Recent insights into the regulatory networks of NLRP3 inflammasome activation

Structural Mechanism for GSDMD Targeting by Autoprocessed Caspases in Pyroptosis

(2020) Kun Wang et al.   CELL

An Acetylation Switch of the NLRP3 Inflammasome Regulates Aging-Associated Chronic Inflammation and Insulin Resistance

(2020) Ming He et al.   Cell Metabolism

Direct binding to NLRP3 pyrin domain is a novel strategy to prevent NLRP3‐driven inflammation and gouty arthritis

(2020) Gabsik Yang et al.   Arthritis & Rheumatology

Discovery and optimization of 4-oxo-2-thioxo-thiazolidinones as NOD-like receptor (NLR) family, pyrin domain-containing protein 3 (NLRP3) inhibitors

(2020) Yun Chen et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

EphA2 phosphorylates NLRP 3 and inhibits inflammasomes in airway epithelial cells

(2020) Ao Zhang et al.   EMBO REPORTS

Bruton tyrosine kinase deficiency augments NLRP3 inflammasome activation and causes IL-1β–mediated colitis

(2020) Liming Mao et al.   JOURNAL OF CLINICAL INVESTIGATION

Myeloid PTEN promotes chemotherapy-induced NLRP3-inflammasome activation and antitumour immunity

(2020) Yi Huang et al.   NATURE CELL BIOLOGY

STING promotes NLRP3 localization in ER and facilitates NLRP3 deubiquitination to activate the inflammasome upon HSV-1 infection

(2020) Wenbiao Wang et al.   PLoS Pathogens

Inhibition of Bruton tyrosine kinase in patients with severe COVID-19

(2020) Mark Roschewski et al.   Science Immunology

Cullin1 binds and promotes NLRP3 ubiquitination to repress systematic inflammasome activation

(2019) Pin Wan et al.   FASEB JOURNAL

Candidalysin Crucially Contributes to Nlrp3 Inflammasome Activation by Candida albicans Hyphae

(2019) Ona Rogiers et al.   mBio

HSP70 is a negative regulator of NLRP3 inflammasome activation

(2019) Pierre Martine et al.   Cell Death & Disease

Cutting Edge: G Protein Subunit β 1 Negatively Regulates NLRP3 Inflammasome Activation

(2019) Tomohiko Murakami et al.   JOURNAL OF IMMUNOLOGY

MCC950 directly targets the NLRP3 ATP-hydrolysis motif for inflammasome inhibition

(2019) Rebecca C. Coll et al.   Nature Chemical Biology

MCC950 closes the active conformation of NLRP3 to an inactive state

(2019) Ana Tapia-Abellán et al.   Nature Chemical Biology

Structural mechanism for NEK7-licensed activation of NLRP3 inflammasome

(2019) Humayun Sharif et al.   NATURE

miR-21 promotes NLRP3 inflammasome activation to mediate pyroptosis and endotoxic shock

(2019) Zhenyi Xue et al.   Cell Death & Disease

Alternative splicing regulates stochastic NLRP3 activity

(2019) Florian Hoss et al.   Nature Communications

MCC950/CRID3 potently targets the NACHT domain of wild-type NLRP3 but not disease-associated mutants for inflammasome inhibition

(2019) Lieselotte Vande Walle et al.   PLOS BIOLOGY

Structural Mechanisms of PTEN Regulation

(2019) Glenn R. Masson et al.   Cold Spring Harbor Perspectives in Medicine

Pharmacological Inhibitors of the NLRP3 Inflammasome

(2019) Ayesha Zahid et al.   Frontiers in Immunology

SUMO1 SUMOylates and SENP3 deSUMOylates NLRP3 to orchestrate the inflammasome activation

(2019) Luyao Shao et al.   FASEB JOURNAL

The Gasdermin-D pore acts as a conduit for IL-1β secretion in mice

(2018) Rosalie Heilig et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The TWIK2 Potassium Efflux Channel in Macrophages Mediates NLRP3 Inflammasome-Induced Inflammation

(2018) Anke Di et al.   IMMUNITY

The Pore-Forming Protein Gasdermin D Regulates Interleukin-1 Secretion from Living Macrophages

(2018) Charles L. Evavold et al.   IMMUNITY

Targeting the NLRP3 inflammasome in inflammatory diseases

(2018) Matthew S. J. Mangan et al.   NATURE REVIEWS DRUG DISCOVERY

The Elusive P2X7 Macropore

(2018) Francesco Di Virgilio et al.   TRENDS IN CELL BIOLOGY

Oridonin is a covalent NLRP3 inhibitor with strong anti-inflammasome activity

(2018) Hongbin He et al.   Nature Communications

The E3 ubiquitin ligase Pellino2 mediates priming of the NLRP3 inflammasome

(2018) Fiachra Humphries et al.   Nature Communications

USP7 and USP47 deubiquitinases regulate NLRP3 inflammasome activation

(2018) Pablo Palazón‐Riquelme et al.   EMBO REPORTS

Chloride regulates dynamic NLRP3-dependent ASC oligomerization and inflammasome priming

