Natural Compounds and Autophagy: Allies Against Neurodegeneration

Emerging Potential of Naturally Occurring Autophagy Modulator against Neurodegeneration

(2020) Md. Ataur Rahman et al.   CURRENT PHARMACEUTICAL DESIGN

Cell-type-specific regulation of neuronal intrinsic excitability by macroautophagy

(2020) Ori J Lieberman et al.   eLife

β-Asarone Inhibits Amyloid-β by Promoting Autophagy in a Cell Model of Alzheimer's Disease

(2020) Nanbu Wang et al.   Frontiers in Pharmacology

Mitophagy in Alzheimer’s Disease and Other Age-Related Neurodegenerative Diseases

(2020) Qian Cai et al.   Cells

Targeting Aggrephagy for the Treatment of Alzheimer’s Disease

(2020) Sandeep Malampati et al.   Cells

Autophagy, Cellular Aging and Age-related Human Diseases

(2020) So Yeong Cheon et al.   Experimental Neurobiology

Lysosomal Exocytosis, Exosome Release and Secretory Autophagy: The Autophagic- and Endo-Lysosomal Systems Go Extracellular

(2020) Sandra Buratta et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Regulation and roles of mitophagy at synapses

(2020) Konstantinos Palikaras et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Autophagy lipidation machinery regulates axonal microtubule dynamics but is dispensable for survival of mammalian neurons

(2020) A. Negrete-Hurtado et al.   Nature Communications

Polyphenols as Caloric-Restriction Mimetics and Autophagy Inducers in Aging Research

(2020) Assylzhan Yessenkyzy et al.   Nutrients

Ferulic Acid Exerts Anti-apoptotic Effects against Ischemic Injury by Activating HSP70/Bcl-2- and HSP70/Autophagy-Mediated Signaling after Permanent Focal Cerebral Ischemia in Rats

(2019) Chin-Yi Cheng et al.   AMERICAN JOURNAL OF CHINESE MEDICINE

Astrocyte Heterogeneity: Impact to Brain Aging and Disease

(2019) Isadora Matias et al.   Frontiers in Aging Neuroscience

A Review of the Role of Green Tea (Camellia sinensis) in Antiphotoaging, Stress Resistance, Neuroprotection, and Autophagy

(2019) Mani Prasanth et al.   Nutrients

Autophagy as a Homeostatic Mechanism in Response to Stress Conditions in the Central Nervous System

(2019) Cristian Gerónimo-Olvera et al.   MOLECULAR NEUROBIOLOGY

Targeting Autophagy to Overcome Human Diseases

(2019) Maria Condello et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Autophagy Activator Drugs: A New Opportunity in Neuroprotection from Misfolded Protein Toxicity

(2019) Stefano Thellung et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mitochondrial integrity in neurodegeneration

(2019) Katrina Cowan et al.   CNS Neuroscience & Therapeutics

Therapeutic modulation of autophagy: which disease comes first?

(2019) Maria Chiara Maiuri et al.   CELL DEATH AND DIFFERENTIATION

The role of melatonin in targeting cell signaling pathways in neurodegeneration

(2019) Mayuri Shukla et al.   Annals of the New York Academy of Sciences

Autophagy dysfunction in Alzheimer’s disease: mechanistic insights and new therapeutic opportunities

(2019) Antonio Di Meco et al.   BIOLOGICAL PSYCHIATRY

Trehalose as a promising therapeutic candidate for the treatment of Parkinson's disease

(2019) Masoomeh Khalifeh et al.   BRITISH JOURNAL OF PHARMACOLOGY

Cubeben induces autophagy via PI3K-AKT-mTOR pathway to protect primary neurons against amyloid beta in Alzheimer’s disease

(2019) Xiangqing Li et al.   CYTOTECHNOLOGY

Autophagy in Alzheimer's disease and promising modulatory effects of herbal medicine

(2019) Qiang Zeng et al.   EXPERIMENTAL GERONTOLOGY

Considerations for the Use of Polyphenols as Therapies in Neurodegenerative Diseases

(2019) Justine Renaud et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Glia-specific autophagy dysfunction in ALS

(2019) Laura Strohm et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Dual Role of Autophagy in Diseases of the Central Nervous System

(2019) Tamara Bar-Yosef et al.   Frontiers in Cellular Neuroscience

Beneficial Role of Phytochemicals on Oxidative Stress and Age-Related Diseases

(2019) Cinzia Forni et al.   Biomed Research International

Amyloid Beta and Phosphorylated Tau-Induced Defective Autophagy and Mitophagy in Alzheimer’s Disease

(2019) P. Hemachandra Reddy et al.   Cells

Diverse Cellular Roles of Autophagy

(2019) Hideaki Morishita et al.   Annual Review of Cell and Developmental Biology

Autophagic death of neural stem cells mediates chronic stress-induced decline of adult hippocampal neurogenesis and cognitive deficits

(2019) Seonghee Jung et al.   Autophagy

Reciprocal Regulation of Chaperone-Mediated Autophagy/Microautophagy and Exosome Release

(2019) Mutsumi Oshima et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Neuronal Autophagy in Synaptic Functions and Psychiatric Disorders

(2019) Toshifumi Tomoda et al.   BIOLOGICAL PSYCHIATRY

Quality Control in Neurons: Mitophagy and Other Selective Autophagy Mechanisms

(2019) Chantell S. Evans et al.   JOURNAL OF MOLECULAR BIOLOGY

Preserving Lysosomal Function in the Aging Brain: Insights from Neurodegeneration

(2019) Wesley Peng et al.   Neurotherapeutics

Autophagy in Synucleinopathy: The Overwhelmed and Defective Machinery

(2019) Marie-Laure Arotcarena et al.   Cells

Enhancing the retrograde axonal transport by curcumin promotes autophagic flux in N2a/APP695swe cells

(2019) Jie Liang et al.   Aging-US

Exploring the bi‐directional relationship between autophagy and Alzheimer’s disease

(2019) Huang Kuang et al.   CNS Neuroscience & Therapeutics

Mechanisms and disease implications of sirtuin-mediated autophagic regulation

(2019) In Hye Lee   EXPERIMENTAL AND MOLECULAR MEDICINE

Quercetin-modified gold-palladium nanoparticles as a potential autophagy inducer for the treatment of Alzheimer's disease

(2019) Yanan Liu et al.   JOURNAL OF COLLOID AND INTERFACE SCIENCE

Autophagy Modulation as a Treatment of Amyloid Diseases

(2019) Zoe Mputhia et al.   MOLECULES

Autophagy as a molecular target of quercetin underlying its protective effects in human diseases

(2019) Milad Ashrafizadeh et al.   ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY

Targeting Autophagy for the Treatment of Alzheimer’s Disease: Challenges and Opportunities

(2019) Jie Liu et al.   Frontiers in Molecular Neuroscience

Nanolipid-Trehalose Conjugates and Nano-Assemblies as Putative Autophagy Inducers

(2019) Eleonora Colombo et al.   Pharmaceutics

Extra virgin olive oil improves synaptic activity, short‐term plasticity, memory, and neuropathology in a tauopathy model

(2019) Elisabetta Lauretti et al.   AGING CELL

Role of phytochemicals as nutraceuticals for cognitive functions affected in ageing

(2019) Melanie‐Jayne R. Howes et al.   BRITISH JOURNAL OF PHARMACOLOGY

Natural Products in Neurodegenerative Diseases: A Great Promise but an Ethical Challenge

(2019) Marco Di Paolo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Overcrowded Crossroads: Mitochondria, Alpha-Synuclein, and the Endo-Lysosomal System Interaction in Parkinson’s Disease

(2019) Kai-Jung Lin et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Autophagy in Myelinating Glia

(2019) Jillian Belgrad et al.   JOURNAL OF NEUROSCIENCE

Resveratrol Activates Neuronal Autophagy Through AMPK in the Ischemic Brain

(2019) Narayana Pineda-Ramírez et al.   MOLECULAR NEUROBIOLOGY

The Autophagy Signaling Pathway: A Potential Multifunctional Therapeutic Target of Curcumin in Neurological and Neuromuscular Diseases

(2019) Lorena Perrone et al.   Nutrients

Dysfunctional Mitochondria and Mitophagy as Drivers of Alzheimer’s Disease Pathogenesis

