Melatonin reverses H2 O2 -induced senescence in SH-SY5Y cells by enhancing autophagy via sirtuin 1 deacetylation of the RelA/p65 subunit of NF-κB

Melatonin and sirtuins: A “not-so unexpected” relationship

(2017) Juan C. Mayo et al.   JOURNAL OF PINEAL RESEARCH

Slowing ageing by design: the rise of NAD+ and sirtuin-activating compounds

(2016) Michael S. Bonkowski et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Melatonin regulates the autophagic flux via activation of alpha-7 nicotinic acetylcholine receptors

(2015) Jae-Kyo Jeong et al.   JOURNAL OF PINEAL RESEARCH

Ceramide metabolism regulates autophagy and apoptotic cell death induced by melatonin in liver cancer cells

(2015) Raquel Ordoñez et al.   JOURNAL OF PINEAL RESEARCH

Melatonin alleviates brain injury in mice subjected to cecal ligation and puncture via attenuating inflammation, apoptosis, and oxidative stress: the role of SIRT1 signaling

(2015) Lei Zhao et al.   JOURNAL OF PINEAL RESEARCH

Caloric restriction, resveratrol and melatonin: Role of SIRT1 and implications for aging and related-diseases

(2015) Margarita R. Ramis et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Longevity pathways converge on autophagy genes to regulate life span inCaenorhabditis elegans

(2014) Márton L. Tóth et al.   Autophagy

Extrapineal melatonin: sources, regulation, and potential functions

(2014) Darío Acuña-Castroviejo et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Sirtuin-1 (SIRT1) Is Required for Promoting Chondrogenic Differentiation of Mesenchymal Stem Cells

(2014) Constanze Buhrmann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Involvement of autophagy in melatonin-induced cytotoxicity in glioma-initiating cells

(2014) Vanesa Martín et al.   JOURNAL OF PINEAL RESEARCH

Metabolic Control by Target of Rapamycin and Autophagy during Ageing - A Mini-Review

(2013) Maria Markaki et al.   GERONTOLOGY

Beclin 1 interactome controls the crosstalk between apoptosis, autophagy and inflammasome activation: Impact on the aging process

(2012) Antero Salminen et al.   AGEING RESEARCH REVIEWS

Autophagy regulates TNFα-mediated joint destruction in experimental arthritis

(2012) Neng-Yu Lin et al.   ANNALS OF THE RHEUMATIC DISEASES

SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice

(2012) Hongwei Yao et al.   JOURNAL OF CLINICAL INVESTIGATION

Melatonin-induced autophagy protects against human prion protein-mediated neurotoxicity

(2012) Jae-Kyo Jeong et al.   JOURNAL OF PINEAL RESEARCH

Melatonin induces autophagy via an mTOR-dependent pathway and enhances clearance of mutant-TGFBIp

(2012) Seung-Il Choi et al.   JOURNAL OF PINEAL RESEARCH

Role of melatonin in the regulation of autophagy and mitophagy: A review

(2012) Ana Coto-Montes et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Negative regulation of inflammation by SIRT1

(2012) Jun Xie et al.   PHARMACOLOGICAL RESEARCH

SIRT1 Activators Suppress Inflammatory Responses through Promotion of p65 Deacetylation and Inhibition of NF-κB Activity

(2012) Hongying Yang et al.   PLoS One

Autophagy and Aging

(2011) David C. Rubinsztein et al.   CELL

SirT1 Regulates Adipose Tissue Inflammation

(2011) M. P. Gillum et al.   DIABETES

Dissecting systemic control of metabolism and aging in the NAD World: The importance of SIRT1 and NAMPT-mediated NAD biosynthesis

(2011) Shin-ichiro Imai   FEBS LETTERS

Extrapineal melatonin: analysis of its subcellular distribution and daily fluctuations

(2011) Carmen Venegas et al.   JOURNAL OF PINEAL RESEARCH

Neurons from senescence-accelerated SAMP8 mice are protected against frailty by the sirtuin 1 promoting agents melatonin and resveratrol

(2011) Rosa Cristòfol et al.   JOURNAL OF PINEAL RESEARCH

Genome-wide analysis reveals mechanisms modulating autophagy in normal brain aging and in Alzheimer's disease

(2010) M. M. Lipinski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sestrin as a Feedback Inhibitor of TOR That Prevents Age-Related Pathologies

(2010) J. H. Lee et al.   SCIENCE

Caloric restriction and resveratrol promote longevity through the Sirtuin-1-dependent induction of autophagy

(2010) E Morselli et al.   Cell Death & Disease

SIRT1: Regulation of longevity via autophagy

(2009) Antero Salminen et al.   CELLULAR SIGNALLING

Anti-aging properties of melatonin in an in vitro murine senescence model: involvement of the sirtuin 1 pathway

(2009) M. Tajes et al.   JOURNAL OF PINEAL RESEARCH

CELL BIOLOGY: Stress Response and Aging

(2009) L. R. Saunders et al.   SCIENCE

Regulation of the aging process by autophagy

(2009) Antero Salminen et al.   TRENDS IN MOLECULAR MEDICINE

Role of non-canonical Beclin 1-independent autophagy in cell death induced by resveratrol in human breast cancer cells

(2008) F Scarlatti et al.   CELL DEATH AND DIFFERENTIATION

Autophagy–physiology and pathophysiology

(2008) Yasuo Uchiyama et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Evaluation of potential pro-survival pathways regulated by melatonin in a murine senescence model

(2008) Javier Gutierrez-Cuesta et al.   JOURNAL OF PINEAL RESEARCH

Prolonged Classical NF-κB Activation Prevents Autophagy uponE. coliStimulation In Vitro: A Potential Resolving Mechanism of Inflammation

(2008) Silke Schlottmann et al.   MEDIATORS OF INFLAMMATION

Restoration of chaperone-mediated autophagy in aging liver improves cellular maintenance and hepatic function

(2008) Cong Zhang et al.   NATURE MEDICINE

A Role for Autophagy in the Extension of Lifespan by Dietary Restriction in C. elegans

(2008) Malene Hansen et al.   PLoS Genetics

A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy

(2008) I. H. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA