Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles

Inhibition of Regulatory-Associated Protein of Mechanistic Target of Rapamycin Prevents Hyperoxia-Induced Lung Injury by Enhancing Autophagy and Reducing Apoptosis in Neonatal Mice

(2016) Angara Sureshbabu et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Neuroprotection by selective neuronal deletion of Atg7 in neonatal brain injury

(2016) Cuicui Xie et al.   Autophagy

Impaired autophagy in macrophages promotes inflammatory eye disease

(2016) Andrea Santeford et al.   Autophagy

Autophagy deficiency in myeloid cells increases susceptibility to obesity-induced diabetes and experimental colitis

(2016) Hae-Youn Lee et al.   Autophagy

Impairment of chaperone-mediated autophagy induces dopaminergic neurodegeneration in rats

(2016) Maria Xilouri et al.   Autophagy

Activation of MTOR in pulmonary epithelium promotes LPS-induced acute lung injury

(2016) Yue Hu et al.   Autophagy

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

(2016) Daniel J Klionsky et al.   Autophagy

Caloric Restriction Mimetics Enhance Anticancer Immunosurveillance

(2016) Federico Pietrocola et al.   CANCER CELL

Fasting-Mimicking Diet Reduces HO-1 to Promote T Cell-Mediated Tumor Cytotoxicity

(2016) Stefano Di Biase et al.   CANCER CELL

Metabolic Control of Longevity

(2016) Carlos López-Otín et al.   CELL

Fanconi Anemia Proteins Function in Mitophagy and Immunity

(2016) Rhea Sumpter et al.   CELL

Aspergillus Cell Wall Melanin Blocks LC3-Associated Phagocytosis to Promote Pathogenicity

(2016) Tonia Akoumianaki et al.   Cell Host & Microbe

Beige Adipocyte Maintenance Is Regulated by Autophagy-Induced Mitochondrial Clearance

(2016) Svetlana Altshuler-Keylin et al.   Cell Metabolism

Lack of Adipocyte AMPK Exacerbates Insulin Resistance and Hepatic Steatosis through Brown and Beige Adipose Tissue Function

(2016) Emilio P. Mottillo et al.   Cell Metabolism

Drp1-Dependent Mitochondrial Autophagy Plays a Protective Role Against Pressure Overload–Induced Mitochondrial Dysfunction and Heart FailureCLINICAL PERSPECTIVE

(2016) Akihiro Shirakabe et al.   CIRCULATION

Systemic Analysis of Atg5 -Null Mice Rescued from Neonatal Lethality by Transgenic ATG5 Expression in Neurons

(2016) Saori R. Yoshii et al.   DEVELOPMENTAL CELL

Increased autophagy in CD4+T cells of rheumatoid arthritis patients results in T-cell hyperactivation and apoptosis resistance

(2016) Jorg van Loosdregt et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Mammalian Target of Rapamycin Inhibition With Rapamycin Mitigates Radiation-Induced Pulmonary Fibrosis in a Murine Model

(2016) Eun Joo Chung et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Autophagy in adhesion and migration

(2016) Candia M. Kenific et al.   JOURNAL OF CELL SCIENCE

LRRK2 interferes with aggresome formation for autophagic clearance

(2016) Yeojin Bang et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

An Autophagic Flux Probe that Releases an Internal Control

(2016) Takeshi Kaizuka et al.   MOLECULAR CELL

Trade talk: Neuro connector

(2016) Monya Baker   NATURE

Noncanonical autophagy inhibits the autoinflammatory, lupus-like response to dying cells

(2016) Jennifer Martinez et al.   NATURE

Cardioprotection and lifespan extension by the natural polyamine spermidine

(2016) Tobias Eisenberg et al.   NATURE MEDICINE

Activating autophagy to potentiate immunogenic chemotherapy and radiation therapy

(2016) Lorenzo Galluzzi et al.   Nature Reviews Clinical Oncology

Autophagy in acute brain injury

(2016) Lorenzo Galluzzi et al.   NATURE REVIEWS NEUROSCIENCE

Cocaine elicits autophagic cytotoxicity via a nitric oxide-GAPDH signaling cascade

(2016) Prasun Guha et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The ATG conjugation systems are important for degradation of the inner autophagosomal membrane

(2016) Kotaro Tsuboyama et al.   SCIENCE

Long-Term Calorie Restriction Enhances Cellular Quality-Control Processes in Human Skeletal Muscle

(2016) Ling Yang et al.   Cell Reports

Systemic lupus erythematosus

(2016) Arvind Kaul et al.   Nature Reviews Disease Primers

Caloric restriction of db/db mice reverts hepatic steatosis and body weight with divergent hepatic metabolism

(2016) Kyung Eun Kim et al.   Scientific Reports

Rapamycin-mediated mTORC2 inhibition is determined by the relative expression of FK506-binding proteins

(2015) Katherine H. Schreiber et al.   AGING CELL

Mechanisms of Autophagy

(2015) Nobuo N. Noda et al.   Annual Review of Biophysics

Combined evaluation of LC3B puncta and HMGB1 expression predicts residual risk of relapse after adjuvant chemotherapy in breast cancer

(2015) Sylvain Ladoire et al.   Autophagy

Autophagy supports color vision

(2015) Zhenqing Zhou et al.   Autophagy

A TRP Channel Senses Lysosome Neutralization by Pathogens to Trigger Their Expulsion

(2015) Yuxuan Miao et al.   CELL

Lack of Neuronal IFN-β-IFNAR Causes Lewy Body- and Parkinson’s Disease-like Dementia

(2015) Patrick Ejlerskov et al.   CELL

Low Dose Administration of Glutamate Triggers a Non-Apoptotic, Autophagic Response in PC12 Cells

(2015) Eleni Stamoula et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Secretory autophagy

(2015) Marisa Ponpuak et al.   CURRENT OPINION IN CELL BIOLOGY

Unsaturated fatty acids induce non-canonical autophagy

(2015) M. Niso-Santano et al.   EMBO JOURNAL

Autophagy in malignant transformation and cancer progression

(2015) L. Galluzzi et al.   EMBO JOURNAL

Altered TFEB-mediated lysosomal biogenesis in Gaucher disease iPSC-derived neuronal cells

(2015) Ola Awad et al.   HUMAN MOLECULAR GENETICS

Gene-gene interaction of ATG5, ATG7, BLK and BANK1 in systemic lupus erythematosus

(2015) Jie Dang et al.   International Journal of Rheumatic Diseases

Pharmacological Inhibition of ULK1 Kinase Blocks Mammalian Target of Rapamycin (mTOR)-dependent Autophagy

(2015) Katy J. Petherick et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Essential role for autophagy in life span extension

(2015) Frank Madeo et al.   JOURNAL OF CLINICAL INVESTIGATION

Mitochondrial Quality Control via the PGC1 -TFEB Signaling Pathway Is Compromised by Parkin Q311X Mutation But Independently Restored by Rapamycin

(2015) A. Siddiqui et al.   JOURNAL OF NEUROSCIENCE

Organelle-Specific Initiation of Autophagy

(2015) Valentina Sica et al.   MOLECULAR CELL

Small Molecule Inhibition of the Autophagy Kinase ULK1 and Identification of ULK1 Substrates

(2015) Daniel F. Egan et al.   MOLECULAR CELL

FGF signalling regulates bone growth through autophagy

(2015) Laura Cinque et al.   NATURE

Unique role for ATG5 in neutrophil-mediated immunopathology during M. tuberculosis infection

(2015) Jacqueline M. Kimmey et al.   NATURE

Molecular characterization of LC3-associated phagocytosis reveals distinct roles for Rubicon, NOX2 and autophagy proteins

(2015) Jennifer Martinez et al.   NATURE CELL BIOLOGY

Haploinsufficiency of TBK1 causes familial ALS and fronto-temporal dementia

(2015) Axel Freischmidt et al.   NATURE NEUROSCIENCE

Compromised autophagy and neurodegenerative diseases

(2015) Fiona M. Menzies et al.   NATURE REVIEWS NEUROSCIENCE

Retinoic Acid Prevents Disruption of Blood-Spinal Cord Barrier by Inducing Autophagic Flux After Spinal Cord Injury

(2015) Yulong Zhou et al.   NEUROCHEMICAL RESEARCH

Reinstating Aberrant mTORC1 Activity in Huntington’s Disease Mice Improves Disease Phenotypes

(2015) John H. Lee et al.   NEURON

Essential role of D1R in the regulation of mTOR complex1 signaling induced by cocaine

(2015) Laurie P. Sutton et al.   NEUROPHARMACOLOGY

Small-molecule enhancers of autophagy modulate cellular disease phenotypes suggested by human genetics

(2015) Szu-Yu Kuo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Macroautophagy is dispensable for growth of KRAS mutant tumors and chloroquine efficacy

(2015) Christina H. Eng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Insulin secretory granules control autophagy in pancreatic   cells

(2015) A. Goginashvili et al.   SCIENCE

Exome sequencing in amyotrophic lateral sclerosis identifies risk genes and pathways

(2015) E. T. Cirulli et al.   SCIENCE

A Noncanonical Autophagy Pathway Restricts Toxoplasma gondii Growth in a Strain-Specific Manner in IFN-γ-Activated Human Cells

(2015) Elizabeth M. Selleck et al.   mBio

Autophagy enhances NFκB activity in specific tissue macrophages by sequestering A20 to boost antifungal immunity

(2015) Masashi Kanayama et al.   Nature Communications

High intensity interval training improves liver and adipose tissue insulin sensitivity

(2015) Katarina Marcinko et al.   Molecular Metabolism

Diagnosis and classification of autoimmune uveitis

(2014) Carlo Selmi   AUTOIMMUNITY REVIEWS

An autophagic mechanism is involved in apoptotic death of rat striatal neurons induced by the non-N-methyl-D-aspartate receptor agonist kainic acid

(2014) Yan Wang et al.   Autophagy

Neuronal injury in rat model of permanent focal cerebral ischemia is associated with activation of autophagic and lysosomal pathways

(2014) Ya-Dan Wen et al.   Autophagy

Involvement of autophagy in hypoxic-excitotoxic neuronal death

(2014) Vanessa Ginet et al.   Autophagy

Pathogenic role of BECN1/Beclin 1 in the development of amyotrophic lateral sclerosis

(2014) Melissa Nassif et al.   Autophagy

Metformin alleviates hepatosteatosis by restoring SIRT1-mediated autophagy induction via an AMP-activated protein kinase-independent pathway

(2014) Young Mi Song et al.   Autophagy

Endoplasmic reticulum stress induced by tunicamycin and thapsigargin protects against transient ischemic brain injury

(2014) Xiangnan Zhang et al.   Autophagy

A novel ATG4B antagonist inhibits autophagy and has a negative impact on osteosarcoma tumors

(2014) Debra Akin et al.   Autophagy

Transient increase in proteinuria, poly-ubiquitylated proteins and ER stress markers in podocyte-specific autophagy-deficient mice following unilateral nephrectomy

(2014) Juan Alejandro Oliva Trejo et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Characterization of VPS34-IN1, a selective inhibitor of Vps34, reveals that the phosphatidylinositol 3-phosphate-binding SGK3 protein kinase is a downstream target of class III phosphoinositide 3-kinase

(2014) Ruzica Bago et al.   BIOCHEMICAL JOURNAL

Acute metformin preconditioning confers neuroprotection against focal cerebral ischaemia by pre-activation of AMPK-dependent autophagy

(2014) Teng Jiang et al.   BRITISH JOURNAL OF PHARMACOLOGY

2-Methoxyestradiol Attenuates Autophagy Activation After Global Ischemia

(2014) Xiao-Yu Xin et al.   CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES

Tumor Vessel Normalization by Chloroquine Independent of Autophagy

(2014) Hannelore Maes et al.   CANCER CELL

Metabolic Control of Autophagy

(2014) Lorenzo Galluzzi et al.   CELL

To Be or Not to Be? How Selective Autophagy and Cell Death Govern Cell Fate

(2014) Douglas R. Green et al.   CELL

Lysosomal membrane permeabilization and autophagy blockade contribute to photoreceptor cell death in a mouse model of retinitis pigmentosa

(2014) N Rodríguez-Muela et al.   CELL DEATH AND DIFFERENTIATION

Essential versus accessory aspects of cell death: recommendations of the NCCD 2015

(2014) L Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

Histone Deacetylase Inhibition Blunts Ischemia/Reperfusion Injury by Inducing Cardiomyocyte Autophagy

(2014) Min Xie et al.   CIRCULATION

mTORC1 signaling controls mammalian skeletal growth through stimulation of protein synthesis

(2014) Jianquan Chen et al.   DEVELOPMENT

The Parasitophorous Vacuole Membrane of Toxoplasma gondii Is Targeted for Disruption by Ubiquitin-like Conjugation Systems of Autophagy

(2014) Jayoung Choi et al.   IMMUNITY

Deficiency of Autophagy in Dendritic Cells Protects against Experimental Autoimmune Encephalomyelitis

(2014) Abhisek Bhattacharya et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

mTORC1 Is Involved in Hypoxia-Induced Pulmonary Hypertension Through the Activation of Notch3

(2014) Wang Wang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Mitophagy-dependent necroptosis contributes to the pathogenesis of COPD

(2014) Kenji Mizumura et al.   JOURNAL OF CLINICAL INVESTIGATION

The role of autophagy in epileptogenesis and in epilepsy-induced neuronal alterations

(2014) Filippo Sean Giorgi et al.   JOURNAL OF NEURAL TRANSMISSION

Inhibition of Autophagy Contributes to Melatonin-Mediated Neuroprotection Against Transient Focal Cerebral Ischemia in Rats

(2014) Yongqiu Zheng et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Deficient Autophagy Results in Mitochondrial Dysfunction and FSGS

(2014) T. Kawakami et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Ischemic Preconditioning Provides Neuroprotection by Induction of AMP-Activated Protein Kinase-Dependent Autophagy in a Rat Model of Ischemic Stroke

(2014) Teng Jiang et al.   MOLECULAR NEUROBIOLOGY

Enhancement of Autophagy by Histone Deacetylase Inhibitor Trichostatin A Ameliorates Neuronal Apoptosis After Subarachnoid Hemorrhage in Rats

(2014) Anwen Shao et al.   MOLECULAR NEUROBIOLOGY

A highly potent and selective Vps34 inhibitor alters vesicle trafficking and autophagy

(2014) Baptiste Ronan et al.   Nature Chemical Biology

Autophagy Activation Contributes to the Neuroprotection of Remote Ischemic Perconditioning Against Focal Cerebral Ischemia in Rats

(2014) Jingyuan Su et al.   NEUROCHEMICAL RESEARCH

Neuroprotective Effects of Autophagy Induced by Rapamycin in Rat Acute Spinal Cord Injury Model

(2014) Zhen-Yu Wang et al.   NEUROIMMUNOMODULATION

How to build an inducible cartilage-specific transgenic mouse

(2014) Esmeralda N Davidson et al.   ARTHRITIS RESEARCH & THERAPY

A dual role for autophagy in a murine model of lung cancer

(2014) Shuan Rao et al.   Nature Communications

Caloric restriction reduces age-related and all-cause mortality in rhesus monkeys