(2019) Anushka Chakravorty et al.   Frontiers in Aging Neuroscience

Autophagic and endo-lysosomal dysfunction in neurodegenerative disease

(2019) Bilal R. Malik et al.   Molecular Brain

Astrocytes autophagy in aging and neurodegenerative disorders

(2019) Jun-Ling Wang et al.   BIOMEDICINE & PHARMACOTHERAPY

Berberine mitigates cognitive decline in an Alzheimer’s Disease Mouse Model by targeting both tau hyperphosphorylation and autophagic clearance

(2019) Ying Chen et al.   BIOMEDICINE & PHARMACOTHERAPY

The effect of curcumin on cognition in Alzheimer’s disease and healthy aging: A systematic review of pre-clinical and clinical studies

(2019) S.D. Voulgaropoulou et al.   BRAIN RESEARCH

Polyphenols and AGEs/RAGE axis. Trends and challenges

(2019) Ileana González et al.   FOOD RESEARCH INTERNATIONAL

The Synaptic Autophagy Cycle

(2019) Ori J. Lieberman et al.   JOURNAL OF MOLECULAR BIOLOGY

Autophagy Induction as a Therapeutic Strategy for Neurodegenerative Diseases

(2019) Alvin Djajadikerta et al.   JOURNAL OF MOLECULAR BIOLOGY

Mechanisms of action of amyloid-beta and its precursor protein in neuronal cell death

(2019) Yong Qi Leong et al.   METABOLIC BRAIN DISEASE

Loss of Parkin contributes to mitochondrial turnover and dopaminergic neuronal loss in aged mice

(2019) Sachiko Noda et al.   NEUROBIOLOGY OF DISEASE

Pericytes: Problems and Promises for CNS Repair

(2019) Fabio Laredo et al.   Frontiers in Cellular Neuroscience

Autophagy and mitophagy biomarkers are reduced in sera of patients with Alzheimer’s disease and mild cognitive impairment

(2019) Massimiliano Castellazzi et al.   Scientific Reports

Safety and tolerability of spermidine supplementation in mice and older adults with subjective cognitive decline

(2018) Claudia Schwarz et al.   Aging-US

Higher spermidine intake is linked to lower mortality: a prospective population-based study

(2018) Stefan Kiechl et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Autophagy in Human Health and Disease: Novel Therapeutic Opportunities

(2018) Francesca Giampieri et al.   ANTIOXIDANTS & REDOX SIGNALING

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

(2018) Lorenzo Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

Mechanisms of protein toxicity in neurodegenerative diseases

(2018) Chang Geon Chung et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Neuronal autophagy and intercellular regulation of homeostasis in the brain

(2018) Aditi Kulkarni et al.   CURRENT OPINION IN NEUROBIOLOGY

Multiple Bioactivities of Traditional Medicinal Herbs for Treatment of Neurodegenerative Diseases

(2018) Gunhyuk Park et al.   Evidence-based Complementary and Alternative Medicine

Bcl-2/E1B-19KD-Interacting Protein 3/Light Chain 3 Interaction Induces Mitophagy in Spinal Cord Injury in Rats Both In Vivo and In Vitro

(2018) Datang Yu et al.   JOURNAL OF NEUROTRAUMA

Inhibition of Peroxynitrite-Induced Mitophagy Activation Attenuates Cerebral Ischemia-Reperfusion Injury

(2018) Jinghan Feng et al.   MOLECULAR NEUROBIOLOGY

A brief history of autophagy from cell biology to physiology and disease

(2018) Noboru Mizushima   NATURE CELL BIOLOGY

Mitochondrial dynamics in adaptive and maladaptive cellular stress responses

(2018) Verónica Eisner et al.   NATURE CELL BIOLOGY

Cargo recognition and degradation by selective autophagy

(2018) Damián Gatica et al.   NATURE CELL BIOLOGY

The coming of age of chaperone-mediated autophagy

(2018) Susmita Kaushik et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Autophagy as a promoter of longevity: insights from model organisms

(2018) Malene Hansen et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Roles for neuronal and glial autophagy in synaptic pruning during development

(2018) Ori J. Lieberman et al.   NEUROBIOLOGY OF DISEASE

Lysosome trafficking and signaling in health and neurodegenerative diseases

(2018) Pearl P.Y. Lie et al.   NEUROBIOLOGY OF DISEASE

Chaperone-mediated autophagy: Advances from bench to bedside

(2018) Wenming Li et al.   NEUROBIOLOGY OF DISEASE

TFEB dysregulation as a driver of autophagy dysfunction in neurodegenerative disease: Molecular mechanisms, cellular processes, and emerging therapeutic opportunities

(2018) Constanza J. Cortes et al.   NEUROBIOLOGY OF DISEASE

Mechanisms of selective autophagy and mitophagy: Implications for neurodegenerative diseases

(2018) Charleen T. Chu   NEUROBIOLOGY OF DISEASE

Resveratrol protects neuronal-like cells expressing mutant Huntingtin from dopamine toxicity by rescuing ATG4-mediated autophagosome formation

(2018) Chiara Vidoni et al.   NEUROCHEMISTRY INTERNATIONAL

Axonal autophagy: Mini-review for autophagy in the CNS

(2018) Andrea K.H. Stavoe et al.   NEUROSCIENCE LETTERS

Malfunctioning of Chaperone-Mediated Autophagy in Parkinson’s Disease: Feats, Constraints, and Flaws of Modulators

(2018) Manish Kumar Tripathi et al.   NEUROTOXICITY RESEARCH

Benefit of Oleuropein Aglycone for Alzheimer’s Disease by Promoting Autophagy

(2018) Joaquín G. Cordero et al.   Oxidative Medicine and Cellular Longevity

Recent Advances in Studies on the Therapeutic Potential of Dietary Carotenoids in Neurodegenerative Diseases

(2018) Kyoung Sang Cho et al.   Oxidative Medicine and Cellular Longevity

Resveratrol attenuates oxidative damage through activating mitophagy in an in vitro model of Alzheimer’s disease

(2018) Hui Wang et al.   TOXICOLOGY LETTERS

Endoplasmic reticulum and mitochondria in diseases of motor and sensory neurons: a broken relationship?

(2018) Nathalie Bernard-Marissal et al.   Cell Death & Disease

Mechanism of neuroprotection by trehalose: controversy surrounding autophagy induction

(2018) He-Jin Lee et al.   Cell Death & Disease

A key role for MAM in mediating mitochondrial dysfunction in Alzheimer disease

(2018) Estela Area-Gomez et al.   Cell Death & Disease

Cardiolipin exposure on the outer mitochondrial membrane modulates α-synuclein

(2018) Tammy Ryan et al.   Nature Communications

Resveratrol ameliorates autophagic flux to promote functional recovery in rats after spinal cord injury

(2018) Peng Wang et al.   Oncotarget

The Potential Protective Effect of Curcumin on Amyloid-β-42 Induced Cytotoxicity in HT-22 Cells

(2018) Lu Zhang et al.   Biomed Research International

Melatonin Regulates Apoptosis and Autophagy Via ROS-MST1 Pathway in Subarachnoid Hemorrhage

(2018) Ligen Shi et al.   Frontiers in Molecular Neuroscience

Chronic Caffeine Treatment Protects Against α-Synucleinopathy by Reestablishing Autophagy Activity in the Mouse Striatum

(2018) Yanan Luan et al.   Frontiers in Neuroscience

Association Between Autophagy and Neurodegenerative Diseases

(2018) Nobuhiro Fujikake et al.   Frontiers in Neuroscience

Ambiguous Effects of Autophagy Activation Following Hypoperfusion/Ischemia

(2018) Michela Ferrucci et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Neuroprotective Role of Trans-Resveratrol in a Murine Model of Familial Alzheimer's Disease

(2018) David Porquet et al.   JOURNAL OF ALZHEIMERS DISEASE

Curcumin: A naturally occurring autophagy modulator

(2018) Abolfazl Shakeri et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Selective autophagy as a potential therapeutic target for neurodegenerative disorders

(2018) Aurora Scrivo et al.   LANCET NEUROLOGY

Geraniol Protects Against the Protein and Oxidative Stress Induced by Rotenone in an In Vitro Model of Parkinson’s Disease

(2018) Karamkolly R. Rekha et al.   NEUROCHEMICAL RESEARCH

Study protocol for a randomised, double-blind, placebo-controlled 12-week pilot phase II trial of Sailuotong (SLT) for cognitive function in older adults with mild cognitive impairment

(2018) Genevieve Z. Steiner et al.   Trials

Spermidine: a physiological autophagy inducer acting as an anti-aging vitamin in humans?

