Gut stem cell aging is driven by mTORC1 via a p38 MAPK-p53 pathway

Fasting Activates Fatty Acid Oxidation to Enhance Intestinal Stem Cell Function during Homeostasis and Aging

(2018) Maria M. Mihaylova et al.   Cell Stem Cell

Calorie Restriction Governs Intestinal Epithelial Regeneration through Cell-Autonomous Regulation of mTORC1 in Reserve Stem Cells

(2018) Maryam Yousefi et al.   Stem Cell Reports

In Vivo Imaging Reveals Existence of Crypt Fission and Fusion in Adult Mouse Intestine

(2017) Lotte Bruens et al.   GASTROENTEROLOGY

Key proteins and pathways that regulate lifespan

(2017) Haihui Pan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interplay between metabolic identities in the intestinal crypt supports stem cell function

(2017) Maria J. Rodríguez-Colman et al.   NATURE

Hierarchy and Plasticity in the Intestinal Stem Cell Compartment

(2017) Maryam Yousefi et al.   TRENDS IN CELL BIOLOGY

Canonical Wnt Signaling Ameliorates Aging of Intestinal Stem Cells

(2017) Kodandaramireddy Nalapareddy et al.   Cell Reports

mTORC1 and SIRT1 Cooperate to Foster Expansion of Gut Adult Stem Cells during Calorie Restriction

(2016) Masaki Igarashi et al.   CELL

Intestinal Phospholipid Remodeling Is Required for Dietary-Lipid Uptake and Survival on a High-Fat Diet

(2016) Bo Wang et al.   Cell Metabolism

The ageing gastrointestinal tract

(2016) Stijn Soenen et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

When stem cells grow old: phenotypes and mechanisms of stem cell aging

(2016) Michael B. Schultz et al.   DEVELOPMENT

mTOR disruption causes intestinal epithelial cell defects and intestinal atrophy postinjury in mice

(2016) Leesa L. Sampson et al.   FASEB JOURNAL

Slowing ageing by design: the rise of NAD+ and sirtuin-activating compounds

(2016) Michael S. Bonkowski et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Systemic Problems: A perspective on stem cell aging and rejuvenation

(2015) Irina M. Conboy et al.   Aging-US

Wnt activity and basal niche position sensitize intestinal stem and progenitor cells to DNA damage

(2015) S. Tao et al.   EMBO JOURNAL

Repression of Mammalian Target of Rapamycin Complex 1 Inhibits Intestinal Regeneration in Acute Inflammatory Bowel Disease Models

(2015) Yuting Guan et al.   JOURNAL OF IMMUNOLOGY

Dormant Intestinal Stem Cells Are Regulated by PTEN and Nutritional Status

(2015) Camilla A. Richmond et al.   Cell Reports

p38 MAPK signaling underlies a cell-autonomous loss of stem cell self-renewal in skeletal muscle of aged mice

(2014) Jennifer D Bernet et al.   NATURE MEDICINE

SnapShot: The Intestinal Crypt

(2013) Hans Clevers et al.   CELL

mTOR is a key modulator of ageing and age-related disease

(2013) Simon C. Johnson et al.   NATURE

Adult intestinal stem cells: critical drivers of epithelial homeostasis and regeneration

(2013) Nick Barker   NATURE REVIEWS MOLECULAR CELL BIOLOGY

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

Tissue-Specific Stem Cells: Lessons from the Skeletal Muscle Satellite Cell

(2012) Andrew S. Brack et al.   Cell Stem Cell

Relief with Rapamycin: mTOR Inhibition Protects against Radiation-Induced Mucositis

(2012) Toren Finkel   Cell Stem Cell

A unifying model for mTORC1-mediated regulation of mRNA translation

(2012) Carson C. Thoreen et al.   NATURE

mTORC1 in the Paneth cell niche couples intestinal stem-cell function to calorie intake

(2012) Ömer H. Yilmaz et al.   NATURE

c-Abl promotes osteoblast expansion by differentially regulating canonical and non-canonical BMP pathways and p16INK4a expression

(2012) Hui-Yi Kua et al.   NATURE CELL BIOLOGY

Manifestations and mechanisms of stem cell aging

(2011) Ling Liu et al.   JOURNAL OF CELL BIOLOGY

A reserve stem cell population in small intestine renders Lgr5-positive cells dispensable

(2011) Hua Tian et al.   NATURE

Interconversion Between Intestinal Stem Cell Populations in Distinct Niches

(2011) N. Takeda et al.   SCIENCE

Spatial Coupling of mTOR and Autophagy Augments Secretory Phenotypes

(2011) M. Narita et al.   SCIENCE

Intestinal Crypt Homeostasis Results from Neutral Competition between Symmetrically Dividing Lgr5 Stem Cells

(2010) Hugo J. Snippert et al.   CELL

Focal Adhesion Kinase Is Required for Intestinal Regeneration and Tumorigenesis Downstream of Wnt/c-Myc Signaling

(2010) Gabrielle H. Ashton et al.   DEVELOPMENTAL CELL

Distinct Effects of p38α Deletion in Myeloid Lineage and Gut Epithelia in Mouse Models of Inflammatory Bowel Disease

(2010) Motoyuki Otsuka et al.   GASTROENTEROLOGY

Loss of Claudin-15, but Not Claudin-2, Causes Na+ Deficiency and Glucose Malabsorption in Mouse Small Intestine

(2010) Atsushi Tamura et al.   GASTROENTEROLOGY

Mouse telomerase reverse transcriptase (mTert) expression marks slowly cycling intestinal stem cells

(2010) R. K. Montgomery et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intestinal Stem Cell Replacement Follows a Pattern of Neutral Drift

(2010) C. Lopez-Garcia et al.   SCIENCE

mTORC1-Mediated Cell Proliferation, But Not Cell Growth, Controlled by the 4E-BPs

(2010) R. J. O. Dowling et al.   SCIENCE

p38MAPK Controls Expression of Multiple Cell Cycle Inhibitors and Islet Proliferation with Advancing Age

(2009) Esther Sook Miin Wong et al.   DEVELOPMENTAL CELL

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

(2009) David E. Harrison et al.   NATURE

TSC–mTOR maintains quiescence and function of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive oxygen species

(2008) Chong Chen et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Biphasic Response of Pancreatic  -Cell Mass to Ablation of Tuberous Sclerosis Complex 2 in Mice

(2008) Y. Shigeyama et al.   MOLECULAR AND CELLULAR BIOLOGY

Bmi1 is expressed in vivo in intestinal stem cells

(2008) Eugenio Sangiorgi et al.   NATURE GENETICS