标题
Diversity and versatility of p38 kinase signalling in health and disease
作者
关键词
-
出版物
NATURE REVIEWS MOLECULAR CELL BIOLOGY
Volume -, Issue -, Pages -
出版商
Springer Science and Business Media LLC
发表日期
2021-01-27
DOI
10.1038/s41580-020-00322-w
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Requirement for epithelial p38α in KRAS-driven lung tumor progression
- (2020) Jessica Vitos-Faleato et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Gut stem cell aging is driven by mTORC1 via a p38 MAPK-p53 pathway
- (2020) Dan He et al. Nature Communications
- A new regulatory mechanism of protein phosphatase 2A activity via SET in acute myeloid leukemia
- (2020) Elena Arriazu et al. Blood Cancer Journal
- p38 MAPK signalling regulates cytokine production in IL-33 stimulated Type 2 Innate Lymphoid cells
- (2020) Tsvetana Petrova et al. Scientific Reports
- Non-Canonical Caspase Activity Antagonizes p38 MAPK Stress-Priming Function to Support Development
- (2020) Benjamin P. Weaver et al. DEVELOPMENTAL CELL
- An updated patent review of p38 MAP kinase inhibitors (2014-2019)
- (2020) Vanessa Haller et al. EXPERT OPINION ON THERAPEUTIC PATENTS
- Protective and Detrimental Roles of p38α MAPK in Different Stages of Nonalcoholic Fatty Liver Disease
- (2020) Seonghwan Hwang et al. HEPATOLOGY
- Blockade of p38 kinase impedes the mobilization of protumorigenic myeloid populations to impact breast cancer metastasis
- (2020) Justin Zonneville et al. INTERNATIONAL JOURNAL OF CANCER
- The p38 Pathway: From Biology to Cancer Therapy
- (2020) Adrián Martínez-Limón et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- The MKK-Dependent Phosphorylation of p38α Is Augmented by Arginine Methylation on Arg49/Arg149 during Erythroid Differentiation
- (2020) Mei-Yin Liu et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Blocking elevated p38 MAPK restores efferocytosis and inflammatory resolution in the elderly
- (2020) Roel P. H. De Maeyer et al. NATURE IMMUNOLOGY
- Reactive oxygen species (ROS) as pleiotropic physiological signalling agents
- (2020) Helmut Sies et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Tumor suppressor death-associated protein kinase 1 inhibits necroptosis by p38 MAPK activation
- (2020) Yung-Hsuan Wu et al. Cell Death & Disease
- Activity-dependent isomerization of Kv4.2 by Pin1 regulates cognitive flexibility
- (2020) Jia–Hua Hu et al. Nature Communications
- A selective p38α/β MAPK inhibitor alleviates neuropathology and cognitive impairment, and modulates microglia function in 5XFAD mouse
- (2020) Min Sung Gee et al. Alzheimers Research & Therapy
- P38 MAPK Promotes Migration and Metastatic Activity of BRAF Mutant Melanoma Cells by Inducing Degradation of PMCA4b
- (2020) Randa Naffa et al. Cells
- TGF-β Signaling
- (2020) Kalliopi Tzavlaki et al. Biomolecules
- Multi-phenotype CRISPR-Cas9 Screen Identifies p38 Kinase as a Target for Adoptive Immunotherapies
- (2020) Devikala Gurusamy et al. CANCER CELL
- The Global Phosphorylation Landscape of SARS-CoV-2 Infection
- (2020) Mehdi Bouhaddou et al. CELL
- Mining the PDB for Tractable Cases Where X-ray Crystallography Combined with Fragment Screens Can Be Used to Systematically Design Protein–Protein Inhibitors: Two Test Cases Illustrated by IL1β-IL1R and p38α–TAB1 Complexes
- (2020) Charlie Nichols et al. JOURNAL OF MEDICINAL CHEMISTRY
- Stress-responsive MTK1 SAPKKK serves as a redox sensor that mediates delayed and sustained activation of SAPKs by oxidative stress
- (2020) Moe Matsushita et al. Science Advances
- Optimal linker length for small molecule PROTACs that selectively target p38α and p38β for degradation
- (2020) Craig Donoghue et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Nuclear P38: Roles in Physiological and Pathological Processes and Regulation of Nuclear Translocation
- (2020) Galia Maik-Rachline et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Functions of p38 MAP Kinases in the Central Nervous System
