Autophagy as a promoter of longevity: insights from model organisms
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Title
Autophagy as a promoter of longevity: insights from model organisms
Authors
Keywords
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Journal
NATURE REVIEWS MOLECULAR CELL BIOLOGY
Volume -, Issue -, Pages -
Publisher
Springer Nature
Online
2018-07-13
DOI
10.1038/s41580-018-0033-y
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Related references
Note: Only part of the references are listed.- Mitochondrial dysfunction and pulmonary hypertension: cause, effect, or both
- (2018) Jeffrey D. Marshall et al. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
- Lipid metabolism and lipophagy in cancer
- (2018) Meenu Maan et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Basal Mitophagy Occurs Independently of PINK1 in Mouse Tissues of High Metabolic Demand
- (2018) Thomas G. McWilliams et al. Cell Metabolism
- The coming of age of chaperone-mediated autophagy
- (2018) Susmita Kaushik et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Mechanism and medical implications of mammalian autophagy
- (2018) Ivan Dikic et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Spermidine in health and disease
- (2018) Frank Madeo et al. SCIENCE
- Differential effects of reticulophagy and mitophagy on nonalcoholic fatty liver disease
- (2018) Lijun Pang et al. Cell Death & Disease
- Neuronal inhibition of the autophagy nucleation complex extends life span in post-reproductive C. elegans
- (2017) Thomas Wilhelm et al. GENES & DEVELOPMENT
- Activation-Induced Autophagy Is Preserved in CD4+ T-Cells in Familial Longevity
- (2017) Yotam Raz et al. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
- Autophagy maintains the metabolism and function of young and old stem cells
- (2017) Theodore T. Ho et al. NATURE
- Hypothalamic stem cells control ageing speed partly through exosomal miRNAs
- (2017) Yalin Zhang et al. NATURE
- Polyglutamine tracts regulate beclin 1-dependent autophagy
- (2017) Avraham Ashkenazi et al. NATURE
- Mitochondrial quality control in amyotrophic lateral sclerosis: towards a common pathway?
- (2017) Bilal Khalil et al. Neural Regeneration Research
- Autophagy and Neurodegeneration: Pathogenic Mechanisms and Therapeutic Opportunities
- (2017) Fiona M. Menzies et al. NEURON
- Mitophagy and age-related pathologies: Development of new therapeutics by targeting mitochondrial turnover
- (2017) Konstantinos Palikaras et al. PHARMACOLOGY & THERAPEUTICS
- Hormetic heat stress and HSF-1 induce autophagy to improve survival and proteostasis in C. elegans
- (2017) Caroline Kumsta et al. Nature Communications
- Promoting Drp1-mediated mitochondrial fission in midlife prolongs healthy lifespan of Drosophila melanogaster
- (2017) Anil Rana et al. Nature Communications
- The cell non-autonomous function of ATG-18 is essential for neuroendocrine regulation of Caenorhabditis elegans lifespan
- (2017) Justin Minnerly et al. PLoS Genetics
- Neuronal Mitophagy in Neurodegenerative Diseases
- (2017) Marta Martinez-Vicente Frontiers in Molecular Neuroscience
- Time-dependent dysregulation of autophagy: Implications in aging and mitochondrial homeostasis in the kidney proximal tubule
- (2016) Takeshi Yamamoto et al. Autophagy
- Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
- (2016) Daniel J Klionsky et al. Autophagy
- Autophagy regulates satellite cell ability to regenerate normal and dystrophic muscles
- (2016) E Fiacco et al. CELL DEATH AND DIFFERENTIATION
- The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging
- (2016) Brian K. Kennedy et al. Cell Metabolism
- Resveratrol and Lifespan in Model Organisms
- (2016) Kathrin Pallauf et al. CURRENT MEDICINAL CHEMISTRY
- VCP/p97 cooperates with YOD1, UBXD1 and PLAA to drive clearance of ruptured lysosomes by autophagy