(2014) Ricki J. Colman et al.   Nature Communications

Autophagy is a critical regulator of memory CD8+ T cell formation

(2014) Daniel J Puleston et al.   eLife

Genetic and Chemical Correction of Cholesterol Accumulation and Impaired Autophagy in Hepatic and Neural Cells Derived from Niemann-Pick Type C Patient-Specific iPS Cells

(2014) Dorothea Maetzel et al.   Stem Cell Reports

Critical Role of FoxO3a in Alcohol-Induced Autophagy and Hepatotoxicity

(2013) Hong-Min Ni et al.   AMERICAN JOURNAL OF PATHOLOGY

Carbon Monoxide Confers Protection in Sepsis by Enhancing Beclin 1-Dependent Autophagy and Phagocytosis

(2013) Seonmin Lee et al.   ANTIOXIDANTS & REDOX SIGNALING

ATG4B/autophagin-1 regulates intestinal homeostasis and protects mice from experimental colitis

(2013) Sandra Cabrera et al.   Autophagy

Cerebral ischemia-reperfusion-induced autophagy protects against neuronal injury by mitochondrial clearance

(2013) Xiangnan Zhang et al.   Autophagy

Host and bacterial factors that regulate LC3 recruitment toListeria monocytogenesduring the early stages of macrophage infection

(2013) Grace Y. Lam et al.   Autophagy

Trehalose delays the progression of amyotrophic lateral sclerosis by enhancing autophagy in motoneurons

(2013) Karen Castillo et al.   Autophagy

Food restriction-induced autophagy modulates degradation of mutant SOD1 in an amyotrophic lateral sclerosis mouse model

(2013) Kunxi Zhang et al.   BRAIN RESEARCH

Excitotoxic glutamate insults block autophagic flux in hippocampal neurons

(2013) Jacqueline R. Kulbe et al.   BRAIN RESEARCH

EGFR-Mediated Beclin 1 Phosphorylation in Autophagy Suppression, Tumor Progression, and Tumor Chemoresistance

(2013) Yongjie Wei et al.   CELL

Noncanonical Autophagy Promotes the Visual Cycle

(2013) Ji-Young Kim et al.   CELL

Autophagy-Mediated Tumor Promotion

(2013) Jessie Yanxiang Guo et al.   CELL

Chaperone-mediated autophagy: roles in disease and aging

(2013) Ana Maria Cuervo et al.   CELL RESEARCH

Diminished Autophagy Limits Cardiac Injury in Mouse Models of Type 1 Diabetes

(2013) Xianmin Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Enhanced autophagy ameliorates cardiac proteinopathy

(2013) Md. Shenuarin Bhuiyan et al.   JOURNAL OF CLINICAL INVESTIGATION

Histone deacetylase 6–mediated selective autophagy regulates COPD-associated cilia dysfunction

(2013) Hilaire C. Lam et al.   JOURNAL OF CLINICAL INVESTIGATION

Phosphofructokinase deficiency impairs ATP generation, autophagy, and redox balance in rheumatoid arthritis T cells

(2013) Zhen Yang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Pharmacological promotion of autophagy alleviates steatosis and injury in alcoholic and non-alcoholic fatty liver conditions in mice

(2013) Chih-Wen Lin et al.   JOURNAL OF HEPATOLOGY

Melatonin-enhanced autophagy protects against neural apoptosis via a mitochondrial pathway in early brain injury following a subarachnoid hemorrhage

(2013) Jingyin Chen et al.   JOURNAL OF PINEAL RESEARCH

The ubiquitin ligase parkin mediates resistance to intracellular pathogens

(2013) Paolo S. Manzanillo et al.   NATURE

p53 status determines the role of autophagy in pancreatic tumour development

(2013) Mathias T. Rosenfeldt et al.   NATURE

Identification of a candidate therapeutic autophagy-inducing peptide

(2013) Sanae Shoji-Kawata et al.   NATURE

De novo mutations in the autophagy gene WDR45 cause static encephalopathy of childhood with neurodegeneration in adulthood

(2013) Hirotomo Saitsu et al.   NATURE GENETICS

Tsc1 (hamartin) confers neuroprotection against ischemia by inducing autophagy

(2013) Michalis Papadakis et al.   NATURE MEDICINE

New concepts in the design of drug-eluting coronary stents

(2013) Scot Garg et al.   Nature Reviews Cardiology

Liver autophagy: much more than just taking out the trash

(2013) Jaime L. Schneider et al.   Nature Reviews Gastroenterology & Hepatology

Antimalarial drug discovery — approaches and progress towards new medicines

(2013) Erika L. Flannery et al.   NATURE REVIEWS MICROBIOLOGY

Propofol prevents cerebral ischemia-triggered autophagy activation and cell death in the rat hippocampus through the NF-κB/p53 signaling pathway