(2018) Frank Madeo et al.   Autophagy

Trehalose induces autophagy via lysosomal-mediated TFEB activation in models of motoneuron degeneration

(2018) Paola Rusmini et al.   Autophagy

p62/SQSTM1 – steering the cell through health and disease

(2018) Pablo Sánchez-Martín et al.   JOURNAL OF CELL SCIENCE

The Potential Use of Plant Natural Products and Plant Extracts with Antioxidant Properties for the Prevention/Treatment of Neurodegenerative Diseases: In Vitro, In Vivo and Clinical Trials

(2018) Franziska Pohl et al.   MOLECULES

Phenolic Compounds Characteristic of the Mediterranean Diet in Mitigating Microglia-Mediated Neuroinflammation

(2018) Ruth Hornedo-Ortega et al.   Frontiers in Cellular Neuroscience

Curcuminoids and novel opportunities for the treatment of Alzheimer's disease: which molecules are actually effective?

(2018) Alexander V. Zholos et al.   Current Molecular Pharmacology

The mammalian ULK1 complex and autophagy initiation

(2017) Maria Zachari et al.   Essays in Biochemistry

Trehalose Improves Cognition in the Transgenic Tg2576 Mouse Model of Alzheimer’s Disease

(2017) Stuart D. Portbury et al.   JOURNAL OF ALZHEIMERS DISEASE

Melatonin reverses H2 O2 -induced senescence in SH-SY5Y cells by enhancing autophagy via sirtuin 1 deacetylation of the RelA/p65 subunit of NF-κB

(2017) Chutikorn Nopparat et al.   JOURNAL OF PINEAL RESEARCH

Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles

(2017) Lorenzo Galluzzi et al.   NATURE REVIEWS DRUG DISCOVERY

Neuronal cell-type classification: challenges, opportunities and the path forward

(2017) Hongkui Zeng et al.   NATURE REVIEWS NEUROSCIENCE

Autophagy and Neurodegeneration: Pathogenic Mechanisms and Therapeutic Opportunities

(2017) Fiona M. Menzies et al.   NEURON

Resveratrol protects against spinal cord injury by activating autophagy and inhibiting apoptosis mediated by the SIRT1/AMPK signaling pathway

(2017) Haosen Zhao et al.   NEUROSCIENCE

Curcumin attenuates paraquat-induced cell death in human neuroblastoma cells through modulating oxidative stress and autophagy

(2017) Thiranut Jaroonwitchawan et al.   NEUROSCIENCE LETTERS

Contacts between the endoplasmic reticulum and other membranes in neurons

(2017) Yumei Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Is trehalose an autophagic inducer? Unraveling the roles of non-reducing disaccharides on autophagic flux and alpha-synuclein aggregation

(2017) Ye-Seul Yoon et al.   Cell Death & Disease

Therapeutic activity of plant-derived alkaloid conophylline on metabolic syndrome and neurodegenerative disease models

(2017) Kazuo Umezawa et al.   Human Cell

Berberine attenuated pro-inflammatory factors and protect against neuronal damage via triggering oligodendrocyte autophagy in spinal cord injury

(2017) Hongyu Wang et al.   Oncotarget

Mitophagy in Parkinson’s Disease: Pathogenic and Therapeutic Implications

(2017) Fei Gao et al.   Frontiers in Neurology

Extra-virgin olive oil ameliorates cognition and neuropathology of the 3xTg mice: role of autophagy

(2017) Elisabetta Lauretti et al.   Annals of Clinical and Translational Neurology

Assessment of Autophagy in Neurons and Brain Tissue

(2017) Irene Benito-Cuesta et al.   Cells

Fucoxanthin provides neuroprotection in models of traumatic brain injury via the Nrf2-ARE and Nrf2-autophagy pathways

(2017) Li Zhang et al.   Scientific Reports

Mitochondria-associated membranes as hubs for neurodegeneration

(2016) Michiel Krols et al.   ACTA NEUROPATHOLOGICA

The crucial impact of lysosomes in aging and longevity

(2016) Didac Carmona-Gutierrez et al.   AGEING RESEARCH REVIEWS

Identification of natural products with neuronal and metabolic benefits through autophagy induction

(2016) Yuying Fan et al.   Autophagy

A novel curcumin analog binds to and activates TFEB in vitro and in vivo independent of MTOR inhibition

(2016) Ju-Xian Song et al.   Autophagy

β-asarone improves learning and memory and reduces Acetyl Cholinesterase and Beta-amyloid 42 levels in APP/PS1 transgenic mice by regulating Beclin-1-dependent autophagy

(2016) Minzhen Deng et al.   BRAIN RESEARCH

Spermidine alleviates experimental autoimmune encephalomyelitis through inducing inhibitory macrophages

(2016) Q Yang et al.   CELL DEATH AND DIFFERENTIATION

Transcriptional regulation of mammalian autophagy at a glance

(2016) Jens Füllgrabe et al.   JOURNAL OF CELL SCIENCE

Trehalose upregulates progranulin expression in human and mouse models of GRN haploinsufficiency: a novel therapeutic lead to treat frontotemporal dementia

(2016) Christopher J. Holler et al.   Molecular Neurodegeneration

Resveratrol alleviates MPTP-induced motor impairments and pathological changes by autophagic degradation of α-synuclein via SIRT1-deacetylated LC3

(2016) Yan-Jie Guo et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Deficient autophagy in microglia impairs synaptic pruning and causes social behavioral defects

(2016) H-J Kim et al.   MOLECULAR PSYCHIATRY

Curcumin and Resveratrol in the Management of Cognitive Disorders: What is the Clinical Evidence?

(2016) Gabriela Mazzanti et al.   MOLECULES

Resveratrol Attenuates Aβ25–35 Caused Neurotoxicity by Inducing Autophagy Through the TyrRS-PARP1-SIRT1 Signaling Pathway

(2016) Haoyue Deng et al.   NEUROCHEMICAL RESEARCH

A Potential Alternative against Neurodegenerative Diseases: Phytodrugs

(2016) Jesús Pérez-Hernández et al.   Oxidative Medicine and Cellular Longevity

Leonurine ameliorates cognitive dysfunction via antagonizing excitotoxic glutamate insults and inhibiting autophagy

(2016) Chunhua Liu et al.   PHYTOMEDICINE

Small heat shock proteins sequester misfolding proteins in near-native conformation for cellular protection and efficient refolding

(2016) Sophia Ungelenk et al.   Nature Communications

Berberine induces autophagy in glioblastoma by targeting the AMPK/mTOR/ULK1-pathway

(2016) Jiwei Wang et al.   Oncotarget

Conophylline Protects Cells in Cellular Models of Neurodegenerative Diseases by Inducing Mammalian Target of Rapamycin (mTOR)-independent Autophagy

(2015) Yukiko Sasazawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Treatment with Trehalose Prevents Behavioral and Neurochemical Deficits Produced in an AAV α-Synuclein Rat Model of Parkinson’s Disease

(2015) Qing He et al.   MOLECULAR NEUROBIOLOGY

The role of quercetin on the survival of neuron-like PC12 cells and the expression of α-synuclein

(2015) BeomS Jeon et al.   Neural Regeneration Research

Trehalose decreases mutant SOD1 expression and alleviates motor deficiency in early but not end-stage amyotrophic lateral sclerosis in a SOD1-G93A mouse model

(2015) Y. Li et al.   NEUROSCIENCE

Reversal effects of crocin on amyloid β-induced memory deficit: Modification of autophagy or apoptosis markers

(2015) Farideh Asadi et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Autophagic activity in neuronal cell death

(2015) Robert W. Button et al.   Neuroscience Bulletin

Oleuropein aglycone induces autophagy via the AMPK/mTOR signalling pathway: a mechanistic insight

(2015) Stefania Rigacci et al.   Oncotarget

Therapeutic Effect of Berberine on Huntington’s Disease Transgenic Mouse Model

(2015) Wenxiao Jiang et al.   PLoS One

Spermidine induces autophagy by inhibiting the acetyltransferase EP300

(2014) F Pietrocola et al.   CELL DEATH AND DIFFERENTIATION

Autophagy in the physiology and pathology of the central nervous system

(2014) V Nikoletopoulou et al.   CELL DEATH AND DIFFERENTIATION

Downregulation of PI3K/Akt/mTOR signaling pathway in curcumin-induced autophagy in APP/PS1 double transgenic mice

