The Roles of the NLRP3 Inflammasome in Neurodegenerative and Metabolic Diseases and in Relevant Advanced Therapeutic Interventions

MoDeSuS: A Machine Learning Tool for Selection of Molecular Descriptors in QSAR Studies Applied to Molecular Informatics

(2019) María Jimena Martínez et al.   Biomed Research International

Recent advances in the mechanisms of NLRP3 inflammasome activation and its inhibitors

(2019) Yang Yang et al.   Cell Death & Disease

Convolutional neural network for cell classification using microscope images of intracellular actin networks

(2019) Ronald Wihal Oei et al.   PLoS One

Accurate Prediction of Biological Assays with High-Throughput Microscopy Images and Convolutional Networks

(2019) Markus Hofmarcher et al.   Journal of Chemical Information and Modeling

Predicting the cytotoxicity of chemicals using ensemble learning methods and molecular fingerprints

(2019) Zimo Yin et al.   JOURNAL OF APPLIED TOXICOLOGY

Islet inflammation in type 2 diabetes

(2019) Marianne Böni-Schnetzler et al.   Seminars in Immunopathology

NLRP3 inflammasome

(2019) Marina Sokolova et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

NLRP3 Inflammasome Promotes Myocardial Remodeling During Diet-Induced Obesity

(2019) Marina Sokolova et al.   Frontiers in Immunology

Neuroinflammation in Alzheimer’s Disease: Microglia, Molecular Participants and Therapeutic Choices

(2019) Haijun Wang et al.   Current Alzheimer Research

Amyloid-beta impairs TOM1-mediated IL-1R1 signaling

(2019) Alessandra Cadete Martini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Trends in incidence of total or type 2 diabetes: systematic review

(2019) Dianna J Magliano et al.   BMJ-British Medical Journal

Identification of novel CDK2 inhibitors by a multistage virtual screening method based on SVM, pharmacophore and docking model

(2019) Jing-Wei Liang et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Advanced Glycation End Products Modulate Amyloidogenic APP Processing and Tau Phosphorylation: A Mechanistic Link between Glycation and the Development of Alzheimer’s Disease

(2018) Kedar Batkulwar et al.   ACS Chemical Neuroscience

Quantum Machine Learning in Chemical Compound Space

(2018) O. Anatole von Lilienfeld   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Adipokines and inflammation: is it a question of weight?

(2018) Vera Francisco et al.   BRITISH JOURNAL OF PHARMACOLOGY

The NLRP3 inflammasome: Role in metabolic disorders and regulation by metabolic pathways

(2018) Danlu Jiang et al.   CANCER LETTERS

Gain of function mutation and inflammasome driven diseases in human and mouse models

(2018) Mario D. Cordero et al.   JOURNAL OF AUTOIMMUNITY

Opportunities and obstacles for deep learning in biology and medicine

(2018) Travers Ching et al.   Journal of the Royal Society Interface

Role of Inflammasomes in Neuroimmune and Neurodegenerative Diseases: A Systematic Review

(2018) Yue Lang et al.   MEDIATORS OF INFLAMMATION

NLRP1 and NLRP3 inflammasomes mediate LPS/ATP‑induced pyroptosis in knee osteoarthritis

(2018) Ling‑Rui Zhao et al.   Molecular Medicine Reports

Targeting the NLRP3 inflammasome in inflammatory diseases

(2018) Matthew S. J. Mangan et al.   NATURE REVIEWS DRUG DISCOVERY

Obesity, Inflammation, Toll-Like Receptor 4 and Fatty Acids

(2018) Marcelo Rogero et al.   Nutrients

A role for tau in learning, memory and synaptic plasticity

(2018) Fabrizio Biundo et al.   Scientific Reports

DPubChem: a web tool for QSAR modeling and high-throughput virtual screening

(2018) Othman Soufan et al.   Scientific Reports

Representability of algebraic topology for biomolecules in machine learning based scoring and virtual screening

(2018) Zixuan Cang et al.   PLoS Computational Biology

Intelligent Image-Activated Cell Sorting

(2018) Nao Nitta et al.   CELL

Deep reinforcement learning for de novo drug design

(2018) Mariya Popova et al.   Science Advances

Machine Learning-based Virtual Screening and Its Applications to Alzheimer’s Drug Discovery: A Review

(2018) Kristy A. Carpenter et al.   CURRENT PHARMACEUTICAL DESIGN

Less Exploited GPCRs in Precision Medicine: Targets for Molecular Imaging and Theranostics

(2018) João Franco Machado et al.   MOLECULES

T Cells in Adipose Tissue: Critical Players in Immunometabolism

(2018) Qun Wang et al.   Frontiers in Immunology

Advances in omics for informed pharmaceutical research and development in the era of systems medicine

(2017) Jane P. F. Bai et al.   Expert Opinion on Drug Discovery

Mechanisms governing inflammasome activation, assembly and pyroptosis induction

(2017) Sannula Kesavardhana et al.   INTERNATIONAL IMMUNOLOGY

Identification of a selective and direct NLRP3 inhibitor to treat inflammatory disorders

(2017) Hua Jiang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Myeloid-derived miR-223 regulates intestinal inflammation via repression of the NLRP3 inflammasome

(2017) Viola Neudecker et al.   JOURNAL OF EXPERIMENTAL MEDICINE

NLRP3 inflammasome assembly is regulated by phosphorylation of the pyrin domain

(2017) Andrea Stutz et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Multiple machine learning based descriptive and predictive workflow for the identification of potential PTP1B inhibitors

(2017) Sharat Chandra et al.   JOURNAL OF MOLECULAR GRAPHICS & MODELLING

Macrophage functions in lean and obese adipose tissue

(2017) Dylan Thomas et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Current role of the NLRP3 inflammasome on obesity and insulin resistance: A systematic review

(2017) Jakeline Rheinheimer et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

MicroRNA‑33 regulates the NLRP3 inflammasome signaling pathway in macrophages

(2017) Qingyun Xie et al.   Molecular Medicine Reports

NLRP3 Inflammasome Inhibitor Ameliorates Amyloid Pathology in a Mouse Model of Alzheimer’s Disease

(2017) Jun Yin et al.   MOLECULAR NEUROBIOLOGY

Microglia-derived ASC specks cross-seed amyloid-β in Alzheimer’s disease

(2017) Carmen Venegas et al.   NATURE

Amelioration of amyloid β-induced retinal inflammatory responses by a LXR agonist TO901317 is associated with inhibition of the NF-κB signaling and NLRP3 inflammasome

(2017) Chunyan Lei et al.   NEUROSCIENCE

Pyroptosis: Gasdermin-Mediated Programmed Necrotic Cell Death

(2017) Jianjin Shi et al.   TRENDS IN BIOCHEMICAL SCIENCES

Inflammasome Priming in Sterile Inflammatory Disease

(2017) Meghana N. Patel et al.   TRENDS IN MOLECULAR MEDICINE

Designing of dual inhibitors for GSK-3β and CDK5: Virtual screening and in vitro biological activities study

(2017) Hongbo Xie et al.   Oncotarget

Inhibition of Miro1 disturbs mitophagy and pancreatic β-cell function interfering insulin release via IRS-Akt-Foxo1 in diabetes

(2017) Lingling Chen et al.   Oncotarget

Late-Onset Cryopyrin-Associated Periodic Syndromes Caused by Somatic NLRP3 Mosaicism—UK Single Center Experience

(2017) Dorota M. Rowczenio et al.   Frontiers in Immunology

Prediction of Organic Reaction Outcomes Using Machine Learning

(2017) Connor W. Coley et al.   ACS Central Science

Optimizing Chemical Reactions with Deep Reinforcement Learning

(2017) Zhenpeng Zhou et al.   ACS Central Science

Inflammasome Complexes: Emerging Mechanisms and Effector Functions

(2016) Vijay A.K. Rathinam et al.   CELL

AutoQSAR: an automated machine learning tool for best-practice quantitative structure–activity relationship modeling

(2016) Steven L Dixon et al.   Future Medicinal Chemistry

Bile Acids Control Inflammation and Metabolic Disorder through Inhibition of NLRP3 Inflammasome

(2016) Chuansheng Guo et al.   IMMUNITY

NLRP3 tyrosine phosphorylation is controlled by protein tyrosine phosphatase PTPN22

(2016) Marianne R. Spalinger et al.   JOURNAL OF CLINICAL INVESTIGATION

Pore-forming activity and structural autoinhibition of the gasdermin family

(2016) Jingjin Ding et al.   NATURE

NEK7 is an essential mediator of NLRP3 activation downstream of potassium efflux

(2016) Yuan He et al.   NATURE

Mechanisms of Aβ Clearance and Degradation by Glial Cells

(2016) Miriam Ries et al.   Frontiers in Aging Neuroscience

Expression of NLRP3 in subcutaneous adipose tissue is associated with coronary atherosclerosis

(2015) Sachiko Bando et al.   ATHEROSCLEROSIS

A Role of the Inflammasome in the Low Storage Capacity of the Abdominal Subcutaneous Adipose Tissue in Obese Adolescents

(2015) Romy Kursawe et al.   DIABETES

Miro1-mediated mitochondrial dysfunction under high nutrient stress is linked to NOD-like receptor 3 (NLRP3)-dependent inflammatory responses in rat pancreatic beta cells

(2015) Jianfeng Gao et al.   FREE RADICAL BIOLOGY AND MEDICINE

The inflammasome: firing up innate immunity

(2015) Thirumala-Devi Kanneganti   IMMUNOLOGICAL REVIEWS

Comparative Modeling and Benchmarking Data Sets for Human Histone Deacetylases and Sirtuin Families

(2015) Jie Xia et al.   Journal of Chemical Information and Modeling

The pathogenic role of the inflammasome in neurodegenerative diseases

(2015) Leslie C. Freeman et al.   JOURNAL OF NEUROCHEMISTRY

Predicting selective liver X receptor β agonists using multiple machine learning methods

(2015) Yali Li et al.   Molecular BioSystems

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE

The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome–mediated inflammatory disease

(2015) Yun-Hee Youm et al.   NATURE MEDICINE

A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases

(2015) Rebecca C Coll et al.   NATURE MEDICINE

Effect of Roux-en-Y Gastric Bypass on the NLRP3 Inflammasome in Adipose Tissue from Obese Rats

(2015) Andreea Oana Mocanu et al.   PLoS One

MLViS: A Web Tool for Machine Learning-Based Virtual Screening in Early-Phase of Drug Discovery and Development

(2015) Selcuk Korkmaz et al.   PLoS One

Apelin inhibits the activation of the nucleotide-binding domain and the leucine-rich, repeat-containing family, pyrin-containing 3 (NLRP3) inflammasome and ameliorates insulin resistance in severely burned rats

(2015) Yunfei Chi et al.   SURGERY

Sodium butyrate alleviates adipocyte inflammation by inhibiting NLRP3 pathway

(2015) Xukai Wang et al.   Scientific Reports

Mechanisms and Functions of Inflammasomes

(2014) Mohamed Lamkanfi et al.   CELL

Adipose Tissue Macrophages Promote Myelopoiesis and Monocytosis in Obesity

(2014) Prabhakara R. Nagareddy et al.   Cell Metabolism

Mitochondrial response to nutrient availability and its role in metabolic disease

(2014) A. W. Gao et al.   EMBO Molecular Medicine

Pannexin-1-Mediated Intracellular Delivery of Muramyl Dipeptide Induces Caspase-1 Activation via Cryopyrin/NLRP3 Independently of Nod2

(2014) N. Marina-Garcia et al.   JOURNAL OF IMMUNOLOGY

Cytosolic Double-Stranded RNA Activates the NLRP3 Inflammasome via MAVS-Induced Membrane Permeabilization and K+Efflux

(2014) Luigi Franchi et al.   JOURNAL OF IMMUNOLOGY

Isoliquiritigenin is a potent inhibitor of NLRP3 inflammasome activation and diet-induced adipose tissue inflammation

(2014) Hiroe Honda et al.   JOURNAL OF LEUKOCYTE BIOLOGY

NRLiSt BDB, the Manually Curated Nuclear Receptors Ligands and Structures Benchmarking Database

(2014) Nathalie Lagarde et al.   JOURNAL OF MEDICINAL CHEMISTRY

Transcriptome analysis of human adipocytes implicates the NOD-like receptor pathway in obesity-induced adipose inflammation

(2014) Zheng Yin et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

The NLRP3 inflammasome is released as a particulate danger signal that amplifies the inflammatory response

(2014) Alberto Baroja-Mazo et al.   NATURE IMMUNOLOGY

Oridonin Attenuates Aβ1–42-Induced Neuroinflammation and Inhibits NF-κB Pathway

(2014) Sulei Wang et al.   PLoS One

Thioredoxin/Txnip: Redoxisome, as a Redox Switch for the Pathogenesis of Diseases

(2014) Eiji Yoshihara et al.   Frontiers in Immunology

Inflammasomes and Metabolic Disease

(2013) Jorge Henao-Mejia et al.   Annual Review of Physiology

Obesity phenotype is related to NLRP3 inflammasome activity and immunological profile of visceral adipose tissue

