A Potential Alternative against Neurodegenerative Diseases: Phytodrugs

Interrelation of Oxidative Stress and Inflammation in Neurodegenerative Disease: Role of TNF

(2015) Roman Fischer et al.   Oxidative Medicine and Cellular Longevity

Perspectives of drug-based neuroprotection targeting mitochondria

(2014) V. Procaccio et al.   REVUE NEUROLOGIQUE

Neuroprotective effect of silymarin in a MPTP mouse model of Parkinson's disease

(2014) Jesús Pérez-H et al.   TOXICOLOGY

Impact of oxidative/nitrosative stress and inflammation on cognitive functions in patients with recurrent depressive disorders

(2014) Piotr Gałecki   MEDICAL SCIENCE MONITOR

Silymarin improved 6-OHDA-induced motor impairment in hemi-parkisonian rats: behavioral and molecular study

(2014) Rasool Haddadi et al.   DARU-Journal of Pharmaceutical Sciences

S-allyl cysteine protects against MPTP-induced striatal and nigral oxidative neurotoxicity in mice: Participation of Nrf2

(2013) Esperanza García et al.   FREE RADICAL RESEARCH

Magnolia polyphenols attenuate oxidative and inflammatory responses in neurons and microglial cells

(2013) Dennis Y Chuang et al.   Journal of Neuroinflammation

Resveratrol decreases inflammation in the brain of mice with mild traumatic brain injury

(2013) Joshua W. Gatson et al.   Journal of Trauma and Acute Care Surgery

Silibinin pretreatment attenuates biochemical and behavioral changes induced by intrastriatal MPP+ injection in rats

(2013) Milind Geed et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Panax notoginsenoside Rb1 ameliorates Alzheimer’s disease by upregulating brain-derived neurotrophic factor and downregulating Tau protein expression

(2013) YU WANG et al.   Experimental and Therapeutic Medicine

Role of NADPH oxidase/ROS in pro-inflammatory mediators-induced airway and pulmonary diseases

(2012) I-Ta Lee et al.   BIOCHEMICAL PHARMACOLOGY

Multiple anti-inflammatory pathways triggered by resveratrol lead to amelioration of staphylococcal enterotoxin B-induced lung injury

(2012) Sadiye Amcaoglu Rieder et al.   BRITISH JOURNAL OF PHARMACOLOGY

Cerebroprotective effects of red ginseng extract pretreatment against ischemia-induced oxidative stress and apoptosis

(2012) So Yeong Cheon et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

Differential effects of polyphenols and alcohol of red wine on the expression of adhesion molecules and inflammatory cytokines related to atherosclerosis: a randomized clinical trial

(2011) Gemma Chiva-Blanch et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Chronic Inflammatory Disorders and Their Redox Control: From Molecular Mechanisms to Therapeutic Opportunities

(2011) Valerio Chiurchiù et al.   ANTIOXIDANTS & REDOX SIGNALING

Alzheimer's Disease: Redox Dysregulation As a Common Denominator for Diverse Pathogenic Mechanisms

(2011) Rommy von Bernhardi et al.   ANTIOXIDANTS & REDOX SIGNALING

Arterial spin labelling reveals an abnormal cerebral perfusion pattern in Parkinson's disease

(2011) T. R. Melzer et al.   BRAIN

S-allyl cysteine attenuates oxidative stress associated cognitive impairment and neurodegeneration in mouse model of streptozotocin-induced experimental dementia of Alzheimer's type

(2011) Hayate Javed et al.   BRAIN RESEARCH

Alzheimer's disease

(2011) Clive Ballard et al.   LANCET

Oxidative Stress in Neurodegenerative Diseases: Mechanisms and Therapeutic Perspectives

(2011) Ailton Melo et al.   Oxidative Medicine and Cellular Longevity

Alzheimer's disease, a multifactorial disorder seeking multitherapies

(2010) Khalid Iqbal et al.   Alzheimers & Dementia

Silymarin Attenuated the Amyloid β Plaque Burden and Improved Behavioral Abnormalities in an Alzheimer’s Disease Mouse Model

(2010) Nakaba MURATA et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Oral pelargonidin exerts dose-dependent neuroprotection in 6-hydroxydopamine rat model of hemi-parkinsonism

(2010) Mehrdad Roghani et al.   BRAIN RESEARCH BULLETIN

Biotransformed blueberry juice protects neurons from hydrogen peroxide-induced oxidative stress and mitogen-activated protein kinase pathway alterations

