Targeting Autophagy for the Treatment of Alzheimer’s Disease: Challenges and Opportunities
Published 2019 View Full Article
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Title
Targeting Autophagy for the Treatment of Alzheimer’s Disease: Challenges and Opportunities
Authors
Keywords
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Journal
Frontiers in Molecular Neuroscience
Volume 12, Issue -, Pages -
Publisher
Frontiers Media SA
Online
2019-08-22
DOI
10.3389/fnmol.2019.00203
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Note: Only part of the references are listed.- Aging and Alzheimer’s disease: Comparison and associations from molecular to system level
- (2018) Xian Xia et al. AGING CELL
- Release the autophage brake on inflammation: The MAPK14/p38α-ULK1 pedal
- (2018) Hua She et al. Autophagy
- Dysfunction of autophagy and endosomal-lysosomal pathways: Roles in pathogenesis of Down syndrome and Alzheimer's Disease
- (2018) Daniel J. Colacurcio et al. FREE RADICAL BIOLOGY AND MEDICINE
- Mechanism and medical implications of mammalian autophagy
- (2018) Ivan Dikic et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- TFEB dysregulation as a driver of autophagy dysfunction in neurodegenerative disease: Molecular mechanisms, cellular processes, and emerging therapeutic opportunities
- (2018) Constanza J. Cortes et al. NEUROBIOLOGY OF DISEASE
- Regulation and Roles of Autophagy at Synapses
- (2018) Vassiliki Nikoletopoulou et al. TRENDS IN CELL BIOLOGY
- Challenges in Communicating and Understanding Predictive Biomarker Imaging for Alzheimer Disease
- (2018) Winston Chiong JAMA Neurology
- Sex Differences in Autophagy Contribute to Female Vulnerability in Alzheimer's Disease
- (2018) Erin E. Congdon Frontiers in Neuroscience
- Stabilizing the Retromer Complex in a Human Stem Cell Model of Alzheimer’s Disease Reduces TAU Phosphorylation Independently of Amyloid Precursor Protein
- (2018) Jessica E. Young et al. Stem Cell Reports
- Autophagy in Age-Associated Neurodegeneration
- (2018) Athanasios Metaxakis et al. Cells
- Autophagy in Aging and Alzheimer's Disease: Pathologic or Protective?
- (2018) Aaron Barnett et al. JOURNAL OF ALZHEIMERS DISEASE
- Alzheimer’s disease
- (2018) Richard Hodson NATURE
- Cyclodextrin has conflicting actions on autophagy flux in vivo in brains of normal and Alzheimer model mice
- (2017) Dun-Sheng Yang et al. HUMAN MOLECULAR GENETICS
- A Becn1 mutation mediates hyperactive autophagic sequestration of amyloid oligomers and improved cognition in Alzheimer's disease
- (2017) Altea Rocchi et al. PLoS Genetics
- Amyloid-β1-42 Induces Reactive Oxygen Species-Mediated Autophagic Cell Death in U87 and SH-SY5Y Cells
- (2017) Hongmei Wang et al. JOURNAL OF ALZHEIMERS DISEASE
- Autophagy flux in CA1 neurons of Alzheimer hippocampus: Increased induction overburdens failing lysosomes to propel neuritic dystrophy
- (2016) Matteo Bordi et al. Autophagy
- Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
- (2016) Daniel J Klionsky et al. Autophagy
- Glial Cells - The Key Elements of Alzheimers Disease
- (2016) David Dzamba et al. Current Alzheimer Research
- Alzheimer's disease
- (2016) Philip Scheltens et al. LANCET
- p62 improves AD-like pathology by increasing autophagy
- (2016) A Caccamo et al. MOLECULAR PSYCHIATRY
- HP-β-cyclodextrin as an inhibitor of amyloid-β aggregation and toxicity
- (2016) Baiping Ren et al. PHYSICAL CHEMISTRY CHEMICAL PHYSICS
- Early etiology of Alzheimer’s disease: tipping the balance toward autophagy or endosomal dysfunction?
