Berberine Inhibits Nod-Like Receptor Family Pyrin Domain Containing 3 Inflammasome Activation and Pyroptosis in Nonalcoholic Steatohepatitis via the ROS/TXNIP Axis

Natural products berberine and curcumin exhibited better ameliorative effects on rats with non-alcohol fatty liver disease than lovastatin

(2018) Wu-wen Feng et al.   BIOMEDICINE & PHARMACOTHERAPY

ShenFu Preparation Protects AML12 Cells Against Palmitic Acid-Induced Injury Through Inhibition of Both JNK/Nox4 and JNK/NFκB Pathways

(2018) Jia-Fu Ji et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Pyroptosis by caspase11/4-gasdermin-D pathway in alcoholic hepatitis in mice and patients

(2018) Elena Khanova et al.   HEPATOLOGY

Pyroptosis: An inflammatory link between NAFLD and NASH with potential therapeutic implications

(2018) Juliane I. Beier et al.   JOURNAL OF HEPATOLOGY

Gasdermin D plays a key role as a pyroptosis executor of non-alcoholic steatohepatitis in humans and mice

(2018) Bing Xu et al.   JOURNAL OF HEPATOLOGY

Berberine, a natural plant alkaloid, synergistically sensitizes human liver cancer cells to sorafenib

(2018) Yuezhao Huang et al.   ONCOLOGY REPORTS

Mouse models of nonalcoholic steatohepatitis Towards optimization of their relevance to human NASH

(2018) Geoff Farrell et al.   HEPATOLOGY

Berberine, an isoquinoline alkaloid suppresses TXNIP mediated NLRP3 inflammasome activation in MSU crystal stimulated RAW 264.7 macrophages through the upregulation of Nrf2 transcription factor and alleviates MSU crystal induced inflammation in rats

(2017) Palani Dinesh et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Current and future pharmacological therapies for NAFLD/NASH

(2017) Yoshio Sumida et al.   JOURNAL OF GASTROENTEROLOGY

NLRP3 inflammasome blockade reduces liver inflammation and fibrosis in experimental NASH in mice

(2017) Auvro R. Mridha et al.   JOURNAL OF HEPATOLOGY

ERK-dependent mTOR pathway is involved in berberine-induced autophagy in hepatic steatosis

(2017) Qin He et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Pyroptosis: Gasdermin-Mediated Programmed Necrotic Cell Death

(2017) Jianjin Shi et al.   TRENDS IN BIOCHEMICAL SCIENCES

Berberine improves glucogenesis and lipid metabolism in nonalcoholic fatty liver disease

(2017) Li Zhao et al.   BMC Endocrine Disorders

Inhibition of NLRP3 inflammasome by thioredoxin-interacting protein in mouse Kupffer cells as a regulatory mechanism for non-alcoholic fatty liver disease development

(2017) Kun He et al.   Oncotarget

LncRNA-uc002mbe.2 Interacting with hnRNPA2B1 Mediates AKT Deactivation and p21 Up-Regulation Induced by Trichostatin in Liver Cancer Cells

(2017) Ting Chen et al.   Frontiers in Pharmacology

Palmitic Acid: Physiological Role, Metabolism and Nutritional Implications

(2017) Gianfranca Carta et al.   Frontiers in Physiology

Demethyleneberberine attenuates non-alcoholic fatty liver disease with activation of AMPK and inhibition of oxidative stress

(2016) Xiaoyan Qiang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

NLRP3 inflammasome as a target of berberine in experimental murine liver injury: interference with P2X7 signalling

(2016) E. Vivoli et al.   CLINICAL SCIENCE

The Therapeutic Effect of Berberine in the Treatment of Nonalcoholic Fatty Liver Disease: A Meta-Analysis

(2016) Xiaoyun Wei et al.   Evidence-based Complementary and Alternative Medicine

Lipid profiling of the therapeutic effects of berberine in patients with nonalcoholic fatty liver disease

(2016) Xinxia Chang et al.   Journal of Translational Medicine

The Potential Mechanisms of Berberine in the Treatment of Nonalcoholic Fatty Liver Disease

(2016) Xiaopeng Zhu et al.   MOLECULES

Berberine augments ATP-induced inflammasome activation in macrophages by enhancing AMPK signaling

(2016) Chen-Guang Li et al.   Oncotarget

Pyroptosis is involved in the pathogenesis of human hepatocellular carcinoma

(2016) Qun Chu et al.   Oncotarget

Berberine Ameliorates Hepatic Steatosis and Suppresses Liver and Adipose Tissue Inflammation in Mice with Diet-induced Obesity

(2016) Ting Guo et al.   Scientific Reports

Berberine prevents progression from hepatic steatosis to steatohepatitis and fibrosis by reducing endoplasmic reticulum stress

(2016) Zhiguo Zhang et al.   Scientific Reports

Hepatitis C Virus Infection of Cultured Human Hepatoma Cells Causes Apoptosis and Pyroptosis in Both Infected and Bystander Cells

(2016) H. M. Kofahi et al.   Scientific Reports

Redox Regulation of NLRP3 Inflammasomes: ROS as Trigger or Effector?

(2015) Justine M. Abais et al.   ANTIOXIDANTS & REDOX SIGNALING

Animal Models of Nonalcoholic Steatohepatitis: Eat, Delete, and Inflame

(2015) Samar H. Ibrahim et al.   DIGESTIVE DISEASES AND SCIENCES

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE

Inflammasome activation and function in liver disease

(2015) Gyongyi Szabo et al.   Nature Reviews Gastroenterology & Hepatology

NLRP3 inflammasome activation is required for fibrosis development in NAFLD

(2014) Alexander Wree et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Both bone marrow-derived and non-bone marrow-derived cells contribute to AIM2 and NLRP3 inflammasome activation in a MyD88-dependent manner in dietary steatohepatitis

(2014) Timea Csak et al.   LIVER INTERNATIONAL

NLRP3 inflammasome activation results in hepatocyte pyroptosis, liver inflammation, and fibrosis in mice

(2013) Alexander Wree et al.   HEPATOLOGY

Nonalcoholic steatohepatitis is the most rapidly growing indication for liver transplantation in patients with hepatocellular carcinoma in the U.S.

(2013) Robert J. Wong et al.   HEPATOLOGY

Caspase-1-mediated regulation of fibrogenesis in diet-induced steatohepatitis

(2012) Laura J Dixon et al.   LABORATORY INVESTIGATION

Fatty acid and endotoxin activate inflammasomes in mouse hepatocytes that release danger signals to stimulate immune cells

(2011) Timea Csak et al.   HEPATOLOGY

Caspase-1-induced pyroptotic cell death

(2011) Edward A. Miao et al.   IMMUNOLOGICAL REVIEWS

Berberine: a potential phytochemical with multispectrum therapeutic activities

(2010) Parameswara Rao Vuddanda et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Dietary sucrose is essential to the development of liver injury in the methionine-choline-deficient model of steatohepatitis

(2009) Michael K. Pickens et al.   JOURNAL OF LIPID RESEARCH

Thioredoxin-interacting protein links oxidative stress to inflammasome activation

(2009) Rongbin Zhou et al.   NATURE IMMUNOLOGY

Berberine: a plant alkaloid with therapeutic potential for central nervous system disorders

(2009) S. K. Kulkarni et al.   PHYTOTHERAPY RESEARCH

Mechanisms of hepatic steatosis in mice fed a lipogenic methionine choline-deficient diet

(2008) Mary E. Rinella et al.   JOURNAL OF LIPID RESEARCH