(2013) D.R. Cui et al.   NEUROSCIENCE

Beneficial Role of Rapamycin in Experimental Autoimmune Myositis

(2013) Nicolas Prevel et al.   PLoS One

TFEB-mediated autophagy rescues midbrain dopamine neurons from  -synuclein toxicity

(2013) M. Decressac et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autosis is a Na+,K+-ATPase-regulated form of cell death triggered by autophagy-inducing peptides, starvation, and hypoxia-ischemia

(2013) Y. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Resveratrol potentiates rapamycin to prevent hyperinsulinemia and obesity in male mice on high fat diet

(2013) O V Leontieva et al.   Cell Death & Disease

Overexpression of Atg5 in mice activates autophagy and extends lifespan

(2013) Jong-Ok Pyo et al.   Nature Communications

The TFEB orthologue HLH-30 regulates autophagy and modulates longevity in Caenorhabditis elegans

(2013) Louis R. Lapierre et al.   Nature Communications

Autophagy Sustains Mitochondrial Glutamine Metabolism and Growth of BrafV600E-Driven Lung Tumors

(2013) A. M. Strohecker et al.   Cancer Discovery

Stimulation of autophagy by rapamycin protects neurons from remote degeneration after acute focal brain damage

(2012) Maria Teresa Viscomi et al.   Autophagy

Structurally Distinct Bacterial TBC-like GAPs Link Arf GTPase to Rab1 Inactivation to Counteract Host Defenses

(2012) Na Dong et al.   CELL

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

Host Cell Autophagy Activated by Antibiotics Is Required for Their Effective Antimycobacterial Drug Action

(2012) Jwa-Jin Kim et al.   Cell Host & Microbe

Pancreatic Acinar Cell-Specific Autophagy Disruption Reduces Coxsackievirus Replication and Pathogenesis In Vivo

(2012) Mehrdad Alirezaei et al.   Cell Host & Microbe

Amino Acid Starvation Induced by Invasive Bacterial Pathogens Triggers an Innate Host Defense Program

(2012) Ivan Tattoli et al.   Cell Host & Microbe

Time-Restricted Feeding without Reducing Caloric Intake Prevents Metabolic Diseases in Mice Fed a High-Fat Diet

(2012) Megumi Hatori et al.   Cell Metabolism

Macrophage Autophagy Plays a Protective Role in Advanced Atherosclerosis

(2012) Xianghai Liao et al.   Cell Metabolism

Defects in autophagy favour adherent-invasive Escherichia coli persistence within macrophages leading to increased pro-inflammatory response

(2012) Pierre Lapaquette et al.   CELLULAR MICROBIOLOGY

Rheb is a Critical Regulator of Autophagy During Myocardial Ischemia

(2012) Sebastiano Sciarretta et al.   CIRCULATION

Excitotoxicity: Bridge to various triggers in neurodegenerative disorders

(2012) Ankita Mehta et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Macrophage Autophagy in Immunity to Cryptococcus neoformans and Candida albicans

(2012) André Moraes Nicola et al.   INFECTION AND IMMUNITY

Therapeutic Effects of Valproate Combined With Lithium Carbonate on MPTP-Induced Parkinsonism in Mice: Possible Mediation Through Enhanced Autophagy

(2012) Xue-zhong Li et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

Impaired Autophagy in Neurons after Disinhibition of Mammalian Target of Rapamycin and Its Contribution to Epileptogenesis

(2012) J. McMahon et al.   JOURNAL OF NEUROSCIENCE

Calorie Restriction Enhances Insulin-Stimulated Glucose Uptake and Akt Phosphorylation in Both Fast-Twitch and Slow-Twitch Skeletal Muscle of 24-Month-Old Rats

(2012) D. A. Sequea et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Role of autophagy in early brain injury after subarachnoid hemorrhage in rats

(2012) Hongbo Zhao et al.   MOLECULAR BIOLOGY REPORTS

Exercise-induced BCL2-regulated autophagy is required for muscle glucose homeostasis

(2012) Congcong He et al.   NATURE

Mitochondrial DNA that escapes from autophagy causes inflammation and heart failure

(2012) Takafumi Oka et al.   NATURE

Activation of autophagy by inflammatory signals limits IL-1β production by targeting ubiquitinated inflammasomes for destruction

(2012) Chong-Shan Shi et al.   NATURE IMMUNOLOGY

Autophagy modulation as a potential therapeutic target for diverse diseases

(2012) David C. Rubinsztein et al.   NATURE REVIEWS DRUG DISCOVERY

Therapeutic Effects of Rapamycin on MPTP-Induced Parkinsonism in Mice

(2012) Kangyong Liu et al.   NEUROCHEMICAL RESEARCH

Autophagy activation is associated with neuroprotection against apoptosis via a mitochondrial pathway in a rat model of subarachnoid hemorrhage

(2012) C.-h. Jing et al.   NEUROSCIENCE

NAD+ administration decreases ischemic brain damage partially by blocking autophagy in a mouse model of brain ischemia

(2012) Chaobo Zheng et al.   NEUROSCIENCE LETTERS

Low Dose Rapamycin Exacerbates Autoimmune Experimental Uveitis

(2012) Zili Zhang et al.   PLoS One

Autophagy in Idiopathic Pulmonary Fibrosis

(2012) Avignat S. Patel et al.   PLoS One

Autophagosomes induced by a bacterial Beclin 1 binding protein facilitate obligatory intracellular infection

