Tumour-derived SPARC drives vascular permeability and extravasation through endothelial VCAM1 signalling to promote metastasis

SPARC/osteonectin is involved in metastatic process to the lung during melanoma progression

(2014) Gerardo Botti et al.   VIRCHOWS ARCHIV

CTLA-4 and PD-1/PD-L1 Blockade: New Immunotherapeutic Modalities with Durable Clinical Benefit in Melanoma Patients

(2013) P. A. Ott et al.   CLINICAL CANCER RESEARCH

Metformin Blocks Melanoma Invasion and Metastasis Development in AMPK/p53-Dependent Manner

(2013) M. Cerezo et al.   MOLECULAR CANCER THERAPEUTICS

Endothelial CCR2 Signaling Induced by Colon Carcinoma Cells Enables Extravasation via the JAK2-Stat5 and p38MAPK Pathway

(2012) Monika Julia Wolf et al.   CANCER CELL

Diverse biological functions of the SPARC family of proteins

(2012) Amy D. Bradshaw   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET

(2012) Héctor Peinado et al.   NATURE MEDICINE

The Epithelial-Mesenchymal Transition (EMT) Regulatory Factor SLUG (SNAI2) Is a Downstream Target of SPARC and AKT in Promoting Melanoma Cell Invasion

(2012) Nina Fenouille et al.   PLoS One

The Initial Hours of Metastasis: The Importance of Cooperative Host-Tumor Cell Interactions during Hematogenous Dissemination

(2012) M. Labelle et al.   Cancer Discovery

ANGPTL4 modulates vascular junction integrity by integrin signaling and disruption of intercellular VE-cadherin and claudin-5 clusters

(2011) R.-L. Huang et al.   BLOOD

Preconditioned Endothelial Progenitor Cells Reduce Formation of Melanoma Metastases through SPARC-Driven Cell-Cell Interactions and Endocytosis

(2011) F. Defresne et al.   CANCER RESEARCH

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

The regulatory function of SPARC in vascular biology

(2011) Lee B. Rivera et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Proteomic Profiling of Human Melanoma Metastatic Cell Line Secretomes

(2011) Micaela Rocco et al.   JOURNAL OF PROTEOME RESEARCH

SPARC functions as an anti-stress factor by inactivating p53 through Akt-mediated MDM2 phosphorylation to promote melanoma cell survival

(2011) N Fenouille et al.   ONCOGENE

p38 MAP kinase is necessary for melanoma-mediated regulation of VE-cadherin disassembly

(2010) Payal Khanna et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Regulation of Endothelial Permeability via Paracellular and Transcellular Transport Pathways

(2010) Yulia Komarova et al.   Annual Review of Physiology

AACR Centennial Series: The Biology of Cancer Metastasis: Historical Perspective

(2010) J. E. Talmadge et al.   CANCER RESEARCH

‘Loss of pigment epithelium-derived factor enables migration, invasion and metastatic spread of human melanoma’

(2009) J L Orgaz et al.   ONCOGENE

The role of the matricellular protein SPARC in the dynamic interaction between the tumor and the host

(2008) Osvaldo L. Podhajcer et al.   CANCER AND METASTASIS REVIEWS

TGFβ Primes Breast Tumors for Lung Metastasis Seeding through Angiopoietin-like 4

(2008) David Padua et al.   CELL

The Interleukin-8 Pathway in Cancer

(2008) D. J.J. Waugh et al.   CLINICAL CANCER RESEARCH

The role of cytoskeleton in the regulation of vascular endothelial barrier function

(2008) Natalia V. Bogatcheva et al.   MICROVASCULAR RESEARCH

PDK1 regulates cancer cell motility by antagonising inhibition of ROCK1 by RhoE

(2008) Sophie Pinner et al.   NATURE CELL BIOLOGY

Cell adhesion dynamics at endothelial junctions: VE-cadherin as a major player

(2008) Dietmar Vestweber et al.   TRENDS IN CELL BIOLOGY