The p38 Pathway: From Biology to Cancer Therapy

MAPKAPK2: the master regulator of RNA-binding proteins modulates transcript stability and tumor progression

(2019) Sourabh Soni et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

p38γ is essential for cell cycle progression and liver tumorigenesis

(2019) Antonia Tomás-Loba et al.   NATURE

A randomized, double-blind, placebo-controlled phase 1b/2 study of ralimetinib, a p38 MAPK inhibitor, plus gemcitabine and carboplatin versus gemcitabine and carboplatin for women with recurrent platinum-sensitive ovarian cancer

(2019) Ignace Vergote et al.   GYNECOLOGIC ONCOLOGY

Targeting p38α Increases DNA Damage, Chromosome Instability, and the Anti-tumoral Response to Taxanes in Breast Cancer Cells

(2018) Begoña Cánovas et al.   CANCER CELL

Osteoblast-Secreted Factors Mediate Dormancy of Metastatic Prostate Cancer in the Bone via Activation of the TGFβRIII–p38MAPK–pS249/T252RB Pathway

(2018) Li-Yuan Yu-Lee et al.   CANCER RESEARCH

MSK1 regulates luminal cell differentiation and metastatic dormancy in ER+ breast cancer

(2018) Sylwia Gawrzak et al.   NATURE CELL BIOLOGY

Mesenchymal MAPKAPK2/HSP27 drives intestinal carcinogenesis

(2018) Ana Henriques et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Insights of Crosstalk between p53 Protein and the MKK3/MKK6/p38 MAPK Signaling Pathway in Cancer

(2018) Lorenzo Stramucci et al.   Cancers

Fibroblasts Mobilize Tumor Cell Glycogen to Promote Proliferation and Metastasis

(2018) Marion Curtis et al.   Cell Metabolism

Phosphorylated RB Promotes Cancer Immunity by Inhibiting NF-κB Activation and PD-L1 Expression

(2018) Xin Jin et al.   MOLECULAR CELL

P38 delta MAPK promotes breast cancer progression and lung metastasis by enhancing cell proliferation and cell detachment

(2017) M Wada et al.   ONCOGENE

p38γ and p38δ: From Spectators to Key Physiological Players

(2017) Ana Cuenda et al.   TRENDS IN BIOCHEMICAL SCIENCES

Tumor p38MAPK signaling enhances breast carcinoma vascularization and growth by promoting expression and deposition of pro-tumorigenic factors

(2017) Michelle Limoge et al.   Oncotarget

Targeting p38 or MK2 Enhances the Anti-Leukemic Activity of Smac-Mimetics

(2016) Najoua Lalaoui et al.   CANCER CELL

The N-Terminal Phosphorylation of RB by p38 Bypasses Its Inactivation by CDKs and Prevents Proliferation in Cancer Cells

(2016) Albert Gubern et al.   MOLECULAR CELL

The Stress Kinase p38  as a Target for Cancer Therapy

(2015) A. Igea et al.   CANCER RESEARCH

Roles of p38α mitogen-activated protein kinase in mouse models of inflammatory diseases and cancer

(2015) Jalaj Gupta et al.   FEBS Journal

p38γ MAPK is required for inflammation-associated colon tumorigenesis

(2015) N Yin et al.   ONCOGENE

Dual Function of p38α MAPK in Colon Cancer: Suppression of Colitis-Associated Tumor Initiation but Requirement for Cancer Cell Survival

(2014) Jalaj Gupta et al.   CANCER CELL

Pro-Oncogenic Role of Alternative p38 Mitogen-Activated Protein Kinases p38  and p38 , Linking Inflammation and Cancer in Colitis-Associated Colon Cancer

(2014) P. del Reino et al.   CANCER RESEARCH

High-Sensitivity Measurements of Multiple Kinase Activities in Live Single Cells

(2014) Sergi Regot et al.   CELL

p38 MAPK Down-regulates Fibulin 3 Expression through Methylation of Gene Regulatory Sequences

(2014) María Arechederra et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Colon cancer cells colonize the lung from established liver metastases through p38 MAPK signalling and PTHLH

(2014) Jelena Urosevic et al.   NATURE CELL BIOLOGY

MAPK Kinase 3 Is a Tumor Suppressor with Reduced Copy Number in Breast Cancer

(2013) A. J. MacNeil et al.   CANCER RESEARCH

SnapShot: p38 MAPK Substrates

(2013) Natalia Trempolec et al.   CELL

Encoding and Decoding Cellular Information through Signaling Dynamics

(2013) Jeremy E. Purvis et al.   CELL

Molecular Pathways: Mitogen-Activated Protein Kinase Pathway Mutations and Drug Resistance

(2013) A. L. Pritchard et al.   CLINICAL CANCER RESEARCH

Inhibition of p38 MAPK sensitizes tumour cells to cisplatin-induced apoptosis mediated by reactive oxygen species and JNK

(2013) Lorena Pereira et al.   EMBO Molecular Medicine

The tumor microenvironment at a glance

(2013) F. R. Balkwill et al.   JOURNAL OF CELL SCIENCE

A role for p38 MAPK in head and neck cancer cell growth and tumor-induced angiogenesis and lymphangiogenesis

(2013) Kantima Leelahavanichkul et al.   Molecular Oncology

Dual specificity phosphatase 1 expression inversely correlates with NF-κB activity and expression in prostate cancer and promotes apoptosis through a p38 MAPK dependent mechanism

(2013) Beatriz Gil-Araujo et al.   Molecular Oncology

Mechanism and consequence of the autoactivation of p38α mitogen-activated protein kinase promoted by TAB1

(2013) Gian Felice De Nicola et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Differential p38-dependent signalling in response to cellular stress and mitogenic stimulation in fibroblasts

(2012) Dagmar Faust et al.   Cell Communication and Signaling

The p57 CDKi integrates stress signals into cell-cycle progression to promote cell survival upon stress

(2012) Manel Joaquin et al.   EMBO JOURNAL

Mammalian MAPK Signal Transduction Pathways Activated by Stress and Inflammation: A 10-Year Update

(2012) John M. Kyriakis et al.   PHYSIOLOGICAL REVIEWS

Inflammatory cytokines in cancer: tumour necrosis factor and interleukin 6 take the stage

(2011) S. I. Grivennikov et al.   ANNALS OF THE RHEUMATIC DISEASES

Activation and Function of the MAPKs and Their Substrates, the MAPK-Activated Protein Kinases

(2011) M. Cargnello et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Genetic analysis of specific and redundant roles for p38  and p38  MAPKs during mouse development

(2011) I. del Barco Barrantes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanisms and functions of p38 MAPK signalling

(2010) Ana Cuadrado et al.   BIOCHEMICAL JOURNAL

Whole genome analysis of p38 SAPK-mediated gene expression upon stress

(2010) Isabel Ferreiro et al.   BMC GENOMICS

p38 Mitogen-Activated Protein Kinase-Driven MAPKAPK2 Regulates Invasion of Bladder Cancer by Modulation of MMP-2 and MMP-9 Activity

(2010) B. Kumar et al.   CANCER RESEARCH

Mechanisms regulating the nuclear translocation of p38 MAP kinase

(2010) Xiaowei Gong et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

DNA Damage Activates a Spatially Distinct Late Cytoplasmic Cell-Cycle Checkpoint Network Controlled by MK2-Mediated RNA Stabilization

(2010) H. Christian Reinhardt et al.   MOLECULAR CELL

Wip1 phosphatase is associated with chromatin and dephosphorylates γH2AX to promote checkpoint inhibition

(2010) L Macůrek et al.   ONCOGENE

p38  Mitogen-Activated Protein Kinase Is Essential for Skin Tumor Development in Mice

(2009) E. M. Schindler et al.   CANCER RESEARCH

MK2 regulates the early stages of skin tumor promotion

(2009) Claus Johansen et al.   CARCINOGENESIS

p38δ and PKD1: Kinase Switches for Insulin Secretion

(2009) Ana Cuenda et al.   CELL

Regulation of PKD by the MAPK p38δ in Insulin Secretion and Glucose Homeostasis

(2009) Grzegorz Sumara et al.   CELL

Differential activation of p38MAPK isoforms by MKK6 and MKK3

(2009) Gaëlle Remy et al.   CELLULAR SIGNALLING

p38MAPK Controls Expression of Multiple Cell Cycle Inhibitors and Islet Proliferation with Advancing Age

(2009) Esther Sook Miin Wong et al.   DEVELOPMENTAL CELL

p38-γ–dependent gene silencing restricts entry into the myogenic differentiation program

(2009) Mark A. Gillespie et al.   JOURNAL OF CELL BIOLOGY

p38 Mitogen-Activated Protein Kinase- and HuR-Dependent Stabilization of p21Cip1 mRNA Mediates the G1/S Checkpoint

(2009) V. Lafarga et al.   MOLECULAR AND CELLULAR BIOLOGY

Cell Density-Dependent Inhibition of Epidermal Growth Factor Receptor Signaling by p38  Mitogen-Activated Protein Kinase via Sprouty2 Downregulation

(2009) A. Swat et al.   MOLECULAR AND CELLULAR BIOLOGY

p38MAPK: stress responses from molecular mechanisms to therapeutics

(2009) Lydia R. Coulthard et al.   TRENDS IN MOLECULAR MEDICINE

Genetic disruption of p38  Tyr323 phosphorylation prevents T-cell receptor-mediated p38  activation and impairs interferon-  production

(2008) L. Jirmanova et al.   BLOOD

Increased p38-MAPK is responsible for chemotherapy resistance in human gastric cancer cells

(2008) Xianling Guo et al.   BMC CANCER

Hepatocyte Necrosis Induced by Oxidative Stress and IL-1α Release Mediate Carcinogen-Induced Compensatory Proliferation and Liver Tumorigenesis

(2008) Toshiharu Sakurai et al.   CANCER CELL

Enzymatic Activity and Substrate Specificity of Mitogen-activated Protein Kinase p38α in Different Phosphorylation States

(2008) Yuan-Yuan Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ATR-dependent Activation of p38 MAP Kinase Is Responsible for Apoptotic Cell Death in Cells Depleted of Cdc7

(2008) Jun-Sub Im et al.   JOURNAL OF BIOLOGICAL CHEMISTRY