Antiviral activity of berberine

Immunological axis of berberine in managing inflammation underlying chronic respiratory inflammatory diseases

(2020) Xin Nee Tew et al.   CHEMICO-BIOLOGICAL INTERACTIONS

A Natural Isoquinoline Alkaloid With Antitumor Activity: Studies of the Biological Activities of Berberine

(2019) Da Liu et al.   Frontiers in Pharmacology

Current Understanding of the Molecular Basis of Venezuelan Equine Encephalitis Virus Pathogenesis and Vaccine Development

(2019) Anuj Sharma et al.   Viruses-Basel

The isoquinoline alkaloid berberine inhibits human cytomegalovirus replication by interfering with the viral Immediate Early-2 (IE2) protein transactivating activity.

(2019) Anna Luganini et al.   ANTIVIRAL RESEARCH

P38 and JNK Mitogen-Activated Protein Kinases Interact With Chikungunya Virus Non-structural Protein-2 and Regulate TNF Induction During Viral Infection in Macrophages

(2019) Tapas Kumar Nayak et al.   Frontiers in Immunology

Novel berberine-based derivatives with potent hypoglycemic activity

(2019) Jian-Ta Wang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Role of mitogen-activated protein kinase signaling in the pathogenesis of dengue virus infection

(2018) Gopinathan Pillai Sreekanth et al.   CELLULAR SIGNALLING

Anti-Inflammatory Effects of Berberine Hydrochloride in an LPS-Induced Murine Model of Mastitis

(2018) Xichun Wang et al.   Evidence-based Complementary and Alternative Medicine

Cell-specific pattern of berberine pleiotropic effects on different human cell lines

(2018) Alessandro Agnarelli et al.   Scientific Reports

Synthesis and Evolution of Berberine Derivatives as a New Class of Antiviral Agents against Enterovirus 71 through the MEK/ERK Pathway and Autophagy

(2018) Yan-Xiang Wang et al.   MOLECULES

Berberine inhibits hepatitis C virus entry by targeting the viral E2 glycoprotein

(2018) Ting-Chun Hung et al.   PHYTOMEDICINE

Antiviral agents targeting the influenza virus: a review and publication analysis

(2018) L. Eyer et al.   VETERINARNI MEDICINA

Pharmacological effects of berberine on mood disorders

(2018) Jie Fan et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Comparison of anti-inflammatory effects of berberine, and its natural oxidative and reduced derivatives from Rhizoma Coptidis in vitro and in vivo

(2018) Cai-Lan Li et al.   PHYTOMEDICINE

Anti-influenza activity of berberine improves prognosis by reducing viral replication in mice

(2018) Yu-Qi Yan et al.   PHYTOTHERAPY RESEARCH

The Intertwined Life Cycles of Enterovirus and Autophagy

(2018) Yasir Mohamud et al.   Virulence

Berberine reduced blood pressure and improved vasodilation in diabetic rats

(2017) Yu-Guang Ma et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Future anti-HBV strategies

(2017) Edward J. Gane   LIVER INTERNATIONAL

Berberine inhibits enterovirus 71 replication by downregulating the MEK/ERK signaling pathway and autophagy

(2017) Huiqiang Wang et al.   Virology Journal

Curcumin inhibits hepatitis B virus infection by down-regulating cccDNA-bound histone acetylation

(2017) Zhi-Qiang Wei et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Activation of the c-Jun NH2-terminal kinase pathway by coronavirus infectious bronchitis virus promotes apoptosis independently of c-Jun

(2017) To Sing Fung et al.   Cell Death & Disease

Berberine produces antidepressant-like effects in ovariectomized mice

(2017) Jie Fan et al.   Scientific Reports

NF-κβ: A Potential Target in the Management of Vascular Complications of Diabetes

(2017) Sachin V. Suryavanshi et al.   Frontiers in Pharmacology

Advances in the study of berberine and its derivatives: a focus on anti-inflammatory and anti-tumor effects in the digestive system

(2016) Kun Zou et al.   ACTA PHARMACOLOGICA SINICA

Inhibitory effects of an aqueous extract from Cortex Phellodendri on the growth and replication of broad-spectrum of viruses in vitro and in vivo

(2016) Jae-Hoon Kim et al.   BMC Complementary and Alternative Medicine

Defining the syndrome associated with congenital Zika virus infection

(2016) Anthony Costello et al.   BULLETIN OF THE WORLD HEALTH ORGANIZATION

Distinct Roles for Human Cytomegalovirus Immediate Early Proteins IE1 and IE2 in the Transcriptional Regulation of MICA and PVR/CD155 Expression

(2016) Benedetta Pignoloni et al.   JOURNAL OF IMMUNOLOGY

The Antiviral Alkaloid Berberine Reduces Chikungunya Virus-Induced Mitogen-Activated Protein Kinase Signaling

(2016) Finny S. Varghese et al.   JOURNAL OF VIROLOGY

Brief History and Characterization of Enhanced Respiratory Syncytial Virus Disease

(2015) Patricio L. Acosta et al.   Clinical and Vaccine Immunology

Inhibition of respiratory syncytial virus replication and virus-induced p38 kinase activity by berberine

(2015) Han-Bo Shin et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Berberine Prevents Intestinal Mucosal Barrier Damage During Early Phase of Sepsis in Rat through the Toll-Like Receptors Signaling Pathway

(2015) Guo-xun Li et al.   KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY

Phosphorylation of Single Stranded RNA Virus Proteins and Potential for Novel Therapeutic Strategies

(2015) Forrest Keck et al.   Viruses-Basel

Downregulation of Cellular c-Jun N-Terminal Protein Kinase and NF-κB Activation by Berberine May Result in Inhibition of Herpes Simplex Virus Replication

(2014) Siwei Song et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

In vitro studies of berberine metabolism and its effect of enzyme induction on HepG2 cells

(2014) Han-Ming Cui et al.   JOURNAL OF ETHNOPHARMACOLOGY

Transportation of Berberine into HepG2, HeLa and SY5Y Cells: A Correlation to Its Anti-Cancer Effect

(2014) Yu-Nong Pang et al.   PLoS One

Dose-Dependent AMPK-Dependent and Independent Mechanisms of Berberine and Metformin Inhibition of mTORC1, ERK, DNA Synthesis and Proliferation in Pancreatic Cancer Cells

(2014) Ming Ming et al.   PLoS One

Inhibition of host extracellular signal-regulated kinase (ERK) activation decreases new world alphavirus multiplication in infected cells

(2014) Kelsey Voss et al.   VIROLOGY

MEK/ERK signaling pathway is required for enterovirus 71 replication in immature dendritic cells

(2014) Weifeng Shi et al.   Virology Journal

ERK signaling is triggered by hepatitis C virus E2 protein through DC-SIGN

(2013) Lan-Juan Zhao et al.   CELL STRESS & CHAPERONES

Contrasting Roles of Mitogen-Activated Protein Kinases in Cellular Entry and Replication of Hepatitis C Virus: MKNK1 Facilitates Cell Entry

(2013) S. Kim et al.   JOURNAL OF VIROLOGY

Epidemiology of Viral Hepatitis and Hepatocellular Carcinoma

(2012) Hashem B. El-Serag   GASTROENTEROLOGY

Synthesis of 9-substituted derivatives of berberine as anti-HIV agents

(2011) Hardik S. Bodiwala et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Inhibition of H1N1 influenza A virus growth and induction of inflammatory mediators by the isoquinoline alkaloid berberine and extracts of goldenseal (Hydrastis canadensis)

(2011) Chad E. Cecil et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Dose–response of berberine on hepatic cytochromes P450 mRNA expression and activities in mice

(2011) Ying Guo et al.   JOURNAL OF ETHNOPHARMACOLOGY

Berberine modulates AP-1 activity to suppress HPV transcription and downstream signaling to induce growth arrest and apoptosis in cervical cancer cells

(2011) Sutapa Mahata et al.   Molecular Cancer

Phosphorylation events during viral infections provide potential therapeutic targets

(2011) Julie A. Keating et al.   REVIEWS IN MEDICAL VIROLOGY

Anti-herpes simplex virus effects of berberine from Coptidis rhizoma, a major component of a Chinese herbal medicine, Ching-Wei-San

(2010) Lengsu William Chin et al.   ARCHIVES OF VIROLOGY

Effects of berberine on matrix accumulation and NF-kappa B signal pathway in alloxan-induced diabetic mice with renal injury

(2010) Weihua Liu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Toll-Like Receptor 4-Mediated Activation of p38 Mitogen-Activated Protein Kinase Is a Determinant of Respiratory Virus Entry and Tropism

(2010) D. Marchant et al.   JOURNAL OF VIROLOGY

Antidiarrheal activity, chemical and toxicity profile ofBerberis aristata

(2010) Padmaja V. Joshi et al.   PHARMACEUTICAL BIOLOGY

Berberine Inhibits HIV Protease Inhibitor-Induced Inflammatory Response by Modulating ER Stress Signaling Pathways in Murine Macrophages

(2010) Weibin Zha et al.   PLoS One

Hepatoprotective activity of berberine is mediated by inhibition of TNF-α, COX-2, and iNOS expression in CCl4-intoxicated mice

(2010) Robert Domitrović et al.   TOXICOLOGY

Enterovirus 71-induced autophagy detected in vitro and in vivo promotes viral replication

(2009) Shu-Chen Huang et al.   JOURNAL OF MEDICAL VIROLOGY

In vitro inhibition of coronavirus replications by the traditionally used medicinal herbal extracts, Cimicifuga rhizoma, Meliae cortex, Coptidis rhizoma, and Phellodendron cortex

(2007) Hye-Young Kim et al.   JOURNAL OF CLINICAL VIROLOGY