(2010) Tri Vuong et al.   BRITISH JOURNAL OF NUTRITION

A structural basis for the inhibition of collagen-stimulated platelet function by quercetin and structurally related flavonoids

(2010) Bernice Wright et al.   BRITISH JOURNAL OF PHARMACOLOGY

Detoxified Extract of Rhus verniciflua Stokes Inhibits Rotenone-Induced Apoptosis in Human Dopaminergic Cells, SH-SY5Y

(2010) Kumar Sapkota et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Neuroprotective Effect of Rosmarinus officinalis Extract on Human Dopaminergic Cell line, SH-SY5Y

(2010) Se-Eun Park et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Anti-inflammatory effects of dietary phenolic compounds in an in vitro model of inflamed human intestinal epithelium

(2010) Thérèse Sergent et al.   CHEMICO-BIOLOGICAL INTERACTIONS

In vitro antioxidant activities and an investigation of neuroprotection by six Salvia species from Iran: A comparative study

(2010) Sareh Asadi et al.   FOOD AND CHEMICAL TOXICOLOGY

Protective effects of Gastrodia elata Blume on MPP+-induced cytotoxicity in human dopaminergic SH-SY5Y cells

(2010) Hua An et al.   JOURNAL OF ETHNOPHARMACOLOGY

Evaluation of Samjunghwan, a traditional medicine, for neuroprotection against damage by amyloid-beta in rat cortical neurons

(2010) Hyo Geun Kim et al.   JOURNAL OF ETHNOPHARMACOLOGY

Melatonin or silymarin reduces maneb- and paraquat-induced Parkinson’s disease phenotype in the mouse

(2010) Naveen Kumar Singhal et al.   JOURNAL OF PINEAL RESEARCH

Antioxidant Activity and Protective Effects of Tripterygium regelii Extract on Hydrogen Peroxide-Induced Injury in Human Dopaminergic Cells, SH-SY5Y

(2010) Bong-Suk Choi et al.   NEUROCHEMICAL RESEARCH

Neurocytoprotective effects of the bioactive constituents of Pueraria thomsonii in 6-hydroxydopamine (6-OHDA)-treated nerve growth factor (NGF)-differentiated PC12 cells

(2010) Chien-Min Lin et al.   PHYTOCHEMISTRY

S-allylcysteine reduces the MPTP-induced striatal cell damage via inhibition of pro-inflammatory cytokine tumor necrosis factor-α and inducible nitric oxide synthase expressions in mice

(2010) Esperanza García et al.   PHYTOMEDICINE

Preventive effect of silymarin in cerebral ischemia–reperfusion-induced brain injury in rats possibly through impairing NF-κB and STAT-1 activation

(2010) Yu-Chang Hou et al.   PHYTOMEDICINE

Mitochondrial dysfunction in amyotrophic lateral sclerosis

(2009) Ping Shi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Anti-Alzheimer and Antioxidant Activities of Coptidis Rhizoma Alkaloids

(2009) Hyun Ah Jung et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Brain Trace Element Concentration of Rats Treated with the Plant Alkaloid, Vincamine

(2009) Abdel-Hasseb A. Fayed   BIOLOGICAL TRACE ELEMENT RESEARCH

Inhibitory Effect ofPoncirus trifoliateon Acetylcholinesterase and Attenuating Activity against Trimethyltin-Induced Learning and Memory Impairment

(2009) Jae Kyeom KIM et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Magnolol and honokiol prevent learning and memory impairment and cholinergic deficit in SAMP8 mice

(2009) Nobuaki Matsui et al.   BRAIN RESEARCH

In vitro dopaminergic neuroprotective and in vivo antiparkinsonian-like effects of Δ3,2-hydroxybakuchiol isolated from Psoralea corylifolia (L.)

(2009) G. Zhao et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Neuroprotective and Antioxidative Effect of Cactus Polysaccharides In Vivo and In Vitro

(2009) Xianju Huang et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Oxidative Stress and Neurodegenerative Diseases: A Review of Upstream and Downstream Antioxidant Therapeutic Options

(2009) Bayani Uttara et al.   Current Neuropharmacology

Protective effect of supercritical fluid rosemary extract, Rosmarinus officinalis, on antioxidants of major organs of aged rats

(2009) S.J. Posadas et al.   EXPERIMENTAL GERONTOLOGY

Effect of silymarin on biochemical parameters of oxidative stress in aged and young rat brain

(2009) F. Galhardi et al.   FOOD AND CHEMICAL TOXICOLOGY

Hexane fraction of Zingiberis Rhizoma Crudus extract inhibits the production of nitric oxide and proinflammatory cytokines in LPS-stimulated BV2 microglial cells via the NF-kappaB pathway

(2009) Hyo Won Jung et al.   FOOD AND CHEMICAL TOXICOLOGY

Piperine, the main alkaloid of Thai black pepper, protects against neurodegeneration and cognitive impairment in animal model of cognitive deficit like condition of Alzheimer’s disease

(2009) Pennapa Chonpathompikunlert et al.   FOOD AND CHEMICAL TOXICOLOGY

l-Theanine, an amino acid in green tea, attenuates β-amyloid-induced cognitive dysfunction and neurotoxicity: Reduction in oxidative damage and inactivation of ERK/p38 kinase and NF-κB pathways

(2009) Tae Il Kim et al.   FREE RADICAL BIOLOGY AND MEDICINE

Silibinin ameliorates oxidative stress induced aberrant crypt foci and lipid peroxidation in 1, 2 dimethylhydrazine induced rat colon cancer

(2009) Nagarajan Sangeetha et al.   INVESTIGATIONAL NEW DRUGS

Effects of the hook of Uncaria rhynchophylla on neurotoxicity in the 6-hydroxydopamine model of Parkinson's disease

(2009) Jin Sup Shim et al.   JOURNAL OF ETHNOPHARMACOLOGY

Chrysanthemum morifolium Ramat (CM) extract protects human neuroblastoma SH-SY5Y cells against MPP+-induced cytotoxicity

(2009) In Su Kim et al.   JOURNAL OF ETHNOPHARMACOLOGY

Panaxatriol saponins extracted from Panax notoginseng induces thioredoxin-1 and prevents 1-methyl-4-phenylpyridinium ion-induced neurotoxicity

(2009) Fu-Cheng Luo et al.   JOURNAL OF ETHNOPHARMACOLOGY

Protective effect of selaginellin on glutamate-induced cytotoxicity and apoptosis in differentiated PC12 cells

(2009) Chen-Jing Wang et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Effect of Purple Sweet Potato Anthocyanins on β-Amyloid-Mediated PC-12 Cells Death by Inhibition of Oxidative Stress

(2009) Junli Ye et al.   NEUROCHEMICAL RESEARCH

In vivo amyloid imaging in autopsy-confirmed Parkinson disease with dementia

(2009) M. A. Burack et al.   NEUROLOGY

Beneficial effects of carnosic acid on dieldrin-induced dopaminergic neuronal cell death

(2009) Jeong Ae Park et al.   NEUROREPORT

Cryptotanshinone, a compound from Salvia miltiorrhiza modulates amyloid precursor protein metabolism and attenuates β-amyloid deposition through upregulating α-secretase in vivo and in vitro

(2009) Zhengrong Mei et al.   NEUROSCIENCE LETTERS

Ashwagandha leaf extract: A potential agent in treating oxidative damage and physiological abnormalities seen in a mouse model of Parkinson's disease

(2009) Srinivasagam RajaSankar et al.   NEUROSCIENCE LETTERS

Mitochondrial Disorders in the Nervous System

(2008) Salvatore DiMauro et al.   Annual Review of Neuroscience

Peroxynitrite induced formation of the neurotoxins 5-S-cysteinyl-dopamine and DHBT-1: Implications for Parkinson’s disease and protection by polyphenols

(2008) David Vauzour et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Bakuchiol analogs inhibit monoamine transporters and regulate monoaminergic functions

(2008) Gang Zhao et al.   BIOCHEMICAL PHARMACOLOGY

Abnormally phosphorylated tau is associated with neuronal and axonal loss in experimental autoimmune encephalomyelitis and multiple sclerosis

(2008) J. M. Anderson et al.   BRAIN

Effects of the extract of Anemopaegma mirandum (Catuaba) on Rotenone-induced apoptosis in human neuroblastomas SH-SY5Y cells

(2008) Deyse Valverde G. De Andrade et al.   BRAIN RESEARCH

Effects of long-term administration of a cocoa polyphenolic extract (Acticoa powder) on cognitive performances in aged rats

(2008) Jean-François Bisson et al.   BRITISH JOURNAL OF NUTRITION

An open-label trial of Korean red ginseng as an adjuvant treatment for cognitive impairment in patients with Alzheimers disease

(2008) J.-H. Heo et al.   EUROPEAN JOURNAL OF NEUROLOGY

Lipid peroxidation, mitochondrial dysfunction and neurochemical and behavioural deficits in different neurotoxic models: Protective role of S-allylcysteine

(2008) Esperanza Garcia et al.   FREE RADICAL RESEARCH

Neuroprotective effect of Bacopa monnieri on beta-amyloid-induced cell death in primary cortical culture

(2008) Nanteetip Limpeanchob et al.   JOURNAL OF ETHNOPHARMACOLOGY

Neuroprotective effects of Dioscorea opposita on scopolamine-induced memory impairment in in vivo behavioral tests and in vitro assays

(2008) Min Hye Yang et al.   JOURNAL OF ETHNOPHARMACOLOGY

Anthocyanin Content, Antioxidant Activity, and Selected Physical Properties of Flowable Purple-Fleshed Sweetpotato Purees

(2008) L.E. Steed et al.   JOURNAL OF FOOD SCIENCE

Neuroprotection and enhanced neurogenesis by extract from the tropical plant Knema laurina after inflammatory damage in living brain tissue

(2008) Ines Häke et al.   JOURNAL OF NEUROIMMUNOLOGY

Grape-Derived Polyphenolics Prevent A  Oligomerization and Attenuate Cognitive Deterioration in a Mouse Model of Alzheimer's Disease

(2008) J. Wang et al.   JOURNAL OF NEUROSCIENCE

Neuroprotective Effect of Smilacis chinae Rhizome on NMDA-Induced Neurotoxicity In Vitro and Focal Cerebral Ischemia In Vivo

(2008) Ju Yeon Ban et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Nobiletin, a Citrus Flavonoid, Improves Memory Impairment and A  Pathology in a Transgenic Mouse Model of Alzheimer's Disease

(2008) H. Onozuka et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Paeonol attenuates neurotoxicity and ameliorates cognitive impairment induced by d-galactose in ICR mice

(2008) Shu-Zhi Zhong et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Cytoprotective Effect of Valeriana officinalis Extract on an In Vitro Experimental Model of Parkinson Disease

(2008) Diêgo Madureira de Oliveria et al.   NEUROCHEMICAL RESEARCH

Neuroprotective Effects of Chalcones from Myracrodruon urundeuva on 6-Hydroxydopamine-Induced Cytotoxicity in Rat Mesencephalic Cells

(2008) Hélio V. Nobre-Júnior et al.   NEUROCHEMICAL RESEARCH

The Blood-Brain Barrier in Health and Chronic Neurodegenerative Disorders

(2008) Berislav V. Zlokovic   NEURON

Luteolin protects dopaminergic neurons from inflammation-induced injury through inhibition of microglial activation

(2008) Han-Qing Chen et al.   NEUROSCIENCE LETTERS

Methanol extract of Ficus leaf inhibits the production of nitric oxide and proinflammatory cytokines in LPS-stimulated microglia via the MAPK pathway

(2008) Hyo Won Jung et al.   PHYTOTHERAPY RESEARCH

Neuroprotective effect of genistein in 6-hydroxydopamine Hemi-parkinsonian rat model

(2008) Tourandokht Baluchnejadmojarad et al.   PHYTOTHERAPY RESEARCH

Centella asiaticaextract selectively decreases amyloidβlevels in hippocampus of Alzheimer's disease animal model

(2008) Muralikrishnan Dhanasekaran et al.   PHYTOTHERAPY RESEARCH

In vitroBACE-1 Inhibitory Phenolic Components from the Seeds ofPsoralea corylifolia

(2008) Yeon Choi et al.   PLANTA MEDICA

Rosmarinic acid protects human dopaminergic neuronal cells against hydrogen peroxide-induced apoptosis

(2008) Hyo Jung Lee et al.   TOXICOLOGY

Nobiletin, a citrus flavonoid with neurotrophic action, augments protein kinase A-mediated phosphorylation of the AMPA receptor subunit, GluR1, and the postsynaptic receptor response to glutamate in murine hippocampus

(2007) Kentaro Matsuzaki et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Pedicularioside A from Buddleia lindleyana inhibits cell death induced by 1-methyl-4-phenylpyridinium ions (MPP+) in primary cultures of rat mesencephalic neurons

(2007) Yan-Yun Li et al.   EUROPEAN JOURNAL OF PHARMACOLOGY