Deficient autophagy in microglia impairs synaptic pruning and causes social behavioral defects

Schizophrenia risk from complex variation of complement component 4

(2016) Aswin Sekar et al.   NATURE

Impaired macrophage autophagy increases the immune response in obese mice by promoting proinflammatory macrophage polarization

(2015) Kun Liu et al.   Autophagy

Microglial M1/M2 polarization and metabolic states

(2015) Ruben Orihuela et al.   BRITISH JOURNAL OF PHARMACOLOGY

NMDA receptor dysfunction in autism spectrum disorders

(2015) Eun-Jae Lee et al.   CURRENT OPINION IN PHARMACOLOGY

Dysregulated brain immunity and neurotrophin signaling in Rett syndrome and autism spectrum disorders

(2015) Theoharis C. Theoharides et al.   JOURNAL OF NEUROIMMUNOLOGY

Differential Roles of M1 and M2 Microglia in Neurodegenerative Diseases

(2015) Yu Tang et al.   MOLECULAR NEUROBIOLOGY

The idiosyncratic brain: distortion of spontaneous connectivity patterns in autism spectrum disorder

(2015) Avital Hahamy et al.   NATURE NEUROSCIENCE

Immune mediators in the brain and peripheral tissues in autism spectrum disorder

(2015) Myka L. Estes et al.   NATURE REVIEWS NEUROSCIENCE

The role of inflammation and microglial activation in the pathophysiology of psychiatric disorders

(2015) G.Z. Réus et al.   NEUROSCIENCE

Microglia in the pathogenesis of autism spectrum disorders

(2015) Ryuta Koyama et al.   NEUROSCIENCE RESEARCH

Prenatal factors associated with autism spectrum disorder (ASD)

(2015) A. Ornoy et al.   REPRODUCTIVE TOXICOLOGY

Disease-Associated Mutations of TREM2 Alter the Processing of N-Linked Oligosaccharides in the Golgi Apparatus

(2015) Ji-Seon Park et al.   TRAFFIC

Abnormal wiring of the connectome in adults with high-functioning autism spectrum disorder

(2015) Ulrika Roine et al.   Molecular Autism

Activity-dependent neuroprotective protein (ADNP) exhibits striking sexual dichotomy impacting on autistic and Alzheimer’s pathologies

(2015) A Malishkevich et al.   Translational Psychiatry

The role of inflammation in schizophrenia

(2015) Norbert Müller et al.   Frontiers in Neuroscience

The AMPK-PPARGC1A pathway is required for antimicrobial host defense through activation of autophagy

(2014) Chul-Su Yang et al.   Autophagy

Autophagy in microglia degrades extracellular β-amyloid fibrils and regulates the NLRP3 inflammasome

(2014) Mi-Hyang Cho et al.   Autophagy

Update on diagnostic classification in autism

(2014) Bryan H. King et al.   CURRENT OPINION IN PSYCHIATRY

Vancomycin blocks autophagy and induces interleukin-1β release in macrophages

(2014) Young Eun Ha et al.   JOURNAL OF ANTIBIOTICS

A SWI/SNF-related autism syndrome caused by de novo mutations in ADNP

(2014) Céline Helsmoortel et al.   NATURE GENETICS

Deficient neuron-microglia signaling results in impaired functional brain connectivity and social behavior

(2014) Yang Zhan et al.   NATURE NEUROSCIENCE

Loss of mTOR-Dependent Macroautophagy Causes Autistic-like Synaptic Pruning Deficits

(2014) Guomei Tang et al.   NEURON

A Starring Role for Microglia in Brain Sex Differences

(2014) Kathryn M. Lenz et al.   NEUROSCIENTIST

Transcriptome analysis reveals dysregulation of innate immune response genes and neuronal activity-dependent genes in autism

(2014) Simone Gupta et al.   Nature Communications

Evidence linking oxidative stress, mitochondrial dysfunction, and inflammation in the brain of individuals with autism

(2014) Daniel A. Rossignol et al.   Frontiers in Physiology

Maternal Inflammation Contributes to Brain Overgrowth and Autism-Associated Behaviors through Altered Redox Signaling in Stem and Progenitor Cells

(2014) Janel E. Le Belle et al.   Stem Cell Reports

Identification of Small Exonic CNV from Whole-Exome Sequence Data and Application to Autism Spectrum Disorder

