Roles of p38α mitogen-activated protein kinase in mouse models of inflammatory diseases and cancer

Dual Function of p38α MAPK in Colon Cancer: Suppression of Colitis-Associated Tumor Initiation but Requirement for Cancer Cell Survival

(2014) Jalaj Gupta et al.   CANCER CELL

Pro-Oncogenic Role of Alternative p38 Mitogen-Activated Protein Kinases p38  and p38 , Linking Inflammation and Cancer in Colitis-Associated Colon Cancer

(2014) P. del Reino et al.   CANCER RESEARCH

Counter-regulation of T cell effector function by differentially activated p38

(2014) Muhammad S. Alam et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Macrophage Deletion of p38  Partially Impairs Lipopolysaccharide-Induced Cellular Activation

(2014) Y. J. Kang et al.   JOURNAL OF IMMUNOLOGY

p38 Mitogen-activated protein kinase accelerates emphysema in mouse model of chronic obstructive pulmonary disease

(2014) Hiroyuki Amano et al.   JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION

Colon cancer cells colonize the lung from established liver metastases through p38 MAPK signalling and PTHLH

(2014) Jelena Urosevic et al.   NATURE CELL BIOLOGY

The kinase p38 activated by the metabolic regulator AMPK and scaffold TAB1 drives the senescence of human T cells

(2014) Alessio Lanna et al.   NATURE IMMUNOLOGY

Anti-inflammatory effects of LASSBio-998, a new drug candidate designed to be a p38 MAPK inhibitor, in an experimental model of acute lung inflammation

(2014) Aline C. Brando Lima et al.   Pharmacological Reports

Inhibition of p38 MAPK Signaling Augments Skin Tumorigenesis via NOX2 Driven ROS Generation

(2014) Liang Liu et al.   PLoS One

MK2 and Fas Receptor Contribute to the Severity of CNS Demyelination

(2014) Silvia M. Tietz et al.   PLoS One

Ubiquitin-conjugating enzyme Ubc13 controls breast cancer metastasis through a TAK1-p38 MAP kinase cascade

(2014) X. Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phosphorylated p38, a negative prognostic biomarker, complements TNM staging prognostication in colorectal cancer

(2014) Xin-Juan Fan et al.   TUMOR BIOLOGY

A paracrine network regulates the cross-talk between human lung stem cells and the stroma

(2014) E. Josue Ruiz et al.   Nature Communications

Th17 Cells in Cancer: The Ultimate Identity Crisis

(2014) Stefanie R. Bailey et al.   Frontiers in Immunology

Sunlight UV-Induced Skin Cancer Relies upon Activation of the p38  Signaling Pathway

(2013) K. Liu et al.   CANCER RESEARCH

SnapShot: p38 MAPK Substrates

(2013) Natalia Trempolec et al.   CELL

SnapShot: p38 MAPK Signaling

(2013) Natalia Trempolec et al.   CELL

Inhibition of p38 MAPK sensitizes tumour cells to cisplatin-induced apoptosis mediated by reactive oxygen species and JNK

(2013) Lorena Pereira et al.   EMBO Molecular Medicine

Tuning of Protein Kinase Circuitry by p38α Is Vital for Epithelial Tissue Homeostasis

(2013) Celia Caballero-Franco et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Emerging Role of p38 Mitogen-Activated Protein Kinase in Multiple Sclerosis and Its Models

(2013) D. N. Krementsov et al.   MOLECULAR AND CELLULAR BIOLOGY

Cross Talk between the Akt and p38  Pathways in Macrophages Downstream of Toll-Like Receptor Signaling

(2013) V. A. McGuire et al.   MOLECULAR AND CELLULAR BIOLOGY

Characterization of LY2228820 Dimesylate, a Potent and Selective Inhibitor of p38 MAPK with Antitumor Activity

(2013) R. M. Campbell et al.   MOLECULAR CANCER THERAPEUTICS

Activation of p38 mitogen-activated protein kinase in ovalbumin and ozone-induced mouse model of asthma

(2013) Li Liang et al.   RESPIROLOGY

A Reversible Gene-Targeting Strategy Identifies Synthetic Lethal Interactions between MK2 and p53 in the DNA Damage Response In Vivo

(2013) Sandra Morandell et al.   Cell Reports

Antiinflammatory functions of p38 in mouse models of rheumatoid arthritis: Advantages of targeting upstream kinases MKK-3 or MKK-6

(2012) Monica Guma et al.   ARTHRITIS AND RHEUMATISM

Roles of p38 MAPKs in invasion and metastasis

(2012) Ivan del Barco Barrantes et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Blocking p38/ERK crosstalk affects colorectal cancer growth by inducing apoptosis in vitro and in preclinical mouse models

(2012) Fulvio Chiacchiera et al.   CANCER LETTERS

p38  Inhibits Liver Fibrogenesis and Consequent Hepatocarcinogenesis by Curtailing Accumulation of Reactive Oxygen Species

(2012) T. Sakurai et al.   CANCER RESEARCH

Phosphorylated p38 and JNK MAPK proteins in hepatocellular carcinoma

(2012) Shen-Nien Wang et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Mechanism for p38α-mediated Experimental Autoimmune Encephalomyelitis

(2012) Kana Namiki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chronic Obstructive Pulmonary Disease and Risk of Lung Cancer: The Importance of Smoking and Timing of Diagnosis

(2012) Helen A. Powell et al.   Journal of Thoracic Oncology

Signaling via the kinase p38α programs dendritic cells to drive TH17 differentiation and autoimmune inflammation

(2012) Gonghua Huang et al.   NATURE IMMUNOLOGY

p38  and p38  kinases regulate the Toll-like receptor 4 (TLR4)-induced cytokine production by controlling ERK1/2 protein kinase pathway activation

(2012) A. Risco et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Deletion of p38-alpha mitogen-activated protein kinase within the intestinal epithelium promotes colon tumorigenesis

(2012) Derek Wakeman et al.   SURGERY

Murine Cytomegalovirus (MCMV) Infection Upregulates P38 MAP kinase in Aortas of Apo E KO Mice: a Molecular Mechanism for MCMV-Induced Acceleration of Atherosclerosis

(2012) Yajarayma J. Tang-Feldman et al.   Journal of Cardiovascular Translational Research

Activation of p38 MAPK in CD4 T cells controls IL-17 production and autoimmune encephalomyelitis

(2011) R. Noubade et al.   BLOOD

Lack of the T cell-specific alternative p38 activation pathway reduces autoimmunity and inflammation

(2011) L. Jirmanova et al.   BLOOD

Mice Lacking MSK1 and MSK2 Show Reduced Skin Tumor Development in a Two-Stage Chemical Carcinogenesis Model

(2011) Simon Chang et al.   CANCER INVESTIGATION

Activation and Function of the MAPKs and Their Substrates, the MAPK-Activated Protein Kinases

(2011) M. Cargnello et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

A Novel Function of p38-Regulated/Activated Kinase in Endothelial Cell Migration and Tumor Angiogenesis

(2011) N. Yoshizuka et al.   MOLECULAR AND CELLULAR BIOLOGY

p38 MAP kinase plays a functional role in UVB-Induced mouse skin carcinogenesis

(2011) Sally E. Dickinson et al.   MOLECULAR CARCINOGENESIS

Endothelial and Macrophage-Specific Deficiency of P38α MAPK Does Not Affect the Pathogenesis of Atherosclerosis in ApoE−/− Mice

(2011) Rozina Kardakaris et al.   PLoS One

Genetic analysis of specific and redundant roles for p38  and p38  MAPKs during mouse development

(2011) I. del Barco Barrantes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanisms and functions of p38 MAPK signalling

(2010) Ana Cuadrado et al.   BIOCHEMICAL JOURNAL

Targeting the p38 MAPK Pathway Inhibits Irinotecan Resistance in Colon Adenocarcinoma

(2010) S. Paillas et al.   CANCER RESEARCH

Down-regulation of p38 mitogen-activated protein kinase activation and proinflammatory cytokine production by mitogen-activated protein kinase inhibitors in inflammatory bowel disease

(2010) G. Docena et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Regulation of the severity of neuroinflammation and demyelination by TLR-ASK1-p38 pathway

(2010) Xiaoli Guo et al.   EMBO Molecular Medicine

Distinct Effects of p38α Deletion in Myeloid Lineage and Gut Epithelia in Mouse Models of Inflammatory Bowel Disease

(2010) Motoyuki Otsuka et al.   GASTROENTEROLOGY

Critical role for apoptosis signal-regulating kinase 1 in the development of inflammatory K/BxN serum-induced arthritis

(2010) Stephen J. Mnich et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

A Benzothiophene Inhibitor of Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 Inhibits Tumor Necrosis Factor   Production and Has Oral Anti-Inflammatory Efficacy in Acute and Chronic Models of Inflammation

(2010) R. J. Mourey et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Epithelial p38α Controls Immune Cell Recruitment in the Colonic Mucosa

(2010) Young Jun Kang et al.   PLoS Pathogens

Evaluation of the efficacy and safety of pamapimod, a p38 MAP kinase inhibitor, in a double-blind, methotrexate-controlled study of patients with active rheumatoid arthritis

(2009) Stanley B. Cohen et al.   ARTHRITIS AND RHEUMATISM

Efficacy, pharmacodynamics, and safety of VX-702, a novel p38 MAPK inhibitor, in rheumatoid arthritis: Results of two randomized, double-blind, placebo-controlled clinical studies

(2009) Nemanja Damjanov et al.   ARTHRITIS AND RHEUMATISM

Inhibition of the p38 Kinase Suppresses the Proliferation of Human ER-Negative Breast Cancer Cells

(2009) L. Chen et al.   CANCER RESEARCH

p38  Mitogen-Activated Protein Kinase Is Essential for Skin Tumor Development in Mice

(2009) E. M. Schindler et al.   CANCER RESEARCH

MK2 regulates the early stages of skin tumor promotion

(2009) Claus Johansen et al.   CARCINOGENESIS

p38α blockade inhibits colorectal cancer growth in vivo by inducing a switch from HIF1α- to FoxO-dependent transcription

(2009) F Chiacchiera et al.   CELL DEATH AND DIFFERENTIATION

ASK1 and ASK2 differentially regulate the counteracting roles of apoptosis and inflammation in tumorigenesis

(2009) Takayuki Iriyama et al.   EMBO JOURNAL

Apoptosis Signal-Regulating Kinase 1 Regulates Colitis and Colitis-Associated Tumorigenesis by the Innate Immune Responses

(2009) Yoku Hayakawa et al.   GASTROENTEROLOGY

Regulation of the immune response by stress-activated protein kinases

(2009) Mercedes Rincón et al.   IMMUNOLOGICAL REVIEWS

Role of MAPK Kinase 6 in Arthritis: Distinct Mechanism of Action in Inflammation and Cytokine Expression

(2009) T. Yoshizawa et al.   JOURNAL OF IMMUNOLOGY

Selective p38α Inhibitors Clinically Evaluated for the Treatment of Chronic Inflammatory Disorders

(2009) David M. Goldstein et al.   JOURNAL OF MEDICINAL CHEMISTRY

Targeting innate immunity protein kinase signalling in inflammation

(2009) Matthias Gaestel et al.   NATURE REVIEWS DRUG DISCOVERY

A potent and selective p38 inhibitor protects against bone damage in murine collagen-induced arthritis: a comparison with neutralization of mouse TNFα

(2008) K Mihara et al.   BRITISH JOURNAL OF PHARMACOLOGY

Hepatocyte Necrosis Induced by Oxidative Stress and IL-1α Release Mediate Carcinogen-Induced Compensatory Proliferation and Liver Tumorigenesis

(2008) Toshiharu Sakurai et al.   CANCER CELL

p38α MAPK inhibits JNK activation and collaborates with IκB kinase 2 to prevent endotoxin-induced liver failure

(2008) Jan Heinrichsdorff et al.   EMBO REPORTS

Cancer-related inflammation

(2008) Alberto Mantovani et al.   NATURE

The kinase p38α serves cell type–specific inflammatory functions in skin injury and coordinates pro- and anti-inflammatory gene expression

(2008) Chun Kim et al.   NATURE IMMUNOLOGY

The kinases MSK1 and MSK2 act as negative regulators of Toll-like receptor signaling

(2008) Olga Ananieva et al.   NATURE IMMUNOLOGY

Relative corticosteroid insensitivity of alveolar macrophages in severe asthma compared with non-severe asthma

(2008) P Bhavsar et al.   THORAX

Increased activation of p38 MAPK in COPD

(2007) T. Renda et al.   EUROPEAN RESPIRATORY JOURNAL