- (2015) Aleksandar Peric et al. ACTA NEUROPATHOLOGICA
- Progressive endolysosomal deficits impair autophagic clearance beginning at early asymptomatic stages in fALS mice
- (2015) Yuxiang Xie et al. Autophagy
- Glial alterations from early to late stages in a model of Alzheimer's disease: Evidence of autophagy involvement in Aβ internalization
- (2015) Carlos Pomilio et al. HIPPOCAMPUS
- Neuronal-Targeted TFEB Accelerates Lysosomal Degradation of APP, Reducing A Generation and Amyloid Plaque Pathogenesis
- (2015) Q. Xiao et al. JOURNAL OF NEUROSCIENCE
- Presenilin 1 Maintains Lysosomal Ca2+ Homeostasis via TRPML1 by Regulating vATPase-Mediated Lysosome Acidification
- (2015) Ju-Hyun Lee et al. Cell Reports
- Dual roles for autophagy: Degradation and secretion of Alzheimer's disease Aβ peptide
- (2014) Per Nilsson et al. BIOESSAYS
- Defective macroautophagic turnover of brain lipids in the TgCRND8 Alzheimer mouse model: prevention by correcting lysosomal proteolytic deficits
- (2014) Dun-Sheng Yang et al. BRAIN
- Genetic Reduction of Mammalian Target of Rapamycin Ameliorates Alzheimer's Disease-Like Cognitive and Pathological Deficits by Restoring Hippocampal Gene Expression Signature
- (2014) A. Caccamo et al. JOURNAL OF NEUROSCIENCE
- Single-Walled Carbon Nanotubes Alleviate Autophagic/Lysosomal Defects in Primary Glia from a Mouse Model of Alzheimer’s Disease
- (2014) Xue Xue et al. NANO LETTERS
- Pharmacological chaperones stabilize retromer to limit APP processing
- (2014) Vincent J Mecozzi et al. Nature Chemical Biology
- Evidence for autophagic gridlock in aging and neurodegeneration
- (2014) Mathieu F. Bakhoum et al. Translational Research
- Dysfunctional autophagy in Alzheimer’s disease: pathogenic roles and therapeutic implications
- (2014) Jun-Hua Liang et al. Neuroscience Bulletin
- mTOR regulates tau phosphorylation and degradation: implications for Alzheimer's disease and other tauopathies
- (2013) Antonella Caccamo et al. AGING CELL
- Beyond amyloid: Getting real about nonamyloid targets in Alzheimer's disease
- (2013) Karl Herrup et al. Alzheimers & Dementia
- Mesenchymal stem cells enhance autophagy and increase β-amyloid clearance in Alzheimer disease models
- (2013) Jin Young Shin et al. Autophagy
- Latrepirdine (Dimebon®), a potential Alzheimer therapeutic, regulates autophagy and neuropathology in an Alzheimer mouse model
- (2013) John W. Steele et al. Autophagy
- Chaperone-mediated autophagy: roles in disease and aging
- (2013) Ana Maria Cuervo et al. CELL RESEARCH
- TFEB regulates lysosomal proteostasis
- (2013) Wensi Song et al. HUMAN MOLECULAR GENETICS
- Mammalian Target of Rapamycin (mTor) Mediates Tau Protein Dyshomeostasis
- (2013) Zhi Tang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- TFEB-mediated autophagy rescues midbrain dopamine neurons from -synuclein toxicity
- (2013) M. Decressac et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Aβ Secretion and Plaque Formation Depend on Autophagy
- (2013) Per Nilsson et al. Cell Reports
- Presenilins and -Secretase: Structure, Function, and Role in Alzheimer Disease
- (2013) B. De Strooper et al. Cold Spring Harbor Perspectives in Medicine
- Methylthioninium chloride (methylene blue) induces autophagy and attenuates tauopathy in vitro and in vivo
- (2012) Erin E. Congdon et al. Autophagy
- Degradation of tau protein by autophagy and proteasomal pathways: Figure 1
- (2012) Yipeng Wang et al. BIOCHEMICAL SOCIETY TRANSACTIONS
- Inhibition of amyloid-beta peptide aggregation rescues the autophagic deficits in the TgCRND8 mouse model of Alzheimer disease
- (2012) Aaron Y. Lai et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Stimulation of autophagy reduces neurodegeneration in a mouse model of human tauopathy
- (2012) Véronique Schaeffer et al. BRAIN
- Autophagosomes initiate distally and mature during transport toward the cell soma in primary neurons
- (2012) Sandra Maday et al. JOURNAL OF CELL BIOLOGY
- Lysosomal calcium homeostasis defects, not proton pump defects, cause endo-lysosomal dysfunction in PSEN-deficient cells
- (2012) Katrijn Coen et al. JOURNAL OF CELL BIOLOGY
- Correlation of Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the Literature
- (2012) Peter T. Nelson et al. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
- A Role for Presenilins in Autophagy Revisited: Normal Acidification of Lysosomes in Cells Lacking PSEN1 and PSEN2
- (2012) X. Zhang et al. JOURNAL OF NEUROSCIENCE
