Melatonin alleviates cadmium-induced liver injury by inhibiting the TXNIP-NLRP3 inflammasome

Innate Immunity and Inflammation in NAFLD/NASH

(2016) Marco Arrese et al.   DIGESTIVE DISEASES AND SCIENCES

Interleukin-1 and inflammasomes in alcoholic liver disease/acute alcoholic hepatitis and nonalcoholic fatty liver disease/nonalcoholic steatohepatitis

(2016) Herbert Tilg et al.   HEPATOLOGY

Melatonin enhances mitophagy and mitochondrial biogenesis in rats with carbon tetrachloride-induced liver fibrosis

(2016) Jung-Woo Kang et al.   JOURNAL OF PINEAL RESEARCH

Melatonin attenuated early brain injury induced by subarachnoid hemorrhage via regulating NLRP3 inflammasome and apoptosis signaling

(2016) Yushu Dong et al.   JOURNAL OF PINEAL RESEARCH

Melatonin as an antioxidant: under promises but over delivers

(2016) Russel J. Reiter et al.   JOURNAL OF PINEAL RESEARCH

On the significance of an alternate pathway of melatonin synthesis via 5-methoxytryptamine: comparisons across species

(2016) Dun-Xian Tan et al.   JOURNAL OF PINEAL RESEARCH

Melatonin alleviates acute lung injury through inhibiting the NLRP3 inflammasome

(2016) Yong Zhang et al.   JOURNAL OF PINEAL RESEARCH

Melatonin’s role in preventing toxin-related and sepsis-mediated hepatic damage: A review

(2016) Eduardo Esteban-Zubero et al.   PHARMACOLOGICAL RESEARCH

Cadmium induces NLRP3 inflammasome-dependent pyroptosis in vascular endothelial cells

(2016) Haiyan Chen et al.   TOXICOLOGY LETTERS

New insights into salvianolic acid A action: Regulation of the TXNIP/NLRP3 and TXNIP/ChREBP pathways ameliorates HFD-induced NAFLD in rats

(2016) Chunchun Ding et al.   Scientific Reports

Reactive Oxygen Species-Induced TXNIP Drives Fructose-Mediated Hepatic Inflammation and Lipid Accumulation Through NLRP3 Inflammasome Activation

(2015) Xian Zhang et al.   ANTIOXIDANTS & REDOX SIGNALING

Hepatic oxidative stress and inflammatory responses with cadmium exposure in male mice

(2015) Ling Liu et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Disruption of the NF-κB/NLRP3 connection by melatonin requires retinoid-related orphan receptor-α and blocks the septic response in mice

(2015) José A. García et al.   FASEB JOURNAL

Insight into the oxidative stress induced by lead and/or cadmium in blood, liver and kidneys

(2015) Vesna Matović et al.   FOOD AND CHEMICAL TOXICOLOGY

Endoplasmic Reticulum Stress Activates the Inflammasome via NLRP3- and Caspase-2-Driven Mitochondrial Damage

(2015) Denise N. Bronner et al.   IMMUNITY

Thioredoxin-Interacting Protein Deficiency Protects against Diabetic Nephropathy

(2015) A. Shah et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Protective effects of selenium against cadmium induced hematological disturbances, immunosuppressive, oxidative stress and hepatorenal damage in rats

(2015) Mohamed E. El-Boshy et al.   JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY

A REDD1/TXNIP pro-oxidant complex regulates ATG4B activity to control stress-induced autophagy and sustain exercise capacity

(2015) Shuxi Qiao et al.   Nature Communications

Mechanisms and Functions of Inflammasomes

(2014) Mohamed Lamkanfi et al.   CELL

Thioredoxin-interacting protein mediates hepatic lipogenesis and inflammation via PRMT1 and PGC-1α regulation in vitro and in vivo

(2014) Min-Jung Park et al.   JOURNAL OF HEPATOLOGY

Melatonin blunts the mitochondrial/NLRP3 connection and protects against radiation-induced oral mucositis

(2014) Francisco Ortiz et al.   JOURNAL OF PINEAL RESEARCH

A review of metal-catalyzed molecular damage: protection by melatonin

(2014) Alejandro Romero et al.   JOURNAL OF PINEAL RESEARCH

Melatonin alleviatesEchis carinatusvenom-induced toxicities by modulating inflammatory mediators and oxidative stress

