Novel Noncatalytic Substrate-Selective p38α-Specific MAPK Inhibitors with Endothelial-Stabilizing and Anti-Inflammatory Activity

Therapeutic Potential of p38 MAP Kinase Inhibition in the Management of Cardiovascular Disease

(2014) Marie Fisk et al.   American Journal of Cardiovascular Drugs

Mitochondrial p38β and Manganese Superoxide Dismutase Interaction Mediated by Estrogen in Cardiomyocytes

(2014) Han Liu et al.   PLoS One

Determination of Protein-ligand Interactions Using Differential Scanning Fluorimetry

(2014) Mirella Vivoli et al.   Jove-Journal of Visualized Experiments

Global analysis of phosphorylation networks in humans

(2013) Jianfei Hu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

DEF Pocket in p38α Facilitates Substrate Selectivity and Mediates Autophosphorylation

(2013) Netanel Tzarum et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Emerging Role of p38 Mitogen-Activated Protein Kinase in Multiple Sclerosis and Its Models

(2013) D. N. Krementsov et al.   MOLECULAR AND CELLULAR BIOLOGY

Efficacy and safety of the oral p38 inhibitor PH-797804 in chronic obstructive pulmonary disease: a randomised clinical trial

(2013) William MacNee et al.   THORAX

Efficacy and safety of the p38 MAPK inhibitor losmapimod for patients with chronic obstructive pulmonary disease: a randomised, double-blind, placebo-controlled trial

(2013) Henrik Watz et al.   Lancet Respiratory Medicine

Febrile-Range Hyperthermia Modifies Endothelial and Neutrophilic Functions to Promote Extravasation

(2012) Mohan E. Tulapurkar et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Febrile-range hyperthermia augments reversible TNF-α-induced hyperpermeability in human microvascular lung endothelial cells

(2012) Nirav G. Shah et al.   INTERNATIONAL JOURNAL OF HYPERTHERMIA

TRAF6 Protein Couples Toll-like Receptor 4 Signaling to Src Family Kinase Activation and Opening of Paracellular Pathway in Human Lung Microvascular Endothelia

(2012) Anguo Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Toll-like Receptor Agonists and Febrile Range Hyperthermia Synergize to Induce Heat Shock Protein 70 Expression and Extracellular Release

(2012) Aditi Gupta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Optimization of the Additive CHARMM All-Atom Protein Force Field Targeting Improved Sampling of the Backbone ϕ, ψ and Side-Chain χ1 and χ2 Dihedral Angles

(2012) Robert B. Best et al.   Journal of Chemical Theory and Computation

Balancing target flexibility and target denaturation in computational fragment-based inhibitor discovery

(2012) Theresa J. Foster et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

TGF- 1 Induces Endothelial Cell Apoptosis by Shifting VEGF Activation of p38MAPK from the Prosurvival p38  to Proapoptotic p38 

(2012) G. Ferrari et al.   MOLECULAR CANCER RESEARCH

p38 Mitogen-Activated Protein Kinase Pathways in Asthma and COPD

(2011) Kian Fan Chung   CHEST

Inhibition of p38 Mitogen-Activated Protein Kinase Improves Nitric Oxide–Mediated Vasodilatation and Reduces Inflammation in Hypercholesterolemia

(2011) Joseph Cheriyan et al.   CIRCULATION

The role of p38 mitogen-activated protein kinase in the pathogenesis of inflammatory bowel disease

(2011) Ya Jing FENG et al.   Journal of Digestive Diseases

Mechanisms and functions of p38 MAPK signalling

(2010) Ana Cuadrado et al.   BIOCHEMICAL JOURNAL

Two additive mechanisms impair the differentiation of 'substrate-selective' p38 inhibitors from classical p38 inhibitors in vitro

(2010) Bart S Hendriks et al.   BMC Systems Biology

Automated Selection of Compounds with Physicochemical Properties To Maximize Bioavailability and Druglikeness

(2010) Taiji Oashi et al.   Journal of Chemical Information and Modeling

Efficacy, pharmacodynamics, and safety of VX-702, a novel p38 MAPK inhibitor, in rheumatoid arthritis: Results of two randomized, double-blind, placebo-controlled clinical studies

(2009) Nemanja Damjanov et al.   ARTHRITIS AND RHEUMATISM

Development of Extracellular Signal-Regulated Kinase Inhibitors

(2009) Kimberly Burkhard et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

CHARMM general force field: A force field for drug-like molecules compatible with the CHARMM all-atom additive biological force fields

(2009) K. Vanommeslaeghe et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Mitogen Activated Protein Kinase Activated Protein Kinase 2 Regulates Actin Polymerization and Vascular Leak in Ventilator Associated Lung Injury

(2009) Mahendra Damarla et al.   PLoS One

TLR4 Signaling Is Coupled to SRC Family Kinase Activation, Tyrosine Phosphorylation of Zonula Adherens Proteins, and Opening of the Paracellular Pathway in Human Lung Microvascular Endothelia

(2008) Ping Gong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The kinase p38α serves cell type–specific inflammatory functions in skin injury and coordinates pro- and anti-inflammatory gene expression

(2008) Chun Kim et al.   NATURE IMMUNOLOGY

The kinases MSK1 and MSK2 act as negative regulators of Toll-like receptor signaling

(2008) Olga Ananieva et al.   NATURE IMMUNOLOGY