(2018) Jack P. Green et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SUMO-mediated regulation of NLRP3 modulates inflammasome activity

(2018) Rachael Barry et al.   Nature Communications

Interleukin-1β Maturation Triggers Its Relocation to the Plasma Membrane for Gasdermin-D-Dependent and -Independent Secretion

(2018) Mercedes Monteleone et al.   Cell Reports

Brefeldin A–sensitive ER-Golgi vesicle trafficking contributes to NLRP3-dependent caspase-1 activation

(2018) Sujeong Hong et al.   FASEB JOURNAL

Cholesterol Homeostatic Regulator SCAP-SREBP2 Integrates NLRP3 Inflammasome Activation and Cholesterol Biosynthetic Signaling in Macrophages

(2018) Chuansheng Guo et al.   IMMUNITY

PtdIns4P on dispersed trans-Golgi network mediates NLRP3 inflammasome activation

(2018) Jueqi Chen et al.   NATURE

Src-family kinase-Cbl axis negatively regulates NLRP3 inflammasome activation

(2018) I-Che Chung et al.   Cell Death & Disease

Progressive waves of IL-1β release by primary human monocytes via sequential activation of vesicular and gasdermin D-mediated secretory pathways

(2018) Claudia Semino et al.   Cell Death & Disease

NLRP3 lacking the leucine-rich repeat domain can be fully activated via the canonical inflammasome pathway

(2018) Iva Hafner-Bratkovič et al.   Nature Communications

The fungal peptide toxin Candidalysin activates the NLRP3 inflammasome and causes cytolysis in mononuclear phagocytes

(2018) Lydia Kasper et al.   Nature Communications

Regulation of NLRP3 Inflammasome by Phosphorylation

(2018) Nan Song et al.   Frontiers in Immunology

LncRNA ANRIL promotes NLRP3 inflammasome activation in uric acid nephropathy through miR-122-5p/BRCC3 axis

(2018) Jiacai Hu et al.   BIOCHIMIE

By Capturing Inflammatory Lipids Released from Dying Cells, the Receptor CD14 Induces Inflammasome-Dependent Phagocyte Hyperactivation

(2017) Ivan Zanoni et al.   IMMUNITY

Bruton tyrosine kinase inhibition: Clinical relevance beyond B cells

(2017) Balaji Banoth et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

DNA demethylation of inflammasome-associated genes is enhanced in patients with cryopyrin-associated periodic syndromes

(2017) Roser Vento-Tormo et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Human NACHT, LRR, and PYD domain–containing protein 3 (NLRP3) inflammasome activity is regulated by and potentially targetable through Bruton tyrosine kinase

(2017) Xiao Liu et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The intracellular chloride channel proteins CLIC1 and CLIC4 induce IL-1β transcription and activate the NLRP3 inflammasome

(2017) Raquel Domingo-Fernández et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of a selective and direct NLRP3 inhibitor to treat inflammatory disorders

(2017) Hua Jiang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

NLRP3 inflammasome assembly is regulated by phosphorylation of the pyrin domain

(2017) Andrea Stutz et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Protein kinase D at the Golgi controls NLRP3 inflammasome activation

(2017) Zhirong Zhang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

ARIH2 Ubiquitinates NLRP3 and Negatively Regulates NLRP3 Inflammasome Activation in Macrophages

(2017) Akira Kawashima et al.   JOURNAL OF IMMUNOLOGY

Effect of interleukin-1β inhibition with canakinumab on incident lung cancer in patients with atherosclerosis: exploratory results from a randomised, double-blind, placebo-controlled trial

(2017) Paul M Ridker et al.   LANCET

NLRP3 Phosphorylation Is an Essential Priming Event for Inflammasome Activation

(2017) Nan Song et al.   MOLECULAR CELL

MARK4 regulates NLRP3 positioning and inflammasome activation through a microtubule-dependent mechanism

(2017) Xuan Li et al.   Nature Communications

CLICs-dependent chloride efflux is an essential and proximal upstream event for NLRP3 inflammasome activation

(2017) Tiantian Tang et al.   Nature Communications

Dectin-2 is a primary receptor for NLRP3 inflammasome activation in dendritic cell response to Histoplasma capsulatum

(2017) Tzu-Hsuan Chang et al.   PLoS Pathogens

Bruton’s Tyrosine Kinase: An Emerging Key Player in Innate Immunity

(2017) Alexander N. R. Weber et al.   Frontiers in Immunology

Bile Acids Control Inflammation and Metabolic Disorder through Inhibition of NLRP3 Inflammasome

(2016) Chuansheng Guo et al.   IMMUNITY

K + Efflux-Independent NLRP3 Inflammasome Activation by Small Molecules Targeting Mitochondria

(2016) Christina J. Groß et al.   IMMUNITY

Human Monocytes Engage an Alternative Inflammasome Pathway

(2016) Moritz M. Gaidt et al.   IMMUNITY

NLRP3 tyrosine phosphorylation is controlled by protein tyrosine phosphatase PTPN22

(2016) Marianne R. Spalinger et al.   JOURNAL OF CLINICAL INVESTIGATION

Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores

(2016) Xing Liu et al.   NATURE

NEK7 is an essential mediator of NLRP3 activation downstream of potassium efflux

(2016) Yuan He et al.   NATURE

NLRP3 inflammasome inhibition is disrupted in a group of auto-inflammatory disease CAPS mutations

(2016) Leanne Mortimer et al.   NATURE IMMUNOLOGY

An endogenous caspase-11 ligand elicits interleukin-1 release from living dendritic cells

(2016) Ivan Zanoni et al.   SCIENCE

The E3 ubiquitin ligase TRIM31 attenuates NLRP3 inflammasome activation by promoting proteasomal degradation of NLRP3

(2016) Hui Song et al.   Nature Communications

Crystal structure of NOD2 and its implications in human disease

(2016) Sakiko Maekawa et al.   Nature Communications

NLRP3 Activation Was Regulated by DNA Methylation Modification duringMycobacterium tuberculosisInfection

(2016) Meili Wei et al.   Biomed Research International

The Inflammasomes and Autoinflammatory Syndromes

(2015) Lori Broderick et al.   Annual Review of Pathology-Mechanisms of Disease

Dopamine Controls Systemic Inflammation through Inhibition of NLRP3 Inflammasome

(2015) Yiqing Yan et al.   CELL

Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion

(2015) Wan-ting He et al.   CELL RESEARCH

Caspase-11 Requires the Pannexin-1 Channel and the Purinergic P2X7 Pore to Mediate Pyroptosis and Endotoxic Shock

(2015) Dahai Yang et al.   IMMUNITY

Lipopolysaccharide Primes the NALP3 Inflammasome by Inhibiting Its Ubiquitination and Degradation Mediated by the SCFFBXL2E3 Ligase

(2015) SeungHye Han et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Genome-wide CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) Screen Identifies NEK7 as an Essential Component of NLRP3 Inflammasome Activation

(2015) Jonathan L. Schmid-Burgk et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MAVS Promotes Inflammasome Activation by Targeting ASC for K63-Linked Ubiquitination via the E3 Ligase TRAF3

(2015) Kai Guan et al.   JOURNAL OF IMMUNOLOGY

Anti-inflammatory therapies in myocardial infarction

(2015) Antonio Abbate et al.   LANCET

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

(2015) Nobuhiko Kayagaki et al.   NATURE

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE

NLRP3 activation and mitosis are mutually exclusive events coordinated by NEK7, a new inflammasome component

(2015) Hexin Shi et al.   NATURE IMMUNOLOGY

Targeting B cell receptor signaling with ibrutinib in diffuse large B cell lymphoma

(2015) Wyndham H Wilson et al.   NATURE MEDICINE

A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases

(2015) Rebecca C Coll et al.   NATURE MEDICINE

Small heterodimer partner interacts with NLRP3 and negatively regulates activation of the NLRP3 inflammasome

(2015) Chul-Su Yang et al.   Nature Communications

Bruton’s tyrosine kinase is essential for NLRP3 inflammasome activation and contributes to ischaemic brain injury

(2015) Minako Ito et al.   Nature Communications

Human caspase-4 and caspase-5 regulate the one-step non-canonical inflammasome activation in monocytes

(2015) Elena Viganò et al.   Nature Communications

Diverse Activators of the NLRP3 Inflammasome Promote IL-1β Secretion by Triggering Necrosis

(2015) Sean P. Cullen et al.   Cell Reports

The linear ubiquitin assembly complex (LUBAC) is essential for NLRP3 inflammasome activation

(2014) Mary A. Rodgers et al.   JOURNAL OF EXPERIMENTAL MEDICINE

P2X7 Receptor Differentially Couples to Distinct Release Pathways for IL-1  in Mouse Macrophage

(2014) P. Pelegrin et al.   JOURNAL OF IMMUNOLOGY

Cytosolic Double-Stranded RNA Activates the NLRP3 Inflammasome via MAVS-Induced Membrane Permeabilization and K+Efflux

(2014) Luigi Franchi et al.   JOURNAL OF IMMUNOLOGY

The adaptor ASC has extracellular and 'prionoid' activities that propagate inflammation

(2014) Bernardo S Franklin et al.   NATURE IMMUNOLOGY

IKKα negatively regulates ASC-dependent inflammasome activation

(2014) Bradley N. Martin et al.   Nature Communications

The Adaptor MAVS Promotes NLRP3 Mitochondrial Localization and Inflammasome Activation

(2013) Naeha Subramanian et al.   CELL

Modulatory mechanisms controlling the NLRP3 inflammasome in inflammation: recent developments

(2013) Moritz Haneklaus et al.   CURRENT OPINION IN IMMUNOLOGY

Mitochondrial Cardiolipin Is Required for Nlrp3 Inflammasome Activation

(2013) Shankar S. Iyer et al.   IMMUNITY

K+ Efflux Is the Common Trigger of NLRP3 Inflammasome Activation by Bacterial Toxins and Particulate Matter

(2013) Raúl Muñoz-Planillo et al.   IMMUNITY

3,4-Methylenedioxy-β-nitrostyrene Inhibits NLRP3 Inflammasome Activation by Blocking Assembly of the Inflammasome

(2013) Yuan He et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Mitochondrial Antiviral Protein MAVS Associates with NLRP3 and Regulates Its Inflammasome Activity

(2013) S. Park et al.   JOURNAL OF IMMUNOLOGY

Phosphorylation of the adaptor ASC acts as a molecular switch that controls the formation of speck-like aggregates and inflammasome activity

(2013) Hideki Hara et al.   NATURE IMMUNOLOGY

Microtubule-driven spatial arrangement of mitochondria promotes activation of the NLRP3 inflammasome

(2013) Takuma Misawa et al.   NATURE IMMUNOLOGY

IRAK-1 bypasses priming and directly links TLRs to rapid NLRP3 inflammasome activation

(2013) K.-M. Lin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal Structure of NLRC4 Reveals Its Autoinhibition Mechanism

(2013) Z. Hu et al.   SCIENCE

The NLRP3 inflammasome activation in human or mouse cells, sensitivity causes puzzle

(2013) Hongbin Wang et al.   Protein & Cell

Multiple Binding Sites on the Pyrin Domain of ASC Protein Allow Self-association and Interaction with NLRP3 Protein

(2012) Parimala R. Vajjhala et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Non-transcriptional Priming and Deubiquitination Regulate NLRP3 Inflammasome Activation

(2012) Christine Juliana et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Deubiquitinases Regulate the Activity of Caspase-1 and Interleukin-1β Secretion via Assembly of the Inflammasome

(2012) Gloria Lopez-Castejon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Colonel Bruton's Kinase Defined the Molecular Basis of X-Linked Agammaglobulinemia, the First Primary Immunodeficiency

(2012) W. N. Khan   JOURNAL OF IMMUNOLOGY

Deubiquitination of NLRP3 by BRCC3 Critically Regulates Inflammasome Activity

(2012) Bénédicte F. Py et al.   MOLECULAR CELL

The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP

(2012) Geun-Shik Lee et al.   NATURE

Critical role for calcium mobilization in activation of the NLRP3 inflammasome

(2012) T. Murakami et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

GBP5 Promotes NLRP3 Inflammasome Assembly and Immunity in Mammals

(2012) A. R. Shenoy et al.   SCIENCE

Non-canonical inflammasome activation targets caspase-11

(2011) Nobuhiko Kayagaki et al.   NATURE

(1,3)- -Glucans Activate Both Dectin-1 and NLRP3 Inflammasome in Human Macrophages

(2010) P. Kankkunen et al.   JOURNAL OF IMMUNOLOGY

A role for mitochondria in NLRP3 inflammasome activation

(2010) Rongbin Zhou et al.   NATURE

Schistosoma mansoni triggers Dectin-2, which activates the Nlrp3 inflammasome and alters adaptive immune responses

(2010) M. Ritter et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fungal pathogen recognition by the NLRP3 inflammasome

(2010) Sophie Joly et al.   Virulence

Immunological and Inflammatory Functions of the Interleukin-1 Family

(2009) Charles A. Dinarello   Annual Review of Immunology

An Essential Role for the NLRP3 Inflammasome in Host Defense against the Human Fungal Pathogen Candida albicans

(2009) Amy G. Hise et al.   Cell Host & Microbe

Cutting Edge: NF- B Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression

(2009) F. G. Bauernfeind et al.   JOURNAL OF IMMUNOLOGY

Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence

(2009) Olaf Gross et al.   NATURE