Protein kinase p38α signaling in dendritic cells regulates colon inflammation and tumorigenesis

Functions of Murine Dendritic Cells

(2016) Vivek Durai et al.   IMMUNITY

Unsupervised High-Dimensional Analysis Aligns Dendritic Cells across Tissues and Species

(2016) Martin Guilliams et al.   IMMUNITY

Inflammatory networks underlying colorectal cancer

(2016) Audrey Lasry et al.   NATURE IMMUNOLOGY

Innate lymphoid cells as regulators of immunity, inflammation and tissue homeostasis

(2016) Christoph S N Klose et al.   NATURE IMMUNOLOGY

Interleukin-22: Immunobiology and Pathology

(2015) Jarrod A. Dudakov et al.   Annual Review of Immunology

Roles of p38α mitogen-activated protein kinase in mouse models of inflammatory diseases and cancer

(2015) Jalaj Gupta et al.   FEBS Journal

Interferon and IL-27 antagonize the function of group 2 innate lymphoid cells and type 2 innate immune responses

(2015) Kazuyo Moro et al.   NATURE IMMUNOLOGY

Interleukin-22: A likely target for treatment of autoimmune diseases

(2014) Xuyan Yang et al.   AUTOIMMUNITY REVIEWS

Dual Function of p38α MAPK in Colon Cancer: Suppression of Colitis-Associated Tumor Initiation but Requirement for Cancer Cell Survival

(2014) Jalaj Gupta et al.   CANCER CELL

Intestinal dendritic cells in the regulation of mucosal immunity

(2014) Vasileios Bekiaris et al.   IMMUNOLOGICAL REVIEWS

The Dendritic Cell Lineage: Ontogeny and Function of Dendritic Cells and Their Subsets in the Steady State and the Inflamed Setting

(2013) Miriam Merad et al.   Annual Review of Immunology

Advantages and limitations of mouse models to deplete dendritic cells

(2013) Janneke van Blijswijk et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Intestinal dendritic cells: Their role in intestinal inflammation, manipulation by the gut microbiota and differences between mice and men

(2013) Elizabeth R. Mann et al.   IMMUNOLOGY LETTERS

The Role of Macrophages and Dendritic Cells in the Initiation of Inflammation in IBD

(2013) Erin C. Steinbach et al.   INFLAMMATORY BOWEL DISEASES

Control of T Cell Fates and Immune Tolerance by p38  Signaling in Mucosal CD103+ Dendritic Cells

(2013) G. Huang et al.   JOURNAL OF IMMUNOLOGY

Lyn activity protects mice from DSS colitis and regulates the production of IL-22 from innate lymphoid cells

(2013) J L Bishop et al.   Mucosal Immunology

High susceptibility to liver injury in IL-27 p28 conditional knockout mice involves intrinsic interferon-γ dysregulation of CD4+T cells

(2012) Song Zhang et al.   HEPATOLOGY

IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine

(2012) Samuel Huber et al.   NATURE

Signaling via the kinase p38α programs dendritic cells to drive TH17 differentiation and autoimmune inflammation

(2012) Gonghua Huang et al.   NATURE IMMUNOLOGY

Inflammation and colorectal cancer: colitis-associated neoplasia

(2012) Sergei I. Grivennikov   Seminars in Immunopathology

Recent advances in IL-22 biology

(2011) L. A. Zenewicz et al.   INTERNATIONAL IMMUNOLOGY

A Novel Role for Interleukin-27 (IL-27) as Mediator of Intestinal Epithelial Barrier Protection Mediated via Differential Signal Transducer and Activator of Transcription (STAT) Protein Signaling and Induction of Antibacterial and Anti-inflammatory Proteins

(2011) Julia Diegelmann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The role of p38 mitogen-activated protein kinase in the pathogenesis of inflammatory bowel disease

(2011) Ya Jing FENG et al.   Journal of Digestive Diseases

IL-23–responsive innate lymphoid cells are increased in inflammatory bowel disease

(2011) Alessandra Geremia et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Transcriptional Suppression of IL-27 Production by Mycobacterium tuberculosis-Activated p38 MAPK via Inhibition of AP-1 Binding

(2011) J. Zhang et al.   JOURNAL OF IMMUNOLOGY

Intestinal homeostasis and its breakdown in inflammatory bowel disease

(2011) Kevin J. Maloy et al.   NATURE

Induction of regulatory Tr1 cells and inhibition of TH17 cells by IL-27

(2011) Caroline Pot et al.   SEMINARS IN IMMUNOLOGY

Gut-associated lymphoid tissue, T cell trafficking, and chronic intestinal inflammation

(2010) Iurii Koboziev et al.   Annals of the New York Academy of Sciences

Inflammatory Bowel Disease

(2010) Arthur Kaser et al.   Annual Review of Immunology

Intestinal inflammation abrogates the tolerogenic properties of MLN CD103+ dendritic cells

(2010) Sophie Laffont et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Distinct Effects of p38α Deletion in Myeloid Lineage and Gut Epithelia in Mouse Models of Inflammatory Bowel Disease

(2010) Motoyuki Otsuka et al.   GASTROENTEROLOGY

Mechanisms of intestinal inflammation and development of associated cancers: Lessons learned from mouse models

(2010) Aya M. Westbrook et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci

(2010) Andre Franke et al.   NATURE GENETICS

Activation of  -Catenin in Dendritic Cells Regulates Immunity Versus Tolerance in the Intestine

(2010) S. Manicassamy et al.   SCIENCE

Regulatory Lymphocytes and Intestinal Inflammation

(2009) Ana Izcue et al.   Annual Review of Immunology

IL-6 and Stat3 Are Required for Survival of Intestinal Epithelial Cells and Development of Colitis-Associated Cancer

(2009) Sergei Grivennikov et al.   CANCER CELL

Regulation of JNK and p38 MAPK in the immune system: Signal integration, propagation and termination

(2009) Gonghua Huang et al.   CYTOKINE

Regulatory T Cells Reinforce Intestinal Homeostasis

(2009) Michael J. Barnes et al.   IMMUNITY

IL-27 Regulates Homeostasis of the Intestinal CD4+ Effector T Cell Pool and Limits Intestinal Inflammation in a Murine Model of Colitis

(2009) A. E. Troy et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: IL-27 Induces the Transcription Factor c-Maf, Cytokine IL-21, and the Costimulatory Receptor ICOS that Coordinately Act Together to Promote Differentiation of IL-10-Producing Tr1 Cells

(2009) C. Pot et al.   JOURNAL OF IMMUNOLOGY

Common variants at five new loci associated with early-onset inflammatory bowel disease

(2009) Marcin Imielinski et al.   NATURE GENETICS

Innate and Adaptive Interleukin-22 Protects Mice from Inflammatory Bowel Disease

(2008) Lauren A. Zenewicz et al.   IMMUNITY

IL-27R deficiency delays the onset of colitis and protects from helminth-induced pathology in a model of chronic IBD

(2008) Alejandro V. Villarino et al.   INTERNATIONAL IMMUNOLOGY