Clock Protein Bmal1 and Nrf2 Cooperatively Control Aging or Oxidative Response and Redox Homeostasis by Regulating Rhythmic Expression of Prdx6

Association between circadian rhythms and neurodegenerative diseases

(2019) Yue Leng et al.   LANCET NEUROLOGY

BMAL1 controls glucose uptake through paired-homeodomain transcription factor 4 in differentiated Caco-2 cells

(2019) Whitney Sussman et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

BMAL1-Driven Tissue Clocks Respond Independently to Light to Maintain Homeostasis

(2019) Patrick-Simon Welz et al.   CELL

Resveratrol Prevents Acrylamide-Induced Mitochondrial Dysfunction and Inflammatory Responses via Targeting Circadian Regulator Bmal1 and Cry1 in Hepatocytes

(2019) Xintong Tan et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Molecular Mechanism of Cellular Oxidative Stress Sensing by Keap1

(2019) Takafumi Suzuki et al.   Cell Reports

Sulforaphane-Induced Klf9/Prdx6 Axis Acts as a Molecular Switch to Control Redox Signaling and Determines Fate of Cells

(2019) Bhavana Chhunchha et al.   Cells

Diurnal oscillations of endogenous H2O2 sustained by p66Shc regulate circadian clocks

(2019) Jian-Fei Pei et al.   NATURE CELL BIOLOGY

Hydrogen peroxide modulates clock gene expression via PRX2-STAT3-REV-ERBα/β pathway

(2019) Guohua Ji et al.   FREE RADICAL BIOLOGY AND MEDICINE

Untimely oxidative stress in β-cells leads to diabetes – Role of circadian clock in β-cell function

(2018) J. Lee et al.   FREE RADICAL BIOLOGY AND MEDICINE

The phospholipase A2activity of peroxiredoxin 6

(2018) Aron B. Fisher   JOURNAL OF LIPID RESEARCH

Disruption of the Circadian Clock Alters Antioxidative Defense via the SIRT1-BMAL1 Pathway in 6-OHDA-Induced Models of Parkinson’s Disease

(2018) Yali Wang et al.   Oxidative Medicine and Cellular Longevity

NRF2 regulates core and stabilizing circadian clock loops, coupling redox and timekeeping in Mus musculus

(2018) Ryan S Wible et al.   eLife

Antioxidant response elements: Discovery, classes, regulation and potential applications

(2018) Azhwar Raghunath et al.   Redox Biology

Sumoylation-deficient Prdx6 repairs aberrant Sumoylation-mediated Sp1 dysregulation-dependent Prdx6 repression and cell injury in aging and oxidative stress

(2018) Bhavana Chhunchha et al.   Aging-US

Circadian clock protein BMAL1 regulates IL-1β in macrophages via NRF2

(2018) James O. Early et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tea polyphenols direct Bmal1-driven ameliorating of the redox imbalance and mitochondrial dysfunction in hepatocytes

(2018) Guoyuan Qi et al.   FOOD AND CHEMICAL TOXICOLOGY

Ginkgolic Acid Rescues Lens Epithelial Cells from Injury Caused by Redox Regulated-Aberrant Sumoylation Signaling by Reviving Prdx6 and Sp1 Expression and Activities

(2018) Bhavana Chhunchha et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The aging clock: circadian rhythms and later life

(2017) Suzanne Hood et al.   JOURNAL OF CLINICAL INVESTIGATION

Sulforaphane reactivates cellular antioxidant defense by inducing Nrf2/ARE/Prdx6 activity during aging and oxidative stress

(2017) Eri Kubo et al.   Scientific Reports

Delivery of a protein transduction domain-mediated Prdx6 protein ameliorates oxidative stress-induced injury in human and mouse neuronal cells

(2016) Shatrunjai P. Singh et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Antioxidant N-acetyl-L-cysteine ameliorates symptoms of premature aging associated with the deficiency of the circadian protein BMAL1

(2016) Roman V. Kondratov et al.   Aging-US

Circadian clock-coordinated hepatic lipid metabolism: only transcriptional regulation?

