Complement Component C5a Primes Retinal Pigment Epithelial Cells for Inflammasome Activation by Lipofuscin-mediated Photooxidative Damage

Light induces NLRP3 inflammasome activation in retinal pigment epithelial cells via lipofuscin-mediated photooxidative damage

(2015) Carolina Brandstetter et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Interleukin-1β Level Is Increased in Vitreous of Patients with Neovascular Age-Related Macular Degeneration (nAMD) and Polypoidal Choroidal Vasculopathy (PCV)

(2015) Min Zhao et al.   PLoS One

Complement C5a potentiates uric acid crystal-induced IL-1β production

(2014) Ling-Ling An et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Vinpocetine inhibits amyloid-beta induced activation of NF-κB, NLRP3 inflammasome and cytokine production in retinal pigment epithelial cells

(2014) Ruozhou Tom Liu et al.   EXPERIMENTAL EYE RESEARCH

Cholesterol Crystals Induce Complement-Dependent Inflammasome Activation and Cytokine Release

(2014) E. O. Samstad et al.   JOURNAL OF IMMUNOLOGY

The Oxidative Stress Product Carboxyethylpyrrole Potentiates TLR2/TLR1 Inflammatory Signaling in Macrophages

(2014) Ali M. Saeed et al.   PLoS One

DICER1/AluRNA dysmetabolism induces Caspase-8–mediated cell death in age-related macular degeneration

(2014) Younghee Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IL-18 Attenuates Experimental Choroidal Neovascularization as a Potential Therapy for Wet Age-Related Macular Degeneration

(2014) S. L. Doyle et al.   Science Translational Medicine

Relationship between Systemic Cytokines and Complement Factor H Y402H Polymorphism in Patients With Dry Age-Related Macular Degeneration

(2013) Sijia Cao et al.   AMERICAN JOURNAL OF OPHTHALMOLOGY

Cutting Edge: The NLRP3 Inflammasome Links Complement-Mediated Inflammation and IL-1  Release

(2013) F. Laudisi et al.   JOURNAL OF IMMUNOLOGY

A2E Induces IL-1ß Production in Retinal Pigment Epithelial Cells via the NLRP3 Inflammasome

(2013) Owen A. Anderson et al.   PLoS One

DICER1 Loss and Alu RNA Induce Age-Related Macular Degeneration via the NLRP3 Inflammasome and MyD88

(2012) Valeria Tarallo et al.   CELL

Oxidative stress activates NLRP3 inflammasomes in ARPE-19 cells—Implications for age-related macular degeneration (AMD)

(2012) Anu Kauppinen et al.   IMMUNOLOGY LETTERS

Age-related macular degeneration

(2012) Laurence S Lim et al.   LANCET

NLRP3 has a protective role in age-related macular degeneration through the induction of IL-18 by drusen components

(2012) Sarah L Doyle et al.   NATURE MEDICINE

C5a contributes to intraocular inflammation by affecting retinal pigment epithelial cells and immune cells

(2011) M. Hu et al.   BRITISH JOURNAL OF OPHTHALMOLOGY

Critical functions of priming and lysosomal damage for NLRP3 activation

(2010) Veit Hornung et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Effects of lipid peroxidation products on lipofuscinogenesis and autophagy in human retinal pigment epithelial cells

(2010) Tim U. Krohne et al.   EXPERIMENTAL EYE RESEARCH

C5a, But Not C3a, Increases VEGF Secretion in ARPE-19 Human Retinal Pigment Epithelial Cells

(2009) Daniel N. Cortright et al.   CURRENT EYE RESEARCH

Lipid peroxidation products reduce lysosomal protease activities in human retinal pigment epithelial cells via two different mechanisms of action

(2009) Tim U. Krohne et al.   EXPERIMENTAL EYE RESEARCH

Inflammasomes: too big to miss

(2009) Andrea Stutz et al.   JOURNAL OF CLINICAL INVESTIGATION

Systemic Complement Activation in Age-Related Macular Degeneration

(2008) Hendrik P. N. Scholl et al.   PLoS One