- (2016) Chrisovalantis Papadopoulos et al. EMBO JOURNAL
- Ectopic fat deposition contributes to age-associated pathology inCaenorhabditis elegans
- (2016) Konstantinos Palikaras et al. JOURNAL OF LIPID RESEARCH
- Autophagy in kidney disease and aging: lessons from rodent models
- (2016) Olivia Lenoir et al. KIDNEY INTERNATIONAL
- The Mitochondrial Basis of Aging
- (2016) Nuo Sun et al. MOLECULAR CELL
- Autophagy maintains stemness by preventing senescence
- (2016) Laura García-Prat et al. NATURE
- Tricellular junctions regulate intestinal stem cell behaviour to maintain homeostasis
- (2016) Martin Resnik-Docampo et al. NATURE CELL BIOLOGY
- Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents
- (2016) Dongryeol Ryu et al. NATURE MEDICINE
- Ubiquitin-Dependent And Independent Signals In Selective Autophagy
- (2016) Aliaksandr Khaminets et al. TRENDS IN CELL BIOLOGY
- Autophagy and Immune Senescence
- (2016) Hanlin Zhang et al. TRENDS IN MOLECULAR MEDICINE
- C. elegans S6K Mutants Require a Creatine-Kinase-like Effector for Lifespan Extension
- (2016) Philip R. McQuary et al. Cell Reports
- Sex difference in pathology of the ageing gut mediates the greater response of female lifespan to dietary restriction
- (2016) Jennifer C Regan et al. eLife
- Sex- and tissue-specific changes in mTOR signaling with age in C57BL/6J mice
- (2015) Emma L. Baar et al. AGING CELL
- Transcriptional and epigenetic regulation of autophagy in aging
- (2015) Louis R Lapierre et al. Autophagy
- Iron-Starvation-Induced Mitophagy Mediates Lifespan Extension upon Mitochondrial Stress in C. elegans
- (2015) Alfonso Schiavi et al. CURRENT BIOLOGY
- Autophagy Enhances Intestinal Epithelial Tight Junction Barrier Function by Targeting Claudin-2 Protein Degradation
- (2015) Prashant K. Nighot et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Measuring In Vivo Mitophagy
- (2015) Nuo Sun et al. MOLECULAR CELL
- Mutations in LRRK2 potentiate age-related impairment of autophagic flux
- (2015) Shamol Saha et al. Molecular Neurodegeneration
- Coordination of mitophagy and mitochondrial biogenesis during ageing in C. elegans
- (2015) Konstantinos Palikaras et al. NATURE
- Molecular characterization of LC3-associated phagocytosis reveals distinct roles for Rubicon, NOX2 and autophagy proteins
- (2015) Jennifer Martinez et al. NATURE CELL BIOLOGY
- Haploinsufficiency of TBK1 causes familial ALS and fronto-temporal dementia
- (2015) Axel Freischmidt et al. NATURE NEUROSCIENCE
- The Roles of PINK1, Parkin, and Mitochondrial Fidelity in Parkinson’s Disease
- (2015) Alicia M. Pickrell et al. NEURON
- Lysosomal signaling molecules regulate longevity in Caenorhabditis elegans
- (2015) A. Folick et al. SCIENCE
- Distinct Shifts in Microbiota Composition during Drosophila Aging Impair Intestinal Function and Drive Mortality
- (2015) Rebecca I. Clark et al. Cell Reports
- Decreased BECN1 mRNA Expression in Human Breast Cancer is Associated With Estrogen Receptor-Negative Subtypes and Poor Prognosis
- (2015) Hao Tang et al. EBioMedicine
- Promoting basal levels of autophagy in the nervous system enhances longevity and oxidant resistance in adult Drosophila
- (2014) Anne Simonsen et al. Autophagy
- A lifespan-extending form of autophagy employs the vacuole-vacuole fusion machinery
- (2014) Fusheng Tang et al. Autophagy
- Longevity pathways converge on autophagy genes to regulate life span inCaenorhabditis elegans
- (2014) Márton L. Tóth et al. Autophagy
- Autophagy is required for extension of yeast chronological life span by rapamycin
- (2014) Ashley L. Alvers et al. Autophagy
- You Are What You Host: Microbiome Modulation of the Aging Process
- (2014) Caroline Heintz et al. CELL
- Crohn's Disease: Loss of Tolerance or a Disorder of Autophagy?
- (2014) Marianne R. Spalinger et al. DIGESTIVE DISEASES
- Induction of autophagy supports the bioenergetic demands of quiescent muscle stem cell activation
- (2014) Ann H Tang et al. EMBO JOURNAL
- The paradox of mitochondrial dysfunction and extended longevity
- (2014) Erin Munkácsy et al. EXPERIMENTAL GERONTOLOGY
- Downregulation of E3 Ubiquitin Ligases and Mitophagy-Related Genes in Skeletal Muscle of Physically Inactive, Frail Older Women: A Cross-Sectional Comparison
- (2014) M. J. Drummond et al. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
- Autophagy Is Required for Glucose Homeostasis and Lung Tumor Maintenance
- (2014) G. Karsli-Uzunbas et al. Cancer Discovery
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- (2014) Matthew Ulgherait et al. Cell Reports
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- (2014) Silvia Carnio et al. Cell Reports
- Lifespan Extension by Methionine Restriction Requires Autophagy-Dependent Vacuolar Acidification
- (2014) Christoph Ruckenstuhl et al. PLoS Genetics
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- (2013) Fabio Demontis et al. AGING CELL
- The Hallmarks of Aging
- (2013) Carlos López-Otín et al. CELL
- Reproduction, Fat Metabolism, and Life Span: What Is the Connection?
- (2013) Malene Hansen et al. Cell Metabolism
- The machinery of macroautophagy
- (2013) Yuchen Feng et al. CELL RESEARCH
- Autophagy sequesters damaged lysosomes to control lysosomal biogenesis and kidney injury
- (2013) Ikuko Maejima et al. EMBO JOURNAL
- -6 Polyunsaturated fatty acids extend life span through the activation of autophagy
- (2013) E. J. O'Rourke et al. GENES & DEVELOPMENT
- Identification of a candidate therapeutic autophagy-inducing peptide
- (2013) Sanae Shoji-Kawata et al. NATURE
- MXL-3 and HLH-30 transcriptionally link lipolysis and autophagy to nutrient availability
- (2013) Eyleen J. O’Rourke et al. NATURE CELL BIOLOGY
- De novo mutations in the autophagy gene WDR45 cause static encephalopathy of childhood with neurodegeneration in adulthood
- (2013) Hirotomo Saitsu et al. NATURE GENETICS
- Restoring polyamines protects from age-induced memory impairment in an autophagy-dependent manner
- (2013) Varun K Gupta et al. NATURE NEUROSCIENCE
- Parkin overexpression during aging reduces proteotoxicity, alters mitochondrial dynamics, and extends lifespan
- (2013) A. Rana et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Organ-specific mediation of lifespan extension: More than a gut feeling?
- (2012) Michael Rera et al. AGEING RESEARCH REVIEWS
- Mutation in TECPR2 Reveals a Role for Autophagy in Hereditary Spastic Paraparesis
- (2012) Danit Oz-Levi et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Exome Sequencing Reveals De Novo WDR45 Mutations Causing a Phenotypically Distinct, X-Linked Dominant Form of NBIA
- (2012) Tobias B. Haack et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Autophagosome assembly and cargo capture in the distal axon
- (2012) Sandra Maday et al. Autophagy
- The pathways of mitophagy for quality control and clearance of mitochondria
- (2012) G Ashrafi et al. CELL DEATH AND DIFFERENTIATION
- Contribution of Impaired Mitochondrial Autophagy to Cardiac Aging
- (2012) Debapriya Dutta et al. CIRCULATION RESEARCH
- Loss of autophagy in hypothalamic POMC neurons impairs lipolysis
- (2012) Susmita Kaushik et al. EMBO REPORTS
- An early age increase in vacuolar pH limits mitochondrial function and lifespan in yeast
- (2012) Adam L. Hughes et al. NATURE
- Recessive mutations in EPG5 cause Vici syndrome, a multisystem disorder with defective autophagy
- (2012) Thomas Cullup et al. NATURE GENETICS
- SQSTM1 mutations in frontotemporal lobar degeneration and amyotrophic lateral sclerosis
- (2012) E. Rubino et al. NEUROLOGY
- Intestinal barrier dysfunction links metabolic and inflammatory markers of aging to death in Drosophila
- (2012) M. Rera et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- MiR-34 modulates Caenorhabditis elegans lifespan via repressing the autophagy gene atg9
- (2011) Jurong Yang et al. AGE
- Selective autophagy mediated by autophagic adapter proteins
- (2011) Terje Johansen et al. Autophagy
- The autophagy initiating kinase ULK1 is regulated via opposing phosphorylation by AMPK and mTOR
- (2011) Dan Egan et al. Autophagy
- Autophagy and Lipid Metabolism Coordinately Modulate Life Span in Germline-less C. elegans
- (2011) Louis R. Lapierre et al. CURRENT BIOLOGY
- Effect of Aging and Anti-Aging Caloric Restriction on the Endocrine Regulation of Rat Liver Autophagy
- (2011) A. Donati et al. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
- TFEB Links Autophagy to Lysosomal Biogenesis
- (2011) C. Settembre et al. SCIENCE
- Mitochondria and the Autophagy-Inflammation-Cell Death Axis in Organismal Aging
- (2011) D. R. Green et al. SCIENCE
- FOXO/4E-BP Signaling in Drosophila Muscles Regulates Organism-wide Proteostasis during Aging
- (2010) Fabio Demontis et al. CELL
- Insulin-like Signaling Determines Survival during Stress via Posttranscriptional Mechanisms in C. elegans
- (2010) Gawain McColl et al. Cell Metabolism
- Mechanisms of Life Span Extension by Rapamycin in the Fruit Fly Drosophila melanogaster
- (2010) Ivana Bjedov et al. Cell Metabolism
- α-Synuclein impairs macroautophagy: implications for Parkinson’s disease
- (2010) Ashley R. Winslow et al. JOURNAL OF CELL BIOLOGY
- Separating cause from effect: how does insulin/IGF signalling control lifespan in worms, flies and mice?
- (2010) M. D. W. Piper et al. JOURNAL OF INTERNAL MEDICINE
- Neural mechanisms of ageing and cognitive decline
- (2010) Nicholas A. Bishop et al. NATURE
- The genetics of ageing
- (2010) Cynthia J. Kenyon NATURE
- Autophagy is defective in collagen VI muscular dystrophies and its reactivation rescues myofiber degeneration
- (2010) Paolo Grumati et al. NATURE MEDICINE
- Mechanisms of mitophagy
- (2010) Richard J. Youle et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Genome-wide analysis reveals mechanisms modulating autophagy in normal brain aging and in Alzheimer's disease
- (2010) M. M. Lipinski et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Caloric restriction and resveratrol promote longevity through the Sirtuin-1-dependent induction of autophagy
- (2010) E Morselli et al. Cell Death & Disease
- Insulin/IGF-like signalling, the central nervous system and aging
- (2009) Susan Broughton et al. BIOCHEMICAL JOURNAL
- Skeletal muscle autophagy and apoptosis during aging: Effects of calorie restriction and life-long exercise
- (2009) Stephanie Eva Wohlgemuth et al. EXPERIMENTAL GERONTOLOGY
- Autophagy regulates lipid metabolism
- (2009) Rajat Singh et al. NATURE
- Induction of autophagy by spermidine promotes longevity
- (2009) Tobias Eisenberg et al. NATURE CELL BIOLOGY
- Identification of the SPG15 Gene, Encoding Spastizin, as a Frequent Cause of Complicated Autosomal-Recessive Spastic Paraplegia, Including Kjellin Syndrome
- (2008) Sylvain Hanein et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Autophagy in the Pathogenesis of Disease
- (2008) Beth Levine et al. CELL
- Stress-Response Hormesis and Aging: “That which Does Not Kill Us Makes Us Stronger”
- (2008) David Gems et al. Cell Metabolism
- A Role for Autophagy in the Extension of Lifespan by Dietary Restriction in C. elegans
- (2008) Malene Hansen et al. PLoS Genetics
- Fat Metabolism Links Germline Stem Cells and Longevity in C. elegans
- (2008) M. C. Wang et al. SCIENCE
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