- Regulation of Presynaptic Neurotransmission by Macroautophagy
- (2012) Daniela Hernandez et al. NEURON
- Abnormal accumulation of autophagic vesicles correlates with axonal and synaptic pathology in young Alzheimer’s mice hippocampus
- (2011) Raquel Sanchez-Varo et al. ACTA NEUROPATHOLOGICA
- Therapeutic effects of remediating autophagy failure in a mouse model of Alzheimer disease by enhancing lysosomal proteolysis
- (2011) Dun-Sheng Yang et al. Autophagy
- A small-molecule enhancer of autophagy decreases levels of Aβ and APP-CTF via Atg5-dependent autophagy pathway
- (2011) Yuan Tian et al. FASEB JOURNAL
- Presenilin Is Necessary for Efficient Proteolysis through the Autophagy-Lysosome System in a -Secretase-Independent Manner
- (2011) K. M. Neely et al. JOURNAL OF NEUROSCIENCE
- The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics
- (2011) Eric Karran et al. NATURE REVIEWS DRUG DISCOVERY
- Control of autophagy as a therapy for neurodegenerative disease
- (2011) Harry Harris et al. Nature Reviews Neurology
- Autophagy failure in Alzheimer's disease—locating the primary defect
- (2011) Ralph A. Nixon et al. NEUROBIOLOGY OF DISEASE
- Deconstruction for Reconstruction: The Role of Proteolysis in Neural Plasticity and Disease
- (2011) Baris Bingol et al. NEURON
- Inducing Autophagy by Rapamycin Before, but Not After, the Formation of Plaques and Tangles Ameliorates Cognitive Deficits
- (2011) Smita Majumder et al. PLoS One
- Reversal of autophagy dysfunction in the TgCRND8 mouse model of Alzheimer's disease ameliorates amyloid pathologies and memory deficits
- (2010) Dun-Sheng Yang et al. BRAIN
- Dendritic Function of Tau Mediates Amyloid-β Toxicity in Alzheimer's Disease Mouse Models
- (2010) Lars M. Ittner et al. CELL
- Lysosomal Proteolysis and Autophagy Require Presenilin 1 and Are Disrupted by Alzheimer-Related PS1 Mutations
- (2010) Ju-Hyun Lee et al. CELL
- Molecular Interplay between Mammalian Target of Rapamycin (mTOR), Amyloid-β, and Tau
- (2010) Antonella Caccamo et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- A Mouse Model of Amyloid Oligomers: Their Contribution to Synaptic Alteration, Abnormal Tau Phosphorylation, Glial Activation, and Neuronal Loss In Vivo
- (2010) T. Tomiyama et al. JOURNAL OF NEUROSCIENCE
- Depletion of Beclin-1 due to proteolytic cleavage by caspases in the Alzheimer's disease brain
- (2010) Troy T. Rohn et al. NEUROBIOLOGY OF DISEASE
- Inhibition of mTOR by Rapamycin Abolishes Cognitive Deficits and Reduces Amyloid-β Levels in a Mouse Model of Alzheimer's Disease
- (2010) Patricia Spilman et al. PLoS One
- Genome-wide analysis reveals mechanisms modulating autophagy in normal brain aging and in Alzheimer's disease
- (2010) M. M. Lipinski et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Autophagy protects neuron from Aβ-induced cytotoxicity
- (2009) Shih-Ya Hung et al. Autophagy
- Oxidative damage to the promoter region of SQSTM1/p62 is common to neurodegenerative disease
- (2009) Yifeng Du et al. NEUROBIOLOGY OF DISEASE
- Abeta42-Induced Neurodegeneration via an Age-Dependent Autophagic-Lysosomal Injury in Drosophila
- (2009) Daijun Ling et al. PLoS One
- SYMPOSIUM: Clearance of Aβ from the Brain in Alzheimer's Disease: Aβ-Degrading Enzymes in Alzheimer's Disease
- (2008) James Scott Miners et al. BRAIN PATHOLOGY
- Autophagic-lysosomal perturbation enhances tau aggregation in transfectants with induced wild-type tau expression
- (2008) Tadanori Hamano et al. EUROPEAN JOURNAL OF NEUROSCIENCE
- Age-associated oxidative damage to the p62 promoter: implications for Alzheimer disease
- (2008) Yifeng Du et al. FREE RADICAL BIOLOGY AND MEDICINE
- mTOR-dependent signalling in Alzheimer's disease
- (2008) Jin-Jing Pei et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid β accumulation in mice
- (2008) Fiona Pickford et al. JOURNAL OF CLINICAL INVESTIGATION
- Activation of the Amyloid Cascade in Apolipoprotein E4 Transgenic Mice Induces Lysosomal Activation and Neurodegeneration Resulting in Marked Cognitive Deficits
- (2008) H. Belinson et al. JOURNAL OF NEUROSCIENCE
- Autophagy Induction and Autophagosome Clearance in Neurons: Relationship to Autophagic Pathology in Alzheimer's Disease
- (2008) B. Boland et al. JOURNAL OF NEUROSCIENCE
- Differential Regulation of Dynein and Kinesin Motor Proteins by Tau
- (2008) R. Dixit et al. SCIENCE
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