(2016) Frédéric Gachon et al.   Aging-US

Deficiency of circadian protein CLOCK reduces lifespan and increases age-related cataract development in mice

(2016) Yuliya V. Dubrovsky et al.   Aging-US

Nrf2 reduces allergic asthma in mice through enhanced airway epithelial cytoprotective function

(2015) Thomas E. Sussan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

The antioxidative potential of farrerol occurs via the activation of Nrf2 mediated HO-1 signaling in RAW 264.7 cells

(2015) Xinxin Ci et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Characterizations of Three Major Cysteine Sensors of Keap1 in Stress Response

(2015) Ryota Saito et al.   MOLECULAR AND CELLULAR BIOLOGY

Nrf2 Signaling and the Slowed Aging Phenotype: Evidence from Long-Lived Models

(2015) Danielle R. Bruns et al.   Oxidative Medicine and Cellular Longevity

Imaging of Intracellular and Extracellular ROS Levels in Atherosclerotic Mouse Aortas Ex Vivo: Effects of Lipid Lowering by Diet or Atorvastatin

(2015) Matias Ekstrand et al.   PLoS One

Aberrant sumoylation signaling evoked by reactive oxygen species impairs protective function of Prdx6 by destabilization and repression of its transcription

(2014) Bhavana Chhunchha et al.   FEBS Journal

The circadian clock regulates rhythmic activation of the NRF2/glutathione-mediated antioxidant defense pathway to modulate pulmonary fibrosis

(2014) V. Pekovic-Vaughan et al.   GENES & DEVELOPMENT

Nrf2 Amplifies Oxidative Stress via Induction of Klf9

(2014) Shoshanna N. Zucker et al.   MOLECULAR CELL

Cellular mechanisms and physiological consequences of redox-dependent signalling

(2014) Kira M. Holmström et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Oxidative stress and its downstream signaling in aging eyes

(2014) Maria Pinazo-duran et al.   Clinical Interventions in Aging

Curcumin abates hypoxia-induced oxidative stress based-ER stress-mediated cell death in mouse hippocampal cells (HT22) by controlling Prdx6 and NF-κB regulation

(2013) Bhavana Chhunchha et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Transcriptional Control of Antioxidant Defense by the Circadian Clock

(2013) Sonal A. Patel et al.   ANTIOXIDANTS & REDOX SIGNALING

Keratinocyte Growth Factor and Glucocorticoid Induction of Human Peroxiredoxin 6 Gene Expression Occur by Independent Mechanisms That Are Synergistic

(2013) Ibrul Chowdhury et al.   ANTIOXIDANTS & REDOX SIGNALING

Regulation of Circadian Clocks by Redox Homeostasis

(2013) Alessandra Stangherlin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oxidative stress mediated neuronal damage in the corpus striatum of 6-hydroxydopamine lesioned Parkinson's rats: Neuroprotection by Serotonin, GABA and Bone Marrow Cells Supplementation

(2013) Korah P. Kuruvilla et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Bmal1 and  -Cell Clock Are Required for Adaptation to Circadian Disruption, and Their Loss of Function Leads to Oxidative Stress-Induced  -Cell Failure in Mice

(2013) J. Lee et al.   MOLECULAR AND CELLULAR BIOLOGY

Regulatory Nexus of Synthesis and Degradation Deciphers Cellular Nrf2 Expression Levels

(2013) T. Suzuki et al.   MOLECULAR AND CELLULAR BIOLOGY

ROS Stress Resets Circadian Clocks to Coordinate Pro-Survival Signals

(2013) Teruya Tamaru et al.   PLoS One

Toward clinical application of the Keap1–Nrf2 pathway

(2013) Takafumi Suzuki et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Nrf2-regulated phase II enzymes are induced by chronic ambient nanoparticle exposure in young mice with age-related impairments

(2012) Hongqiao Zhang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Validation of the multiple sensor mechanism of the Keap1-Nrf2 system

(2012) Kai Takaya et al.   FREE RADICAL BIOLOGY AND MEDICINE

Timing to Perfection: The Biology of Central and Peripheral Circadian Clocks

(2012) Urs Albrecht   NEURON

Nrf2 is controlled by two distinct β-TrCP recognition motifs in its Neh6 domain, one of which can be modulated by GSK-3 activity

(2012) S Chowdhry et al.   ONCOGENE

Transcriptional Protein Sp1 Regulates LEDGF Transcription by Directly Interacting with Its Cis-Elements in GC-Rich Region of TATA-Less Gene Promoter

(2012) Dhirendra P. Singh et al.   PLoS One

Diurnal Variation of Hepatic Antioxidant Gene Expression in Mice

(2012) Yi-Qiao Xu et al.   PLoS One

Deficiency of Prdx6 in lens epithelial cells induces ER stress response-mediated impaired homeostasis and apoptosis

(2011) Nigar Fatma et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Fumaric acid esters exert neuroprotective effects in neuroinflammation via activation of the Nrf2 antioxidant pathway

(2011) Ralf A. Linker et al.   BRAIN

Circadian clock protein BMAL1 regulates cellular senescence in vivo

(2011) Rohini V. Khapre et al.   CELL CYCLE

Peroxiredoxin 6 Phosphorylation and Subsequent Phospholipase A2Activity Are Required for Agonist-mediated Activation of NADPH Oxidase in Mouse Pulmonary Microvascular Endothelium and Alveolar Macrophages

(2011) Shampa Chatterjee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SCF/ -TrCP Promotes Glycogen Synthase Kinase 3-Dependent Degradation of the Nrf2 Transcription Factor in a Keap1-Independent Manner

(2011) P. Rada et al.   MOLECULAR AND CELLULAR BIOLOGY

Specificity protein, Sp1-mediated increased expression of Prdx6 as a curcumin-induced antioxidant defense in lens epithelial cells against oxidative stress

(2011) B Chhunchha et al.   Cell Death & Disease

Discovery of the Negative Regulator of Nrf2, Keap1: A Historical Overview

(2010) Ken Itoh et al.   ANTIOXIDANTS & REDOX SIGNALING

Peroxiredoxin 6: A Bifunctional Enzyme with Glutathione Peroxidase and Phospholipase A2 Activities

(2010) Aron B. Fisher   ANTIOXIDANTS & REDOX SIGNALING

Circadian Proteins and Genotoxic Stress Response

(2010) Marina P. Antoch et al.   CIRCULATION RESEARCH

Temperature as a Universal Resetting Cue for Mammalian Circadian Oscillators

(2010) E. D. Buhr et al.   SCIENCE

Protein expression profiling of lens epithelial cells from Prdx6-depleted mice and their vulnerability to UV radiation exposure

(2009) Eri Kubo et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Binding of peroxiredoxin 6 to substrate determines differential phospholipid hydroperoxide peroxidase and phospholipase A 2 activities

(2009) Yefim Manevich et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

TAT-mediated peroxiredoxin 5 and 6 protein transduction protects against high-glucose-induced cytotoxicity in retinal pericytes

(2009) Eri Kubo et al.   LIFE SCIENCES

NRF2 Cysteine Residues Are Critical for Oxidant/Electrophile-Sensing, Kelch-Like ECH-Associated Protein-1-Dependent Ubiquitination-Proteasomal Degradation, and Transcription Activation

(2009) X. He et al.   MOLECULAR PHARMACOLOGY

TAT-mediated PRDX6 protein transduction protects against eye lens epithelial cell death and delays lens opacity

(2008) Eri Kubo et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

CLOCK/BMAL1 regulates human nocturnin transcription through binding to the E-box of nocturnin promoter

(2008) Ran Li et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Physiological significance of a peripheral tissue circadian clock

(2008) K. A. Lamia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA