The Potential Use of Plant Natural Products and Plant Extracts with Antioxidant Properties for the Prevention/Treatment of Neurodegenerative Diseases: In Vitro, In Vivo and Clinical Trials

Toward Therapy of Human Prion Diseases

(2018) Adriano Aguzzi et al.   Annual Review of Pharmacology and Toxicology

The Neuroprotective Effects of Thymoquinone: A Review

(2018) Tahereh Farkhondeh et al.   Dose-Response

Novel vanillin derivatives: Synthesis, anti-oxidant, DNA and cellular protection properties

(2018) Matteo Scipioni et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Revalorisation of rapeseed pomace extracts: An in vitro study into its anti-oxidant and DNA protective properties

(2018) Franziska Pohl et al.   FOOD CHEMISTRY

Reversible Conformational Conversion of α-Synuclein into Toxic Assemblies by Glucosylceramide

(2018) Friederike Zunke et al.   NEURON

Drug Synergy Slows Aging and Improves Healthspan through IGF and SREBP Lipid Signaling

(2018) Tesfahun Dessale Admasu et al.   DEVELOPMENTAL CELL

Efficacy and Adverse Effects of Ginkgo Biloba for Cognitive Impairment and Dementia: A Systematic Review and Meta-Analysis

(2018) Meng-Shan Tan et al.   JOURNAL OF ALZHEIMERS DISEASE

Animal models of neurodegenerative diseases

(2018) Ted M. Dawson et al.   NATURE NEUROSCIENCE

Nrf2-Inducers Counteract Neurodegeneration in Frataxin-Silenced Motor Neurons: Disclosing New Therapeutic Targets for Friedreich’s Ataxia

(2017) Sara Petrillo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Comparison of Antioxidant Evaluation Assays for Investigating Antioxidative Activity of Gallic Acid and Its Alkyl Esters in Different Food Matrices

(2017) Natthaporn Phonsatta et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Combination therapy with octyl gallate and ferulic acid improves cognition and neurodegeneration in a transgenic mouse model of Alzheimer's disease

(2017) Takashi Mori et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Epigallocatechin Gallate Has a Neurorescue Effect in a Mouse Model of Parkinson Disease

(2017) Qi Xu et al.   JOURNAL OF NUTRITION

Bridging the gap: large animal models in neurodegenerative research

(2017) S. L. Eaton et al.   MAMMALIAN GENOME

Natural Dietary Supplementation of Anthocyanins via PI3K/Akt/Nrf2/HO-1 Pathways Mitigate Oxidative Stress, Neurodegeneration, and Memory Impairment in a Mouse Model of Alzheimer’s Disease

(2017) Tahir Ali et al.   MOLECULAR NEUROBIOLOGY

Chemical Composition and Biological Activity of Allium cepa L. and Allium × cornutum (Clementi ex Visiani 1842) Methanolic Extracts

(2017) Željana Fredotović et al.   MOLECULES

In vitro assessment of the indirect antioxidant activity of Sulforaphane in redox imbalance vanadium-induced

(2017) Giuseppa Visalli et al.   NATURAL PRODUCT RESEARCH

Caffeine as symptomatic treatment for Parkinson disease (Café-PD)

(2017) Ronald B. Postuma et al.   NEUROLOGY

Extracts from two ubiquitous Mediterranean plants ameliorate cellular and animal models of neurodegenerative proteinopathies

(2017) Michelle Briffa et al.   NEUROSCIENCE LETTERS

The Neuroprotective Effects of Phenolic Acids: Molecular Mechanism of Action

(2017) et al.   Nutrients

Three-Dimensional Models of the Human Brain Development and Diseases

(2017) Mehdi Jorfi et al.   Advanced Healthcare Materials

Beneficial Effects of Sulforaphane Treatment in Alzheimer's Disease May Be Mediated through Reduced HDAC1/3 and Increased P75NTR Expression

(2017) Jingzhu Zhang et al.   Frontiers in Aging Neuroscience

Modeling Human Neurological and Neurodegenerative Diseases: From Induced Pluripotent Stem Cells to Neuronal Differentiation and Its Applications in Neurotrauma

(2017) Hisham Bahmad et al.   Frontiers in Molecular Neuroscience

Reactive Oxygen Species: Stuck in the Middle of Neurodegeneration

(2017) David A. Patten et al.   JOURNAL OF ALZHEIMERS DISEASE

Grape Derived Polyphenols Attenuate Tau Neuropathology in a Mouse Model of Alzheimer's Disease

(2017) Jun Wang et al.   JOURNAL OF ALZHEIMERS DISEASE

Treatment with Caffeic Acid and Resveratrol Alleviates Oxidative Stress Induced Neurotoxicity in Cell and Drosophila Models of Spinocerebellar Ataxia Type3

(2017) Yu-Ling Wu et al.   Scientific Reports

Neural Differentiation in the Third Dimension: Generating a Human Midbrain

(2016) Rebecca M. Marton et al.   Cell Stem Cell

Anthoxanthin Polyphenols Attenuate AβOligomer-induced Neuronal Responses Associated with Alzheimer's Disease

(2016) Kayla M. Pate et al.   CNS Neuroscience & Therapeutics

Asparagine endopeptidase is an innovative therapeutic target for neurodegenerative diseases

(2016) Zhentao Zhang et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Natural Products as Sources of New Drugs from 1981 to 2014

(2016) David J. Newman et al.   JOURNAL OF NATURAL PRODUCTS

Allium cepaExtract and Quercetin Protect Neuronal Cells from Oxidative Stress via PKC-εInactivation/ERK1/2 Activation

(2016) Bo Kyung Lee et al.   Oxidative Medicine and Cellular Longevity

Sinapic Acid and Its Derivatives as Medicine in Oxidative Stress-Induced Diseases and Aging

(2016) Chunye Chen   Oxidative Medicine and Cellular Longevity

Sulforaphane and Other Nutrigenomic Nrf2 Activators: Can the Clinician’s Expectation Be Matched by the Reality?

(2016) Christine A. Houghton et al.   Oxidative Medicine and Cellular Longevity

Sorbus alnifolia protects dopaminergic neurodegeneration in Caenorhabditis elegans

(2016) Se-Myeong Cheon et al.   PHARMACEUTICAL BIOLOGY

Study into the polyphenol content and antioxidant activity of rapeseed pomace extracts

(2016) F. Pohl et al.   PROCEEDINGS OF THE NUTRITION SOCIETY

Caloric restriction blocks neuropathology and motor deficits in Machado–Joseph disease mouse models through SIRT1 pathway

(2016) Janete Cunha-Santos et al.   Nature Communications

Sulforaphane protects against rotenone-induced neurotoxicity in vivo: Involvement of the mTOR, Nrf2 and autophagy pathways

(2016) Qian Zhou et al.   Scientific Reports

Safety and Clinical Effects of Mesenchymal Stem Cells Secreting Neurotrophic Factor Transplantation in Patients With Amyotrophic Lateral Sclerosis

(2016) Panayiota Petrou et al.   JAMA Neurology

Antioxidants inhibit neuronal toxicity in Parkinson's disease-linked LRRK2

(2016) Dario C. Angeles et al.   Annals of Clinical and Translational Neurology

Induction of NRF2-mediated gene expression by dietary phytochemical flavones apigenin and luteolin

(2015) Ximena Paredes-Gonzalez et al.   BIOPHARMACEUTICS & DRUG DISPOSITION

Long-term treatment with Ginkgo biloba extract EGb 761 improves symptoms and pathology in a transgenic mouse model of Alzheimer’s disease

(2015) Xu Liu et al.   BRAIN BEHAVIOR AND IMMUNITY

Using C. elegans to discover therapeutic compounds for ageing-associated neurodegenerative diseases

(2015) Xi Chen et al.   Chemistry Central Journal

Neurosupportive Role of Vanillin, a Natural Phenolic Compound, on Rotenone Induced Neurotoxicity in SH-SY5Y Neuroblastoma Cells

(2015) Chinnasamy Dhanalakshmi et al.   Evidence-based Complementary and Alternative Medicine

Drosophilaas anIn VivoModel for Human Neurodegenerative Disease

(2015) Leeanne McGurk et al.   GENETICS

Synergistic, additive and antagonistic effects of Potentilla fruticosa combined with EGb761 on antioxidant capacities and the possible mechanism

(2015) Shanshan Wang et al.   INDUSTRIAL CROPS AND PRODUCTS

Investigation of the potential synergistic effect of resveratrol with other phenolic compounds: A case of binary phenolic mixtures

(2015) Danijela Skroza et al.   JOURNAL OF FOOD COMPOSITION AND ANALYSIS

Neuroprotective Effects of the Cultivated Chondrus crispus in a C. elegans Model of Parkinson’s Disease

(2015) Jinghua Liu et al.   Marine Drugs

The re-emergence of natural products for drug discovery in the genomics era

(2015) Alan L. Harvey et al.   NATURE REVIEWS DRUG DISCOVERY

Attenuation of neuromotor deficits by natural antioxidants of Decalepis hamiltonii in transgenic Drosophila model of Parkinson’s disease

