Article
Behavioral Sciences
Alexander B. Pupyshev, Victor M. Belichenko, Michael V. Tenditnik, Alim A. Bashirzade, Nina I. Dubrovina, Marina V. Ovsyukova, Anna A. Akopyan, Larisa A. Fedoseeva, Tatiana A. Korolenko, Tamara G. Amstislavskaya, Maria A. Tikhonova
Summary: By comparing the effects of rapamycin and trehalose in the treatment of Alzheimer's disease, it was found that trehalose can effectively induce autophagy and improve AD-related behavioral and neuronal deficits, with the best outcomes achieved with the combined treatment.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2022)
Review
Pharmacology & Pharmacy
Alexander B. Pupyshev, Tatyana P. Klyushnik, Anna A. Akopyan, Sandeep Kumar Singh, Maria A. Tikhonova
Summary: Trehalose is a promising approach for the treatment of neurodegenerative diseases through its induction of autophagy. It has anti-inflammatory, antioxidant, and neuroprotective effects, reducing the accumulation of abnormal proteins. Trehalose activates lysosome and autophagosome biogenesis pathways. However, further research is needed to understand its pharmacodynamics. Trehalose has demonstrated potential in treating diseases such as Alzheimer's, Parkinson's, and Huntington's in animal models.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Lili Cao, Siming Zhou, Xueshan Qiu, Shui Qiu
Summary: Trehalose can alleviate high fat-induced osteoporosis by modulating autophagy to inhibit apoptosis. Additionally, SIRT3 is also involved in the therapeutic effects of Trehalose.
Article
Neurosciences
Naoki Segi, Tomoya Ozaki, Yuji Suzuki, Jun Ouchida, Shiro Imagama, Kenji Kadomatsu, Kazuma Sakamoto
Summary: The autophagy-lysosome pathway is crucial for cellular clearance and cellular processes. Impairment of this pathway leads to human diseases, including neurodegenerative diseases and malignancies. In developing neurons, autophagy plays a role in axon determination.
EXPERIMENTAL NEUROLOGY
(2022)
Article
Virology
Alex E. Clark, Zhe Zhu, Florian Krach, Jeremy N. Rich, Gene W. Yeo, Deborah H. Spector
Summary: Trehalose has been shown to restrict ZIKV infection in neural progenitor cells and ZIKV primarily spreads cell-to-cell within these cells. Neutralizing antibodies are not effective in preventing ZIKV spread in neural progenitor cells.
JOURNAL OF VIROLOGY
(2021)
Article
Medicine, Research & Experimental
Yongli Wang, Xingcun Li, Hongliang Gao, Qian Lu
Summary: This study found that trehalose can delay the onset of postmenopausal osteoporosis in rats by inducing and enhancing autophagy flow through the Akt/TFEB pathway. The trehalose group showed better histological and cellular outcomes compared to the model group.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Hai-Jun He, Xi Xiong, Shuoting Zhou, Xing-Ru Zhang, Xuemiao Zhao, Lingli Chen, Cheng-Long Xie
Summary: The study shows that curcumin has neuroprotective effects in Parkinson's disease, both in vitro and in vivo. It inhibits cell apoptosis and induces autophagy through the AKT/mTOR signaling pathway. This leads to reduced accumulation of α-synuclein and improved parkinsonian disability scores.
NEUROCHEMISTRY INTERNATIONAL
(2022)
Article
Pharmacology & Pharmacy
Zhuangzhuang Li, Qingxiu Yao, Yuxin Tian, Yumeng Jiang, Maoxiang Xu, Hui Wang, Yuanping Xiong, Jia Fang, Wen Lu, Dongzhen Yu, Haibo Shi
Summary: Trehalose protects auditory cells from cisplatin-induced damage by enhancing autophagy and alleviating apoptosis, oxidative stress, and mitochondrial dysfunction.
BIOCHEMICAL PHARMACOLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Mario Cazzola, Paola Rogliani, Filomena Mazzeo, Maria Gabriella Matera
Summary: The Sputnik V COVID-19 vaccine, a vector vaccine, shows high efficacy above 97% in real world data, with the advantages of low cost and no need for ultra-cold storage. However, there are important shortcomings such as potential reduction in immunogenicity, decrease in antibody titres with age, and reduced neutralizing capacity against certain virus variants.
RESPIRATORY MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Anthony Cunha, Alexandra Gaubert, Julien Verget, Marie-Laure Thiolat, Philippe Barthelemy, Benjamin Dehay
Summary: This study proposes a new pharmaceutical technology that delivers trehalose using nanotechnology to restore autophagy function and treat neurodegenerative diseases.
Article
Food Science & Technology
Shanyao Pan, Shanshan Guo, Jiaru Dai, Yanrong Gu, Guoxiang Wang, Yulong Wang, Zhenghong Qin, Li Luo
Summary: Exercise and trehalose can improve learning and memory, activate autophagy, and modulate autophagy through different pathways in aged mice. However, a combination of exercise and trehalose does not exert synergistic effects.
FOOD SCIENCE AND HUMAN WELLNESS
(2022)
Article
Developmental Biology
Hang Zhao, Lin Shi, Ruiyan Kong, Zhengran Li, Fuli Liu, Huiqing Zhao, Zhouhua Li
Summary: The study revealed that autophagy in tumor neighboring cells promotes tumor growth, while nutrients from neighboring cells sustain tumor growth.
DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Rasha Abu-Khudir, Wafaa M. Ibrahim, Mohammed E. Shams, Afrah F. Salama
Summary: The study demonstrated that trehalose has cardioprotective effects against doxorubicin-induced cardiotoxicity, likely mediated through suppression of oxidative stress and autophagy.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Ziyu Wu, Min Zhou, Xueting Tang, Jiaqi Zeng, Yazhou Li, Yuning Sun, Jia Huang, Lin Chen, Mimi Wan, Chun Mao
Summary: The study reports a carrier-free nanomotor that utilizes nitric oxide (NO) as a driving force to induce autophagy of macrophages and improve abnormal lipid metabolism in atherosclerosis. The nanomotor achieves precise targeting and high biological availability with the use of trehalose, L-arginine, and phosphatidylserine.
Article
Biochemistry & Molecular Biology
Irene Benito-Cuesta, Lara Ordonez-Gutierrez, Francisco Wandosell
Summary: Trehalose has been shown to induce autophagy in neurons and protect against amyloid protein aggregation, reducing Aβ levels and modulating the interaction between APP and BACE1 to prevent amyloidogenic processing.