- (2020) Prita R. Asih et al. Frontiers in Molecular Neuroscience
- An Interferon-Driven Oxysterol-Based Defense against Tumor-Derived Extracellular Vesicles
- (2019) Angelica Ortiz et al. CANCER CELL
- P-TEFb Activation by RBM7 Shapes a Pro-survival Transcriptional Response to Genotoxic Stress
- (2019) Andrii Bugai et al. MOLECULAR CELL
- Macrophage p38α promotes nutritional steatohepatitis through M1 polarization
- (2019) Xiang Zhang et al. JOURNAL OF HEPATOLOGY
- G protein-coupled receptors activate p38 MAPK via a non-canonical TAB1-TAB2 and TAB1-TAB3 dependent pathway in endothelial cells
- (2019) Neil J. Grimsey et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- BRN2 suppresses apoptosis, reprograms DNA damage repair, and is associated with a high somatic mutation burden in melanoma
- (2019) Katharine Herbert et al. GENES & DEVELOPMENT
- ADAM17 selectively activates the IL‐6 trans‐signaling/ERK MAPK axis in KRAS‐addicted lung cancer
- (2019) Mohamed I Saad et al. EMBO Molecular Medicine
- Autophagy-induced senescence is regulated by p38α signaling
- (2019) Konstantin Slobodnyuk et al. Cell Death & Disease
- Functional Network Analysis Reveals the Relevance of SKIIP in the Regulation of Alternative Splicing by p38 SAPK
- (2019) Caterina Carbonell et al. Cell Reports
- p38 Stabilizes Snail by Suppressing DYRK2-Mediated Phosphorylation that is Required for GSK3β-βTrCP-Induced Snail Degradation
- (2019) Ki-Jun Ryu et al. CANCER RESEARCH
- Prmt7 promotes myoblast differentiation via methylation of p38MAPK on arginine residue 70
- (2019) Hyeon-Ju Jeong et al. CELL DEATH AND DIFFERENTIATION
- PI31 Is an Adaptor Protein for Proteasome Transport in Axons and Required for Synaptic Development
- (2019) Kai Liu et al. DEVELOPMENTAL CELL
- IKKα Kinase Regulates the DNA Damage Response and Drives Chemo-resistance in Cancer
- (2019) Carlota Colomer et al. MOLECULAR CELL
- Alternative ZAP70-p38 signals prime a classical p38 pathway through LAT and SOS to support regulatory T cell differentiation
- (2019) Jesse E. Jun et al. Science Signaling
- Regulation of tumor angiogenesis and mesenchymal–endothelial transition by p38α through TGF-β and JNK signaling
- (2019) Raquel Batlle et al. Nature Communications
- Activation of DR3 signaling causes loss of ILC3s and exacerbates intestinal inflammation
- (2019) Jingyu Li et al. Nature Communications
- Astrocytic p38α MAPK drives NMDA receptor-dependent long-term depression and modulates long-term memory
- (2019) Marta Navarrete et al. Nature Communications
- Inhibition of p38 MAPK in the brain through nasal administration of p38 inhibitor loaded in chitosan nanocapsules
- (2019) Álvaro Casadomé-Perales et al. Nanomedicine
- Tanycytes Regulate Lipid Homeostasis by Sensing Free Fatty Acids and Signaling to Key Hypothalamic Neuronal Populations via FGF21 Secretion
- (2019) Sarah Geller et al. Cell Metabolism
- A randomized, double-blind, placebo-controlled phase 1b/2 study of ralimetinib, a p38 MAPK inhibitor, plus gemcitabine and carboplatin versus gemcitabine and carboplatin for women with recurrent platinum-sensitive ovarian cancer
- (2019) Ignace Vergote et al. GYNECOLOGIC ONCOLOGY
- Zc3h10 Acts as a Transcription Factor and Is Phosphorylated to Activate the Thermogenic Program
- (2019) Danielle Yi et al. Cell Reports
- p38α Mitogen-Activated Protein Kinase Is a Druggable Target in Pancreatic Adenocarcinoma
- (2019) Ling Yang et al. Frontiers in Oncology
- Targeting p38α Increases DNA Damage, Chromosome Instability, and the Anti-tumoral Response to Taxanes in Breast Cancer Cells
- (2018) Begoña Cánovas et al. CANCER CELL
- Reciprocal Regulation of DUSP9 and DUSP16 Expression by HIF-1 Controls ERK and p38 MAP Kinase Activity and Mediates Chemotherapy-Induced Breast Cancer Stem Cell Enrichment
- (2018) Haiquan Lu et al. CANCER RESEARCH
- Myeloid p38α signaling promotes intestinal IGF‐1 production and inflammation‐associated tumorigenesis
- (2018) Catrin Youssif et al. EMBO Molecular Medicine
- Selective inhibition of the p38α MAPK–MK2 axis inhibits inflammatory cues including inflammasome priming signals
- (2018) Chun Wang et al. JOURNAL OF EXPERIMENTAL MEDICINE
- DNA Replication Determines Timing of Mitosis by Restricting CDK1 and PLK1 Activation
- (2018) Bennie Lemmens et al. MOLECULAR CELL
- MSK1 regulates luminal cell differentiation and metastatic dormancy in ER+ breast cancer
- (2018) Sylwia Gawrzak et al. NATURE CELL BIOLOGY
- Intensity and duration of TCR signaling is limited by p38 phosphorylation of ZAP-70T293and destabilization of the signalosome
- (2018) Maria Letizia Giardino Torchia et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- MK2 contributes to tumor progression by promoting M2 macrophage polarization and tumor angiogenesis
- (2018) Lucia Suarez-Lopez et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Dynamic activation and regulation of the mitogen-activated protein kinase p38
- (2018) Ganesan Senthil Kumar et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Role of p38/MAPKs in Alzheimer’s disease: implications for amyloid beta toxicity targeted therapy
- (2018) Ghazaleh Kheiri et al. REVIEWS IN THE NEUROSCIENCES
- The nuclear translocation of the kinases p38 and JNK promotes inflammation-induced cancer
- (2018) Galia Maik-Rachline et al. Science Signaling
- Inflammatory but not mitogenic contexts prime synovial fibroblasts for compensatory signaling responses to p38 inhibition
- (2018) Douglas S. Jones et al. Science Signaling
- Inhibition of the ER stress IRE1α inflammatory pathway protects against cell death in mitochondrial complex I mutant cells
- (2018) Meghan S. Soustek et al. Cell Death & Disease
- Phosphorylation of Parkin at serine 131 by p38 MAPK promotes mitochondrial dysfunction and neuronal death in mutant A53T α-synuclein model of Parkinson’s disease
- (2018) Jialong Chen et al. Cell Death & Disease
- Inhibiting p38 MAPK alpha rescues axonal retrograde transport defects in a mouse model of ALS
- (2018) Katherine L. Gibbs et al. Cell Death & Disease
- p38-MK2 signaling axis regulates RNA metabolism after UV-light-induced DNA damage
- (2018) Marina E. Borisova et al. Nature Communications
- p38-mediated phosphorylation at T367 induces EZH2 cytoplasmic localization to promote breast cancer metastasis
- (2018) Talha Anwar et al. Nature Communications
- Mutual Stabilization between TRIM9 Short Isoform and MKK6 Potentiates p38 Signaling to Synergistically Suppress Glioblastoma Progression
- (2018) Kunpeng Liu et al. Cell Reports
- Metabolic benefits of inhibition of p38α in white adipose tissue in obesity
- (2018) Shengjie Zhang et al. PLOS BIOLOGY
- p38α blocks brown adipose tissue thermogenesis through p38δ inhibition
- (2018) Nuria Matesanz et al. PLOS BIOLOGY
- The nuclear translocation of the kinases p38 and JNK promotes inflammation-induced cancer
- (2018) Galia Maik-Rachline et al. Science Signaling
- Inflammatory but not mitogenic contexts prime synovial fibroblasts for compensatory signaling responses to p38 inhibition
- (2018) Douglas S. Jones et al. Science Signaling
- An exploratory clinical study of p38α kinase inhibition in Alzheimer's disease
- (2018) Philip Scheltens et al. Annals of Clinical and Translational Neurology
- Inhibition of the Stromal p38MAPK/MK2 Pathway Limits Breast Cancer Metastases and Chemotherapy-Induced Bone Loss
- (2018) Bhavna Murali et al. CANCER RESEARCH
- Fibroblasts Mobilize Tumor Cell Glycogen to Promote Proliferation and Metastasis
- (2018) Marion Curtis et al. Cell Metabolism
- IL-33 regulates cytokine production and neutrophil recruitment via the p38 MAPK-activated kinases MK2/3
- (2018) Pierre C. McCarthy et al. IMMUNOLOGY AND CELL BIOLOGY
- P38α/JNK signaling restrains erythropoiesis by suppressing Ezh2-mediated epigenetic silencing of Bim
- (2018) Ping Hu et al. Nature Communications
