Cathepsin B Is Required for NLRP3 Inflammasome Activation in Macrophages, Through NLRP3 Interaction

HSP70 is a negative regulator of NLRP3 inflammasome activation

(2019) Pierre Martine et al.   Cell Death & Disease

The role of lysosomal cysteine cathepsins in NLRP3 inflammasome activation

(2019) Rhiannon I. Campden et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

A role for cathepsin Z in neuroinflammation provides mechanistic support for an epigenetic risk factor in multiple sclerosis

(2017) Euan R. O. Allan et al.   Journal of Neuroinflammation

Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion

(2015) Wan-ting He et al.   CELL RESEARCH

IL-1β production is dependent on the activation of purinergic receptors and NLRP3 pathway in human macrophages

(2015) Thomas Gicquel et al.   FASEB JOURNAL

IL-1α and inflammasome-independent IL-1β promote neutrophil infiltration following alum vaccination

(2015) Ewa Oleszycka et al.   FEBS Journal

Multiple Cathepsins Promote Pro–IL-1β Synthesis and NLRP3-Mediated IL-1β Activation

(2015) Gregory M. Orlowski et al.   JOURNAL OF IMMUNOLOGY

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE

Inflammasomes: mechanism of action, role in disease and therapeutics

(2015) Haitao Guo et al.   NATURE MEDICINE

Liver X Receptor ligand cytotoxicity in colon cancer cells and not in normal colon epithelial cells depends on LXRβ subcellular localization

(2015) Flavie Courtaut et al.   Oncotarget

Unified Polymerization Mechanism for the Assembly of ASC-Dependent Inflammasomes

(2014) Alvin Lu et al.   CELL

Liver X receptor β activation induces pyroptosis of human and murine colon cancer cells

(2014) V Derangère et al.   CELL DEATH AND DIFFERENTIATION

The NLRP3 inflammasome is released as a particulate danger signal that amplifies the inflammatory response

(2014) Alberto Baroja-Mazo et al.   NATURE IMMUNOLOGY

The adaptor ASC has extracellular and 'prionoid' activities that propagate inflammation

(2014) Bernardo S Franklin et al.   NATURE IMMUNOLOGY

Activation of NLRP3 inflammasome by crystalline structures via cell surface contact

(2014) Aswin Hari et al.   Scientific Reports

The Adaptor MAVS Promotes NLRP3 Mitochondrial Localization and Inflammasome Activation

(2013) Naeha Subramanian et al.   CELL

Microtubule-driven spatial arrangement of mitochondria promotes activation of the NLRP3 inflammasome

(2013) Takuma Misawa et al.   NATURE IMMUNOLOGY

Acute lipopolysaccharide priming boosts inflammasome activation independently of inflammasome sensor induction

(2012) Kate Schroder et al.   IMMUNOBIOLOGY

Non-transcriptional Priming and Deubiquitination Regulate NLRP3 Inflammasome Activation

(2012) Christine Juliana et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Deubiquitination of NLRP3 by BRCC3 Critically Regulates Inflammasome Activity

(2012) Bénédicte F. Py et al.   MOLECULAR CELL

Chemotherapy-triggered cathepsin B release in myeloid-derived suppressor cells activates the Nlrp3 inflammasome and promotes tumor growth

(2012) Mélanie Bruchard et al.   NATURE MEDICINE

ATP release and purinergic signaling: a common pathway for particle-mediated inflammasome activation

(2012) N Riteau et al.   Cell Death & Disease

The Inflammasome NLRs in Immunity, Inflammation, and Associated Diseases

(2011) Beckley K. Davis et al.   Annual Review of Immunology

Cysteine cathepsins: From structure, function and regulation to new frontiers

(2011) Vito Turk et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Fine-tuning nucleophosmin in macrophage differentiation and activation

(2011) L. Guery et al.   BLOOD

Sensing damage by the NLRP3 inflammasome

(2011) Jaklien C. Leemans et al.   IMMUNOLOGICAL REVIEWS

Molecular Mechanism of NLRP3 Inflammasome Activation

(2010) Chengcheng Jin et al.   JOURNAL OF CLINICAL IMMUNOLOGY

A role for mitochondria in NLRP3 inflammasome activation

(2010) Rongbin Zhou et al.   NATURE

NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

(2010) Peter Duewell et al.   NATURE

Cholesterol Crystals Activate the NLRP3 Inflammasome in Human Macrophages: A Novel Link between Cholesterol Metabolism and Inflammation

(2010) Kristiina Rajamäki et al.   PLoS One

Cutting Edge: NF- B Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression

(2009) F. G. Bauernfeind et al.   JOURNAL OF IMMUNOLOGY

Thioredoxin-interacting protein links oxidative stress to inflammasome activation

(2009) Rongbin Zhou et al.   NATURE IMMUNOLOGY

Malarial Hemozoin Is a Nalp3 Inflammasome Activating Danger Signal

(2009) Catherine Dostert et al.   PLoS One

Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

(2008) Veit Hornung et al.   NATURE IMMUNOLOGY