(2013) Christopher S. Poultney et al.   AMERICAN JOURNAL OF HUMAN GENETICS

β-Amyloid is transmitted via neuronal connections along axonal membranes

(2013) Ha-Lim Song et al.   ANNALS OF NEUROLOGY

Autophagy in obesity and atherosclerosis: Interrelationships between cholesterol homeostasis, lipoprotein metabolism and autophagy in macrophages and other systems

(2013) Mireille Ouimet   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Microglia Are Essential to Masculinization of Brain and Behavior

(2013) K. M. Lenz et al.   JOURNAL OF NEUROSCIENCE

Autophagy has a key role in the pathophysiology of schizophrenia

(2013) A Merenlender-Wagner et al.   MOLECULAR PSYCHIATRY

Dynamic microglial alterations underlie stress-induced depressive-like behavior and suppressed neurogenesis

(2013) T Kreisel et al.   MOLECULAR PSYCHIATRY

Layer V cortical neurons require microglial support for survival during postnatal development

(2013) Masaki Ueno et al.   NATURE NEUROSCIENCE

Neuronal Autophagy and Neurodevelopmental Disorders

(2013) Kyung-Min Lee et al.   Experimental Neurobiology

Guidelines for the use and interpretation of assays for monitoring autophagy

(2012) Daniel J. Klionsky et al.   Autophagy

Macrophage Autophagy Plays a Protective Role in Advanced Atherosclerosis

(2012) Xianghai Liao et al.   Cell Metabolism

Cellular and synaptic network defects in autism

(2012) João Peça et al.   CURRENT OPINION IN NEUROBIOLOGY

Sporadic autism exomes reveal a highly interconnected protein network of de novo mutations

(2012) Brian J. O’Roak et al.   NATURE

Microglia Sculpt Postnatal Neural Circuits in an Activity and Complement-Dependent Manner

(2012) Dorothy P. Schafer et al.   NEURON

Evidence of microglial activation in autism and its possible role in brain underconnectivity

(2012) Juan I. Rodriguez et al.   Neuron Glia Biology

Multiplex Targeted Sequencing Identifies Recurrently Mutated Genes in Autism Spectrum Disorders

(2012) B. J. O'Roak et al.   SCIENCE

Synaptic Dysfunction in Neurodevelopmental Disorders Associated with Autism and Intellectual Disabilities

(2012) H. Y. Zoghbi et al.   Cold Spring Harbor Perspectives in Biology

Microglial Activation in Young Adults With Autism Spectrum Disorder

(2012) Katsuaki Suzuki et al.   JAMA Psychiatry

SHANK3 mutations identified in autism lead to modification of dendritic spine morphology via an actin-dependent mechanism

(2011) C M Durand et al.   MOLECULAR PSYCHIATRY

Autophagy in immunity and inflammation

(2011) Beth Levine et al.   NATURE

Synaptic Pruning by Microglia Is Necessary for Normal Brain Development

(2011) R. C. Paolicelli et al.   SCIENCE

Microglial Activation and Increased Microglial Density Observed in the Dorsolateral Prefrontal Cortex in Autism

(2010) John T. Morgan et al.   BIOLOGICAL PSYCHIATRY

Autophagy gone awry in neurodegenerative diseases

(2010) Esther Wong et al.   NATURE NEUROSCIENCE

Increased dendritic spine densities on cortical projection neurons in autism spectrum disorders

(2009) Jeffrey J. Hutsler et al.   BRAIN RESEARCH

A synaptic trek to autism

(2009) Thomas Bourgeron   CURRENT OPINION IN NEUROBIOLOGY

Pharmacological Inhibition of mTORC1 Suppresses Anatomical, Cellular, and Behavioral Abnormalities in Neural-Specific Pten Knock-Out Mice

(2009) J. Zhou et al.   JOURNAL OF NEUROSCIENCE

Okadaic acid increases autophagosomes in rat neurons: Implications for Alzheimer's disease

(2008) Seung Yong Yoon et al.   JOURNAL OF NEUROSCIENCE RESEARCH

The NALP3 inflammasome is involved in the innate immune response to amyloid-β

(2008) Annett Halle et al.   NATURE IMMUNOLOGY