- Cell-to-Cell Heterogeneity in p38-Mediated Cross-Inhibition of JNK Causes Stochastic Cell Death
- (2018) Haruko Miura et al. Cell Reports
- The role of Pitx2 and Pitx3 in muscle stem cells gives new insights into P38α MAP kinase and redox regulation of muscle regeneration
- (2018) Aurore Lhonore et al. eLife
- TLR8-Mediated Metabolic Control of Human Treg Function: A Mechanistic Target for Cancer Immunotherapy
- (2018) Lingyun Li et al. Cell Metabolism
- Protein kinase p38α signaling in dendritic cells regulates colon inflammation and tumorigenesis
- (2018) Tingting Zheng et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- p38α MAPK signaling drives pharmacologically reversible brain and gastrointestinal phenotypes in the SERT Ala56 mouse
- (2018) Matthew J. Robson et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The protein kinase p38α destabilizes p63 to limit epidermal stem cell frequency and tumorigenic potential
- (2018) Min-Kyung Choo et al. Science Signaling
- The p38α Stress Kinase Suppresses Aneuploidy Tolerance by Inhibiting Hif-1α
- (2018) Susana Simões-Sousa et al. Cell Reports
- Protein imbalance in the development of skeletal muscle wasting in tumour-bearing mice
- (2018) Jacob L. Brown et al. Journal of Cachexia Sarcopenia and Muscle
- Oncogenic RAS Signaling Promotes Tumor Immunoresistance by Stabilizing PD-L1 mRNA
- (2017) Matthew A. Coelho et al. IMMUNITY
- Novel Noncatalytic Substrate-Selective p38α-Specific MAPK Inhibitors with Endothelial-Stabilizing and Anti-Inflammatory Activity
- (2017) Nirav G. Shah et al. JOURNAL OF IMMUNOLOGY
- The p38-MK2/3 Module Is Critical for IL-33–Induced Signaling and Cytokine Production in Dendritic Cells
- (2017) Christiane Göpfert et al. JOURNAL OF IMMUNOLOGY
- MK2 Phosphorylates RIPK1 to Prevent TNF-Induced Cell Death
- (2017) Isabel Jaco et al. MOLECULAR CELL
- Recent Advances in the Inhibition of p38 MAPK as a Potential Strategy for the Treatment of Alzheimer’s Disease
- (2017) Jong Kil Lee et al. MOLECULES
- Interplay between metabolic identities in the intestinal crypt supports stem cell function
- (2017) Maria J. Rodríguez-Colman et al. NATURE
- p38MAPK/MK2-dependent phosphorylation controls cytotoxic RIPK1 signalling in inflammation and infection
- (2017) Manoj B. Menon et al. NATURE CELL BIOLOGY
- MK2 phosphorylation of RIPK1 regulates TNF-mediated cell death
- (2017) Yves Dondelinger et al. NATURE CELL BIOLOGY
- Regulation of Hippo pathway transcription factor TEAD by p38 MAPK-induced cytoplasmic translocation
- (2017) Kimberly C. Lin et al. NATURE CELL BIOLOGY
- Structural Basis for the Subversion of MAP Kinase Signaling by an Intrinsically Disordered Parasite Secreted Agonist
- (2017) Erika Pellegrini et al. STRUCTURE
- p38γ and p38δ: From Spectators to Key Physiological Players
- (2017) Ana Cuenda et al. TRENDS IN BIOCHEMICAL SCIENCES
- MKK6 controls T3-mediated browning of white adipose tissue
- (2017) Nuria Matesanz et al. Nature Communications
- Praja1 E3 ubiquitin ligase promotes skeletal myogenesis through degradation of EZH2 upon p38α activation
- (2017) Silvia Consalvi et al. Nature Communications
- Phosphorylation of LAMP2A by p38 MAPK couples ER stress to chaperone-mediated autophagy
- (2017) Wenming Li et al. Nature Communications
- Dendritic cell MST1 inhibits Th17 differentiation
- (2017) Chunxiao Li et al. Nature Communications
- Induction of oxidative metabolism by the p38α/MK2 pathway
- (2017) Natalia Trempolec et al. Scientific Reports
- miRNA-32 Drives Brown Fat Thermogenesis and Trans-activates Subcutaneous White Fat Browning in Mice
- (2017) Raymond Ng et al. Cell Reports
- Changes in the free-energy landscape of p38α MAP kinase through its canonical activation and binding events as studied by enhanced molecular dynamics simulations
- (2017) Antonija Kuzmanic et al. eLife
- MMI‐0100 Inhibits Cardiac Fibrosis in a Mouse Model Overexpressing Cardiac Myosin Binding Protein C
- (2017) Qinghang Meng et al. Journal of the American Heart Association
- Genetic Correction of SOD1 Mutant iPSCs Reveals ERK and JNK Activated AP1 as a Driver of Neurodegeneration in Amyotrophic Lateral Sclerosis
- (2017) Akshay Bhinge et al. Stem Cell Reports
- Neuronal p38α mediates synaptic and cognitive dysfunction in an Alzheimer’s mouse model by controlling β-amyloid production
- (2017) Sandra Colié et al. Scientific Reports
- Targeting p38 or MK2 Enhances the Anti-Leukemic Activity of Smac-Mimetics
- (2016) Najoua Lalaoui et al. CANCER CELL
- ERK and p38 MAPK Activities Determine Sensitivity to PI3K/mTOR Inhibition via Regulation of MYC and YAP
- (2016) Taru Muranen et al. CANCER RESEARCH
- Metabolic Stress-Induced Phosphorylation of KAP1 Ser473 Blocks Mitochondrial Fusion in Breast Cancer Cells
- (2016) C.-T. Cheng et al. CANCER RESEARCH
- Proline isomerisation as a novel regulatory mechanism for p38MAPK activation and functions
- (2016) A Brichkina et al. CELL DEATH AND DIFFERENTIATION
- p38α Activates Purine Metabolism to Initiate Hematopoietic Stem/Progenitor Cell Cycling in Response to Stress
- (2016) Daiki Karigane et al. Cell Stem Cell
- p38MAPK builds a hyaluronan cancer niche to drive lung tumorigenesis
- (2016) Anna Brichkina et al. GENES & DEVELOPMENT
- A senescence secretory switch mediated by PI3K/AKT/mTOR activation controls chemoprotective endothelial secretory responses
- (2016) Eric H. Bent et al. GENES & DEVELOPMENT
- Effect of Losmapimod on Cardiovascular Outcomes in Patients Hospitalized With Acute Myocardial Infarction
- (2016) Michelle L. O’Donoghue et al. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Loss of Functionally Redundant p38 Isoforms in T Cells Enhances Regulatory T Cell Induction
- (2016) Morisada Hayakawa et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The N-Terminal Phosphorylation of RB by p38 Bypasses Its Inactivation by CDKs and Prevents Proliferation in Cancer Cells
- (2016) Albert Gubern et al. MOLECULAR CELL
- Mechanism of early dissemination and metastasis in Her2+ mammary cancer
- (2016) Kathryn L. Harper et al. NATURE
- Excessive fatty acid oxidation induces muscle atrophy in cancer cachexia
- (2016) Tomoya Fukawa et al. NATURE MEDICINE
- Cell Signaling and Stress Responses
- (2016) Gökhan S. Hotamisligil et al. Cold Spring Harbor Perspectives in Biology
- Inactivation of nuclear GSK3β by Ser389 phosphorylation promotes lymphocyte fitness during DNA double-strand break response
- (2016) Tina M. Thornton et al. Nature Communications
- Mechanical cell competition kills cells via induction of lethal p53 levels
- (2016) Laura Wagstaff et al. Nature Communications
- miR-625-3p regulates oxaliplatin resistance by targeting MAP2K6-p38 signalling in human colorectal adenocarcinoma cells
- (2016) Mads Heilskov Rasmussen et al. Nature Communications
- Thioredoxin-interacting protein regulates haematopoietic stem cell ageing and rejuvenation by inhibiting p38 kinase activity
- (2016) Haiyoung Jung et al. Nature Communications
- Mincle-mediated translational regulation is required for strong nitric oxide production and inflammation resolution
- (2016) Wook-Bin Lee et al. Nature Communications
- CUG-binding protein 1 regulates HSC activation and liver fibrogenesis
- (2016) Xingxin Wu et al. Nature Communications
- ASK1 signalling regulates brown and beige adipocyte function
- (2016) Kazuki Hattori et al. Nature Communications
- The lipid sensor GPR120 promotes brown fat activation and FGF21 release from adipocytes
- (2016) Tania Quesada-López et al. Nature Communications
- BMP7 retards peripheral myelination by activating p38 MAPK in Schwann cells
- (2016) Xiaoyu Liu et al. Scientific Reports
- MAPK-Mediated YAP Activation Controls Mechanical-Tension-Induced Pulmonary Alveolar Regeneration
- (2016) Zhe Liu et al. Cell Reports
- Targeting Human Central Nervous System Protein Kinases: An Isoform Selective p38αMAPK Inhibitor That Attenuates Disease Progression in Alzheimer’s Disease Mouse Models