(2012) H. Niu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autophagy inhibitor Lys05 has single-agent antitumor activity and reproduces the phenotype of a genetic autophagy deficiency

(2012) Q. McAfee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Atg7 Modulates p53 Activity to Regulate Cell Cycle and Survival During Metabolic Stress

(2012) I. H. Lee et al.   SCIENCE

The Legionella Effector RavZ Inhibits Host Autophagy Through Irreversible Atg8 Deconjugation

(2012) A. Choy et al.   SCIENCE

Rapamycin-Induced Insulin Resistance Is Mediated by mTORC2 Loss and Uncoupled from Longevity

(2012) D. W. Lamming et al.   SCIENCE

Akt-Mediated Regulation of Autophagy and Tumorigenesis Through Beclin 1 Phosphorylation

(2012) R. C. Wang et al.   SCIENCE

Nicotinamide phosphoribosyltransferase protects against ischemic stroke through SIRT1-dependent adenosine monophosphate-activated kinase pathway

(2011) Pei Wang et al.   ANNALS OF NEUROLOGY

SQSTM1 Mutations in Familial and Sporadic Amyotrophic Lateral Sclerosis

(2011) Faisal Fecto   ARCHIVES OF NEUROLOGY

Bacterial toxins can inhibit host cell autophagy through cAMP generation

(2011) Shahab Shahnazari et al.   Autophagy

Rapamycin treatment augments motor neuron degeneration in SOD1G93Amouse model of amyotrophic lateral sclerosis

(2011) Xiaojie Zhang et al.   Autophagy

In vivo optical imaging for evaluating the efficacy of edaravone after transient cerebral ischemia in mice

(2011) Ning Liu et al.   BRAIN RESEARCH

Microautophagy: lesser-known self-eating

(2011) Wen-wen Li et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Autophagy-deficient mice develop multiple liver tumors

(2011) A. Takamura et al.   GENES & DEVELOPMENT

Copy number variations on chromosome 12q14 in patients with normal tension glaucoma

(2011) John H. Fingert et al.   HUMAN MOLECULAR GENETICS

Caloric Restriction Ameliorates Angiotensin II–Induced Mitochondrial Remodeling and Cardiac Hypertrophy

(2011) Piet Finckenberg et al.   HYPERTENSION

Azithromycin blocks autophagy and may predispose cystic fibrosis patients to mycobacterial infection

(2011) Maurizio Renna et al.   JOURNAL OF CLINICAL INVESTIGATION

Dendrimer-mediated siRNA delivery knocks down Beclin 1 and potentiates NMDA-mediated toxicity in rat cortical neurons

(2011) María D. Pérez-Carrión et al.   JOURNAL OF NEUROCHEMISTRY

Melatonin attenuates kainic acid-induced neurotoxicity in mouse hippocampus via inhibition of autophagy and α-synuclein aggregation

(2011) Chia-Fu Chang et al.   JOURNAL OF PINEAL RESEARCH

Image-based genome-wide siRNA screen identifies selective autophagy factors

(2011) Anthony Orvedahl et al.   NATURE

The role of antimalarial agents in the treatment of SLE and lupus nephritis

(2011) Senq-J Lee et al.   Nature Reviews Nephrology

Autophagy is involved in traumatic brain injury-induced cell death and contributes to functional outcome deficits in mice

(2011) C.-L. Luo et al.   NEUROSCIENCE

The Burkholderia pseudomallei Type III Secretion System and BopA Are Required for Evasion of LC3-Associated Phagocytosis

(2011) Lan Gong et al.   PLoS One

Preconditioning Involves Selective Mitophagy Mediated by Parkin and p62/SQSTM1

(2011) Chengqun Huang et al.   PLoS One

Autophagy-Dependent Anticancer Immune Responses Induced by Chemotherapeutic Agents in Mice

(2011) M. Michaud et al.   SCIENCE

Mitochondria and the Autophagy-Inflammation-Cell Death Axis in Organismal Aging

(2011) D. R. Green et al.   SCIENCE

Resveratrol Attenuates Renal Hypertrophy in Early-Stage Diabetes by Activating AMPK

(2010) Da-Fa Ding et al.   AMERICAN JOURNAL OF NEPHROLOGY

Autophagic Protein LC3B Confers Resistance against Hypoxia-induced Pulmonary Hypertension

(2010) Seon-Jin Lee et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Treatment with rapamycin prevents fibrosis in tight-skin and bleomycin-induced mouse models of systemic sclerosis

(2010) Ayumi Yoshizaki et al.   ARTHRITIS AND RHEUMATISM

Suppression of autophagy permits successful enzyme replacement therapy in a lysosomal storage disorder—murine Pompe disease

(2010) Nina Raben et al.   Autophagy

Autophagy activation is associated with neuroprotection in a rat model of focal cerebral ischemic preconditioning

