yiannopoulou et al.   Therapeutic Advances in Neurological Disorders

Bone Marrow-Derived Mesenchymal Stem Cells Attenuate Amyloid β-Induced Memory Impairment and Apoptosis by Inhibiting Neuronal Cell Death

(2010) J. K. Lee et al.   Current Alzheimer Research

MAPK Signal Transduction Underlying Brain Inflammation and Gliosis as Therapeutic Target

(2009) Bozena Kaminska et al.   Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology

Cell-derived soluble oligomers of human amyloid-β peptides disturb cellular homeostasis and induce apoptosis in primary hippocampal neurons

(2009) Ting-Ting Yang et al.   JOURNAL OF NEURAL TRANSMISSION