Nutraceutical Strategies for Suppressing NLRP3 Inflammasome Activation: Pertinence to the Management of COVID-19 and Beyond

An Acetylation Switch of the NLRP3 Inflammasome Regulates Aging-Associated Chronic Inflammation and Insulin Resistance

(2020) Ming He et al.   Cell Metabolism

Inflammasomes contributing to inflammation in arthritis

(2020) Lotte Spel et al.   IMMUNOLOGICAL REVIEWS

Through Reducing ROS Production, IL-10 Suppresses Caspase-1-Dependent IL-1β Maturation, thereby Preventing Chronic Neuroinflammation and Neurodegeneration

(2020) Yun Gao et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Role of NLRP3 Inflammasome in Infection-related, Immune-mediated and Autoimmune Skin Diseases

(2020) Dan Wang et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

Melatonin protects the retina from experimental non‐exudative age‐relatd macular degeneration in mice

(2020) Hernán H. Diéguez et al.   JOURNAL OF PINEAL RESEARCH

Nutraceuticals have potential for boosting the type 1 interferon response to RNA viruses including influenza and coronavirus

(2020) Mark F. McCarty et al.   PROGRESS IN CARDIOVASCULAR DISEASES

Reactive oxygen species play a role in P2X7 receptor-mediated IL-6 production in spinal astrocytes

(2020) Frances M. Munoz et al.   Purinergic Signalling

Spirulina maxima extract prevents activation of the NLRP3 inflammasome by inhibiting ERK signaling

(2020) Sungwoo Chei et al.   Scientific Reports

Berberine Inhibits Nod-Like Receptor Family Pyrin Domain Containing 3 Inflammasome Activation and Pyroptosis in Nonalcoholic Steatohepatitis via the ROS/TXNIP Axis

(2020) Weijian Mai et al.   Frontiers in Pharmacology

The Roles of the NLRP3 Inflammasome in Neurodegenerative and Metabolic Diseases and in Relevant Advanced Therapeutic Interventions

(2020) Rameez Hassan Pirzada et al.   Genes

Metformin Treatment Was Associated with Decreased Mortality in COVID-19 Patients with Diabetes in a Retrospective Analysis

(2020) Pan Luo et al.   AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

C‐phycocyanin protects against ethanol‐induced gastric ulcers in rats: Role of HMGB1/NLRP3/NF‐κB pathway

(2020) Amany Abdel‐mageed Alzokaky et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Sulforaphane ameliorates serum starvation‐induced muscle atrophy via activation of the Nrf2 pathway in cultured C2C12 cells

(2020) Jae Yun Moon et al.   CELL BIOLOGY INTERNATIONAL

Interleukin-1 and the Inflammasome as Therapeutic Targets in Cardiovascular Disease

(2020) Antonio Abbate et al.   CIRCULATION RESEARCH

Hydrogen sulfide alleviates liver injury via S-sulfhydrated-Keap1/Nrf2/LRP1 pathway

(2020) Shuang Zhao et al.   HEPATOLOGY

Aloin suppresses lipopolysaccharide-induced acute lung injury by inhibiting NLRP3/NF-κB via activation of SIRT1 in mice

(2020) Jiaji Lei et al.   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

Zinc and respiratory tract infections: Perspectives for COVID‑19 (Review)

(2020) Anatoly Skalny et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

COVID-19 and the role of chronic inflammation in patients with obesity

(2020) Sonja Chiappetta et al.   INTERNATIONAL JOURNAL OF OBESITY

Berberine suppresses influenza virus-triggered NLRP3 inflammasome activation in macrophages by inducing mitophagy and decreasing mitochondrial ROS

(2020) Hui Liu et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Association of zinc administration with growth suppression of intracranial aneurysms via induction of A20

(2020) Kosuke Hayashi et al.   JOURNAL OF NEUROSURGERY

N-Acetylcysteine: a potential therapeutic agent for SARS-CoV-2

(2020) Francis L. Poe et al.   MEDICAL HYPOTHESES

Serum Hydrogen Sulfide and Outcome Association in Pneumonia by the SARS-CoV-2 Coronavirusxs

(2020) Georgios Renieris et al.   SHOCK

Novel Coronavirus-Induced NLRP3 Inflammasome Activation: A Potential Drug Target in the Treatment of COVID-19

(2020) Adnan Shah   Frontiers in Immunology

SIRT1 Alleviates LPS-Induced IL-1β Production by Suppressing NLRP3 Inflammasome Activation and ROS Production in Trophoblasts

(2020) Sumi Park et al.   Cells

Cathepsin B Is Required for NLRP3 Inflammasome Activation in Macrophages, Through NLRP3 Interaction

(2020) Angélique Chevriaux et al.   Frontiers in Cell and Developmental Biology

Association between treatment with colchicine and improved survival in a single-centre cohort of adult hospitalised patients with COVID-19 pneumonia and acute respiratory distress syndrome

(2020) Mirko Scarsi et al.   ANNALS OF THE RHEUMATIC DISEASES

Antiviral activity of berberine

(2020) Alicja Warowicka et al.   ARCHIVES OF VIROLOGY

The Minimal Effect of Zinc on the Survival of Hospitalized Patients With COVID-19

(2020) Jasper Seth Yao et al.   CHEST

Aging, Male Sex, Obesity, and Metabolic Inflammation Create the Perfect Storm for COVID-19

(2020) Franck Mauvais-Jarvis   DIABETES

N-acetylcysteine as a potential treatment for novel coronavirus disease 2019

(2020) Rangel-Méndez Jorge-Aarón et al.   Future Microbiology

Successful Treatment of Covid-19 Associated Cytokine Release Syndrome with Colchicine. A Case Report and Review of Literature

(2020) Nahal Mansouri et al.   IMMUNOLOGICAL INVESTIGATIONS

Melatonin prevents endothelial dysfunction in SLE by activating the nuclear receptor retinoic acid-related orphan receptor-α

(2020) Huijing Huang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Physiological concentrations of bilirubin control inflammatory response by inhibiting NF-κB and inflammasome activation

(2020) Yufei Li et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Treatment of SARS-CoV-2 with high dose oral zinc salts: A report on four patients

(2020) Eric Finzi   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

Nutraceutical Compounds Targeting Inflammasomes in Human Diseases

(2020) Beatriz Castejón-Vega et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Increasing complexity of NLRP3 inflammasome regulation

(2020) Julien Moretti et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Visceral Adiposity and High Intramuscular Fat Deposition Independently Predict Critical Illness in Patients with Sars‐COV‐2

(2020) Yang Yang et al.   Obesity

Early IL-1 receptor blockade in severe inflammatory respiratory failure complicating COVID-19

(2020) Raphaël Cauchois et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Outcomes of 3,737 COVID-19 patients treated with hydroxychloroquine/azithromycin and other regimens in Marseille, France: A retrospective analysis

(2020) Jean-Christophe Lagier et al.   Travel Medicine and Infectious Disease

KEAP1, a cysteine-based sensor and a drug target for the prevention and treatment of chronic disease

(2020) Sharadha Dayalan Naidu et al.   Open Biology

Use of Anakinra to Prevent Mechanical Ventilation in Severe COVID‐19: A Case Series

(2020) Iris Navarro‐Millán et al.   Arthritis & Rheumatology

Severe COVID-19: NLRP3 Inflammasome Dysregulated

(2020) Daan F. van den Berg et al.   Frontiers in Immunology

Targeting the NLRP3 Inflammasome in Severe COVID-19

(2020) Tracey L. Freeman et al.   Frontiers in Immunology

SIRT1 agonism modulates cardiac NLRP3 inflammasome through pyruvate dehydrogenase during ischemia and reperfusion

(2020) Ying Han et al.   Redox Biology

Clock Protein Bmal1 and Nrf2 Cooperatively Control Aging or Oxidative Response and Redox Homeostasis by Regulating Rhythmic Expression of Prdx6

(2020) Bhavana Chhunchha et al.   Cells

The Integrative Role of Sulforaphane in Preventing Inflammation, Oxidative Stress and Fatigue: A Review of a Potential Protective Phytochemical

(2020) Ruheea Taskin Ruhee et al.   Antioxidants

Targeting the Heme-Heme Oxygenase System to Prevent Severe Complications Following COVID-19 Infections

(2020) Frank A. D. T. G. Wagener et al.   Antioxidants

Effect of Colchicine vs Standard Care on Cardiac and Inflammatory Biomarkers and Clinical Outcomes in Patients Hospitalized With Coronavirus Disease 2019

(2020) Spyridon G. Deftereos et al.   JAMA Network Open

The development of a targeted and more potent, anti-Inflammatory derivative of colchicine: Implications for gout

(2020) Guillaume Paré et al.   BIOCHEMICAL PHARMACOLOGY

Identification of potential inhibitors against SARS-CoV-2 by targeting proteins responsible for envelope formation and virion assembly using docking based virtual screening, and pharmacokinetics approaches

(2020) Deep Bhowmik et al.   INFECTION GENETICS AND EVOLUTION

The role of visceral adiposity in the severity of COVID-19: Highlights from a unicenter cross-sectional pilot study in Germany

(2020) Antonia Petersen et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

The Protective Effects of Melatonin on Aluminum-Induced Hepatotoxicity and Nephrotoxicity in Rats

(2020) Mohamed S. Othman et al.   Oxidative Medicine and Cellular Longevity

Plasma Membrane Pores Drive Inflammatory Cell Death

(2020) Benedikt Kolbrink et al.   Frontiers in Cell and Developmental Biology

Recent insights into the regulatory networks of NLRP3 inflammasome activation

(2020) Alexander N. R. Weber et al.   JOURNAL OF CELL SCIENCE

Inhibiting the NLRP3 Inflammasome

(2020) Lina Y. El-Sharkawy et al.   MOLECULES

Efficacy and Safety of Berberine Alone or Combined with Statins for the Treatment of Hyperlipidemia: A Systematic Review and Meta-Analysis of Randomized Controlled Clinical Trials

(2019) Li-Shuang Zhang et al.   AMERICAN JOURNAL OF CHINESE MEDICINE

Comparative localization of cystathionine beta synthases and cystathionine gamma lyase in canine, non-human primate and human retina

(2019) Alireza Badiei et al.   EXPERIMENTAL EYE RESEARCH

Zinc inhibited LPS-induced inflammatory responses by upregulating A20 expression in microglia BV2 cells

(2019) Li Hongxia et al.   JOURNAL OF AFFECTIVE DISORDERS

Hydrogen sulfide protects against DSS-induced colitis by inhibiting NLRP3 inflammasome

(2019) Ming Qin et al.   FREE RADICAL BIOLOGY AND MEDICINE

The effect of palmitic acid on inflammatory response in macrophages: an overview of molecular mechanisms

(2019) Jan Korbecki et al.   INFLAMMATION RESEARCH

Glucosamine inhibits IL-1β expression by preserving mitochondrial integrity and disrupting assembly of the NLRP3 inflammasome

(2019) Hsiao-Wen Chiu et al.   Scientific Reports

Recent Strategies in Resveratrol Delivery Systems

(2019) Noelia D. Machado et al.   ChemPlusChem

Berberine inhibits NLRP3 Inflammasome pathway in human triple-negative breast cancer MDA-MB-231 cell

(2019) Mingjiang Yao et al.   BMC Complementary and Alternative Medicine

MAVS O-GlcNAcylation Is Essential for Host Antiviral Immunity against Lethal RNA Viruses

(2019) Nan Song et al.   Cell Reports

The effects of phycocyanin on bleomycin-induced pulmonary fibrosis and the intestinal microbiota in C57BL/6 mice

(2019) Yuanyuan Xie et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Control of the inflammasome by the ubiquitin system

(2019) Gloria Lopez‐Castejon   FEBS Journal

Apocynin alleviates lung injury by suppressing NLRP3 inflammasome activation and NF-κB signaling in acute pancreatitis

(2019) Hong-zhong Jin et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

A diet rich in taurine, cysteine, folate, B12 and betaine may lessen risk for Alzheimer’s disease by boosting brain synthesis of hydrogen sulfide

(2019) Mark F. McCarty et al.   MEDICAL HYPOTHESES

NLRP3 inflammasome activation drives tau pathology

(2019) Christina Ising et al.   NATURE

Emerging Activators and Regulators of Inflammasomes and Pyroptosis

(2019) Yansong Xue et al.   TRENDS IN IMMUNOLOGY

Dietary Curcumin: Correlation between Bioavailability and Health Potential

(2019) Michele Dei Cas et al.   Nutrients

Association between Metformin and a Lower Risk of Age-Related Macular Degeneration in Patients with Type 2 Diabetes

(2019) Yu-Yen Chen et al.   Journal of Ophthalmology

Melatonin Target Proteins: Too Many or Not Enough?

(2019) Lei Liu et al.   Frontiers in Endocrinology

Targeting NLRP3 Inflammasome Activation in Severe Asthma

(2019) Efthymia Theofani et al.   Journal of Clinical Medicine

Ferulic acid prevents oxidative stress, inflammation, and liver injury via upregulation of Nrf2/HO-1 signaling in methotrexate-induced rats

(2019) Ayman M. Mahmoud et al.   ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH

A new research hot spot: The role of NLRP3 inflammasome activation, a key step in pyroptosis, in diabetes and diabetic complications

(2019) Zi-Wei Yu et al.   LIFE SCIENCES

Saturated Fatty Acids Undergo Intracellular Crystallization and Activate the NLRP3 Inflammasome in MacrophagesHighlights

(2018) Tadayoshi Karasawa et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

O-Linked β-N-Acetylglucosamine Modification of A20 Enhances the Inhibition of NF-κB (Nuclear Factor-κB) Activation and Elicits Vascular Protection After Acute Endoluminal Arterial InjuryHighlights

(2018) Dan Yao et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Alpha lipoic acid exerts antioxidant effect via Nrf2/HO-1 pathway activation and suppresses hepatic stellate cells activation induced by methotrexate in rats

(2018) Ahmed M. Fayez et al.   BIOMEDICINE & PHARMACOTHERAPY

Apocynin inhibited NLRP3/XIAP signalling to alleviate renal fibrotic injury in rat diabetic nephropathy

(2018) Rui Xin et al.   BIOMEDICINE & PHARMACOTHERAPY

MPTP-driven NLRP3 inflammasome activation in microglia plays a central role in dopaminergic neurodegeneration

(2018) Eunju Lee et al.   CELL DEATH AND DIFFERENTIATION

Assessments of cellular melatonin receptor signaling pathways: β-arrestin recruitment, receptor internalization, and impedance variations

(2018) Clémence Dupré et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

ATP/P2X7-NLRP3 axis of dendritic cells participates in the regulation of airway inflammation and hyper-responsiveness in asthma by mediating HMGB1 expression and secretion

(2018) Ruiting Li et al.   EXPERIMENTAL CELL RESEARCH

Ferulic acid protects against heat stress-induced intestinal epithelial barrier dysfunction in IEC-6 cells via the PI3K/Akt-mediated Nrf2/HO-1 signaling pathway

(2018) Shasha He et al.   INTERNATIONAL JOURNAL OF HYPERTHERMIA

The Zinc Sensing Receptor, ZnR/GPR39, in Health and Disease

(2018) Michal Hershfinkel   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Saturated fatty acids, obesity, and the nucleotide oligomerization domain–like receptor protein 3 (NLRP3) inflammasome in asthmatic patients

(2018) Lisa G. Wood et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Curcumin Suppresses IL-1β Secretion and Prevents Inflammation through Inhibition of the NLRP3 Inflammasome

(2018) Haipeng Yin et al.   JOURNAL OF IMMUNOLOGY

Inhibition of the hepatic Nlrp3 protects dopaminergic neurons via attenuating systemic inflammation in a MPTP/p mouse model of Parkinson’s disease

(2018) Chen Qiao et al.   Journal of Neuroinflammation

Zinc Inhibits Phosphate-Induced Vascular Calcification through TNFAIP3-Mediated Suppression of NF-κB

(2018) Jakob Voelkl et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Ferulic acid may target MyD88-mediated pro-inflammatory signaling – Implications for the health protection afforded by whole grains, anthocyanins, and coffee

(2018) Mark F. McCarty et al.   MEDICAL HYPOTHESES

Circadian modification network of a core clock driver BMAL1 to harmonize physiology from brain to peripheral tissues

(2018) Teruya Tamaru et al.   NEUROCHEMISTRY INTERNATIONAL

A20 critically controls microglia activation and inhibits inflammasome-dependent neuroinflammation

(2018) Sofie Voet et al.   Nature Communications

Ferulic Acid Supplementation Improves Lipid Profiles, Oxidative Stress, and Inflammatory Status in Hyperlipidemic Subjects: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

(2018) Akkarach Bumrungpert et al.   Nutrients

Evaluation on the effect of hydrogen sulfide on the NLRP3 signaling pathway and its involvement in the pathogenesis of atherosclerosis

(2018) Li-Ming Yue et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Ferulic Acid Rescues LPS-Induced Neurotoxicity via Modulation of the TLR4 Receptor in the Mouse Hippocampus

(2018) Shafiq Ur Rehman et al.   MOLECULAR NEUROBIOLOGY

Efficacy and safety of berberine for dyslipidaemias: a systematic review and meta-analysis of randomized clinical trials

(2018) Jianqing Ju et al.   PHYTOMEDICINE

Circadian clock protein BMAL1 regulates IL-1β in macrophages via NRF2

(2018) James O. Early et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NLRP3 inflammasome activation in inflammaging

(2018) Eicke Latz et al.   SEMINARS IN IMMUNOLOGY

Selenium Attenuates Staphylococcus aureus Mastitis in Mice by Inhibiting the Activation of the NALP3 Inflammasome and NF-κB/MAPK Pathway

(2018) Junkun Ma et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

Glucosamine improves survival in a mouse model of sepsis and attenuates sepsis-induced lung injury and inflammation

(2018) Ji-Sun Hwang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

β-arrestin2 regulates the anti-inflammatory effects of Salmeterol in lipopolysaccharide-stimulated BV2 cells

(2018) Monika Sharma et al.   JOURNAL OF NEUROIMMUNOLOGY

Periodontal ligament fibroblasts migration injury via ROS/TXNIP/Nlrp3 inflammasome pathway with Porphyromonas gingivalis lipopolysaccharide

(2018) Dawei Lian et al.   MOLECULAR IMMUNOLOGY

Upregulation of proteins of the NLRP3 inflammasome in patients with periodontitis and uncontrolled type 2 diabetes

(2018) Ana Lilia García‐Hernández et al.   ORAL DISEASES

Berberine ameliorates lipopolysaccharide-induced acute lung injury via the PERK-mediated Nrf2/HO-1 signaling axis

(2018) Yuan Liang et al.   PHYTOTHERAPY RESEARCH

The mechanisms of NLRP3 inflammasome/pyroptosis activation and their role in Parkinson's disease

(2018) Shuo Wang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Nitric oxide protected against NADPH oxidase-derived superoxide generation in vascular endothelium: Critical role for heme oxygenase-1

(2018) Mengjuan Luo et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Negative regulation of NLRP3 inflammasome by SIRT1 in vascular endothelial cells

(2017) Yanxiang Li et al.   IMMUNOBIOLOGY

Ferulic acid inhibits neuro-inflammation in mice exposed to chronic unpredictable mild stress

(2017) Ya-Min Liu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Ferulic acid exerts neuroprotective effects against cerebral ischemia/reperfusion-induced injury via antioxidant and anti-apoptotic mechanisms in vitro and in vivo

(2017) Zhongkun Ren et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Hydrogen sulfide inhibits NLRP3 inflammasome activation and reduces cytokine production bothin vitroand in a mouse model of inflammation

(2017) Mariela Castelblanco et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Endogenous hydrogen sulphide attenuates NLRP3 inflammasome-mediated neuroinflammation by suppressing the P2X7 receptor after intracerebral haemorrhage in rats

(2017) Hengli Zhao et al.   Journal of Neuroinflammation

Melatonin alleviates cadmium-induced liver injury by inhibiting the TXNIP-NLRP3 inflammasome

(2017) Zhengwang Cao et al.   JOURNAL OF PINEAL RESEARCH

Resveratrol pretreatment attenuates traumatic brain injury in rats by suppressing NLRP3 inflammasome activation via SIRT1

(2017) Peng Zou et al.   Molecular Medicine Reports

cGAS drives noncanonical-inflammasome activation in age-related macular degeneration

(2017) Nagaraj Kerur et al.   NATURE MEDICINE

Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease

(2017) Paul M Ridker et al.   NEW ENGLAND JOURNAL OF MEDICINE

NADPH Oxidase 2 Regulates NLRP3 Inflammasome Activation in the Brain after Traumatic Brain Injury

(2017) Merry W. Ma et al.   Oxidative Medicine and Cellular Longevity

Melatonin protects against blood-brain barrier damage by inhibiting the TLR4/ NF-κB signaling pathway after LPS treatment in neonatal rats

(2017) Yingying Hu et al.   Oncotarget

Curcumin Ameliorates Diabetic Nephropathy by Suppressing NLRP3 Inflammasome Signaling

(2017) Miaomiao Lu et al.   Biomed Research International

The role of sodium hydrosulfide in attenuating the aging process via PI3K/AKT and CaMKKβ/AMPK pathways

(2017) Xubo Chen et al.   Redox Biology

Hydrogen Sulphide Treatment Increases Insulin Sensitivity and Improves Oxidant Metabolism through the CaMKKbeta-AMPK Pathway in PA-Induced IR C2C12 Cells

(2017) Xubo Chen et al.   Scientific Reports

Effect of zinc supplementation on serum zinc concentration and T cell proliferation in nursing home elderly: a randomized, double-blind, placebo-controlled trial

(2016) Junaidah B Barnett et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

NLRP3 inflammasome signaling is activated by low-level lysosome disruption but inhibited by extensive lysosome disruption: roles for K+ efflux and Ca2+ influx

(2016) Michael A. Katsnelson et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

RORα is not a receptor for melatonin (response to DOI 10.1002/bies.201600018)

(2016) Andrzej T. Slominski et al.   BIOESSAYS

NLRP3 inflammasome as a target of berberine in experimental murine liver injury: interference with P2X7 signalling

(2016) E. Vivoli et al.   CLINICAL SCIENCE

Hydrogen Sulfide Induces Keap1 S-sulfhydration and Suppresses Diabetes-Accelerated Atherosclerosis via Nrf2 Activation

(2016) Liping Xie et al.   DIABETES

Medical Application ofSpirulina platensisDerived C-Phycocyanin

(2016) Qian Liu et al.   Evidence-based Complementary and Alternative Medicine

Angiotensin(1–7) attenuated Angiotensin II-induced hepatocyte EMT by inhibiting NOX-derived H 2 O 2 -activated NLRP3 inflammasome/IL-1β/Smad circuit

(2016) Li-Li Zhang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Taurine Supplementation Lowers Blood Pressure and Improves Vascular Function in Prehypertension

(2016) Qianqian Sun et al.   HYPERTENSION

Inhibitory effects of omega-3 fatty acids on early brain injury after subarachnoid hemorrhage in rats: Possible involvement of G protein-coupled receptor 120/β-arrestin2/TGF-β activated kinase-1 binding protein-1 signaling pathway

(2016) Jia Yin et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Amyloid β induces NLRP3 inflammasome activation in retinal pigment epithelial cells via NADPH oxidase- and mitochondria-dependent ROS production

(2016) Ke Wang et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

Melatonin attenuated early brain injury induced by subarachnoid hemorrhage via regulating NLRP3 inflammasome and apoptosis signaling

(2016) Yushu Dong et al.   JOURNAL OF PINEAL RESEARCH

Melatonin alleviates acute lung injury through inhibiting the NLRP3 inflammasome

(2016) Yong Zhang et al.   JOURNAL OF PINEAL RESEARCH

Palmitic acid induces interleukin-1β secretion via NLRP3 inflammasomes and inflammatory responses through ROS production in human placental cells

(2016) Koumei Shirasuna et al.   JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Targeting inflammatory mediators with ferulic acid, a dietary polyphenol, for the suppression of monosodium urate crystal-induced inflammation in rats

(2016) Hari Madhuri Doss et al.   LIFE SCIENCES

Resveratrol Protects against Sepsis-Associated Encephalopathy and Inhibits the NLRP3/IL-1βAxis in Microglia

(2016) Da-ming Sui et al.   MEDIATORS OF INFLAMMATION

Colchicine to decrease NLRP3-activated inflammation and improve obesity-related metabolic dysregulation

(2016) Andrew P. Demidowich et al.   MEDICAL HYPOTHESES

NEK7 is an essential mediator of NLRP3 activation downstream of potassium efflux

(2016) Yuan He et al.   NATURE

Melatonin in Retinal Physiology and Pathology: The Case of Age-Related Macular Degeneration

(2016) Janusz Blasiak et al.   Oxidative Medicine and Cellular Longevity

Neutrophil P2X7 receptors mediate NLRP3 inflammasome-dependent IL-1β secretion in response to ATP

(2016) Mausita Karmakar et al.   Nature Communications

Cytoprotective mechanism of ferulic acid against high glucose-induced oxidative stress in cardiomyocytes and hepatocytes

(2016) Yuan Song et al.   Food & Nutrition Research

Curcumin Represses NLRP3 Inflammasome Activation via TLR4/MyD88/NF-κB and P2X7R Signaling in PMA-Induced Macrophages

(2016) Fanqi Kong et al.   Frontiers in Pharmacology

Disruption of the NF-κB/NLRP3 connection by melatonin requires retinoid-related orphan receptor-α and blocks the septic response in mice

(2015) José A. García et al.   FASEB JOURNAL

Discovery of novel FFA4 (GPR120) receptor agonists with β-arrestin2-biased characteristics

(2015) Ang Li et al.   Future Medicinal Chemistry

A20 Restricts Ubiquitination of Pro-Interleukin-1β Protein Complexes and Suppresses NLRP3 Inflammasome Activity

(2015) Bao H. Duong et al.   IMMUNITY

Resveratrol inhibits the acetylated α-tubulin-mediated assembly of the NLRP3-inflammasome

(2015) Takuma Misawa et al.   INTERNATIONAL IMMUNOLOGY

Complement Component C5a Primes Retinal Pigment Epithelial Cells for Inflammasome Activation by Lipofuscin-mediated Photooxidative Damage

(2015) Carolina Brandstetter et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Resveratrol inhibits NLRP3 inflammasome activation by preserving mitochondrial integrity and augmenting autophagy

(2015) Ya-Ping Chang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

K+Efflux Agonists Induce NLRP3 Inflammasome Activation Independently of Ca2+Signaling

(2015) Michael A. Katsnelson et al.   JOURNAL OF IMMUNOLOGY

The pathogenic role of the inflammasome in neurodegenerative diseases

(2015) Leslie C. Freeman et al.   JOURNAL OF NEUROCHEMISTRY

P2X7R blockade prevents NLRP3 inflammasome activation and brain injury in a rat model of intracerebral hemorrhage: involvement of peroxynitrite

(2015) Liang Feng et al.   Journal of Neuroinflammation

Maternal high-zinc diet attenuates intestinal inflammation by reducing DNA methylation and elevating H3K9 acetylation in the A20 promoter of offspring chicks

(2015) Changwu Li et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Melatonin: an ancient molecule that makes oxygen metabolically tolerable

(2015) Lucien C. Manchester et al.   JOURNAL OF PINEAL RESEARCH

The Keap1-Nrf2-antioxidant response element pathway: A review of its regulation by melatonin and the proteasome

(2015) Jerry Vriend et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Curcumin suppresses NLRP3 inflammasome activation and protects against LPS-induced septic shock

(2015) Zizhen Gong et al.   MOLECULAR NUTRITION & FOOD RESEARCH

NADPH Oxidase-Dependent NLRP3 Inflammasome Activation and its Important Role in Lung Fibrosis by Multiwalled Carbon Nanotubes

(2015) Bingbing Sun et al.   Small

Cofactor-independent antiphospholipid antibodies activate the NLRP3-inflammasome via endosomal NADPH-oxidase: implications for the antiphospholipid syndrome

(2015) Nadine Müller-Calleja et al.   THROMBOSIS AND HAEMOSTASIS

Homocysteine and the risk of age-related macular degeneration: a systematic review and meta-analysis

(2015) Peirong Huang et al.   Scientific Reports

NADPH Oxidase-Induced NALP3 Inflammasome Activation Is Driven by Thioredoxin-Interacting Protein Which Contributes to Podocyte Injury in Hyperglycemia

(2015) Pan Gao et al.   Journal of Diabetes Research

CaMKKβ-Dependent Activation of AMP-Activated Protein Kinase Is Critical to Suppressive Effects of Hydrogen Sulfide on Neuroinflammation

(2014) Xiaomei Zhou et al.   ANTIOXIDANTS & REDOX SIGNALING

CLOCK/BMAL1 regulates circadian change of mouse hepatic insulin sensitivity by SIRT1

(2014) Ben Zhou et al.   HEPATOLOGY

A Key Role for Redox Signaling in Rapid P2X7 Receptor-Induced IL-1  Processing in Human Monocytes

(2014) J. Hewinson et al.   JOURNAL OF IMMUNOLOGY

New Insights into Acne Pathogenesis: Propionibacterium Acnes Activates the Inflammasome

(2014) Emmanuel Contassot et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Zinc: An antioxidant and anti-inflammatory agent: Role of zinc in degenerative disorders of aging

(2014) Ananda S. Prasad   JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY

Resveratrol ameliorates hepatic metaflammation and inhibits NLRP3 inflammasome activation

(2014) Soo Jin Yang et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Negative regulation of the NLRP3 inflammasome by A20 protects against arthritis

(2014) Lieselotte Vande Walle et al.   NATURE

Structural insight into the molecular mechanism of allosteric activation of human cystathionine β-synthase byS-adenosylmethionine

(2014) June Ereño-Orbea et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DICER1/AluRNA dysmetabolism induces Caspase-8–mediated cell death in age-related macular degeneration

(2014) Younghee Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NLRP3 inflammasome activation by mitochondrial ROS in bronchial epithelial cells is required for allergic inflammation

(2014) S R Kim et al.   Cell Death & Disease

The structural basis for the negative regulation of thioredoxin by thioredoxin-interacting protein

(2014) Jungwon Hwang et al.   Nature Communications

Cytoprotective Effect of Alpha-Lipoic Acid on Paraquat-Exposed Human Bronchial Epithelial Cells via Activation of Nuclear Factor Erythroid Related Factor-2 Pathway

(2013) Yong-Sik Kim et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Protective effect of lipoic acid against oxidative stress is mediated by Keap1/Nrf2-dependent heme oxygenase-1 induction in the RGC-5 cellline

(2013) Yoshiki Koriyama et al.   BRAIN RESEARCH

β-arrestin protects neurons by mediating endogenous opioid arrest of inflammatory microglia

(2013) X Feng et al.   CELL DEATH AND DIFFERENTIATION

Therapeutic Effect of C-Phycocyanin Extracted from Blue Green Algae in a Rat Model of Acute Lung Injury Induced by Lipopolysaccharide

(2013) Pak-on Leung et al.   Evidence-based Complementary and Alternative Medicine

Microtubule-driven spatial arrangement of mitochondria promotes activation of the NLRP3 inflammasome

(2013) Takuma Misawa et al.   NATURE IMMUNOLOGY

Phycocyanin and phycocyanobilin from Spirulina platensis protect against diabetic nephropathy by inhibiting oxidative stress

(2012) Jing Zheng et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Curcumin uptake and metabolism

(2012) Manfred Metzler et al.   BIOFACTORS

DICER1 Loss and Alu RNA Induce Age-Related Macular Degeneration via the NLRP3 Inflammasome and MyD88

(2012) Valeria Tarallo et al.   CELL

Thioredoxin-Interacting Protein Mediates ER Stress-Induced β Cell Death through Initiation of the Inflammasome

(2012) Christine M. Oslowski et al.   Cell Metabolism

Genetic support for the role of the NLRP3 inflammasome in psoriasis susceptibility

(2012) Maria Carlström et al.   EXPERIMENTAL DERMATOLOGY

Oxidative stress activates NLRP3 inflammasomes in ARPE-19 cells—Implications for age-related macular degeneration (AMD)

(2012) Anu Kauppinen et al.   IMMUNOLOGY LETTERS

Melatonin modulates TLR4-mediated inflammatory genes through MyD88- and TRIF-dependent signaling pathways in lipopolysaccharide-stimulated RAW264.7 cells

(2012) Mi-Zhen Xia et al.   JOURNAL OF PINEAL RESEARCH

Melatonin suppresses proinflammatory mediators in lipopolysaccharide-stimulated CRL1999 cells via targeting MAPK, NF-κB, c/EBPβ, and p300 signaling

(2012) Dingbo Shi et al.   JOURNAL OF PINEAL RESEARCH

NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice

(2012) Michael T. Heneka et al.   NATURE

Hydrogen Sulfide Lowers Proliferation and Induces Protective Autophagy in Colon Epithelial Cells

(2012) Ya C. Wu et al.   PLoS One

Bioavailability of resveratrol

(2011) Thomas Walle   Annals of the New York Academy of Sciences

The inflammasome: an integrated view

(2011) Olaf Gross et al.   IMMUNOLOGICAL REVIEWS

Hydrogen Sulfide Inhibits High Glucose-induced Matrix Protein Synthesis by Activating AMP-activated Protein Kinase in Renal Epithelial Cells

(2011) Hak Joo Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Smoking, Dietary Betaine, Methionine, and Vitamin D in Monozygotic Twins with Discordant Macular Degeneration: Epigenetic Implications

(2011) Johanna M. Seddon et al.   OPHTHALMOLOGY

GPR120 Is an Omega-3 Fatty Acid Receptor Mediating Potent Anti-inflammatory and Insulin-Sensitizing Effects

(2010) Da Young Oh et al.   CELL

Glucosamine regulation of LPS-mediated inflammation in human bronchial epithelial cells

(2010) Yuh-Lin Wu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Inhibition of NF- B Signaling by A20 Through Disruption of Ubiquitin Enzyme Complexes

(2010) N. Shembade et al.   SCIENCE

Zn2+ Inhibits Coronavirus and Arterivirus RNA Polymerase Activity In Vitro and Zinc Ionophores Block the Replication of These Viruses in Cell Culture

(2010) Aartjan J. W. te Velthuis et al.   PLoS Pathogens

Nox4 NADPH oxidase mediates oxidative stress and apoptosis caused by TNF-α in cerebral vascular endothelial cells

(2009) Shyamali Basuroy et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

The interleukin 1 inhibitor rilonacept in treatment of chronic gouty arthritis: results of a placebo-controlled, monosequence crossover, non-randomised, single-blind pilot study

(2009) R Terkeltaub et al.   ANNALS OF THE RHEUMATIC DISEASES

Folic Acid, Pyridoxine, and Cyanocobalamin Combination Treatment and Age-Related Macular Degeneration in Women

(2009) William G. Christen et al.   ARCHIVES OF INTERNAL MEDICINE

AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity

(2009) Carles Cantó et al.   NATURE

Thioredoxin-interacting protein links oxidative stress to inflammasome activation

(2009) Rongbin Zhou et al.   NATURE IMMUNOLOGY

Endosomal Nox2 Facilitates Redox-Dependent Induction of NF-κB by TNF-α

(2008) Qiang Li et al.   ANTIOXIDANTS & REDOX SIGNALING

SIRT1 longevity factor suppresses NF-κB -driven immune responses: regulation of aging via NF-κB acetylation?

(2008) Antero Salminen et al.   BIOESSAYS

Unknown

(2008) Ananda Prasad   MOLECULAR MEDICINE

Direct and indirect antioxidant properties of inducers of cytoprotective proteins

(2008) Albena T. Dinkova-Kostova et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Molecular Basis for the Unique Deubiquitinating Activity of the NF-κB Inhibitor A20

(2007) Su-Chang Lin et al.   JOURNAL OF MOLECULAR BIOLOGY