(2014) Chen Wang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Resveratrol Partially Prevents Rotenone-Induced Neurotoxicity in Dopaminergic SH-SY5Y Cells through Induction of Heme Oxygenase-1 Dependent Autophagy

(2014) Tsu-Kung Lin et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Proteostasis and the Aging Proteome in Health and Disease

(2014) R. I. Morimoto et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Crosstalk Between Macroautophagy and Chaperone-Mediated Autophagy: Implications for the Treatment of Neurological Diseases

(2014) Haijian Wu et al.   MOLECULAR NEUROBIOLOGY

Systemic stress signalling: understanding the cell non-autonomous control of proteostasis

(2014) Rebecca C. Taylor et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Effects of Long-Term Treatment with Quercetin on Cognition and Mitochondrial Function in a Mouse Model of Alzheimer’s Disease

(2014) Dong-Mei Wang et al.   NEUROCHEMICAL RESEARCH

Cucurbitacin E Has Neuroprotective Properties and Autophagic Modulating Activities on Dopaminergic Neurons

(2014) Anne-Marie Arel-Dubeau et al.   Oxidative Medicine and Cellular Longevity

Role of D-Limonene in Autophagy Induced by Bergamot Essential Oil in SH-SY5Y Neuroblastoma Cells

(2014) Rossella Russo et al.   PLoS One

Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins

(2014) B. G. Wilhelm et al.   SCIENCE

Alzheimer’s disease drug-development pipeline: few candidates, frequent failures

(2014) Jeffrey L Cummings et al.   Alzheimers Research & Therapy

Proteostasis and neurodegeneration: The roles of proteasomal degradation and autophagy

(2013) Keiji Tanaka et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Boosting chaperone-mediated autophagy in vivo mitigates α-synuclein-induced neurodegeneration

(2013) Maria Xilouri et al.   BRAIN

The machinery of macroautophagy

(2013) Yuchen Feng et al.   CELL RESEARCH

Chaperone-mediated autophagy: roles in disease and aging

(2013) Ana Maria Cuervo et al.   CELL RESEARCH

Converging Mechanisms in ALS and FTD: Disrupted RNA and Protein Homeostasis

(2013) Shuo-Chien Ling et al.   NEURON

Regulation of Mammalian Autophagy by Class II and III PI 3-Kinases through PI3P Synthesis

(2013) Kelly Devereaux et al.   PLoS One

Astrocyte-Specific Overexpression of Nrf2 Delays Motor Pathology and Synuclein Aggregation throughout the CNS in the Alpha-Synuclein Mutant (A53T) Mouse Model

(2012) L. Gan et al.   JOURNAL OF NEUROSCIENCE

Herbal Extracts and Phytochemicals: Plant Secondary Metabolites and the Enhancement of Human Brain function

(2012) David O. Kennedy et al.   Advances in Nutrition

Autophagy for tissue homeostasis and neuroprotection

(2010) Guillermo Mariño et al.   CURRENT OPINION IN CELL BIOLOGY

Pharma–nutrition interface: The gap is narrowing

(2010) Niki A. Georgiou et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Cargo recognition failure is responsible for inefficient autophagy in Huntington's disease

(2010) Marta Martinez-Vicente et al.   NATURE NEUROSCIENCE

Genome-wide analysis reveals mechanisms modulating autophagy in normal brain aging and in Alzheimer's disease

(2010) M. M. Lipinski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chemistry and Biochemistry of Dietary Polyphenols

(2010) Rong Tsao   Nutrients

Regulation Mechanisms and Signaling Pathways of Autophagy

(2009) Congcong He et al.   Annual Review of Genetics

The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid β accumulation in mice

(2008) Fiona Pickford et al.   JOURNAL OF CLINICAL INVESTIGATION

Autophagic Death of Adult Hippocampal Neural Stem Cells Following Insulin Withdrawal

(2008) Seong-Woon Yu et al.   STEM CELLS