BRN2 suppresses apoptosis, reprograms DNA damage repair, and is associated with a high somatic mutation burden in melanoma

Bi-allelic Loss of CDKN2A Initiates Melanoma Invasion via BRN2 Activation

(2018) Hanlin Zeng et al.   CANCER CELL

BRN2, a POUerful driver of melanoma phenotype switching and metastasis

(2018) Mitchell E. Fane et al.   Pigment Cell & Melanoma Research

Brn2 Alone Is Sufficient to Convert Astrocytes into Neural Progenitors and Neurons

(2018) Xiaoqing Zhu et al.   STEM CELLS AND DEVELOPMENT

Drosha drives the formation of DNA:RNA hybrids around DNA break sites to facilitate DNA repair

(2018) Wei-Ting Lu et al.   Nature Communications

Predicting response to checkpoint inhibitors in melanoma beyond PD-L1 and mutational burden

(2018) Carl Morrison et al.   Journal for ImmunoTherapy of Cancer

15 years of PhosphoSitePlus®: integrating post-translationally modified sites, disease variants and isoforms

(2018) Peter V Hornbeck et al.   NUCLEIC ACIDS RESEARCH

Translation reprogramming is an evolutionarily conserved driver of phenotypic plasticity and therapeutic resistance in melanoma

(2017) Paola Falletta et al.   GENES & DEVELOPMENT

PARPs and ADP-ribosylation: recent advances linking molecular functions to biological outcomes

(2017) Rebecca Gupte et al.   GENES & DEVELOPMENT

Transcription-Coupled DNA Double-Strand Break Repair: Active Genes Need Special Care

(2017) Aline Marnef et al.   JOURNAL OF MOLECULAR BIOLOGY

The master role of microphthalmia-associated transcription factor in melanocyte and melanoma biology

(2017) Akinori Kawakami et al.   LABORATORY INVESTIGATION

ATM, ATR, and DNA-PK: The Trinity at the Heart of the DNA Damage Response

(2017) Andrew N. Blackford et al.   MOLECULAR CELL

ProHits-viz: a suite of web tools for visualizing interaction proteomics data

(2017) James D R Knight et al.   NATURE METHODS

Meta-analysis of DNA double-strand break response kinetics

(2017) Jakub A. Kochan et al.   NUCLEIC ACIDS RESEARCH

Mutational and putative neoantigen load predict clinical benefit of adoptive T cell therapy in melanoma

(2017) Martin Lauss et al.   Nature Communications

NFIB Mediates BRN2 Driven Melanoma Cell Migration and Invasion Through Regulation of EZH2 and MITF

(2017) Mitchell E. Fane et al.   EBioMedicine

MITF and BRN2 contribute to metastatic growth after dissemination of melanoma

(2017) Jacinta L. Simmons et al.   Scientific Reports

Ever-Changing Landscapes: Transcriptional Enhancers in Development and Evolution

(2016) Hannah K. Long et al.   CELL

In silico studies of the interaction between BRN2 protein and MORE DNA

(2016) Ivan Evangelista do Vale Coelho et al.   JOURNAL OF MOLECULAR MODELING

Data Independent Acquisition analysis in ProHits 4.0

(2016) Guomin Liu et al.   Journal of Proteomics

Sequential regulatory loops as key gatekeepers for neuronal reprogramming in human cells

(2016) Yuanchao Xue et al.   NATURE NEUROSCIENCE

Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq

(2016) I. Tirosh et al.   SCIENCE

Germline MC1R status influences somatic mutation burden in melanoma

(2016) Carla Daniela Robles-Espinoza et al.   Nature Communications

The Master Neural Transcription Factor BRN2 Is an Androgen Receptor–Suppressed Driver of Neuroendocrine Differentiation in Prostate Cancer

(2016) Jennifer L. Bishop et al.   Cancer Discovery

Selective influence of Sox2 on POU transcription factor binding in embryonic and neural stem cells

(2015) T. K. Mistri et al.   EMBO REPORTS

Poly(ADP-ribosyl)ation-dependent Transient Chromatin Decondensation and Histone Displacement following Laser Microirradiation

(2015) Hilmar Strickfaden et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes

(2015) Jean-Philippe Lambert et al.   Journal of Proteomics

The Genetic Evolution of Melanoma from Precursor Lesions

(2015) A. Hunter Shain et al.   NEW ENGLAND JOURNAL OF MEDICINE

Genomic correlates of response to CTLA-4 blockade in metastatic melanoma

(2015) E. M. Van Allen et al.   SCIENCE

Decoding the regulatory landscape of melanoma reveals TEADS as regulators of the invasive cell state

(2015) Annelien Verfaillie et al.   Nature Communications

AKT1 Activation Promotes Development of Melanoma Metastases

(2015) Joseph H. Cho et al.   Cell Reports

A Systematic Analysis of Factors Localized to Damaged Chromatin Reveals PARP-Dependent Recruitment of Transcription Factors

(2015) Lior Izhar et al.   Cell Reports

Incorporating DNA shearing in standard affinity purification allows simultaneous identification of both soluble and chromatin-bound interaction partners

(2014) Jean-Philippe Lambert et al.   Journal of Proteomics

Genetic Basis for Clinical Response to CTLA-4 Blockade in Melanoma

(2014) Alexandra Snyder et al.   NEW ENGLAND JOURNAL OF MEDICINE

GSVA: gene set variation analysis for microarray and RNA-Seq data

(2013) Sonja Hänzelmann et al.   BMC BIOINFORMATICS

Hierarchical Mechanisms for Direct Reprogramming of Fibroblasts to Neurons

(2013) Orly L. Wapinski et al.   CELL

POU transcription factors in melanocytes and melanoma

(2013) Robert Besch et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

SAINTexpress: Improvements and additional features in Significance Analysis of INTeractome software

(2013) Guoci Teo et al.   Journal of Proteomics

Signatures of mutational processes in human cancer

(2013) Ludmil B. Alexandrov et al.   NATURE

Mapping differential interactomes by affinity purification coupled with data-independent mass spectrometry acquisition

(2013) Jean-Philippe Lambert et al.   NATURE METHODS

Large-scale gene function analysis with the PANTHER classification system

(2013) Huaiyu Mi et al.   Nature Protocols

POU domain transcription factor BRN2 is crucial for expression of ASCL1, ND1 and neuroendocrine marker molecules and cell growth in small cell lung cancer

(2013) Jun Ishii et al.   PATHOLOGY INTERNATIONAL

SOX2 Co-Occupies Distal Enhancer Elements with Distinct POU Factors in ESCs and NPCs to Specify Cell State

(2013) Michael A. Lodato et al.   PLoS Genetics

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

The Role of the PI3K-AKT Pathway in Melanoma

(2012) Michael A. Davies   CANCER JOURNAL

A Landscape of Driver Mutations in Melanoma

(2012) Eran Hodis et al.   CELL

A Phosphatidylinositol 3-Kinase-Pax3 Axis Regulates Brn-2 Expression in Melanoma

(2012) E. Bonvin et al.   MOLECULAR AND CELLULAR BIOLOGY

Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma

(2012) Michael Krauthammer et al.   NATURE GENETICS

Oncogenic BRAF Induces Melanoma Cell Invasion by Downregulating the cGMP-Specific Phosphodiesterase PDE5A

(2011) Imanol Arozarena et al.   CANCER CELL

E2F1 promotes the recruitment of DNA repair factors to sites of DNA double-strand breaks

(2011) Jie Chen et al.   CELL CYCLE

Direct Reprogramming of Adult Human Fibroblasts to Functional Neurons under Defined Conditions

(2011) Rajesh Ambasudhan et al.   Cell Stem Cell

iProphet: Multi-level Integrative Analysis of Shotgun Proteomic Data Improves Peptide and Protein Identification Rates and Error Estimates

(2011) David Shteynberg et al.   MOLECULAR & CELLULAR PROTEOMICS

Global quantification of mammalian gene expression control

(2011) Björn Schwanhäusser et al.   NATURE

More than just a focus: The chromatin response to DNA damage and its role in genome integrity maintenance

(2011) Jiri Lukas et al.   NATURE CELL BIOLOGY

Inverse expression states of the BRN2 and MITF transcription factors in melanoma spheres and tumour xenografts regulate the NOTCH pathway

(2011) A E Thurber et al.   ONCOGENE

Essential role of microphthalmia transcription factor for DNA replication, mitosis and genomic stability in melanoma

(2011) T Strub et al.   ONCOGENE

BRCA1 is a new MITF target gene

(2011) Laurent Beuret et al.   Pigment Cell & Melanoma Research

Melanoma cell invasiveness is regulated by miR-211 suppression of the BRN2 transcription factor

(2011) Glen M. Boyle et al.   Pigment Cell & Melanoma Research

Cancer stem cells versus phenotype-switching in melanoma

(2010) Keith S. Hoek et al.   Pigment Cell & Melanoma Research

Genome-wide analysis of POU3F2/BRN2 promoter occupancy in human melanoma cells reveals Kitl as a novel regulated target gene

(2010) Dominique Kobi et al.   Pigment Cell & Melanoma Research

A guided tour of the Trans-Proteomic Pipeline

(2010) Eric W. Deutsch et al.   PROTEOMICS

edgeR: a Bioconductor package for differential expression analysis of digital gene expression data

(2009) M. D. Robinson et al.   BIOINFORMATICS

Intravital Imaging Reveals Transient Changes in Pigment Production and Brn2 Expression during Metastatic Melanoma Dissemination

(2009) S. Pinner et al.   CANCER RESEARCH

ProteoWizard: open source software for rapid proteomics tools development

(2008) Darren Kessner et al.   BIOINFORMATICS

Brn-2 Represses Microphthalmia-Associated Transcription Factor Expression and Marks a Distinct Subpopulation of Microphthalmia-Associated Transcription Factor-Negative Melanoma Cells

(2008) J. Goodall et al.   CANCER RESEARCH

Histologic and epidemiologic correlates of P-MAPK, Brn-2, pRb, p53, and p16 immunostaining in cutaneous melanomas

(2008) Naomi M. Richmond-Sinclair et al.   MELANOMA RESEARCH

POU domain transcription factors: BRN2 as a regulator of melanocytic growth and tumourigenesis

(2008) Anthony L. Cook et al.   Pigment Cell & Melanoma Research

Oncogenic BRAF Regulates Melanoma Proliferation through the Lineage Specific Factor MITF

(2008) Claudia Wellbrock et al.   PLoS One