(2010) Rui Sheng et al.   Autophagy

Reversal of autophagy dysfunction in the TgCRND8 mouse model of Alzheimer's disease ameliorates amyloid pathologies and memory deficits

(2010) Dun-Sheng Yang et al.   BRAIN

Lysosomal Proteolysis and Autophagy Require Presenilin 1 and Are Disrupted by Alzheimer-Related PS1 Mutations

(2010) Ju-Hyun Lee et al.   CELL

C/EBPβ Controls Exercise-Induced Cardiac Growth and Protects against Pathological Cardiac Remodeling

(2010) Pontus Boström et al.   CELL

Mechanisms of Life Span Extension by Rapamycin in the Fruit Fly Drosophila melanogaster

(2010) Ivana Bjedov et al.   Cell Metabolism

Defective Hepatic Autophagy in Obesity Promotes ER Stress and Causes Insulin Resistance

(2010) Ling Yang et al.   Cell Metabolism

Neutrophil extracellular trap cell death requires both autophagy and superoxide generation

(2010) Quinten Remijsen et al.   CELL RESEARCH

Profound Cardioprotection With Chloramphenicol Succinate in the Swine Model of Myocardial Ischemia-Reperfusion Injury

(2010) J. A. Sala-Mercado et al.   CIRCULATION

Autophagy regulation by p53

(2010) Maria Chiara Maiuri et al.   CURRENT OPINION IN CELL BIOLOGY

Autophagy Reduces Acute Ethanol-Induced Hepatotoxicity and Steatosis in Mice

(2010) Wen–Xing Ding et al.   GASTROENTEROLOGY

Tsc2 gene inactivation causes a more severe epilepsy phenotype than Tsc1 inactivation in a mouse model of Tuberous Sclerosis Complex

(2010) L.-H. Zeng et al.   HUMAN MOLECULAR GENETICS

Overexpression of optineurin E50K disrupts Rab8 interaction and leads to a progressive retinal degeneration in mice

(2010) Zai-Long Chi et al.   HUMAN MOLECULAR GENETICS

Laforin, the most common protein mutated in Lafora disease, regulates autophagy

(2010) Carmen Aguado et al.   HUMAN MOLECULAR GENETICS

Genetic variation in the autophagy gene ULK1 and risk of Crohnʼs disease

(2010) Liesbet Henckaerts et al.   INFLAMMATORY BOWEL DISEASES

AMP-activated Protein Kinase Signaling Activation by Resveratrol Modulates Amyloid-β Peptide Metabolism

(2010) Valérie Vingtdeux et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular Interplay between Mammalian Target of Rapamycin (mTOR), Amyloid-β, and Tau

(2010) Antonella Caccamo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autophagy influences glomerular disease susceptibility and maintains podocyte homeostasis in aging mice

(2010) Björn Hartleben et al.   JOURNAL OF CLINICAL INVESTIGATION

Rapamycin inhibits relapsing experimental autoimmune encephalomyelitis by both effector and regulatory T cells modulation

(2010) Marianna Esposito et al.   JOURNAL OF NEUROIMMUNOLOGY

Rapamycin Protects against Neuron Death in In Vitro andIn Vivo Models of Parkinson's Disease

(2010) C. Malagelada et al.   JOURNAL OF NEUROSCIENCE

Pathogenic Lysosomal Depletion in Parkinson's Disease

(2010) B. Dehay et al.   JOURNAL OF NEUROSCIENCE

Rapamycin induces growth retardation by disrupting angiogenesis in the growth plate

(2010) Óscar Álvarez-García et al.   KIDNEY INTERNATIONAL

Defective CFTR induces aggresome formation and lung inflammation in cystic fibrosis through ROS-mediated autophagy inhibition

(2010) Alessandro Luciani et al.   NATURE CELL BIOLOGY

Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

(2010) Kiichi Nakahira et al.   NATURE IMMUNOLOGY

Trehalose ameliorates dopaminergic and tau pathology in parkin deleted/tau overexpressing mice through autophagy activation

(2010) Jose A. Rodríguez-Navarro et al.   NEUROBIOLOGY OF DISEASE

Inhibition of the mammalian target of rapamycin pathway by rapamycin blocks cocaine-induced locomotor sensitization

(2010) J. Wu et al.   NEUROSCIENCE

Selective Molecular Alterations in the Autophagy Pathway in Patients with Lewy Body Disease and in Models of α-Synucleinopathy

(2010) Leslie Crews et al.   PLoS One

Inhibition of mTOR by Rapamycin Abolishes Cognitive Deficits and Reduces Amyloid-β Levels in a Mouse Model of Alzheimer's Disease

(2010) Patricia Spilman et al.   PLoS One

Autophagy protein microtubule-associated protein 1 light chain-3B (LC3B) activates extrinsic apoptosis during cigarette smoke-induced emphysema

(2010) Z.-H. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An Autophagy-Enhancing Drug Promotes Degradation of Mutant  1-Antitrypsin Z and Reduces Hepatic Fibrosis

(2010) T. Hidvegi et al.   SCIENCE

Caloric restriction and resveratrol promote longevity through the Sirtuin-1-dependent induction of autophagy

