TGF-β Signaling

Specificity, versatility, and control of TGF-β family signaling

(2019) Rik Derynck et al.   Science Signaling

Role of soluble endoglin in BMP9 signaling

(2019) Aleksandra Lawera et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural basis for distinct roles of SMAD2 and SMAD3 in FOXH1 pioneer-directed TGF-β signaling

(2019) Eric Aragón et al.   GENES & DEVELOPMENT

Long noncoding RNA NORAD regulates transforming growth factor-β signaling and epithelial-to-mesenchymal transition-like phenotype

(2018) Natsumi Kawasaki et al.   CANCER SCIENCE

A Milieu Molecule for TGF-β Required for Microglia Function in the Nervous System

(2018) Yan Qin et al.   CELL

The Long (lncRNA) and Short (miRNA) of It: TGFβ-Mediated Control of RNA-Binding Proteins and Noncoding RNAs

(2018) Harinarayanan Janakiraman et al.   MOLECULAR CANCER RESEARCH

Publisher Correction: Contextual determinants of TGFβ action in development, immunity and cancer

(2018) Charles J. David et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Contextual determinants of TGFβ action in development, immunity and cancer

(2018) Charles J. David et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

TGF-β uses a novel mode of receptor activation to phosphorylate SMAD1/5 and induce epithelial-to-mesenchymal transition

(2018) Anassuya Ramachandran et al.   eLife

Resolving the Combinatorial Complexity of Smad Protein Complex Formation and Its Link to Gene Expression

(2018) Philippe Lucarelli et al.   Cell Systems

The SMAD2/3 interactome reveals that TGFβ controls m6A mRNA methylation in pluripotency

(2018) Alessandro Bertero et al.   NATURE

Structural basis of latent TGF-β1 presentation and activation by GARP on human regulatory T cells

(2018) Stéphanie Liénart et al.   SCIENCE

Transforming Growth Factor-β (TGF-β) Directly Activates the JAK1-STAT3 Axis to Induce Hepatic Fibrosis in Coordination with the SMAD Pathway

(2017) Liu-Ya Tang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Force interacts with macromolecular structure in activation of TGF-β

(2017) Xianchi Dong et al.   NATURE

TGF-β promotes PI3K-AKT signaling and prostate cancer cell migration through the TRAF6-mediated ubiquitylation of p85α

(2017) Anahita Hamidi et al.   Science Signaling

Structural basis for genome wide recognition of 5-bp GC motifs by SMAD transcription factors

(2017) Pau Martin-Malpartida et al.   Nature Communications

TGF-β promotes PI3K-AKT signaling and prostate cancer cell migration through the TRAF6-mediated ubiquitylation of p85α

(2017) Anahita Hamidi et al.   Science Signaling

Regulation of the TGF-β pathway by deubiquitinases in cancer

(2016) Sijia Liu et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

YAP/TAZ Are Mechanoregulators of TGF- -Smad Signaling and Renal Fibrogenesis

(2016) S. G. Szeto et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Direct Regulation of Alternative Splicing by SMAD3 through PCBP1 Is Essential to the Tumor-Promoting Role of TGF-β

(2016) Veenu Tripathi et al.   MOLECULAR CELL

Signals and Receptors

(2016) Carl-Henrik Heldin et al.   Cold Spring Harbor Perspectives in Biology

Signaling Cross Talk between TGF-β/Smad and Other Signaling Pathways

(2016) Kunxin Luo   Cold Spring Harbor Perspectives in Biology

Structural Biology and Evolution of the TGF-β Family

(2016) Andrew P. Hinck et al.   Cold Spring Harbor Perspectives in Biology

Signaling Receptors for TGF-β Family Members

(2016) Carl-Henrik Heldin et al.   Cold Spring Harbor Perspectives in Biology

Posttranslational Regulation of Smads

(2016) Pinglong Xu et al.   Cold Spring Harbor Perspectives in Biology

Regulation of the Bioavailability of TGF-β and TGF-β-Related Proteins

(2016) Ian B. Robertson et al.   Cold Spring Harbor Perspectives in Biology

TGF-β and the TGF-β Family: Context-Dependent Roles in Cell and Tissue Physiology

(2016) Masato Morikawa et al.   Cold Spring Harbor Perspectives in Biology

LATS-YAP/TAZ controls lineage specification by regulating TGFβ signaling and Hnf4α expression during liver development

(2016) Da-Hye Lee et al.   Nature Communications

Smad2 and Smad3 have differential sensitivity in relaying TGFβ signaling and inversely regulate early lineage specification

(2016) Ling Liu et al.   Scientific Reports

SET9-Mediated Regulation of TGF-β Signaling Links Protein Methylation to Pulmonary Fibrosis

(2016) Maximilianos Elkouris et al.   Cell Reports

TRAF6 promotes TGFβ-induced invasion and cell-cycle regulation via Lys63-linked polyubiquitination of Lys178 in TGFβ type I receptor

(2015) Reshma Sundar et al.   CELL CYCLE

Cell Density Sensing Alters TGF-β Signaling in a Cell-Type-Specific Manner, Independent from Hippo Pathway Activation

(2015) Flore Nallet-Staub et al.   DEVELOPMENTAL CELL

CIN85 modulates TGFβ signaling by promoting the presentation of TGFβ receptors on the cell surface

(2015) Ihor Yakymovych et al.   JOURNAL OF CELL BIOLOGY

A Long Noncoding RNA Activated by TGF-β Promotes the Invasion-Metastasis Cascade in Hepatocellular Carcinoma

(2014) Ji-hang Yuan et al.   CANCER CELL

Nodal·Gdf1 Heterodimers with Bound Prodomains Enable Serum-independent Nodal Signaling and Endoderm Differentiation

(2014) Christophe Fuerer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Transcriptional Regulators TAZ and YAP Direct Transforming Growth Factor β-induced Tumorigenic Phenotypes in Breast Cancer Cells

(2014) Samantha E. Hiemer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TRAF6 Stimulates the Tumor-Promoting Effects of TGF  Type I Receptor Through Polyubiquitination and Activation of Presenilin 1

(2014) S. K. Gudey et al.   Science Signaling

Time-resolved dissection of early phosphoproteome and ensuing proteome changes in response to TGF- 

(2014) R. C. J. D'Souza et al.   Science Signaling

Stabilization of Snail through AKT/GSK-3β signaling pathway is required for TNF-α-induced epithelial–mesenchymal transition in prostate cancer PC3 cells

(2013) Hao Wang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

TGF-β-activated Kinase 1 (Tak1) Mediates Agonist-induced Smad Activation and Linker Region Phosphorylation in Embryonic Craniofacial Neural Crest-derived Cells

(2013) Kenji Yumoto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Zinc Finger Protein 451 Is a Novel Smad Corepressor in Transforming Growth Factor-β Signaling

(2013) Yili Feng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Type III TGF-β receptor promotes FGF2-mediated neuronal differentiation in neuroblastoma

(2013) Erik H. Knelson et al.   JOURNAL OF CLINICAL INVESTIGATION

Retromer maintains basolateral distribution of the type II TGF-β receptor via the recycling endosome

(2013) Xueqian Yin et al.   MOLECULAR BIOLOGY OF THE CELL

c-Cbl-Mediated Neddylation Antagonizes Ubiquitination and Degradation of the TGF-β Type II Receptor

(2013) Wei Zuo et al.   MOLECULAR CELL

TRAF4 Promotes TGF-β Receptor Signaling and Drives Breast Cancer Metastasis

(2013) Long Zhang et al.   MOLECULAR CELL

Smad6 inhibits non-canonical TGF-β1 signalling by recruiting the deubiquitinase A20 to TRAF6

(2013) Su Myung Jung et al.   Nature Communications

Circulating Angiogenic Modulatory Factors Predict Survival and Functional Class in Pulmonary Arterial Hypertension

(2013) Rajeev Malhotra et al.   Pulmonary Circulation

JAK-2 as a novel mediator of the profibrotic effects of transforming growth factor β in systemic sclerosis

(2012) Clara Dees et al.   ARTHRITIS AND RHEUMATISM

Oligomeric interactions of TGF-β and BMP receptors

(2012) Marcelo Ehrlich et al.   FEBS LETTERS

p21-activated Kinase 2 (PAK2) Inhibits TGF-β Signaling in Madin-Darby Canine Kidney (MDCK) Epithelial Cells by Interfering with the Receptor-Smad Interaction

(2012) Xiaohua Yan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The TGFβ Receptor-interacting Protein km23-1/DYNLRB1 Plays an Adaptor Role in TGFβ1 Autoinduction via Its Association with Ras

(2012) Qunyan Jin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TGF- -induced activation of mTOR complex 2 drives epithelial-mesenchymal transition and cell invasion

(2012) S. Lamouille et al.   JOURNAL OF CELL SCIENCE

TGFβ signalling in context

(2012) Joan Massagué   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Genome-wide mechanisms of Smad binding

(2012) M Morikawa et al.   ONCOGENE

TACE Activation by MAPK-Mediated Regulation of Cell Surface Dimerization and TIMP3 Association

(2012) P. Xu et al.   Science Signaling

The TGF-β co-receptor, CD109, promotes internalization and degradation of TGF-β receptors

(2011) Albane A. Bizet et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Master Transcription Factors Determine Cell-Type-Specific Responses to TGF-β Signaling

(2011) Alan C. Mullen et al.   CELL

A Poised Chromatin Platform for TGF-β Access to Master Regulators

(2011) Qiaoran Xi et al.   CELL

Ablation of Smurf2 reveals an inhibition in TGF-β signalling through multiple mono-ubiquitination of Smad3

(2011) Liu-Ya Tang et al.   EMBO JOURNAL

TGF-β signalling is mediated by two autonomously functioning TβRI:TβRII pairs

(2011) Tao Huang et al.   EMBO JOURNAL

A Smad action turnover switch operated by WW domain readers of a phosphoserine code

(2011) E. Aragon et al.   GENES & DEVELOPMENT

Polyubiquitination of Transforming Growth Factor β (TGFβ)-associated Kinase 1 Mediates Nuclear Factor-κB Activation in Response to Different Inflammatory Stimuli

(2011) Anahita Hamidi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CD109-mediated degradation of TGF-β receptors and inhibition of TGF-β responses involve regulation of SMAD7 and Smurf2 localization and function

(2011) Albane A. Bizet et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

TSC-22 Promotes Transforming Growth Factor  -Mediated Cardiac Myofibroblast Differentiation by Antagonizing Smad7 Activity

(2011) X. Yan et al.   MOLECULAR AND CELLULAR BIOLOGY

Recruitment of TIF1γ to Chromatin via Its PHD Finger-Bromodomain Activates Its Ubiquitin Ligase and Transcriptional Repressor Activities

(2011) Eleonora Agricola et al.   MOLECULAR CELL

USP15 is a deubiquitylating enzyme for receptor-activated SMADs

(2011) Masafumi Inui et al.   NATURE CELL BIOLOGY

Differential regulation of the two RhoA-specific GEF isoforms Net1/Net1A by TGF-β and miR-24: role in epithelial-to-mesenchymal transition

(2011) E Papadimitriou et al.   ONCOGENE

TRAF6 ubiquitinates TGFβ type I receptor to promote its cleavage and nuclear translocation in cancer

(2011) Yabing Mu et al.   Nature Communications

Alternative splicing of SMADs in differentiation and tissue homeostasis

(2010) Shijie Tao et al.   DEVELOPMENT GROWTH & DIFFERENTIATION

The Crumbs Complex Couples Cell Density Sensing to Hippo-Dependent Control of the TGF-β-SMAD Pathway

(2010) Xaralabos Varelas et al.   DEVELOPMENTAL CELL

Negative Regulation of TGFβ Signaling by the Kinase LKB1 and the Scaffolding Protein LIP1

(2010) Anita Morén et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Murine Protein Serine/Threonine Kinase 38 Stimulates TGF-β Signaling in a Kinase-dependent Manner via Direct Phosphorylation of Smad Proteins

(2010) Hyun-A Seong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MTMR4 Attenuates Transforming Growth Factor β (TGFβ) Signaling by Dephosphorylating R-Smads in Endosomes

(2010) Junjing Yu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Smad7 Inhibits Transforming Growth Factor-β Family Type I Receptors through Two Distinct Modes of Interaction

(2010) Yuto Kamiya et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neuropilin-1 Mediates Divergent R-Smad Signaling and the Myofibroblast Phenotype

(2010) Ying Cao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ternary Complex of Transforming Growth Factor-β1 Reveals Isoform-specific Ligand Recognition and Receptor Recruitment in the Superfamily

(2010) Sergei Radaev et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Distinct role of endocytosis for Smad and non-Smad TGF-β signaling regulation in hepatocytes

(2010) Christoph Meyer et al.   JOURNAL OF HEPATOLOGY

Type II Transforming Growth Factor-β Receptor Recycling Is Dependent upon the Clathrin Adaptor Protein Dab2

(2010) Sumedha G. Penheiter et al.   MOLECULAR BIOLOGY OF THE CELL

PARP-1 Attenuates Smad-Mediated Transcription

(2010) Peter Lönn et al.   MOLECULAR CELL

Smad Proteins Bind a Conserved RNA Sequence to Promote MicroRNA Maturation by Drosha

(2010) Brandi N. Davis et al.   MOLECULAR CELL

Betaglycan has Two Independent Domains Required for High Affinity TGF-β Binding: Proteolytic Cleavage Separates the Domains and Inactivates the Neutralizing Activity of the Soluble Receptor

(2009) Valentín Mendoza et al.   BIOCHEMISTRY

Emergence, development and diversification of the TGF-β signalling pathway within the animal kingdom

(2009) Lukasz Huminiecki et al.   BMC EVOLUTIONARY BIOLOGY

ALK5 phosphorylation of the endoglin cytoplasmic domain regulates Smad1/5/8 signaling and endothelial cell migration

(2009) Bridgette N. Ray et al.   CARCINOGENESIS

Nuclear CDKs Drive Smad Transcriptional Activation and Turnover in BMP and TGF-β Pathways

(2009) Claudio Alarcón et al.   CELL

FAM/USP9x, a Deubiquitinating Enzyme Essential for TGFβ Signaling, Controls Smad4 Monoubiquitination

(2009) Sirio Dupont et al.   CELL

The regulation of TGF  signal transduction

(2009) A. Moustakas et al.   DEVELOPMENT

Nuclear Export of Smad2 and Smad3 by RanBP3 Facilitates Termination of TGF-β Signaling

(2009) Fangyan Dai et al.   DEVELOPMENTAL CELL

Different Domains Regulate Homomeric and Heteromeric Complex Formation among Type I and Type II Transforming Growth Factor-β Receptors

(2009) Maya Mouler Rechtman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transforming Growth Factor-β (TGF-β1) Activates TAK1 via TAB1-mediated Autophosphorylation, Independent of TGF-β Receptor Kinase Activity in Mesangial Cells

(2009) Sung Il Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human BAMBI Cooperates with Smad7 to Inhibit Transforming Growth Factor-β Signaling

(2009) Xiaohua Yan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Transforming Growth Factor-β Type III Receptor Mediates Distinct Subcellular Trafficking and Downstream Signaling of Activin-like Kinase (ALK)3 and ALK6 Receptors

(2009) Nam Y. Lee et al.   MOLECULAR BIOLOGY OF THE CELL

TACE-Mediated Ectodomain Shedding of the Type I TGF-β Receptor Downregulates TGF-β Signaling

(2009) Cheng Liu et al.   MOLECULAR CELL

Bone morphogenetic protein heterodimers assemble heteromeric type I receptor complexes to pattern the dorsoventral axis

(2009) Shawn C. Little et al.   NATURE CELL BIOLOGY

The E3 Ligase TRAF6 Regulates Akt Ubiquitination and Activation

(2009) W.-L. Yang et al.   SCIENCE

Axin and GSK3- control Smad3 protein stability and modulate TGF- signaling

(2008) X. Guo et al.   GENES & DEVELOPMENT

Endocytosis of the Type III Transforming Growth Factor-β (TGF-β) Receptor through the Clathrin-independent/Lipid Raft Pathway Regulates TGF-β Signaling and Receptor Down-regulation

(2008) Elizabeth C. Finger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

L- and S-endoglin differentially modulate TGF 1 signaling mediated by ALK1 and ALK5 in L6E9 myoblasts

(2008) S. Velasco et al.   JOURNAL OF CELL SCIENCE

Transforming Growth Factor  -Induced Smad1/5 Phosphorylation in Epithelial Cells Is Mediated by Novel Receptor Complexes and Is Essential for Anchorage-Independent Growth

(2008) A. C. Daly et al.   MOLECULAR AND CELLULAR BIOLOGY

Specific Activation of Mitogen-activated Protein Kinase by Transforming Growth Factor-β Receptors in Lipid Rafts Is Required for Epithelial Cell Plasticity

(2008) Wei Zuo et al.   MOLECULAR BIOLOGY OF THE CELL

Cooperative Assembly of TGF-β Superfamily Signaling Complexes Is Mediated by Two Disparate Mechanisms and Distinct Modes of Receptor Binding

(2008) Jay Groppe et al.   MOLECULAR CELL

TRAF6 Mediates Smad-Independent Activation of JNK and p38 by TGF-β

(2008) Motozo Yamashita et al.   MOLECULAR CELL

SMAD proteins control DROSHA-mediated microRNA maturation

(2008) Brandi N. Davis et al.   NATURE

The type I TGF-β receptor engages TRAF6 to activate TAK1 in a receptor kinase-independent manner

(2008) Alessandro Sorrentino et al.   NATURE CELL BIOLOGY

Ligand-dependent ubiquitination of Smad3 is regulated by casein kinase 1 gamma 2, an inhibitor of TGF-β signaling

(2008) X Guo et al.   ONCOGENE