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Title
The Zinc Sensing Receptor, ZnR/GPR39, in Health and Disease
Authors
Keywords
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Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 19, Issue 2, Pages 439
Publisher
MDPI AG
Online
2018-02-02
DOI
10.3390/ijms19020439
References
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- (2017) Qipeng Fan et al. Oncotarget
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- (2017) Matthew A. Petrilli et al. Frontiers in Pharmacology
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- (2016) Christopher A Reid et al. BRITISH JOURNAL OF PHARMACOLOGY
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- (2016) Chen Abramovitch-Dahan et al. JOURNAL OF NEUROCHEMISTRY
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- (2008) Ananda Prasad MOLECULAR MEDICINE
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- (2007) R. Ganesh et al. CLINICAL PEDIATRICS
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