(2010) E Morselli et al.   Cell Death & Disease

RNA interference-mediated downregulation of Beclin1 attenuates cerebral ischemic injury in rats

(2009) Yong-qiu Zheng et al.   ACTA PHARMACOLOGICA SINICA

Postischemic treatment of neonatal cerebral ischemia should target autophagy

(2009) Julien Puyal et al.   ANNALS OF NEUROLOGY

Treatment with sirolimus results in complete responses in patients with autoimmune lymphoproliferative syndrome

(2009) David T. Teachey et al.   BRITISH JOURNAL OF HAEMATOLOGY

Autophagy supportsCandida glabratasurvival during phagocytosis

(2009) Andreas Roetzer et al.   CELLULAR MICROBIOLOGY

Autophagy Is an Essential Component of Drosophila Immunity against Vesicular Stomatitis Virus

(2009) Spencer Shelly et al.   IMMUNITY

Constitutive Reactive Oxygen Species Generation from Autophagosome/Lysosome in Neuronal Oxidative Toxicity

(2009) Chisato Kubota et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pharmacological Inhibition of mTORC1 Suppresses Anatomical, Cellular, and Behavioral Abnormalities in Neural-Specific Pten Knock-Out Mice

(2009) J. Zhou et al.   JOURNAL OF NEUROSCIENCE

Beclin 1 Gene Transfer Activates Autophagy and Ameliorates the Neurodegenerative Pathology in  -Synuclein Models of Parkinson's and Lewy Body Diseases

(2009) B. Spencer et al.   JOURNAL OF NEUROSCIENCE

Discovery of Atg5/Atg7-independent alternative macroautophagy

(2009) Yuya Nishida et al.   NATURE

Listeria monocytogenes ActA-mediated escape from autophagic recognition

(2009) Yuko Yoshikawa et al.   NATURE CELL BIOLOGY

Induction of autophagy by spermidine promotes longevity

(2009) Tobias Eisenberg et al.   NATURE CELL BIOLOGY

Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry

(2009) Leonardo H Travassos et al.   NATURE IMMUNOLOGY

The TBK1 adaptor and autophagy receptor NDP52 restricts the proliferation of ubiquitin-coated bacteria

(2009) Teresa L M Thurston et al.   NATURE IMMUNOLOGY

Rapamycin activation of 4E-BP prevents parkinsonian dopaminergic neuron loss

(2009) Luke S Tain et al.   NATURE NEUROSCIENCE

PINK1-dependent recruitment of Parkin to mitochondria in mitophagy

(2009) C. Vives-Bauza et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of Autophagy Prevents Hippocampal Pyramidal Neuron Death after Hypoxic-Ischemic Injury

(2008) Masato Koike et al.   AMERICAN JOURNAL OF PATHOLOGY

Rapamycin prevents epilepsy in a mouse model of tuberous sclerosis complex

(2008) Ling-Hui Zeng et al.   ANNALS OF NEUROLOGY

Rapamycin affects early fracture healing in mice

(2008) J H Holstein et al.   BRITISH JOURNAL OF PHARMACOLOGY

Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009

(2008) G Kroemer et al.   CELL DEATH AND DIFFERENTIATION

Autophagosome-Independent Essential Function for the Autophagy Protein Atg5 in Cellular Immunity to Intracellular Pathogens

(2008) Zijiang Zhao et al.   Cell Host & Microbe

Loss of Autophagy Diminishes Pancreatic β Cell Mass and Function with Resultant Hyperglycemia

(2008) Hye Seung Jung et al.   Cell Metabolism

Inhibition of human immunodeficiency virus (HIV-1) infection in human peripheral blood leucocytes-SCID reconstituted mice by rapamycin

(2008) F. Nicoletti et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Suppression of autophagy in skeletal muscle uncovers the accumulation of ubiquitinated proteins and their potential role in muscle damage in Pompe disease

(2008) N. Raben et al.   HUMAN MOLECULAR GENETICS

Everolimus for refractory Crohnʼs disease: A case report

(2008) Jérôme Dumortier et al.   INFLAMMATORY BOWEL DISEASES

Protective role of autophagy in neonatal hypoxia–ischemia induced brain injury

(2008) Silvia Carloni et al.   NEUROBIOLOGY OF DISEASE

Neuroprotection of rapamycin in lactacystin-induced neurodegeneration via autophagy enhancement

(2008) Tianhong Pan et al.   NEUROBIOLOGY OF DISEASE

Cystatin C-Cathepsin B Axis Regulates Amyloid Beta Levels and Associated Neuronal Deficits in an Animal Model of Alzheimer's Disease

(2008) Binggui Sun et al.   NEURON

Combined lithium and valproate treatment delays disease onset, reduces neurological deficits and prolongs survival in an amyotrophic lateral sclerosis mouse model

(2008) H.-L. Feng et al.   NEUROSCIENCE

Egr-1 Regulates Autophagy in Cigarette Smoke-Induced Chronic Obstructive Pulmonary Disease

(2008) Zhi-Hua Chen et al.   PLoS One

Autophagy is an adaptive response in desmin-related cardiomyopathy

(2008) P. Tannous et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA