Intensity and duration of TCR signaling is limited by p38 phosphorylation of ZAP-70T293and destabilization of the signalosome

A cycle of Zap70 kinase activation and release from the TCR amplifies and disperses antigenic stimuli

(2016) Zachary B Katz et al.   NATURE IMMUNOLOGY

Recruitment of calcineurin to the TCR positively regulates T cell activation

(2016) Debjani Dutta et al.   NATURE IMMUNOLOGY

Counter-regulation of T cell effector function by differentially activated p38

(2014) Muhammad S. Alam et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Serine-threonine kinases in TCR signaling

(2014) María N Navarro et al.   NATURE IMMUNOLOGY

Structural Basis for Activation of ZAP-70 by Phosphorylation of the SH2-Kinase Linker

(2013) Q. Yan et al.   MOLECULAR AND CELLULAR BIOLOGY

Molecular basis of MAP kinase regulation

(2013) Wolfgang Peti et al.   PROTEIN SCIENCE

Mechanisms of Leukocyte Transendothelial Migration

(2011) William A. Muller   Annual Review of Pathology-Mechanisms of Disease

Fine-tuning of proximal TCR signaling by ZAP-70 tyrosine residues in Jurkat cells

(2011) M. Szabo et al.   INTERNATIONAL IMMUNOLOGY

ZAP-70: An Essential Kinase in T-cell Signaling

(2010) H. Wang et al.   Cold Spring Harbor Perspectives in Biology

T Cell Activation

(2009) Jennifer E. Smith-Garvin et al.   Annual Review of Immunology

p38α Is Active in Vitro and in Vivo When Monophosphorylated at Threonine 180†

(2009) Nadav Askari et al.   BIOCHEMISTRY

The structure, regulation, and function of ZAP-70

(2009) Byron B. Au-Yeung et al.   IMMUNOLOGICAL REVIEWS

T Cell Receptor-mediated Activation of p38α by Mono-phosphorylation of the Activation Loop Results in Altered Substrate Specificity

(2009) Paul R. Mittelstadt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Enzymatic Activity and Substrate Specificity of Mitogen-activated Protein Kinase p38α in Different Phosphorylation States

(2008) Yuan-Yuan Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY