Genetic support for the role of the NLRP3 inflammasome in psoriasis susceptibility

Successful Treatment of Generalized Pustular Psoriasis With the Interleukin-1-Receptor Antagonist Anakinra: Lack of Correlation With IL1RN Mutations

(2013) Manuelle Viguier   ANNALS OF INTERNAL MEDICINE

Combined Analysis of Genome-wide Association Studies for Crohn Disease and Psoriasis Identifies Seven Shared Susceptibility Loci

(2012) David Ellinghaus et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Pharmacokinetic and Pharmacodynamic Properties of Canakinumab, a Human Anti-Interleukin-1β Monoclonal Antibody

(2012) Abhijit Chakraborty et al.   CLINICAL PHARMACOKINETICS

Interleukin-1β Interferes with Epidermal Homeostasis through Induction of Insulin Resistance: Implications for Psoriasis Pathogenesis

(2012) Claudia Buerger et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

A Genome-Wide Scan of Ashkenazi Jewish Crohn's Disease Suggests Novel Susceptibility Loci

(2012) Eimear E. Kenny et al.   PLoS Genetics

The Missense Variation Q705K in CIAS1/NALP3/NLRP3 Gene and an NLRP1 Haplotype Are Associated With Celiac Disease

(2011) Alessandra Pontillo et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Interaction of the inflammasome genes CARD8 and NLRP3 in abdominal aortic aneurysms

(2011) Rebecca L. Roberts et al.   ATHEROSCLEROSIS

Human keratinocytes express AIM2 and respond to dsDNA with IL-1β secretion

(2011) Verena Kopfnagel et al.   EXPERIMENTAL DERMATOLOGY

Mite allergen is a danger signal for the skin via activation of inflammasome in keratinocytes

(2011) Xiuju Dai et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Association of CARD8 with inflammatory bowel disease in Koreans

(2011) Suk-Kyun Yang et al.   JOURNAL OF HUMAN GENETICS

Deep resequencing of GWAS loci identifies independent rare variants associated with inflammatory bowel disease

(2011) Manuel A Rivas et al.   NATURE GENETICS

Cytosolic DNA Triggers Inflammasome Activation in Keratinocytes in Psoriatic Lesions

(2011) Y. Dombrowski et al.   Science Translational Medicine

Two SNPs inNLRP3gene are involved in the predisposition to type-1 diabetes and celiac disease in a pediatric population from northeast Brazil

(2010) A. Pontillo et al.   AUTOIMMUNITY

Interleukin-1 from epithelial cells fosters T cell-dependent skin inflammation

(2010) J. Renne et al.   BRITISH JOURNAL OF DERMATOLOGY

An open-label pilot study of the efficacy and safety of anakinra in patients with psoriatic arthritis refractory to or intolerant of methotrexate (MTX)

(2010) Norma Jung et al.   CLINICAL RHEUMATOLOGY

Evidence of interaction of CARD8 rs2043211 with NALP3 rs35829419 in Crohn's disease

(2010) R L Roberts et al.   GENES AND IMMUNITY

Genetic association between NLRP3 variants and Crohnʼs disease does not replicate in a large UK panel

(2010) Gregory J. Lewis et al.   INFLAMMATORY BOWEL DISEASES

A Comprehensive Analysis of Pattern Recognition Receptors in Normal and Inflamed Human Epidermis: Upregulation of Dectin-1 in Psoriasis

(2010) Heleen D. de Koning et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

EGFR and IL-1 Signaling Synergistically Promote Keratinocyte Antimicrobial Defenses in a Differentiation-Dependent Manner

(2010) Andrew Johnston et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Caspase-5 Expression Is Upregulated in Lesional Psoriatic Skin

(2010) Maria L. Salskov-Iversen et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Generation of pathogenic TH17 cells in the absence of TGF-β signalling

(2010) Kamran Ghoreschi et al.   NATURE

A regulatory variant in CCR6 is associated with rheumatoid arthritis susceptibility

(2010) Yuta Kochi et al.   NATURE GENETICS

Genome-wide association study identifies a psoriasis susceptibility locus at TRAF3IP2

(2010) Eva Ellinghaus et al.   NATURE GENETICS

Genome-wide association analysis identifies three psoriasis susceptibility loci

(2010) Philip E Stuart et al.   NATURE GENETICS

Common variants at TRAF3IP2 are associated with susceptibility to psoriatic arthritis and psoriasis

(2010) Ulrike Hüffmeier et al.   NATURE GENETICS

A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1

(2010) Amy Strange et al.   NATURE GENETICS

Interleukin-1  (IL-1 ) Processing Pathway

(2010) A. Weber et al.   Science Signaling

Combined Polymorphisms in Genes Encoding the Inflammasome Components NALP3 and CARD8 Confer Susceptibility to Crohn's Disease in Swedish Men

(2009) Ida Schoultz et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Genome-wide association scan yields new insights into the immunopathogenesis of psoriasis

(2009) J T Elder   GENES AND IMMUNITY

A Mutation in the Nlrp3 Gene Causing Inflammasome Hyperactivation Potentiates Th17 Cell-Dominant Immune Responses

(2009) Guangxun Meng et al.   IMMUNITY

Interleukin-1 and IL-23 Induce Innate IL-17 Production from γδ T Cells, Amplifying Th17 Responses and Autoimmunity

(2009) Caroline E. Sutton et al.   IMMUNITY

Cutting Edge: NF- B Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression

(2009) F. G. Bauernfeind et al.   JOURNAL OF IMMUNOLOGY

REL, encoding a member of the NF-κB family of transcription factors, is a newly defined risk locus for rheumatoid arthritis

(2009) Peter K Gregersen et al.   NATURE GENETICS

Genome-wide scan reveals association of psoriasis with IL-23 and NF-κB pathways

(2009) Rajan P Nair et al.   NATURE GENETICS

Immune modulation: IL-1, master mediator or initiator of inflammation

(2009) Kingston H G Mills et al.   NATURE MEDICINE

An Autoinflammatory Disease with Deficiency of the Interleukin-1–Receptor Antagonist

(2009) Ivona Aksentijevich et al.   NEW ENGLAND JOURNAL OF MEDICINE

An Autoinflammatory Disease Due to Homozygous Deletion of theIL1RNLocus

(2009) Sreelatha Reddy et al.   NEW ENGLAND JOURNAL OF MEDICINE

Psoriasis

(2009) Frank O. Nestle et al.   NEW ENGLAND JOURNAL OF MEDICINE

Autoinflammatory genes and susceptibility to psoriatic juvenile idiopathic arthritis

(2008) T. G. Day et al.   ARTHRITIS AND RHEUMATISM

Identification of ZNF313 / RNF114 as a novel psoriasis susceptibility gene

(2008) Francesca Capon et al.   HUMAN MOLECULAR GENETICS

Common variants in the NLRP3 region contribute to Crohn's disease susceptibility

(2008) Alexandra-Chloé Villani et al.   NATURE GENETICS

Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease

(2008) Jeffrey C Barrett et al.   NATURE GENETICS

Two pathogenicCIAS1mutations and plasma cytokine profile in a Finnish patient with familial cold autoinflammatory syndrome responsive to anakinra

(2008) O. Kaipiainen‐Seppänen et al.   SCANDINAVIAN JOURNAL OF RHEUMATOLOGY

A Genome-Wide Association Study of Psoriasis and Psoriatic Arthritis Identifies New Disease Loci

(2008) Ying Liu et al.   PLoS Genetics

No association of the CARD8 (TUCAN) c.30T>A (p.C10X) variant with Crohnʼs disease: A study in 3 independent European cohorts

(2007) Carsten Büning et al.   INFLAMMATORY BOWEL DISEASES