(2014) G. D. Katkar et al.   JOURNAL OF PINEAL RESEARCH

China Gets Serious About Its Pollutant-Laden Soil

(2014) C. Larson   SCIENCE

NLRP3 inflammasome activation in d-galactosamine and lipopolysaccharide-induced acute liver failure: Role of heme oxygenase-1

(2013) Seok-Joo Kim et al.   FREE RADICAL BIOLOGY AND MEDICINE

NLRP3 inflammasome activation results in hepatocyte pyroptosis, liver inflammation, and fibrosis in mice

(2013) Alexander Wree et al.   HEPATOLOGY

Cadmium Exposure and Liver Disease among US Adults

(2013) Omar Hyder et al.   JOURNAL OF GASTROINTESTINAL SURGERY

Histones Activate the NLRP3 Inflammasome in Kupffer Cells during Sterile Inflammatory Liver Injury

(2013) H. Huang et al.   JOURNAL OF IMMUNOLOGY

The liver in itai-itai disease (chronic cadmium poisoning): pathological features and metallothionein expression

(2013) Hayato Baba et al.   MODERN PATHOLOGY

Cadmium induced Drp1-dependent mitochondrial fragmentation by disturbing calcium homeostasis in its hepatotoxicity

(2013) S Xu et al.   Cell Death & Disease

Thioredoxin-Interacting Protein Mediates ER Stress-Induced β Cell Death through Initiation of the Inflammasome

(2012) Christine M. Oslowski et al.   Cell Metabolism

Oxidant stress, mitochondria, and cell death mechanisms in drug-induced liver injury: Lessons learned from acetaminophen hepatotoxicity

(2012) Hartmut Jaeschke et al.   DRUG METABOLISM REVIEWS

Inflammasomes in liver diseases

(2012) Gyongyi Szabo et al.   JOURNAL OF HEPATOLOGY

Melatonin attenuates inflammation and promotes regeneration in rabbits with fulminant hepatitis of viral origin

(2012) Almudena Laliena et al.   JOURNAL OF PINEAL RESEARCH

Melatonin prevents hemorrhagic shock-induced liver injury in rats through an Akt-dependent HO-1 pathway

(2012) Jun-Te Hsu et al.   JOURNAL OF PINEAL RESEARCH

Caspase-1-mediated regulation of fibrogenesis in diet-induced steatohepatitis

(2012) Laura J Dixon et al.   LABORATORY INVESTIGATION

Roles of thioredoxin binding protein (TXNIP) in oxidative stress, apoptosis and cancer

(2012) Jianbiao Zhou et al.   MITOCHONDRION

Melatonin protects liver against ischemia and reperfusion injury through inhibition of toll-like receptor signaling pathway

(2011) Jung-Woo Kang et al.   JOURNAL OF PINEAL RESEARCH

Melatonin alleviates lipopolysaccharide-induced hepatic SREBP-1c activation and lipid accumulation in mice

(2011) Xi Chen et al.   JOURNAL OF PINEAL RESEARCH

Cadmium and transport of ions and substances across cell membranes and epithelia

(2010) Emmy Van Kerkhove et al.   BIOMETALS

Preventive effect of phytoglycoprotein (27 kDa) on inflammatory factors at liver injury in cadmium chloride-exposed ICR mice

(2010) Jin Lee et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Transport pathways for cadmium in the intestine and kidney proximal tubule: Focus on the interaction with essential metals

(2010) David A. Vesey   TOXICOLOGY LETTERS

Gender Differences in Acute Cadmium-Induced Systemi Inflammation in Rats

(2009) Milena KATARANOVSKI et al.   BIOMEDICAL AND ENVIRONMENTAL SCIENCES

Cadmium, Environmental Exposure, and Health Outcomes

(2009) Soisungwan Satarug et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Thioredoxin-interacting protein links oxidative stress to inflammasome activation

(2009) Rongbin Zhou et al.   NATURE IMMUNOLOGY

Current status of cadmium as an environmental health problem

(2009) Lars Järup et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Mechanisms of cadmium carcinogenesis☆

(2009) Pius Joseph   TOXICOLOGY AND APPLIED PHARMACOLOGY