The inflammasome: an integrated view

Cutting Edge: Alum Adjuvant Stimulates Inflammatory Dendritic Cells through Activation of the NALP3 Inflammasome

(2014) M. Kool et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Critical Role for Mesothelial Cells in Necrosis-Induced Inflammation through the Recognition of IL-1  Released from Dying Cells

(2014) T. Eigenbrod et al.   JOURNAL OF IMMUNOLOGY

HMGB1 Develops Enhanced Proinflammatory Activity by Binding to Cytokines

(2014) Y. Sha et al.   JOURNAL OF IMMUNOLOGY

Resistant Behçet Disease Responsive to Anakinra

(2013) Costantino Botsios et al.   ANNALS OF INTERNAL MEDICINE

Targeting inflammation by modulating the Jun/AP-1 pathway

(2011) H. B. Schonthaler et al.   ANNALS OF THE RHEUMATIC DISEASES

Mitochondria: Sovereign of inflammation?

(2011) Jürg Tschopp   EUROPEAN JOURNAL OF IMMUNOLOGY

Lysosomal membrane permeabilization causes oxidative stress and ferritin induction in macrophages

(2011) Moumita Ghosh et al.   FEBS LETTERS

Type I Interferon Inhibits Interleukin-1 Production and Inflammasome Activation

(2011) Greta Guarda et al.   IMMUNITY

Differential Expression of NLRP3 among Hematopoietic Cells

(2011) G. Guarda et al.   JOURNAL OF IMMUNOLOGY

Pannexin-1 Is Required for ATP Release during Apoptosis but Not for Inflammasome Activation

(2011) Y. Qu et al.   JOURNAL OF IMMUNOLOGY

TLR signalling augments macrophage bactericidal activity through mitochondrial ROS

(2011) A. Phillip West et al.   NATURE

Activation of the innate immune receptor Dectin-1 upon formation of a ‘phagocytic synapse’

(2011) Helen S. Goodridge et al.   NATURE

Alum interaction with dendritic cell membrane lipids is essential for its adjuvanticity

(2011) Tracy L Flach et al.   NATURE MEDICINE

Hyperuricaemia and gout: state of the art and future perspectives

(2010) N. Dalbeth et al.   ANNALS OF THE RHEUMATIC DISEASES

Differential susceptibility to lethal endotoxaemia in mice deficient in IL-1α, IL-1β or IL-1 receptor type I

(2010) LEO A.B. JOOSTEN et al.   APMIS

Octacalcium phosphate crystals induce inflammation in vivo through interleukin-1 but independent of the NLRP3 inflammasome in mice

(2010) Sharmal Narayan et al.   ARTHRITIS AND RHEUMATISM

The Inflammasomes

(2010) Kate Schroder et al.   CELL

Staphylococcus aureus Evades Lysozyme-Based Peptidoglycan Digestion that Links Phagocytosis, Inflammasome Activation, and IL-1β Secretion

(2010) Takahiro Shimada et al.   Cell Host & Microbe

NF-κB in the regulation of epithelial homeostasis and inflammation

(2010) Andy Wullaert et al.   CELL RESEARCH

Inflammasomes: current understanding and open questions

(2010) Franz Bauernfeind et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Critical functions of priming and lysosomal damage for NLRP3 activation

(2010) Veit Hornung et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Signaling by ROS drives inflammasome activation

(2010) Fabio Martinon   EUROPEAN JOURNAL OF IMMUNOLOGY

Adaptive control of innate immunity

(2010) Anil Shanker   IMMUNOLOGY LETTERS

Sodium Overload and Water Influx Activate the NALP3 Inflammasome

(2010) Christine Schorn et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Role of Potassium in Inflammasome Activation by Bacteria

(2010) Cecilia S. Lindestam Arlehamn et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tyrosine Kinase 2 Controls IL-1  Production at the Translational Level

(2010) M. Radwan et al.   JOURNAL OF IMMUNOLOGY

Inflammasome-Dependent Release of the Alarmin HMGB1 in Endotoxemia

(2010) M. Lamkanfi et al.   JOURNAL OF IMMUNOLOGY

Innate immune processes are sufficient for driving silicosis in mice

(2010) Celine A. Beamer et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Inflammatory Stimuli Regulate Caspase Substrate Profiles