(2013) Nathalie Esser et al.   DIABETOLOGIA

Evaluation and Optimization of Virtual Screening Workflows with DEKOIS 2.0 – A Public Library of Challenging Docking Benchmark Sets

(2013) Matthias R. Bauer et al.   Journal of Chemical Information and Modeling

CD36 coordinates NLRP3 inflammasome activation by facilitating intracellular nucleation of soluble ligands into particulate ligands in sterile inflammation

(2013) Frederick J Sheedy et al.   NATURE IMMUNOLOGY

Inflammasomes and Their Roles in Health and Disease

(2012) Mohamed Lamkanfi et al.   Annual Review of Cell and Developmental Biology

Recognition of Bacteria by Inflammasomes

(2012) Jakob von Moltke et al.   Annual Review of Immunology

The Classification of Microglial Activation Phenotypes on Neurodegeneration and Regeneration in Alzheimer’s Disease Brain

(2012) Megan M. Varnum et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

DoGSiteScorer: a web server for automatic binding site prediction, analysis and druggability assessment

(2012) A. Volkamer et al.   BIOINFORMATICS

The Inflammasome Puts Obesity in the Danger Zone

(2012) Rinke Stienstra et al.   Cell Metabolism

Effect of anti-IL-1β antibody (canakinumab) on insulin secretion rates in impaired glucose tolerance or type 2 diabetes: results of a randomized, placebo-controlled trial

(2012) A. Rissanen et al.   DIABETES OBESITY & METABOLISM

Oxidized Mitochondrial DNA Activates the NLRP3 Inflammasome during Apoptosis

(2012) Kenichi Shimada et al.   IMMUNITY

Non-transcriptional Priming and Deubiquitination Regulate NLRP3 Inflammasome Activation

(2012) Christine Juliana et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Directory of Useful Decoys, Enhanced (DUD-E): Better Ligands and Decoys for Better Benchmarking

(2012) Michael M. Mysinger et al.   JOURNAL OF MEDICINAL CHEMISTRY

Novel crosstalk between ERK MAPK and p38 MAPK leads to homocysteine-NMDA receptor-mediated neuronal cell death

(2012) Ranjana Poddar et al.   JOURNAL OF NEUROCHEMISTRY

Deubiquitination of NLRP3 by BRCC3 Critically Regulates Inflammasome Activity

(2012) Bénédicte F. Py et al.   MOLECULAR CELL

Inflammasomes in health and disease

(2012) Till Strowig et al.   NATURE

NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice

(2012) Michael T. Heneka et al.   NATURE

Immunological complications of obesity

(2012) Thirumala-Devi Kanneganti et al.   NATURE IMMUNOLOGY

Neutrophils mediate insulin resistance in mice fed a high-fat diet through secreted elastase

(2012) Saswata Talukdar et al.   NATURE MEDICINE

Extracellular Ca2+ is a danger signal activating the NLRP3 inflammasome through G protein-coupled calcium sensing receptors

(2012) Manuela Rossol et al.   Nature Communications

Lack of Interleukin-1 Receptor I (IL-1RI) Protects Mice From High-Fat Diet-Induced Adipose Tissue Inflammation Coincident With Improved Glucose Homeostasis

(2011) F. C. McGillicuddy et al.   DIABETES

NNScore 2.0: A Neural-Network Receptor–Ligand Scoring Function

(2011) Jacob D. Durrant et al.   Journal of Chemical Information and Modeling

Obesity and Type 2 Diabetes: What Can Be Unified and What Needs to Be Individualized?

(2011) Robert H. Eckel et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Cutting Edge: Reactive Oxygen Species Inhibitors Block Priming, but Not Activation, of the NLRP3 Inflammasome

(2011) F. Bauernfeind et al.   JOURNAL OF IMMUNOLOGY

Blocking IL-1 Signaling Rescues Cognition, Attenuates Tau Pathology, and Restores Neuronal  -Catenin Pathway Function in an Alzheimer's Disease Model

(2011) M. Kitazawa et al.   JOURNAL OF IMMUNOLOGY

An active role for machine learning in drug development

(2011) Robert F Murphy   Nature Chemical Biology

Fatty acid–induced NLRP3-ASC inflammasome activation interferes with insulin signaling

(2011) Haitao Wen et al.   NATURE IMMUNOLOGY

The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance

(2011) Bolormaa Vandanmagsar et al.   NATURE MEDICINE

Heterogeneity of CNS myeloid cells and their roles in neurodegeneration

(2011) Marco Prinz et al.   NATURE NEUROSCIENCE

ChEMBL: a large-scale bioactivity database for drug discovery

(2011) A. Gaulton et al.   NUCLEIC ACIDS RESEARCH

Inflammasome is a central player in the induction of obesity and insulin resistance

(2011) R. Stienstra et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of IL-1β in type 2 diabetes

(2011) Charles A Dinarello et al.   Current Opinion in Endocrinology Diabetes and Obesity

Diabetes mellitus and Alzheimer's disease: shared pathology and treatment?

(2010) Kawser Akter et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Mechanisms Underlying Inflammation in Neurodegeneration

(2010) Christopher K. Glass et al.   CELL

Pattern Recognition Receptors and Inflammation

(2010) Osamu Takeuchi et al.   CELL

Critical functions of priming and lysosomal damage for NLRP3 activation

(2010) Veit Hornung et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Ranking Chemical Structures for Drug Discovery: A New Machine Learning Approach

(2010) Shivani Agarwal et al.   Journal of Chemical Information and Modeling

StructRank: A New Approach for Ligand-Based Virtual Screening

(2010) Fabian Rathke et al.   Journal of Chemical Information and Modeling

Molecular Mechanism of NLRP3 Inflammasome Activation

(2010) Chengcheng Jin et al.   JOURNAL OF CLINICAL IMMUNOLOGY

A role for mitochondria in NLRP3 inflammasome activation

(2010) Rongbin Zhou et al.   NATURE

Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes

(2010) Seth L Masters et al.   NATURE IMMUNOLOGY

Neuroimmunomodulation in the Pathogenesis of Alzheimer’s Disease

(2010) Inelia Morales et al.   NEUROIMMUNOMODULATION

In-Silico Approaches to Multi-target Drug Discovery

(2010) Xiao Hua Ma et al.   PHARMACEUTICAL RESEARCH

Diabetes-accelerated memory dysfunction via cerebrovascular inflammation and A  deposition in an Alzheimer mouse model with diabetes

(2010) S. Takeda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The NLRP3 Inflammasome: A Sensor for Metabolic Danger?

(2010) K. Schroder et al.   SCIENCE

Toll-like receptors: linking inflammation to metabolism

(2010) A. Christine Könner et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

The Role of Neuroimmunomodulation in Alzheimer's Disease

(2009) Ricardo B. Maccioni et al.   Annals of the New York Academy of Sciences

Type 1 diabetes exaggerates features of Alzheimer's disease in APP transgenic mice

(2009) Corinne G. Jolivalt et al.   EXPERIMENTAL NEUROLOGY

Searching for Target-Selective Compounds Using Different Combinations of Multiclass Support Vector Machine Ranking Methods, Kernel Functions, and Fingerprint Descriptors

(2009) Anne Mai Wassermann et al.   Journal of Chemical Information and Modeling

Thioredoxin-interacting protein links oxidative stress to inflammasome activation

(2009) Rongbin Zhou et al.   NATURE IMMUNOLOGY

CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity

(2009) Satoshi Nishimura et al.   NATURE MEDICINE

Molecular mechanisms involved in inflammasome activation

(2009) Clare Bryant et al.   TRENDS IN CELL BIOLOGY

Predicting small ligand binding sites in proteins using backbone structure

(2008) Andrew J. Bordner   BIOINFORMATICS

Inhibition of toll-like receptor 2 expression improves insulin sensitivity and signaling in muscle and white adipose tissue of mice fed a high-fat diet

(2008) Andréa M Caricilli et al.   JOURNAL OF ENDOCRINOLOGY

Microglial Dysfunction and Defective  -Amyloid Clearance Pathways in Aging Alzheimer's Disease Mice

(2008) S. E. Hickman et al.   JOURNAL OF NEUROSCIENCE

Rapid appearance and local toxicity of amyloid-β plaques in a mouse model of Alzheimer’s disease

(2008) Melanie Meyer-Luehmann et al.   NATURE

The NALP3 inflammasome is involved in the innate immune response to amyloid-β

(2008) Annett Halle et al.   NATURE IMMUNOLOGY

Expression of interleukin-18 is increased in the brains of Alzheimer's disease patients

(2007) Johanna Ojala et al.   NEUROBIOLOGY OF AGING