(2015) S.R. Jahromi et al.   NEUROSCIENCE

Resveratrol: A Focus on Several Neurodegenerative Diseases

(2015) Ester Tellone et al.   Oxidative Medicine and Cellular Longevity

Role of Polyphenols and Other Phytochemicals on Molecular Signaling

(2015) Swapna Upadhyay et al.   Oxidative Medicine and Cellular Longevity

Neuroprotective potential of ferulic acid in the rotenone model of Parkinson’s disease

(2015) Emdadul Haque et al.   Drug Design Development and Therapy

Drosophilaas anIn VivoModel for Human Neurodegenerative Disease

(2015) Leeanne McGurk et al.   GENETICS

The Role of Oxidative Stress in Neurodegenerative Diseases

(2015) Geon Ha Kim et al.   Experimental Neurobiology

Sulforaphane Ameliorates Neurobehavioral Deficits and Protects the Brain From Amyloid β Deposits and Peroxidation in Mice With Alzheimer-Like Lesions

(2014) Rui Zhang et al.   American Journal of Alzheimers Disease and Other Dementias

Systematic Review of Clinical Trials Assessing Pharmacological Properties ofSalviaSpecies on Memory, Cognitive Impairment and Alzheimer's Disease

(2014) Marco Miroddi et al.   CNS Neuroscience & Therapeutics

Antioxidant Activity, Delayed Aging, and Reduced Amyloid-β Toxicity of Methanol Extracts of Tea Seed Pomace from Camellia tenuifolia

(2014) Chia-Cheng Wei et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Sulforaphane enhances proteasomal and autophagic activities in mice and is a potential therapeutic reagent for Huntington's disease

(2014) Yanying Liu et al.   JOURNAL OF NEUROCHEMISTRY

Onion extract (Allium cepaL.), quercetin and catechin up-regulate paraoxonase 1 activity with concomitant protection against low-density lipoprotein oxidation in male Wistar rats subjected to oxidative stress

(2014) Nidhi Jaiswal et al.   JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE

The neuroprotective potential of sinapic acid in the 6-hydroxydopamine-induced hemi-parkinsonian rat

(2014) Kobra Zare et al.   METABOLIC BRAIN DISEASE

Alzheimer’s disease drug-development pipeline: few candidates, frequent failures

(2014) Jeffrey L Cummings et al.   Alzheimers Research & Therapy

Caenorhabditis elegans: a model to investigate oxidative stress and metal dyshomeostasis in Parkinson's disease

(2014) Patricia M. Chege et al.   Frontiers in Aging Neuroscience

Huperzine A: Is it an Effective Disease-Modifying Drug for Alzheimer’s Disease?

(2014) Zhong Ming Qian et al.   Frontiers in Aging Neuroscience

Use of Caenorhabditis elegans as a model to study Alzheimer’s disease and other neurodegenerative diseases

(2014) Adanna G. Alexander et al.   Frontiers in Genetics

Ginkgo biloba Extracts: A Review of the Pharmacokinetics of the Active Ingredients

(2013) Christian Ude et al.   CLINICAL PHARMACOKINETICS

Shifting from the single to the multitarget paradigm in drug discovery

(2013) José L. Medina-Franco et al.   DRUG DISCOVERY TODAY

Grape Pomace as a Sustainable Source of Bioactive Compounds: Extraction, Characterization, and Biotechnological Applications of Phenolics

(2013) Ariel R. Fontana et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Isolation and characterization of bioactive compounds from plant resources: The role of analysis in the ethnopharmacological approach

(2013) G. Brusotti et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Reducing iron in the brain: a novel pharmacologic mechanism of huperzine A in the treatment of Alzheimer's disease

(2013) Xiao-Tian Huang et al.   NEUROBIOLOGY OF AGING

Achieving the Balance between ROS and Antioxidants: When to Use the Synthetic Antioxidants

(2013) Borut Poljsak et al.   Oxidative Medicine and Cellular Longevity

Neuroprotective Effects of a Variety of Pomegranate Juice Extracts against MPTP-Induced Cytotoxicity and Oxidative Stress in Human Primary Neurons

(2013) Nady Braidy et al.   Oxidative Medicine and Cellular Longevity

Ginkgo biloba extract EGb 761® in the treatment of dementia: a pharmacoeconomic analysis of the Austrian setting

(2013) Michael Rainer et al.   WIENER KLINISCHE WOCHENSCHRIFT

Animal models of Parkinson’s disease

(2012) Fabio Blandini et al.   FEBS Journal

A review on antioxidants, prooxidants and related controversy: Natural and synthetic compounds, screening and analysis methodologies and future perspectives