(2010) Nicholas J. Agard et al.   MOLECULAR & CELLULAR PROTEOMICS

A role for mitochondria in NLRP3 inflammasome activation

(2010) Rongbin Zhou et al.   NATURE

NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

(2010) Peter Duewell et al.   NATURE

Genome-wide association study identifies variants in the MHC class I, IL10 and IL23R-IL12RB2 regions associated with Behçet's disease

(2010) Elaine F Remmers et al.   NATURE GENETICS

TRPV2 has a pivotal role in macrophage particle binding and phagocytosis

(2010) Tiffany M Link et al.   NATURE IMMUNOLOGY

The AIM2 inflammasome is critical for innate immunity to Francisella tularensis

(2010) Teresa Fernandes-Alnemri et al.   NATURE IMMUNOLOGY

Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

(2010) Kiichi Nakahira et al.   NATURE IMMUNOLOGY

Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes

(2010) Seth L Masters et al.   NATURE IMMUNOLOGY

Reactive oxygen species-independent activation of the IL-1  inflammasome in cells from patients with chronic granulomatous disease

(2010) F. L. van de Veerdonk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nanoparticles activate the NLR pyrin domain containing 3 (Nlrp3) inflammasome and cause pulmonary inflammation through release of IL-1  and IL-1 

(2010) A. S. Yazdi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Variants of ribonuclease inhibitor that resist oxidation

(2010) Byung-Moon Kim et al.   PROTEIN SCIENCE

Tec-Kinase-Mediated Phosphorylation of Fibroblast Growth Factor 2 is Essential for Unconventional Secretion

(2010) Antje D. Ebert et al.   TRAFFIC

A Reaction-Diffusion Model of ROS-Induced ROS Release in a Mitochondrial Network

(2010) Lufang Zhou et al.   PLoS Computational Biology

IL-1β Processing in Host Defense: Beyond the Inflammasomes

(2010) Mihai G. Netea et al.   PLoS Pathogens

Caspase 1–independent activation of interleukin-1β in neutrophil-predominant inflammation

(2009) Monica Guma et al.   ARTHRITIS AND RHEUMATISM

An Essential Role for the NLRP3 Inflammasome in Host Defense against the Human Fungal Pathogen Candida albicans

(2009) Amy G. Hise et al.   Cell Host & Microbe

Monocytes/macrophages and/or neutrophils are the target of IL-10 in the LPS endotoxemia model

(2009) Marina C. Pils et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Approaching the Asymptote: 20 Years Later

(2009) Ruslan Medzhitov   IMMUNITY

The NLRP3 Inflammasome Mediates In Vivo Innate Immunity to Influenza A Virus through Recognition of Viral RNA

(2009) Irving C. Allen et al.   IMMUNITY

The Intracellular Sensor NLRP3 Mediates Key Innate and Healing Responses to Influenza A Virus via the Regulation of Caspase-1

(2009) Paul G. Thomas et al.   IMMUNITY

Glyburide inhibits the Cryopyrin/Nalp3 inflammasome

(2009) Mohamed Lamkanfi et al.   JOURNAL OF CELL BIOLOGY

TPL-2 negatively regulates interferon-β production in macrophages and myeloid dendritic cells

(2009) Frank Kaiser et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cutting Edge: Necrosis Activates the NLRP3 Inflammasome

(2009) H. Li et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: TNF-  Mediates Sensitization to ATP and Silica via the NLRP3 Inflammasome in the Absence of Microbial Stimulation

(2009) L. Franchi et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: NF- B Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression

(2009) F. G. Bauernfeind et al.   JOURNAL OF IMMUNOLOGY

NLRP3 (NALP3, Cryopyrin) Facilitates In Vivo Caspase-1 Activation, Necrosis, and HMGB1 Release via Inflammasome-Dependent and -Independent Pathways

(2009) S. B. Willingham et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Candida albicans Hyphae Formation Triggers Activation of the Nlrp3 Inflammasome

(2009) S. Joly et al.   JOURNAL OF IMMUNOLOGY

T cells dampen innate immune responses through inhibition of NLRP1 and NLRP3 inflammasomes

(2009) Greta Guarda et al.   NATURE

AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA

(2009) Teresa Fernandes-Alnemri et al.   NATURE

AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC

(2009) Veit Hornung et al.   NATURE

Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence

(2009) Olaf Gross et al.   NATURE

Recognition of RNA virus by RIG-I results in activation of CARD9 and inflammasome signaling for interleukin 1β production

(2009) Hendrik Poeck et al.   NATURE IMMUNOLOGY

An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome

(2009) Tilmann Bürckstümmer et al.   NATURE IMMUNOLOGY

Thioredoxin-interacting protein links oxidative stress to inflammasome activation

(2009) Rongbin Zhou et al.   NATURE IMMUNOLOGY

Inflammatory Bowel Disease and Mutations Affecting the Interleukin-10 Receptor

(2009) Erik-Oliver Glocker et al.   NEW ENGLAND JOURNAL OF MEDICINE

Malarial Hemozoin Is a Nalp3 Inflammasome Activating Danger Signal

(2009) Catherine Dostert et al.   PLoS One

Necrotic cells trigger a sterile inflammatory response through the Nlrp3 inflammasome

(2009) S. S. Iyer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oxidation of potassium channels by ROS: a general mechanism of aging and neurodegeneration?

(2009) Federico Sesti et al.   TRENDS IN CELL BIOLOGY

Caspase-7 Activation by the Nlrc4/Ipaf Inflammasome Restricts Legionella pneumophila Infection

(2009) Anwari Akhter et al.   PLoS Pathogens

Malarial Hemozoin Activates the NLRP3 Inflammasome through Lyn and Syk Kinases

(2009) Marina Tiemi Shio et al.   PLoS Pathogens

Unconventional Mechanisms of Protein Transport to the Cell Surface of Eukaryotic Cells

(2008) Walter Nickel et al.   Annual Review of Cell and Developmental Biology

Regulation of apoptosis by the redox state of cytochrome c

(2008) Guy C. Brown et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Differential requirement for the activation of the inflammasome for processing and release of IL-1  in monocytes and macrophages

(2008) M. G. Netea et al.   BLOOD

Active Caspase-1 Is a Regulator of Unconventional Protein Secretion

(2008) Martin Keller et al.   CELL

Initial description of the human NLRP3 promoter

(2008) J P Anderson et al.   GENES AND IMMUNITY

Receptor-Independent, Direct Membrane Binding Leads to Cell-Surface Lipid Sorting and Syk Kinase Activation in Dendritic Cells

(2008) Gilbert Ng et al.   IMMUNITY

Interferon-inducible Ifi200-family genes in systemic lupus erythematosus

(2008) Divaker Choubey et al.   IMMUNOLOGY LETTERS

Pathogen destruction versus intracellular survival: the role of lipids as phagosomal fate determinants

(2008) Benjamin E. Steinberg et al.   JOURNAL OF CLINICAL INVESTIGATION

Targeted Peptidecentric Proteomics Reveals Caspase-7 as a Substrate of the Caspase-1 Inflammasomes

(2008) Mohamed Lamkanfi et al.   MOLECULAR & CELLULAR PROTEOMICS

The inflammasome recognizes cytosolic microbial and host DNA and triggers an innate immune response

(2008) Daniel A. Muruve et al.   NATURE

Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants

(2008) Stephanie C. Eisenbarth et al.   NATURE

Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production

(2008) Tatsuya Saitoh et al.   NATURE

Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

(2008) Veit Hornung et al.   NATURE IMMUNOLOGY

The NALP3 inflammasome is involved in the innate immune response to amyloid-β

(2008) Annett Halle et al.   NATURE IMMUNOLOGY

Lysosomal membrane permeabilization in cell death

(2008) P Boya et al.   ONCOGENE

The Nalp3 inflammasome is essential for the development of silicosis

(2008) Suzanne L. Cassel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Anthrax lethal toxin and Salmonella elicit the common cell death pathway of caspase-1-dependent pyroptosis via distinct mechanisms

(2008) S. L. Fink et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Innate Immune Activation Through Nalp3 Inflammasome Sensing of Asbestos and Silica

(2008) C. Dostert et al.   SCIENCE

Mitochondria and cellular oxygen sensing in the HIF pathway

(2007) Cormac T. Taylor   BIOCHEMICAL JOURNAL