- (2015) Saktimayee M. Roy et al. ACS Chemical Neuroscience
- A Pleiotropic RNA-Binding Protein Controls Distinct Cell Cycle Checkpoints to Drive Resistance of p53 -Defective Tumors to Chemotherapy
- (2015) Ian G. Cannell et al. CANCER CELL
- The Stress Kinase p38 as a Target for Cancer Therapy
- (2015) A. Igea et al. CANCER RESEARCH
- A Synergistic Interaction between Chk1- and MK2 Inhibitors in KRAS-Mutant Cancer
- (2015) Felix Dietlein et al. CELL
- A First-in-Human Phase I Study of the Oral p38 MAPK Inhibitor, Ralimetinib (LY2228820 Dimesylate), in Patients with Advanced Cancer
- (2015) A. Patnaik et al. CLINICAL CANCER RESEARCH
- Roles of p38α mitogen-activated protein kinase in mouse models of inflammatory diseases and cancer
- (2015) Jalaj Gupta et al. FEBS Journal
- Molecular mechanisms linking amyloid β toxicity and Tau hyperphosphorylation in Alzheimer׳s disease
- (2015) A. Lloret et al. FREE RADICAL BIOLOGY AND MEDICINE
- Stress kinases in the modulation of metabolism and energy balance
- (2015) Elisa Manieri et al. JOURNAL OF MOLECULAR ENDOCRINOLOGY
- Role of Reactive Oxygen Species in the Abrogation of Oxaliplatin Activity by Cetuximab in Colorectal Cancer
- (2015) Valeria Santoro et al. JNCI-Journal of the National Cancer Institute
- Stress Induces p38 MAPK-Mediated Phosphorylation and Inhibition of Drosha-Dependent Cell Survival
- (2015) Qian Yang et al. MOLECULAR CELL
- Systematic discovery of linear binding motifs targeting an ancient protein interaction surface on MAP kinases
- (2015) A. Zeke et al. Molecular Systems Biology
- mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype
- (2015) Nicolás Herranz et al. NATURE CELL BIOLOGY
- Selective inhibition of the p38 alternative activation pathway in infiltrating T cells inhibits pancreatic cancer progression
- (2015) Muhammad S Alam et al. NATURE MEDICINE
- The scaffold protein RACK1 mediates the RANKL-dependent activation of p38 MAPK in osteoclast precursors
- (2015) Jingjing Lin et al. Science Signaling
- The E3 ubiquitin ligase Itch inhibits p38α signaling and skin inflammation through the ubiquitylation of Tab1
- (2015) Balamayooran Theivanthiran et al. Science Signaling
- MK2 inhibitory peptide delivered in nanopolyplexes prevents vascular graft intimal hyperplasia
- (2015) Brian C. Evans et al. Science Translational Medicine
- The p38α mitogen-activated protein kinase is a key regulator of myelination and remyelination in the CNS
- (2015) S-H Chung et al. Cell Death & Disease
- Oscillation of p38 activity controls efficient pro-inflammatory gene expression
- (2015) Taichiro Tomida et al. Nature Communications
- Tumour-derived SPARC drives vascular permeability and extravasation through endothelial VCAM1 signalling to promote metastasis
- (2015) Mélanie Tichet et al. Nature Communications
- The stress-responsive kinases MAPKAPK2/MAPKAPK3 activate starvation-induced autophagy through Beclin 1 phosphorylation
- (2015) Yongjie Wei et al. eLife
- Role of Reactive Oxygen Species in the Abrogation of Oxaliplatin Activity by Cetuximab in Colorectal Cancer
- (2015) Valeria Santoro et al. JNCI-Journal of the National Cancer Institute
- The scaffold protein RACK1 mediates the RANKL-dependent activation of p38 MAPK in osteoclast precursors
- (2015) Jingjing Lin et al. Science Signaling
- The E3 ubiquitin ligase Itch inhibits p38α signaling and skin inflammation through the ubiquitylation of Tab1
- (2015) Balamayooran Theivanthiran et al. Science Signaling
- The case for inhibiting p38 mitogen-activated protein kinase in heart failure
- (2015) Pelin Arabacilar et al. Frontiers in Pharmacology
- PP2AC Level Determines Differential Programming of p38-TSC-mTOR Signaling and Therapeutic Response to p38-Targeted Therapy in Colorectal Cancer
- (2015) Yanjie Zhang et al. EBioMedicine
- p38 MAPK in cardioprotection - are we there yet?
- (2014) E D Martin et al. BRITISH JOURNAL OF PHARMACOLOGY
- Dual Function of p38α MAPK in Colon Cancer: Suppression of Colitis-Associated Tumor Initiation but Requirement for Cancer Cell Survival
- (2014) Jalaj Gupta et al. CANCER CELL
- p38 MAPK: A Potential Target of Chronic Pain
- (2014) X. Lin et al. CURRENT MEDICINAL CHEMISTRY
- F-Box Only Protein 31 (FBXO31) Negatively Regulates p38 Mitogen-activated Protein Kinase (MAPK) Signaling by Mediating Lysine 48-linked Ubiquitination and Degradation of Mitogen-activated Protein Kinase Kinase 6 (MKK6)
- (2014) Jia Liu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Counter-regulation of T cell effector function by differentially activated p38
- (2014) Muhammad S. Alam et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Macrophage Deletion of p38 Partially Impairs Lipopolysaccharide-Induced Cellular Activation
- (2014) Y. J. Kang et al. JOURNAL OF IMMUNOLOGY
- Losmapimod, a novel p38 mitogen-activated protein kinase inhibitor, in non-ST-segment elevation myocardial infarction: a randomised phase 2 trial
- (2014) L Kristin Newby et al. LANCET
- Colon cancer cells colonize the lung from established liver metastases through p38 MAPK signalling and PTHLH
- (2014) Jelena Urosevic et al. NATURE CELL BIOLOGY
- The kinase p38 activated by the metabolic regulator AMPK and scaffold TAB1 drives the senescence of human T cells
- (2014) Alessio Lanna et al. NATURE IMMUNOLOGY
- In vivo RNAi screening identifies a mechanism of sorafenib resistance in liver cancer
- (2014) Ramona Rudalska et al. NATURE MEDICINE
- Allosteric enhancement of MAP kinase p38α's activity and substrate selectivity by docking interactions
- (2014) Yuji Tokunaga et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Ubiquitin-conjugating enzyme Ubc13 controls breast cancer metastasis through a TAK1-p38 MAP kinase cascade
- (2014) X. Wu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- TNF and MAP kinase signalling pathways
- (2014) Guadalupe Sabio et al. SEMINARS IN IMMUNOLOGY
- p38MAPK Plays a Crucial Role in Stromal-Mediated Tumorigenesis
- (2014) E. Alspach et al. Cancer Discovery
- SnapShot: p38 MAPK Substrates
- (2013) Natalia Trempolec et al. CELL
- Inhibition of p38 MAPK sensitizes tumour cells to cisplatin-induced apoptosis mediated by reactive oxygen species and JNK
- (2013) Lorena Pereira et al. EMBO Molecular Medicine
- Beta-Like Importins Mediate the Nuclear Translocation of Mitogen-Activated Protein Kinases
- (2013) E. Zehorai et al. MOLECULAR AND CELLULAR BIOLOGY
- Disruption of TAB1/p38α Interaction Using a Cell-permeable Peptide Limits Myocardial Ischemia/Reperfusion Injury
- (2013) Qingyang Wang et al. MOLECULAR THERAPY
- Mechanism and consequence of the autoactivation of p38α mitogen-activated protein kinase promoted by TAB1
- (2013) Gian Felice De Nicola et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Efficacy and safety of the oral p38 inhibitor PH-797804 in chronic obstructive pulmonary disease: a randomised clinical trial
- (2013) William MacNee et al. THORAX
- The TGF -induced phosphorylation and activation of p38 mitogen-activated protein kinase is mediated by MAP3K4 and MAP3K10 but not TAK1
- (2013) G. P. Sapkota Open Biology
- The many faces of p38 mitogen-activated protein kinase in progenitor/stem cell differentiation
- (2012) Feride Oeztuerk-Winder et al. BIOCHEMICAL JOURNAL
- Differential p38-dependent signalling in response to cellular stress and mitogenic stimulation in fibroblasts
- (2012) Dagmar Faust et al. Cell Communication and Signaling
- The stress-activated protein kinases p38α/β and JNK1/2 cooperate with Chk1 to inhibit mitotic entry upon DNA replication arrest
- (2012) Alba Llopis et al. CELL CYCLE
- Gadd45γ and Map3k4 Interactions Regulate Mouse Testis Determination via p38 MAPK-Mediated Control of Sry Expression
- (2012) Nick Warr et al. DEVELOPMENTAL CELL
- Ubiquitination-mediated regulation of interferon responses
- (2012) Serge Y. Fuchs GROWTH FACTORS
- Mammalian MAPK Signal Transduction Pathways Activated by Stress and Inflammation: A 10-Year Update
- (2012) John M. Kyriakis et al. PHYSIOLOGICAL REVIEWS
- Serine/threonine acetylation of TGF -activated kinase (TAK1) by Yersinia pestis YopJ inhibits innate immune signaling
- (2012) N. Paquette et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- p38MAPK is a novel DNA damage response-independent regulator of the senescence-associated secretory phenotype
- (2011) Adam Freund et al. EMBO JOURNAL
- A novel cardioprotective p38-MAPK/mTOR pathway
- (2011) Gonzalo Hernández et al. EXPERIMENTAL CELL RESEARCH
- Role of p38 Protein Kinase in the Ligand-independent Ubiquitination and Down-regulation of the IFNAR1 Chain of Type I Interferon Receptor
- (2011) Sabyasachi Bhattacharya et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Acetylation of a Conserved Lysine Residue in the ATP Binding Pocket of p38 Augments Its Kinase Activity during Hypertrophy of Cardiomyocytes
- (2011) V. B. Pillai et al. MOLECULAR AND CELLULAR BIOLOGY
- Genetic analysis of specific and redundant roles for p38 and p38 MAPKs during mouse development
- (2011) I. del Barco Barrantes et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Mechanisms and functions of p38 MAPK signalling
- (2010) Ana Cuadrado et al. BIOCHEMICAL JOURNAL
- Mechanisms of mRNA translation of interferon stimulated genes
- (2010) Sonali Joshi et al. CYTOKINE
- Cross-talk between the p38α and JNK MAPK Pathways Mediated by MAP Kinase Phosphatase-1 Determines Cellular Sensitivity to UV Radiation
- (2010) Christopher J. Staples et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The p38 MAPK pathway is essential for skeletogenesis and bone homeostasis in mice
- (2010) Matthew B. Greenblatt et al. JOURNAL OF CLINICAL INVESTIGATION
- p38 Mitogen-Activated Protein Kinase Promotes Cell Survival in Response to DNA Damage but Is Not Required for the G2 DNA Damage Checkpoint in Human Cancer Cells
- (2010) M. S. Phong et al. MOLECULAR AND CELLULAR BIOLOGY
- Oxidation-induced intramolecular disulfide bond inactivates mitogen-activated protein kinase kinase 6 by inhibiting ATP binding
- (2010) Y. Diao et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Regulation of the immune response by stress-activated protein kinases
- (2009) Mercedes Rincón et al. IMMUNOLOGICAL REVIEWS
- T Cell Receptor-mediated Activation of p38α by Mono-phosphorylation of the Activation Loop Results in Altered Substrate Specificity
- (2009) Paul R. Mittelstadt et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- A Role for p38 Stress-Activated Protein Kinase in Regulation of Cell Growth via TORC1
- (2009) M. Cully et al. MOLECULAR AND CELLULAR BIOLOGY
- Targeting innate immunity protein kinase signalling in inflammation
- (2009) Matthias Gaestel et al. NATURE REVIEWS DRUG DISCOVERY
- The p38 MAPK stress pathway as a tumor suppressor or more?
- (2008) Mathew Loesch Frontiers in Bioscience-Landmark
- MAPKAP kinase 2-deficiency prevents neurons from cell death by reducing neuroinflammation – relevance in a mouse model of Parkinson’s disease
- (2008) Tobias Thomas et al. JOURNAL OF NEUROCHEMISTRY
- Phosphorylation by p38 MAPK as an Alternative Pathway for GSK3 Inactivation
- (2008) T. M. Thornton et al. SCIENCE
- Activation of MKK6, an upstream activator of p38, in Alzheimer's disease
- (2003) Xiongwei Zhu et al. JOURNAL OF NEUROCHEMISTRY
- p38 Kinase Is Activated in the Alzheimer's Disease Brain
- (2003) Kenneth Hensley et al. JOURNAL OF NEUROCHEMISTRY
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started