(2012) Márcio Carocho et al.   FOOD AND CHEMICAL TOXICOLOGY

Importance of Brassica napus as a medicinal food plant

(2012) Soodabeh Saeidnia   Journal of Medicinal Plants Research

Natural Products As Sources of New Drugs over the 30 Years from 1981 to 2010

(2012) David J. Newman et al.   JOURNAL OF NATURAL PRODUCTS

Ginkgo biloba extract EGb 761® in dementia with neuropsychiatric features: A randomised, placebo-controlled trial to confirm the efficacy and safety of a daily dose of 240 mg

(2012) Horst Herrschaft et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Mechanism of Oxidative Stress in Neurodegeneration

(2012) Sonia Gandhi et al.   Oxidative Medicine and Cellular Longevity

Neuroprotective effect of sinapic acid in a mouse model of amyloid β1–42 protein-induced Alzheimer's disease

(2012) Hyung Eun Lee et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Genetically engineered mouse models of the trinucleotide-repeat spinocerebellar ataxias

(2011) Melissa A.C. Ingram et al.   BRAIN RESEARCH BULLETIN

Antioxidant properties of natural polyphenols and their therapeutic potentials for Alzheimer's disease

(2011) Dong-Young Choi et al.   BRAIN RESEARCH BULLETIN

Antiapoptotic Drugs: A Therapautic Strategy for the Prevention of Neurodegenerative Diseases

(2011) Francesc X. Sureda et al.   CURRENT PHARMACEUTICAL DESIGN

Antioxidant and prooxidant properties of flavonoids

(2011) D. Procházková et al.   FITOTERAPIA

Stability of phytochemicals as sources of anti-inflammatory nutraceuticals in beverages — A review

(2011) Niamh Harbourne et al.   FOOD RESEARCH INTERNATIONAL

The development of fruit-based functional foods targeting the health and wellness market: a review

(2011) Dongxiao Sun-Waterhouse   INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY

Identification of anthocyanins in black soybean (Glycine max (L.) Merr.) varieties

(2011) Kwangoh Koh et al.   JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE

Biological activity of piceatannol: Leaving the shadow of resveratrol

(2011) Hanna Piotrowska et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

Protective Effects of Walnut Extract Against Amyloid Beta Peptide-Induced Cell Death and Oxidative Stress in PC12 Cells

(2011) Balu Muthaiyah et al.   NEUROCHEMICAL RESEARCH

A phase II trial of huperzine A in mild to moderate Alzheimer disease

(2011) M. S. Rafii et al.   NEUROLOGY

Phytochemicals of Brassicaceae in plant protection and human health – Influences of climate, environment and agronomic practice

(2011) Maria Björkman et al.   PHYTOCHEMISTRY

Evaluation of antioxidant activity of vanillin by using multiple antioxidant assays

(2010) Akihiro Tai et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Antioxidant activity and cell toxicity of pressurised liquid extracts from 20 selected plant species in Jeju, Korea

(2010) Mi-Bo Kim et al.   FOOD CHEMISTRY

Natural and synthetic antioxidants: An updated overview

(2010) Agnieszka Augustyniak et al.   FREE RADICAL RESEARCH

Synthesis, Inhibitory Activity of Cholinesterases, and Neuroprotective Profile of Novel 1,8-Naphthyridine Derivatives

(2010) Cristóbal de los Ríos et al.   JOURNAL OF MEDICINAL CHEMISTRY

A brief history of levodopa

(2010) Oleh Hornykiewicz   JOURNAL OF NEUROLOGY

Synaptic Plasticity in the Hippocampus of a APP/PS1 Mouse Model of Alzheimer's Disease Is Impaired in Old but Not Young Mice

(2010) Simon Gengler et al.   PLoS One

Recent developments in Alzheimer's disease therapeutics

(2009) Michael S Rafii et al.   BMC Medicine

Oxidative Stress and Neurodegenerative Diseases: A Review of Upstream and Downstream Antioxidant Therapeutic Options

(2009) Bayani Uttara et al.   Current Neuropharmacology

Antioxidant properties of resveratrol: A structure–activity insight

(2009) İlhami Gülçin   Innovative Food Science & Emerging Technologies

Neuroprotective Effects of Onion Extract and Quercetin Against Ischemic Neuronal Damage in the Gerbil Hippocampus

(2009) In Koo Hwang et al.   JOURNAL OF MEDICINAL FOOD

Vanillin Improves and Prevents Trinitrobenzene Sulfonic Acid-Induced Colitis in Mice

(2009) S.-L. Wu et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Ageing populations: the challenges ahead

(2009) Kaare Christensen et al.   LANCET

Ginkgo biloba for Prevention of DementiaA Randomized Controlled Trial

(2008) Steven T. DeKosky   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION