p38α MAPK signaling drives pharmacologically reversible brain and gastrointestinal phenotypes in the SERT Ala56 mouse

Socially dominant mice in C57BL6 background show increased social motivation

(2018) Thaddeus Kunkel et al.   BEHAVIOURAL BRAIN RESEARCH

Gut-immune-brain dysfunction in Autism: Importance of sex

(2018) Ashley M. Kopec et al.   BRAIN RESEARCH

An isoform-selective p38α mitogen-activated protein kinase inhibitor rescues early entorhinal cortex dysfunctions in a mouse model of Alzheimer's disease

(2018) Grazia Rutigliano et al.   NEUROBIOLOGY OF AGING

5-HT release in nucleus accumbens rescues social deficits in mouse autism model

(2018) Jessica J. Walsh et al.   NATURE

A role for the serotonin reuptake transporter in the brain and intestinal features of autism spectrum disorders and developmental antidepressant exposure

(2017) Kara Gross Margolis   JOURNAL OF CHEMICAL NEUROANATOMY

16p11.2 deletion syndrome mice perseverate with active coping response to acute stress - rescue by blocking 5-HT2A receptors

(2017) Chris M. Panzini et al.   JOURNAL OF NEUROCHEMISTRY

Retention of normal glia function by an isoform-selective protein kinase inhibitor drug candidate that modulates cytokine production and cognitive outcomes

(2017) Zhengqiu Zhou et al.   Journal of Neuroinflammation

The Gain-of-Function Integrin β3 Pro33 Variant Alters the Serotonin System in the Mouse Brain

(2017) Michael R. Dohn et al.   JOURNAL OF NEUROSCIENCE

Polygenic transmission disequilibrium confirms that common and rare variation act additively to create risk for autism spectrum disorders

(2017) Daniel J Weiner et al.   NATURE GENETICS

The BTBR mouse model of idiopathic autism – Current view on mechanisms

(2017) K.Z. Meyza et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Adult enteric nervous system in health is maintained by a dynamic balance between neuronal apoptosis and neurogenesis

(2017) Subhash Kulkarni et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Leveraging blood serotonin as an endophenotype to identify de novo and rare variants involved in autism

(2017) Rui Chen et al.   Molecular Autism

An autism-associated serotonin transporter variant disrupts multisensory processing

(2017) J K Siemann et al.   Translational Psychiatry

Serotonin rebalances cortical tuning and behavior linked to autism symptoms in 15q11-13 CNV mice

(2017) Nobuhiro Nakai et al.   Science Advances

Serotonin neuron abnormalities in the BTBR mouse model of autism

(2016) Yue-Ping Guo et al.   Autism Research

5HT2Areceptor blockade in dorsomedial striatum reduces repetitive behaviors in BTBR mice

(2016) D. A. Amodeo et al.   GENES BRAIN AND BEHAVIOR

Serotonin transporter variant drives preventable gastrointestinal abnormalities in development and function

(2016) Kara Gross Margolis et al.   JOURNAL OF CLINICAL INVESTIGATION

A Randomized, Double-Blind, Placebo-Controlled Trial of Low-Dose Sertraline in Young Children With Fragile X Syndrome

(2016) Laura Greiss Hess et al.   JOURNAL OF DEVELOPMENTAL AND BEHAVIORAL PEDIATRICS

An interplay between the serotonin transporter (SERT) and 5-HT receptors controls stimulus-secretion coupling in sympathoadrenal chromaffin cells

(2016) Rebecca L. Brindley et al.   NEUROPHARMACOLOGY

The serotonin system in autism spectrum disorder: From biomarker to animal models

(2016) C.L. Muller et al.   NEUROSCIENCE

Differential patterning of genes involved in serotonin metabolism and transport in extra-embryonic tissues of the mouse

(2016) Hsiao-Huei Wu et al.   PLACENTA

Human Beta Cells Produce and Release Serotonin to Inhibit Glucagon Secretion from Alpha Cells

(2016) Joana Almaça et al.   Cell Reports

Targeting Human Central Nervous System Protein Kinases: An Isoform Selective p38αMAPK Inhibitor That Attenuates Disease Progression in Alzheimer’s Disease Mouse Models

(2015) Saktimayee M. Roy et al.   ACS Chemical Neuroscience

Genetic research in autism spectrum disorders

(2015) Elise B. Robinson et al.   CURRENT OPINION IN PEDIATRICS

Serotonin and colonic motility

(2015) D. M. Kendig et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Acute dietary tryptophan manipulation differentially alters social behavior, brain serotonin and plasma corticosterone in three inbred mouse strains

(2015) Wynne Q. Zhang et al.   NEUROPHARMACOLOGY

Behavioral, perceptual, and neural alterations in sensory and multisensory function in autism spectrum disorder

(2015) Sarah H. Baum et al.   PROGRESS IN NEUROBIOLOGY

Serotonin transporter clustering in blood lymphocytes predicts the outcome on anhedonia scores in naïve depressive patients treated with antidepressant medication

(2015) Tania Rivera-Baltanas et al.   Annals of General Psychiatry

Novel agonists for serotonin 5-HT7 receptors reverse metabotropic glutamate receptor-mediated long-term depression in the hippocampus of wild-type and Fmr1 KO mice, a model of Fragile X Syndrome

(2015) Lara Costa et al.   Frontiers in Behavioral Neuroscience

A requirement of serotonergic p38α mitogen-activated protein kinase for peripheral immune system activation of CNS serotonin uptake and serotonin-linked behaviors

(2015) N L Baganz et al.   Translational Psychiatry

Oxytocin regulates gastrointestinal motility, inflammation, macromolecular permeability, and mucosal maintenance in mice

(2014) Martha G. Welch et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Maternal immune activation leads to activated inflammatory macrophages in offspring

(2014) Charity E. Onore et al.   BRAIN BEHAVIOR AND IMMUNITY

Pharmacological rescue of Ras signaling, GluA1-dependent synaptic plasticity, and learning deficits in a fragile X model

(2014) C.-S. Lim et al.   GENES & DEVELOPMENT

The Familial Risk of Autism

(2014) Sven Sandin et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Inhibition of Neuronal p38α, but not p38β MAPK, Provides Neuroprotection Against Three Different Neurotoxic Insults

(2014) Bin Xing et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Target Engagement Analysis and Link to Pharmacodynamic Endpoint for a Novel Class of CNS-penetrant and Efficacious p38α MAPK Inhibitors

(2014) Adam D. Bachstetter et al.   Journal of Neuroimmune Pharmacology

Cytokine aberrations in autism spectrum disorder: a systematic review and meta-analysis

(2014) A Masi et al.   MOLECULAR PSYCHIATRY

The mouse that roared: neural mechanisms of social hierarchy

(2014) Fei Wang et al.   TRENDS IN NEUROSCIENCES

Costs of Autism Spectrum Disorders in the United Kingdom and the United States

(2014) Ariane V. S. Buescher et al.   JAMA Pediatrics

Modeling clinically relevant blast parameters based on scaling principles produces functional & histological deficits in rats

(2013) Ryan C. Turner et al.   EXPERIMENTAL NEUROLOGY

Plasma cytokine profiling in sibling pairs discordant for autism spectrum disorder

(2013) Valerio Napolioni et al.   Journal of Neuroinflammation

Prenatal Stress Induces Schizophrenia-Like Alterations of Serotonin 2A and Metabotropic Glutamate 2 Receptors in the Adult Offspring: Role of Maternal Immune System

(2013) T. Holloway et al.   JOURNAL OF NEUROSCIENCE

Drug discovery for autism spectrum disorder: challenges and opportunities

(2013) Anirvan Ghosh et al.   NATURE REVIEWS DRUG DISCOVERY

Development of Novel In Vivo Chemical Probes to Address CNS Protein Kinase Involvement in Synaptic Dysfunction

(2013) D. Martin Watterson et al.   PLoS One

LPS Exposure Increases Maternal Corticosterone Levels, Causes Placental Injury and Increases IL-1Β Levels in Adult Rat Offspring: Relevance to Autism

(2013) Thiago B. Kirsten et al.   PLoS One

Atypical antipsychotics in the treatment of children and adolescents with pervasive developmental disorders

(2013) Laura C. Politte et al.   PSYCHOPHARMACOLOGY

5-Hydroxytryptamine (serotonin) in the gastrointestinal tract

(2013) Michael D. Gershon   Current Opinion in Endocrinology Diabetes and Obesity

Genetic background modulates phenotypes of serotonin transporter Ala56 knock-in mice

(2013) Travis M Kerr et al.   Molecular Autism

Inflammatory macrophage phenotype in BTBR T+tf/J mice

(2013) Charity E. Onore et al.   Frontiers in Neuroscience

Gastrointestinal Dysfunction in Autism: Parental Report, Clinical Evaluation, and Associated Factors

(2012) Phillip Gorrindo et al.   Autism Research

Absence of social conditioned place preference in BTBR T+tf/J mice: Relevance for social motivation testing in rodent models of autism

(2012) Brandon L. Pearson et al.   BEHAVIOURAL BRAIN RESEARCH

Activation of 5-HT7 Serotonin Receptors Reverses Metabotropic Glutamate Receptor-Mediated Synaptic Plasticity in Wild-Type and Fmr1 Knockout Mice, a Model of Fragile X Syndrome

(2012) Lara Costa et al.   BIOLOGICAL PSYCHIATRY

Head-twitch response in rodents induced by the hallucinogen 2,5-dimethoxy-4-iodoamphetamine: a comprehensive history, a re-evaluation of mechanisms, and its utility as a model

(2012) Clint E. Canal et al.   Drug Testing and Analysis

Maternal immune activation by poly(I:C) induces expression of cytokines IL-1β and IL-13, chemokine MCP-1 and colony stimulating factor VEGF in fetal mouse brain

(2012) Géraldine Arrode-Brusés et al.   Journal of Neuroinflammation

Modeling an autism risk factor in mice leads to permanent immune dysregulation

(2012) E. Y. Hsiao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autism gene variant causes hyperserotonemia, serotonin receptor hypersensitivity, social impairment and repetitive behavior

(2012) J. Veenstra-VanderWeele et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Double-Blind Placebo-Controlled Trial of Fluoxetine for Repetitive Behaviors and Global Severity in Adult Autism Spectrum Disorders

(2011) Eric Hollander et al.   AMERICAN JOURNAL OF PSYCHIATRY

Microglial p38α MAPK is a key regulator of proinflammatory cytokine up-regulation induced by toll-like receptor (TLR) ligands or beta-amyloid (Aβ)

(2011) Adam D Bachstetter et al.   Journal of Neuroinflammation

Essential Roles of Enteric Neuronal Serotonin in Gastrointestinal Motility and the Development/Survival of Enteric Dopaminergic Neurons

(2011) Z. Li et al.   JOURNAL OF NEUROSCIENCE

Networking in Autism: Leveraging Genetic, Biomarker and Model System Findings in the Search for New Treatments

(2011) Jeremy Veenstra-VanderWeele et al.   NEUROPSYCHOPHARMACOLOGY

SLC6 Neurotransmitter Transporters: Structure, Function, and Regulation

(2011) A. S. Kristensen et al.   PHARMACOLOGICAL REVIEWS

Family-based association study of ITGB3 in autism spectrum disorder and its endophenotypes

(2010) Valerio Napolioni et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Density and function of central serotonin (5-HT) transporters, 5-HT1A and 5-HT2A receptors, and effects of their targeting on BTBR T+tf/J mouse social behavior

(2010) Georgianna G. Gould et al.   JOURNAL OF NEUROCHEMISTRY

Interaction of 5-HT2A and 5-HT2C Receptors in R(-)-2,5-Dimethoxy-4-iodoamphetamine-Elicited Head Twitch Behavior in Mice

(2010) W. E. Fantegrossi et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Interleukin-1 Receptor Activation by Systemic Lipopolysaccharide Induces Behavioral Despair Linked to MAPK Regulation of CNS Serotonin Transporters

(2010) Chong-Bin Zhu et al.   NEUROPSYCHOPHARMACOLOGY

Evaluation, Diagnosis, and Treatment of Gastrointestinal Disorders in Individuals With ASDs: A Consensus Report

(2010) Timothy Buie et al.   PEDIATRICS

The serotonin 2C receptor potently modulates the head-twitch response in mice induced by a phenethylamine hallucinogen

(2010) Clinton E. Canal et al.   PSYCHOPHARMACOLOGY

Association and gene-gene interaction of SLC6A4 and ITGB3 in autism

(2009) D.Q. Ma et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

Modeling rare gene variation to gain insight into the oldest biomarker in autism: construction of the serotonin transporter Gly56Ala knock-in mouse

(2009) Jeremy Veenstra-VanderWeele et al.   Journal of Neurodevelopmental Disorders

5-HT4 Receptor-Mediated Neuroprotection and Neurogenesis in the Enteric Nervous System of Adult Mice

(2009) M.-T. Liu et al.   JOURNAL OF NEUROSCIENCE

Immune transcriptome alterations in the temporal cortex of subjects with autism

(2008) Krassimira Garbett et al.   NEUROBIOLOGY OF DISEASE

Enhanced activity of human serotonin transporter variants associated with autism

(2008) H. C Prasad et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Going with the Flow: Trafficking-Dependent and -Independent Regulation of Serotonin Transport

(2008) Jennifer A. Steiner et al.   TRAFFIC

Autism-like behavioral phenotypes in BTBR T+tf/J mice

(2007) H. G. McFarlane et al.   GENES BRAIN AND BEHAVIOR